Vil1 (villin 1) - Rat Genome Database

Name: Vil1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Vil1 (villin 1) Rattus norvegicus

Analyze

Symbol:

Vil1

Name:

villin 1

RGD ID:

1307048

Description:

Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ion binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including actin cytoskeleton organization; regulation of actin filament organization; and regulation of cell morphogenesis. Predicted to be located in several cellular components, including brush border; filopodium tip; and ruffle. Predicted to be active in actin cytoskeleton; cytoplasm; and lamellipodium. Orthologous to human VIL1 (villin 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 3,3',5,5'-tetrabromobisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC316521; Vil; villin; villin-1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	VIL1 (villin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Vil1 (villin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Vil1 (villin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	VIL1 (villin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	VIL1 (villin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Vil1 (villin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	VIL1 (villin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	VIL1 (villin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Vil1 (villin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	VIL1 (villin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Vil1 (villin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	vil1 (villin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gel	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gsnl-1	Alliance	DIOPT (OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	qua	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	vil1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	83,440,248 - 83,467,963 (+)	NCBI		GRCr8
mRatBN7.2	9	75,991,141 - 76,018,860 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	75,991,141 - 76,018,858 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	84,436,168 - 84,463,861 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	89,565,114 - 89,592,807 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	87,951,296 - 87,978,989 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	81,689,802 - 81,717,623 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	81,689,802 - 81,717,621 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	81,454,351 - 81,482,172 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	73,748,632 - 73,776,347 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	73,895,763 - 73,923,376 (+)	NCBI
Celera	9	73,564,428 - 73,592,138 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alacrima, achalasia, and impaired intellectual development syndrome (ISO)

cerebrotendinous xanthomatosis (ISO)

cholestasis (ISO)

genetic disease (ISO)

myofibrillar myopathy 1 (ISO)

Neurodevelopmental Disorders (ISO)

paroxysmal nonkinesigenic dyskinesia 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

andrographolide (ISO)

antirheumatic drug (ISO)

arsenic acid (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

caffeine (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (EXP)

copper(II) sulfate (ISO)

cordycepin (ISO)

cyclosporin A (ISO)

DAPT (EXP)

deoxynivalenol (ISO)

diarsenic trioxide (ISO)

dichloroacetic acid (ISO)

dodecanoic acid (ISO)

endosulfan (EXP)

folic acid (ISO)

furan (EXP)

genistein (ISO)

L-methionine (ISO)

MeIQx (ISO)

methotrexate (ISO)

N-Nitrosopyrrolidine (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

quercetin (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

tanespimycin (ISO)

Theaflavin 3,3'-digallate (ISO)

tributylstannane (ISO)

trichloroethene (ISO)

triclosan (ISO)

triptonide (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament capping (ISO)

actin filament depolymerization (ISO)

actin filament polymerization (ISO)

actin filament severing (IBA,ISO)

actin polymerization or depolymerization (IBA)

barbed-end actin filament capping (IBA,ISO)

biological_process (ND)

cellular response to epidermal growth factor stimulus (ISO)

cellular response to hepatocyte growth factor stimulus (ISO)

cytoplasmic actin-based contraction involved in cell motility (ISO)

epidermal growth factor receptor signaling pathway (ISO)

epithelial cell differentiation (ISO)

intestinal D-glucose absorption (ISO)

microvillus assembly (ISO)

positive regulation of actin filament bundle assembly (ISO)

positive regulation of actin filament depolymerization (ISO)

positive regulation of cell migration (ISO)

positive regulation of epithelial cell migration (ISO)

positive regulation of lamellipodium morphogenesis (ISO)

positive regulation of multicellular organism growth (ISO)

positive regulation of protein localization to plasma membrane (ISO)

regulation of actin nucleation (ISO)

regulation of cell shape (ISO)

regulation of lamellipodium morphogenesis (IBA,ISO)

regulation of microvillus length (ISO)

regulation of wound healing (ISO)

response to bacterium (ISO)

terminal web assembly (ISO)

Cellular Component

actin cytoskeleton (IBA)

actin filament bundle (ISO)

brush border (ISO)

cytoplasm (IBA)

filopodium (ISO)

filopodium tip (ISO)

lamellipodium (IBA,ISO)

microvillus (ISO)

plasma membrane (ISO)

ruffle (ISO)

Molecular Function

actin filament binding (IBA,ISO)

calcium ion binding (ISO)

cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ISO)

identical protein binding (ISO)

lysophosphatidic acid binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (IBA,ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:11500485	PMID:12477932	PMID:12937273	PMID:14594952	PMID:15096633	PMID:15272027	PMID:15342783	PMID:16008578	PMID:16921170	PMID:17182858	PMID:17229814	PMID:17606613
PMID:18054784	PMID:18198174	PMID:19056867	PMID:19808673	PMID:21492153	PMID:21606356	PMID:22114352	PMID:23376485	PMID:25002582	PMID:28704336

Genomics

Comparative Map Data

Vil1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	83,440,248 - 83,467,963 (+)	NCBI		GRCr8
mRatBN7.2	9	75,991,141 - 76,018,860 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	75,991,141 - 76,018,858 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	84,436,168 - 84,463,861 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	89,565,114 - 89,592,807 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	87,951,296 - 87,978,989 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	81,689,802 - 81,717,623 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	81,689,802 - 81,717,621 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	81,454,351 - 81,482,172 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	73,748,632 - 73,776,347 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	73,895,763 - 73,923,376 (+)	NCBI
Celera	9	73,564,428 - 73,592,138 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

VIL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	218,419,123 - 218,453,295 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	218,419,121 - 218,453,295 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	219,283,846 - 219,318,018 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	218,996,722 - 219,022,489 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	219,113,984 - 219,139,746	NCBI
Celera	2	213,050,445 - 213,080,856 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	211,136,728 - 211,167,137 (+)	NCBI		HuRef
CHM1_1	2	219,290,456 - 219,320,861 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	218,905,241 - 218,939,415 (+)	NCBI		T2T-CHM13v2.0

Vil1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	74,448,543 - 74,474,719 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	74,448,535 - 74,474,718 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	74,409,384 - 74,435,560 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	74,409,376 - 74,435,559 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	74,455,958 - 74,482,134 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	74,342,613 - 74,368,721 (+)	NCBI		MGSCv36	mm8
Celera	1	74,966,841 - 74,993,216 (+)	NCBI		Celera
Cytogenetic Map	1	C3	NCBI
cM Map	1	38.54	NCBI

Vil1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	14,935,456 - 14,961,011 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	14,935,450 - 14,961,011 (-)	NCBI	ChiLan1.0	ChiLan1.0

VIL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	121,048,369 - 121,080,415 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	121,063,336 - 121,095,726 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	105,677,371 - 105,711,293 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	224,274,548 - 224,304,550 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	224,274,548 - 224,304,550 (+)	Ensembl	panpan1.1		panPan2

VIL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	25,065,887 - 25,090,238 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	25,065,180 - 25,090,705 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	25,885,686 - 25,911,804 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	25,081,617 - 25,107,747 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	25,080,855 - 25,106,518 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	24,986,923 - 25,013,216 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	24,920,579 - 24,946,677 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	24,940,950 - 24,966,867 (+)	NCBI		UU_Cfam_GSD_1.0

Vil1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	174,571,737 - 174,595,717 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936569	914,512 - 938,608 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936569	914,511 - 938,481 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VIL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	120,463,566 - 120,492,580 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	120,463,470 - 120,494,772 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	133,479,112 - 133,508,225 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VIL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	104,311,048 - 104,350,846 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	104,320,074 - 104,347,289 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	95,055,245 - 95,084,515 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Vil1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624823	6,566,687 - 6,588,599 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624823	6,567,107 - 6,593,258 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Vil1
84 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	82
Count of miRNA genes:	66
Interacting mature miRNAs:	68
Transcripts:	ENSRNOT00000021432
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	55847841	77026453	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	56627713	78595166	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	9	56627713	78595166	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56627713	78595166	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	61381434	104821652	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	62072275	96470995	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	62072275	96470995	Rat
61385	Edpm9	Estrogen-dependent pituitary mass QTL 9	3.43	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	63869687	108869687	Rat
731171	Glom6	Glomerulus QTL 6	2.8	0.0003	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	9	64573531	109573531	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	75712843	111552878	Rat

Markers in Region

RH129981

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	76,018,883 - 76,019,040 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	81,717,647 - 81,717,803	NCBI	Rnor6.0
Rnor_5.0	9	81,482,196 - 81,482,352	UniSTS	Rnor5.0
RGSC_v3.4	9	73,776,371 - 73,776,527	UniSTS	RGSC3.4
Celera	9	73,592,162 - 73,592,318	UniSTS
RH 3.4 Map	9	709.2	UniSTS
Cytogenetic Map	9	q33	UniSTS

RH133743

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	76,018,543 - 76,018,761 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	81,717,307 - 81,717,524	NCBI	Rnor6.0
Rnor_5.0	9	81,481,856 - 81,482,073	UniSTS	Rnor5.0
RGSC_v3.4	9	73,776,031 - 73,776,248	UniSTS	RGSC3.4
Celera	9	73,591,822 - 73,592,039	UniSTS
RH 3.4 Map	9	709.89	UniSTS
Cytogenetic Map	9	q33	UniSTS

D9Mco100

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	75,990,039 - 75,990,271 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	81,688,713 - 81,688,944	NCBI	Rnor6.0
Rnor_5.0	9	81,453,262 - 81,453,493	UniSTS	Rnor5.0
Celera	9	73,563,319 - 73,563,550	UniSTS
Cytogenetic Map	9	q33	UniSTS

GDB:542905

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	76,018,119 - 76,018,214 (+)	MAPPER	mRatBN7.2
mRatBN7.2	4	33,575,924 - 33,576,019 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	30,530,901 - 30,530,995	NCBI	Rnor6.0
Rnor_6.0	9	81,716,883 - 81,716,977	NCBI	Rnor6.0
Rnor_5.0	9	81,481,432 - 81,481,526	UniSTS	Rnor5.0
Rnor_5.0	4	30,437,827 - 30,437,921	UniSTS	Rnor5.0
RGSC_v3.4	4	30,219,425 - 30,219,519	UniSTS	RGSC3.4
RGSC_v3.4	9	73,775,607 - 73,775,701	UniSTS	RGSC3.4
Celera	9	73,591,398 - 73,591,492	UniSTS
Celera	4	29,102,522 - 29,102,616	UniSTS
Cytogenetic Map	4	q13	UniSTS
Cytogenetic Map	9	q33	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	6	2	2		2				29	4
Low		20	34	31		31			2	6	36	9
Below cutoff		15	21	8	16	8	3	5	57		1	2	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000021432 ⟹ ENSRNOP00000021432

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	75,991,141 - 76,018,858 (+)	Ensembl
Rnor_6.0 Ensembl	9	81,689,802 - 81,717,621 (+)	Ensembl

RefSeq Acc Id:

NM_001108224 ⟹ NP_001101694

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	83,440,248 - 83,467,963 (+)	NCBI
mRatBN7.2	9	75,991,141 - 76,018,860 (+)	NCBI
Rnor_6.0	9	81,689,802 - 81,717,623 (+)	NCBI
Rnor_5.0	9	81,454,351 - 81,482,172 (+)	NCBI
RGSC_v3.4	9	73,748,632 - 73,776,347 (+)	RGD
Celera	9	73,564,428 - 73,592,138 (+)	RGD

Sequence:

show sequence

CAGGGACCTGGGCACCTACTTCCCCACCCCCTCATCCATTCTCTCTGGGGCCCTATCTTCCCTT
ATATGGTGAAGGAAGTTCCTGGGGGTGGGGGGGTGAGGACAAAGGTCGGTCTCCTGCAGCCAGC
TTGCCACAACTTCCTAAGATCTCCCAGGTGGTGGCTGCCTCTTCCAGACAGGCTCATCCACCAT
GACTAAACTGACTGCCCAAGTCAAAGGCTCTCTCAACACCACCACTCCAGGAATACAAATATGG
AGGATAGAGGCTATGCAGATGGTGCCGGTTCCTTCCAGCACCTTTGGAAGCTTCTTCGATGGTG
ACTGCTATGTAGTCCTGGCTATCCACAAGACCGGCAGCACCCTCTCCTACGATATCCACTACTG
GATTGGCCAGGACTCGTCCCAGGATGAGCAGGGGGCAGCTGCCATCTACACAACACAGATGGAT
GACTACCTGAAGGGCCGGGCTGTCCAGCACCGTGAGGTCCAAGGCCATGAGAGCGACACATTCC
GGAGCTACTTCAAGCAAGGCCTTGTGATCCGGAAAGGGGGCGTGGCTTCTGGCATGAAGCACGT
AGAAACAAACTCCTGTGATGTCCAGCGACTGTTGCACGTCAAGGGCAAGAGGAATGTGCTGGCT
GGAGAGGTGGAAATGTCCTGGAAGAGTTTCAACAGAGGGGATGTCTTCCTGCTGGACCTTGGGA
AGCTTATCATCCAGTGGAATGGGCCAGAGAGTAACCGCATGGAGAGACTTCGGGGCATGACCTT
GGCCAAAGAGATCCGAGACCAGGAGCGGGGTGGACGCACCTACGTAGGCGTGGTGGATGGGGAG
AATGAAGGGGACTCCCCACAGCTGATGGCAATTATGAACCACGTGCTGGGCCCACGCAAGGAAC
TAAAGGCTGCAATTTCTGACTCAGTGGTGGAGCCGGCCGCTAAGGCTGCACTCAAGCTGTACCA
TGTGTCTGATTCAGAAGGAAAAATGGTGGTTAGAGAAGTTGCTACTCAGCCACTCACACAGGAC
TTGCTCAGCCATGAGGACTGTTACATCCTGGACCAGGGAGGCCTGAAGATCTTTGTGTGGAAGG
GAAAAAATGCCAATGCCCAGGAGAGGAGCGGAGCCATGAACCAGGCTTTGAACTTCATCAAAGC
CAAGCAGTACCCACCTAGCACGCAGGTTGAGGTGCAGAATGATGGGGCTGAGTCCGCCATTTTC
CAGCAGCTCTTCCAGAAGTGGACAGTGCCCAATCGGACCTCAGGCCTTGGCAAAACCCACACAG
TGGGCTCTGTGGCCAAGGTGGAACAGGTGAAGTTTGATGCTCTGTCCATGCACGTACGGCCTCA
AGTGGCTGCCCAGCAGAAAATGGTGGATGACGGGAGTGGGGAAGTGCAGGTGTGGCGCATCGAG
GACTTAGAGCTGGTGCCTGTGGAGTCCAAGTGGCTGGGCCATTTCTATGGCGGCGACTGCTACC
TGCTGCTCTATACCTACCTCATAGGCGAGAAGGAGCACTACTTGCTGTATATCTGGCAGGGCAG
CCAGGCCAGCCAGGATGAAATTGCAGCCTCGGCTTACCAAGCTGTCAACCTGGACCAGAAGTAC
AACGACGAGCCAGTGCAGATCCGGGTCACGATGGGCAAGGAGCCGCCGCACCTCATGTCTATCT
TCAAGGGGCGCATGGTGGTTTATCAGGGAGGCACCTCCCGAAAGAACAACGTGGAGCCCGTGCC
CTCTACAAGGCTGTTTCAGGTCCGAGGGACCAGTGCTGATAACACCAAGGCTTTTGAGGTTACA
GCCCGGGCCACCTCCCTCAACTCCAATGATGTCTTCATACTCAAGACTCCGTCCTGCTGCTACC
TGTGGTGTGGAAAGGGCTGCAGTGGGGATGAGCGGGAGATGGCCAAGATGGTTGCTGATACCAT
CTCTCGGACAGAGAAACAAGTGGTGGTCGAGGGGCAGGAGCCAGCCAACTTCTGGATGGCTCTG
GGTGGGAAGGCGCCATATGCCAACACCAAGAGGCTGCAGGAGGAAAACCAAGTCATCACTCCTC
GGCTCTTTGAGTGCTCCAACCAGACTGGGCGCTTTCTGGCCACAGAGATCTTTGACTTCACTCA
GGACGACCTGGAAGAGGATGATGTGTTCCTATTGGATGTCTGGGACCAGGTCTTCTTCTGGATA
GGGAAACACGCCAACGAGGAAGAGAAGAAGGCTGCAGCTACAACTGCACAGGAATACCTCAAGA
CCCACCCCGGAAACAGAGACCCTGAGACCCCTATCATTGTGGTGAAGCAGGGGCACGAGCCCTC
CACCTTCACAGGCTGGTTCCTGGCTTGGGATCCCTTCAAGTGGAGTAACACCAAATCTTATGAT
GACCTCAAGGCCGAGTTGGGAAACTCTGGGGACTGGAGCCAGATTGCTGATGAGGTTATGAGCC
CCAAAGTGGATGTTTTCACTGCCAATACCAGCTTCAGTTCTGGGCCCTTGCCCATCTATCCCCT
GGAGCAGCTGGTAAACAAGCCTGTGGAGGAGCTCCCTGAGGGTGTGGACCCCACCAGGAAGGAG
GAGCACCTGTCCACTGAAGATTTCACTAAGGCTTTGGGGATGACTCCAGCTGCCTTCTCTGCGC
TGCCTCGATGGAAGCAACAAAACCTCAAGAAGGAGAAAGGACTGTTTTGAGAACTGAAGCTCAG
CGTCCAGCAGCTCCTACCCTGCCTTCAAGCCTCCTCCCCACCCCCCATTACTGGCTTTAGTCCT
GTGCCAGTTGAAAATGTCCAATTGTATCTGTGAACCACAGTGTGAAAGTTCCTTCTGTTTATAA
TAGTAATCTGCCCATTCCTTTAGAAATATGCCACAGCCCAGTGGAGTCTTGTTCTAGAGTTTTC
CTTCCTTAGAGCAGCTGAGTACTCCAGGAGACATAGCACCTGGGCTTTTCTCTCAGCTTATCCC
TCACAGCAGGGAGTTGGGGAGTGTTTGGCAGTTTGAAGTCATTCCCACAGAGAGGTCTTTCCTC
ATTGCTGAGGGACCTGTTTTTTGAAAGCTAAAGCCTACAAGGAAGTACTGAGAATCAGGTGTTG
TCTCATCCTCTTTCATACTCAAAAGGGGAAGCTAAGGCCAAGGCTGGGCTTACAAGCTGTAACT
CAGAAGCCTTTGTAAAGCTTCACAGACTCCTCAAATGACAACACCAGGATCATGGGTTTGCTAC
ATGAAGTCCAATCAGAAGCCGACAGAAGGTGATTTTCTCTTAAAACAACTGGTTATCCAGTGTC
CCCAGGAACATGTCCCTTTAAATAAATAAGTCAAACTAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101694	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68981	(Get FASTA)	NCBI Sequence Viewer
	EDL75355	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021432
	ENSRNOP00000021432.4

RefSeq Acc Id:

NP_001101694 ⟸ NM_001108224

- UniProtKB:

B5DFA0 (UniProtKB/TrEMBL), A6JVU7 (UniProtKB/TrEMBL), F7F8Y1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTKLTAQVKGSLNTTTPGIQIWRIEAMQMVPVPSSTFGSFFDGDCYVVLAIHKTGSTLSYDIHY
WIGQDSSQDEQGAAAIYTTQMDDYLKGRAVQHREVQGHESDTFRSYFKQGLVIRKGGVASGMKH
VETNSCDVQRLLHVKGKRNVLAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESNRMERLRGMT
LAKEIRDQERGGRTYVGVVDGENEGDSPQLMAIMNHVLGPRKELKAAISDSVVEPAAKAALKLY
HVSDSEGKMVVREVATQPLTQDLLSHEDCYILDQGGLKIFVWKGKNANAQERSGAMNQALNFIK
AKQYPPSTQVEVQNDGAESAIFQQLFQKWTVPNRTSGLGKTHTVGSVAKVEQVKFDALSMHVRP
QVAAQQKMVDDGSGEVQVWRIEDLELVPVESKWLGHFYGGDCYLLLYTYLIGEKEHYLLYIWQG
SQASQDEIAASAYQAVNLDQKYNDEPVQIRVTMGKEPPHLMSIFKGRMVVYQGGTSRKNNVEPV
PSTRLFQVRGTSADNTKAFEVTARATSLNSNDVFILKTPSCCYLWCGKGCSGDEREMAKMVADT
ISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQEENQVITPRLFECSNQTGRFLATEIFDFT
QDDLEEDDVFLLDVWDQVFFWIGKHANEEEKKAAATTAQEYLKTHPGNRDPETPIIVVKQGHEP
STFTGWFLAWDPFKWSNTKSYDDLKAELGNSGDWSQIADEVMSPKVDVFTANTSFSSGPLPIYP
LEQLVNKPVEELPEGVDPTRKEEHLSTEDFTKALGMTPAAFSALPRWKQQNLKKEKGLF

hide sequence

RefSeq Acc Id:

ENSRNOP00000021432 ⟸ ENSRNOT00000021432

Protein Domains

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DFA0-F1-model_v2	AlphaFold	B5DFA0	1-827	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696753

Promoter ID:

EPDNEW_R7277

Type:

multiple initiation site

Name:

Vil1_1

Description:

villin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	81,689,935 - 81,689,995	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307048	AgrOrtholog
BioCyc Gene	G2FUF-27132	BioCyc
Ensembl Genes	ENSRNOG00000015408	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021432	ENTREZGENE
	ENSRNOT00000021432.6	UniProtKB/TrEMBL
Gene3D-CATH	1.10.950.10	UniProtKB/TrEMBL
	3.40.20.10	UniProtKB/TrEMBL
InterPro	ADF-H/Gelsolin-like_dom	UniProtKB/TrEMBL
	Gelsolin	UniProtKB/TrEMBL
	Gelsolin-like_dom_sf	UniProtKB/TrEMBL
	Gelsolin_dom	UniProtKB/TrEMBL
	Villin_headpiece	UniProtKB/TrEMBL
	Villin_headpiece_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:316521	UniProtKB/TrEMBL
NCBI Gene	316521	ENTREZGENE
PANTHER	Gelsolin	UniProtKB/TrEMBL
	PTHR11977:SF35	UniProtKB/TrEMBL
Pfam	Gelsolin	UniProtKB/TrEMBL
	VHP	UniProtKB/TrEMBL
PhenoGen	Vil1	PhenoGen
PRINTS	GELSOLIN	UniProtKB/TrEMBL
PROSITE	PS51089	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015408	RatGTEx
SMART	GEL	UniProtKB/TrEMBL
	VHP	UniProtKB/TrEMBL
Superfamily-SCOP	Actin depolymerizing proteins	UniProtKB/TrEMBL
	SSF82754	UniProtKB/TrEMBL
	VHP	UniProtKB/TrEMBL
UniProt	A6JVU7	ENTREZGENE, UniProtKB/TrEMBL
	B5DFA0	ENTREZGENE
	F7F8Y1	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	B5DFA0	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Vil1	villin 1	Vil1_predicted	villin 1 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Vil1_predicted	villin 1 (predicted)	Vil_predicted	villin (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Vil_predicted	villin (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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