Tiam1 (TIAM Rac1 associated GEF 1) - Rat Genome Database

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Gene: Tiam1 (TIAM Rac1 associated GEF 1) Rattus norvegicus
Analyze
Symbol: Tiam1
Name: TIAM Rac1 associated GEF 1
RGD ID: 1307455
Description: Enables microtubule binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; positive regulation of Schwann cell chemotaxis; and positive regulation of neurogenesis. Located in several cellular components, including axon; postsynaptic density; and ruffle membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Colocalizes with microtubule. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with language delay and seizures. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: rho guanine nucleotide exchange factor TIAM1; T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,517,527 - 42,866,280 (-)NCBIGRCr8
mRatBN7.21129,031,347 - 29,380,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,031,348 - 29,159,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1137,718,984 - 37,847,530 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01130,419,012 - 30,547,477 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01129,580,961 - 29,709,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01129,931,083 - 30,061,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1129,933,163 - 30,051,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,551,577 - 33,681,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,123,752 - 30,252,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11130,128,732 - 30,252,936 (+)NCBI
Celera1128,721,403 - 28,849,496 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbofuran  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
Cuprizon  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (EXP,ISO)
isoprenaline  (EXP)
mercaptoethanol  (ISO)
methapyrilene  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quartz  (EXP)
rac-lactic acid  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
Soman  (EXP)
temozolomide  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1. Chandra R, etal., Front Mol Neurosci. 2013 May 24;6:13. doi: 10.3389/fnmol.2013.00013. eCollection 2013.
2. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. Connolly BA, etal., Mol Cell Biol. 2005 Jun;25(11):4602-14.
3. The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites. Duman JG, etal., J Neurosci. 2013 Apr 17;33(16):6964-78. doi: 10.1523/JNEUROSCI.3978-12.2013.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. Gupta VK, etal., Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.
7. The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells. Henriquez DR, etal., PLoS One. 2012;7(12):e53123. doi: 10.1371/journal.pone.0053123. Epub 2012 Dec 27.
8. Evidence for the involvement of Tiam1 in axon formation. Kunda P, etal., J Neurosci. 2001 Apr 1;21(7):2361-72.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Miyamoto Y, etal., Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10444-9. Epub 2006 Jun 26.
11. Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts. Otsuki Y, etal., J Biol Chem 2003 Feb 14;278(7):5132-40.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis. Qi H, etal., Cell Growth Differ. 2001 Dec;12(12):603-11.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
19. Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth. Shirazi Fard S, etal., PLoS One. 2010 Mar 19;5(3):e9647. doi: 10.1371/journal.pone.0009647.
20. The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Tolias KF, etal., Neuron. 2005 Feb 17;45(4):525-38.
21. Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells. Veluthakal R, etal., Biochem Pharmacol. 2009 Jan 1;77(1):101-13. doi: 10.1016/j.bcp.2008.09.021. Epub 2008 Sep 27.
22. A novel player in cellular hypertrophy: Gibetagamma/PI3K-dependent activation of the RacGEF TIAM-1 is required for alpha(1)-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes. Vettel C, etal., J Mol Cell Cardiol. 2012 Aug;53(2):165-75. doi: 10.1016/j.yjmcc.2012.04.015. Epub 2012 May 4.
23. NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migration. Xiao L, etal., Glia. 2013 Dec;61(12):2078-99. doi: 10.1002/glia.22578. Epub 2013 Oct 7.
24. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Yamauchi J, etal., Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14889-94. Epub 2005 Oct 3.
25. The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis. Zhang H and Macara IG, Nat Cell Biol. 2006 Mar;8(3):227-37. Epub 2006 Feb 12.
Additional References at PubMed
PMID:8889548   PMID:12024021   PMID:12525493   PMID:14988728   PMID:15723051   PMID:17440041   PMID:18006851   PMID:18805958   PMID:20332120   PMID:20361982   PMID:20826792   PMID:22750946  
PMID:23109420   PMID:23533177   PMID:25032858   PMID:25248834   PMID:25931508   PMID:31597723  


Genomics

Comparative Map Data
Tiam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,517,527 - 42,866,280 (-)NCBIGRCr8
mRatBN7.21129,031,347 - 29,380,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,031,348 - 29,159,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1137,718,984 - 37,847,530 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01130,419,012 - 30,547,477 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01129,580,961 - 29,709,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01129,931,083 - 30,061,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1129,933,163 - 30,051,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,551,577 - 33,681,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,123,752 - 30,252,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11130,128,732 - 30,252,936 (+)NCBI
Celera1128,721,403 - 28,849,496 (-)NCBICelera
Cytogenetic Map11q11NCBI
TIAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382131,118,418 - 31,559,087 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2131,118,416 - 31,559,977 (-)EnsemblGRCh38hg38GRCh38
GRCh372132,490,736 - 32,931,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,412,607 - 31,853,161 (-)NCBINCBI36Build 36hg18NCBI36
Build 342131,238,437 - 31,853,161NCBI
Celera2117,673,700 - 18,114,602 (-)NCBICelera
Cytogenetic Map21q22.11ENTREZGENE
HuRef2117,900,683 - 18,341,390 (-)NCBIHuRef
CHM1_12132,052,512 - 32,493,303 (-)NCBICHM1_1
T2T-CHM13v2.02129,486,163 - 29,927,068 (-)NCBIT2T-CHM13v2.0
Tiam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391689,583,999 - 89,942,488 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1689,583,999 - 89,940,657 (-)EnsemblGRCm39 Ensembl
GRCm381689,787,111 - 90,145,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1689,787,111 - 90,143,769 (-)EnsemblGRCm38mm10GRCm38
MGSCv371689,787,356 - 89,974,944 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361689,675,971 - 89,849,686 (-)NCBIMGSCv36mm8
Celera1689,988,286 - 90,179,618 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.5NCBI
Tiam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540730,803,653 - 30,942,854 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540730,804,769 - 31,178,420 (-)NCBIChiLan1.0ChiLan1.0
TIAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22227,233,667 - 27,675,376 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12122,092,736 - 22,319,849 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02117,483,273 - 17,925,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12130,868,308 - 31,213,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2130,868,308 - 31,016,883 (-)Ensemblpanpan1.1panPan2
TIAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13126,058,858 - 26,440,059 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3125,932,697 - 26,202,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3126,051,519 - 26,432,492 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03126,177,246 - 26,558,745 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3126,049,131 - 26,558,793 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13126,123,696 - 26,504,723 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03126,135,327 - 26,516,773 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03126,641,221 - 27,022,148 (-)NCBIUU_Cfam_GSD_1.0
Tiam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497126,655,584 - 27,016,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650010,688,236 - 10,812,192 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650010,451,599 - 10,812,239 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13194,774,497 - 195,005,089 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113194,774,495 - 195,235,750 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213205,172,464 - 205,307,819 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1260,573,187 - 61,015,599 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl260,865,819 - 61,017,191 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660713,120,127 - 3,563,047 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tiam1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474519,561,195 - 19,760,095 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474519,563,166 - 19,941,511 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tiam1
2445 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:402
Count of miRNA genes:218
Interacting mature miRNAs:258
Transcripts:ENSRNOT00000046486
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat

Markers in Region
D11Got22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21129,218,148 - 29,218,314 (+)MAPPERmRatBN7.2
Rnor_6.01130,119,772 - 30,119,937NCBIRnor6.0
Rnor_5.01133,740,395 - 33,740,560UniSTSRnor5.0
RGSC_v3.41130,064,375 - 30,064,541RGDRGSC3.4
RGSC_v3.41130,064,376 - 30,064,541UniSTSRGSC3.4
RGSC_v3.11130,064,376 - 30,064,541RGD
Celera1128,907,774 - 28,907,939UniSTS
RH 3.4 Map11195.7UniSTS
RH 3.4 Map11195.7RGD
RH 2.0 Map11480.6RGD
Cytogenetic Map11q11UniSTS
RH132417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21129,032,582 - 29,032,786 (+)MAPPERmRatBN7.2
Rnor_6.01129,932,318 - 29,932,521NCBIRnor6.0
Rnor_5.01133,552,812 - 33,553,015UniSTSRnor5.0
RGSC_v3.41130,251,498 - 30,251,701UniSTSRGSC3.4
Celera1128,722,640 - 28,722,843UniSTS
RH 3.4 Map11165.0UniSTS
Cytogenetic Map11q11UniSTS
RH132792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21129,031,568 - 29,031,757 (+)MAPPERmRatBN7.2
Rnor_6.01129,931,304 - 29,931,492NCBIRnor6.0
Rnor_5.01133,551,798 - 33,551,986UniSTSRnor5.0
RGSC_v3.41130,252,527 - 30,252,715UniSTSRGSC3.4
Celera1128,721,624 - 28,721,812UniSTS
RH 3.4 Map11165.0UniSTS
Cytogenetic Map11q11UniSTS
RH141943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21129,135,629 - 29,135,821 (+)MAPPERmRatBN7.2
Rnor_6.01130,036,774 - 30,036,965NCBIRnor6.0
Rnor_5.01133,656,825 - 33,657,016UniSTSRnor5.0
RGSC_v3.41130,149,500 - 30,149,691UniSTSRGSC3.4
Celera1128,825,226 - 28,825,417UniSTS
RH 3.4 Map11165.5UniSTS
Cytogenetic Map11q11UniSTS
AW532393  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21129,150,533 - 29,150,725 (+)MAPPERmRatBN7.2
Rnor_6.01130,051,658 - 30,051,849NCBIRnor6.0
Rnor_5.01133,672,451 - 33,672,642UniSTSRnor5.0
RGSC_v3.41130,132,891 - 30,133,082UniSTSRGSC3.4
Celera1128,840,124 - 28,840,315UniSTS
RH 3.4 Map11169.3UniSTS
Cytogenetic Map11q11UniSTS
TIAM1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21129,033,699 - 29,033,887 (+)MAPPERmRatBN7.2
Rnor_6.01129,933,435 - 29,933,622NCBIRnor6.0
Rnor_5.01133,553,929 - 33,554,116UniSTSRnor5.0
RGSC_v3.41130,250,397 - 30,250,584UniSTSRGSC3.4
Celera1128,723,757 - 28,723,944UniSTS
Cytogenetic Map11q11UniSTS
ha2436  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21129,138,963 - 29,139,703 (+)MAPPERmRatBN7.2
mRatBN7.21565,389,235 - 65,389,920 (+)MAPPERmRatBN7.2
Rnor_6.01130,040,126 - 30,040,865NCBIRnor6.0
Rnor_6.01572,750,995 - 72,751,679NCBIRnor6.0
Rnor_5.01133,660,708 - 33,661,447UniSTSRnor5.0
Rnor_5.01576,323,888 - 76,324,572UniSTSRnor5.0
Celera1564,851,043 - 64,851,727UniSTS
Celera1128,828,579 - 28,829,318UniSTS
Cytogenetic Map11q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 2 2 2 72 4 29
Low 3 29 41 25 19 25 7 7 2 31 12 11 7
Below cutoff 8 14 14 14 1 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046486   ⟹   ENSRNOP00000044001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,031,348 - 29,159,901 (-)Ensembl
Rnor_6.0 Ensembl1129,933,163 - 30,051,103 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109463   ⟹   ENSRNOP00000078510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,031,348 - 29,064,985 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109567   ⟹   ENSRNOP00000089482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,031,348 - 29,159,901 (-)Ensembl
RefSeq Acc Id: NM_001100558   ⟹   NP_001094028
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,517,528 - 42,646,082 (-)NCBI
mRatBN7.21129,031,348 - 29,159,908 (-)NCBI
Rnor_6.01129,931,083 - 30,061,173 (-)NCBI
Rnor_5.01133,551,577 - 33,681,966 (-)NCBI
RGSC_v3.41130,123,752 - 30,252,936 (+)RGD
Celera1128,721,403 - 28,849,496 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088429   ⟹   XP_038944357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,517,527 - 42,645,210 (-)NCBI
mRatBN7.21129,031,347 - 29,158,981 (-)NCBI
RefSeq Acc Id: XM_039088430   ⟹   XP_038944358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,517,527 - 42,866,280 (-)NCBI
mRatBN7.21129,031,347 - 29,380,153 (-)NCBI
RefSeq Acc Id: XM_039088432   ⟹   XP_038944360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,517,527 - 42,866,280 (-)NCBI
mRatBN7.21129,031,347 - 29,380,153 (-)NCBI
RefSeq Acc Id: XM_039088433   ⟹   XP_038944361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,517,527 - 42,702,888 (-)NCBI
mRatBN7.21129,031,347 - 29,216,696 (-)NCBI
RefSeq Acc Id: XM_039088434   ⟹   XP_038944362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,517,527 - 42,739,607 (-)NCBI
mRatBN7.21129,031,347 - 29,253,425 (-)NCBI
RefSeq Acc Id: XM_039088435   ⟹   XP_038944363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,517,527 - 42,551,263 (-)NCBI
mRatBN7.21129,031,347 - 29,065,036 (-)NCBI
RefSeq Acc Id: XM_063270597   ⟹   XP_063126667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,517,527 - 42,866,280 (-)NCBI
RefSeq Acc Id: XM_063270598   ⟹   XP_063126668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,517,527 - 42,692,908 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001094028   ⟸   NM_001100558
- UniProtKB: A0A8I6AC12 (UniProtKB/TrEMBL),   A6JLB5 (UniProtKB/TrEMBL),   D3ZWV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044001   ⟸   ENSRNOT00000046486
RefSeq Acc Id: XP_038944360   ⟸   XM_039088432
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AC12 (UniProtKB/TrEMBL),   A6JLB5 (UniProtKB/TrEMBL),   D3ZWV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944358   ⟸   XM_039088430
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AC12 (UniProtKB/TrEMBL),   A6JLB5 (UniProtKB/TrEMBL),   D3ZWV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944362   ⟸   XM_039088434
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AC12 (UniProtKB/TrEMBL),   A6JLB5 (UniProtKB/TrEMBL),   D3ZWV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944361   ⟸   XM_039088433
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AC12 (UniProtKB/TrEMBL),   A6JLB5 (UniProtKB/TrEMBL),   D3ZWV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944357   ⟸   XM_039088429
- Peptide Label: isoform X1
- UniProtKB: D3ZWV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944363   ⟸   XM_039088435
- Peptide Label: isoform X3
- UniProtKB: A0A8I6G1W3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078510   ⟸   ENSRNOT00000109463
RefSeq Acc Id: ENSRNOP00000089482   ⟸   ENSRNOT00000109567
RefSeq Acc Id: XP_063126667   ⟸   XM_063270597
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AC12 (UniProtKB/TrEMBL),   A6JLB5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126668   ⟸   XM_063270598
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AC12 (UniProtKB/TrEMBL),   A6JLB5 (UniProtKB/TrEMBL)
Protein Domains
DH   PDZ   PH   RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWV8-F1-model_v2 AlphaFold D3ZWV8 1-1590 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307455 AgrOrtholog
BioCyc Gene G2FUF-21970 BioCyc
Ensembl Genes ENSRNOG00000021569 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046486.6 UniProtKB/TrEMBL
  ENSRNOT00000109463.1 UniProtKB/TrEMBL
  ENSRNOT00000109567 ENTREZGENE
  ENSRNOT00000109567.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  6.10.140.680 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Raf-like_ras-bd UniProtKB/TrEMBL
  Tiam1/Tiam2/Sif UniProtKB/TrEMBL
  TIAM1_CC-Ex UniProtKB/TrEMBL
KEGG Report rno:304109 UniProtKB/TrEMBL
NCBI Gene 304109 ENTREZGENE
PANTHER PTHR46001 UniProtKB/TrEMBL
  PTHR46001:SF1 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  Tiam_CC_Ex UniProtKB/TrEMBL
PhenoGen Tiam1 PhenoGen
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021569 RatGTEx
SMART PDZ UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0A8I6AC12 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G1W3 ENTREZGENE, UniProtKB/TrEMBL
  A6JLB5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWV8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Tiam1  TIAM Rac1 associated GEF 1  Tiam1  T-cell lymphoma invasion and metastasis 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Tiam1  T-cell lymphoma invasion and metastasis 1  Tiam1_predicted  T-cell lymphoma invasion and metastasis 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tiam1_predicted  T-cell lymphoma invasion and metastasis 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED