Klhl1 (kelch-like family member 1) - Rat Genome Database

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Gene: Klhl1 (kelch-like family member 1) Rattus norvegicus
Analyze
Symbol: Klhl1
Name: kelch-like family member 1
RGD ID: 1307452
Description: Predicted to act upstream of or within adult walking behavior; cerebellar Purkinje cell layer development; and dendrite development. Predicted to be located in cytoplasm; dendrite; and neuronal cell body. Orthologous to human KLHL1 (kelch like family member 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kelch-like 1; kelch-like 1 (Drosophila); kelch-like protein 1; LOC290426
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81579,106,164 - 79,550,684 (-)NCBIGRCr8
mRatBN7.21572,698,191 - 73,142,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1572,699,094 - 73,142,594 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1576,715,916 - 77,145,753 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01577,801,146 - 78,231,047 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01574,740,051 - 75,169,929 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01580,270,846 - 80,714,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1580,271,731 - 80,713,153 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01583,810,351 - 84,250,513 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41579,306,914 - 79,772,396 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11579,322,860 - 79,787,587 (-)NCBI
Celera1571,996,058 - 72,423,584 (-)NCBICelera
Cytogenetic Map15q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10888605   PMID:16982692   PMID:17005861   PMID:17324934  


Genomics

Comparative Map Data
Klhl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81579,106,164 - 79,550,684 (-)NCBIGRCr8
mRatBN7.21572,698,191 - 73,142,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1572,699,094 - 73,142,594 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1576,715,916 - 77,145,753 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01577,801,146 - 78,231,047 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01574,740,051 - 75,169,929 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01580,270,846 - 80,714,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1580,271,731 - 80,713,153 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01583,810,351 - 84,250,513 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41579,306,914 - 79,772,396 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11579,322,860 - 79,787,587 (-)NCBI
Celera1571,996,058 - 72,423,584 (-)NCBICelera
Cytogenetic Map15q21NCBI
KLHL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381369,700,597 - 70,108,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1369,700,594 - 70,108,493 (-)EnsemblGRCh38hg38GRCh38
GRCh371370,274,729 - 70,682,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361369,172,726 - 69,580,460 (-)NCBINCBI36Build 36hg18NCBI36
Build 341369,172,726 - 69,580,460NCBI
Celera1351,176,734 - 51,584,696 (-)NCBICelera
Cytogenetic Map13q21.33NCBI
HuRef1350,976,143 - 51,384,644 (-)NCBIHuRef
CHM1_11370,242,241 - 70,650,179 (-)NCBICHM1_1
T2T-CHM13v2.01368,922,478 - 69,330,323 (-)NCBIT2T-CHM13v2.0
Klhl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391496,342,695 - 96,756,525 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1496,340,172 - 96,756,538 (-)EnsemblGRCm39 Ensembl
GRCm381496,105,265 - 96,519,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1496,102,736 - 96,519,102 (-)EnsemblGRCm38mm10GRCm38
MGSCv371496,504,484 - 96,918,253 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361494,988,399 - 95,402,168 (-)NCBIMGSCv36mm8
Celera1494,679,542 - 95,128,348 (-)NCBICelera
Cytogenetic Map14E2.1NCBI
cM Map1446.92NCBI
Klhl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540436,304,326 - 36,697,236 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540436,304,862 - 36,696,901 (+)NCBIChiLan1.0ChiLan1.0
KLHL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21471,257,066 - 71,685,817 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11369,847,850 - 70,276,570 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01350,906,581 - 51,335,692 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11369,694,185 - 70,119,241 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1369,691,537 - 70,118,448 (-)Ensemblpanpan1.1panPan2
KLHL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12224,190,862 - 24,554,451 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2224,191,778 - 24,555,120 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2224,044,013 - 24,406,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02224,501,555 - 24,889,956 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2224,502,463 - 24,889,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12224,144,239 - 24,507,168 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02224,230,744 - 24,587,985 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02224,289,783 - 24,660,217 (-)NCBIUU_Cfam_GSD_1.0
Klhl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945135,093,965 - 135,462,773 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651110,511,192 - 10,879,146 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651110,511,200 - 10,879,121 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1142,033,851 - 42,419,734 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11142,033,842 - 42,420,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,253,406 - 46,664,342 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1348,812,816 - 49,237,894 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl348,812,845 - 49,086,381 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660464,765,419 - 5,551,660 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474830,948,029 - 31,387,128 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474830,948,092 - 31,387,128 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhl1
4613 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:405
Count of miRNA genes:238
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000063800
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
724545Niddm54Non-insulin dependent diabetes mellitus QTL 540.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)155079449473699215Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)155284790873690657Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)156099046873690657Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
724548Niddm55Non-insulin dependent diabetes mellitus QTL 550.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)156832736073699069Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium 27
Low 43 4
Below cutoff 1 2 2 2 4 6 22

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000063800   ⟹   ENSRNOP00000061127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1572,699,094 - 73,142,594 (-)Ensembl
Rnor_6.0 Ensembl1580,271,731 - 80,713,153 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095779   ⟹   ENSRNOP00000082174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1572,699,094 - 73,142,168 (-)Ensembl
RefSeq Acc Id: NM_001394673   ⟹   NP_001381602
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81579,106,164 - 79,550,684 (-)NCBI
mRatBN7.21572,698,191 - 73,142,726 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001381602 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02406 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061127.1
  ENSRNOP00000082174
  ENSRNOP00000082174.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000061127   ⟸   ENSRNOT00000063800
RefSeq Acc Id: ENSRNOP00000082174   ⟸   ENSRNOT00000095779
RefSeq Acc Id: NP_001381602   ⟸   NM_001394673
- UniProtKB: A0A8I6G933 (UniProtKB/TrEMBL)
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9J8-F1-model_v2 AlphaFold D4A9J8 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307452 AgrOrtholog
BioCyc Gene G2FUF-12814 BioCyc
Ensembl Genes ENSRNOG00000031100 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063800.2 UniProtKB/TrEMBL
  ENSRNOT00000095779 ENTREZGENE
  ENSRNOT00000095779.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
KEGG Report rno:290426 UniProtKB/TrEMBL
NCBI Gene 290426 ENTREZGENE
PANTHER ACTIN-BINDING PROTEIN IPP UniProtKB/TrEMBL
  KELCH PROTEIN UniProtKB/TrEMBL
  KELCH-LIKE PROTEIN 1 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PhenoGen Klhl1 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031100 RatGTEx
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
UniProt A0A8I6G933 ENTREZGENE, UniProtKB/TrEMBL
  D4A9J8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-01 Klhl1  kelch-like family member 1  Klhl1  kelch-like 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Klhl1  kelch-like 1 (Drosophila)   Klhl1_predicted  kelch-like 1 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Klhl1_predicted  kelch-like 1 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED