(-)-epigallocatechin 3-gallate increases expression ISO AKR1C1 (Homo sapiens) 6480464 epigallocatechin gallate results in increased expression of AKR1C1 mRNA CTD PMID:32512070 (E)-cinnamyl alcohol increases expression ISO AKR1C1 (Homo sapiens) 6480464 cinnamyl alcohol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 (S)-naringenin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 naringenin binds to and results in decreased activity of AKR1C1 protein CTD PMID:16962702 1,10-phenanthroline decreases activity ISO AKR1C1 (Homo sapiens) 6480464 1 and 10-phenanthroline results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 1,2-dichloroethane decreases expression ISO Akr1c6 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of AKR1C6 mRNA CTD PMID:28189721 and PMID:28960355 1,7-phenanthroline decreases activity ISO AKR1C1 (Homo sapiens) 6480464 1 and 7-phenanthroline results in decreased activity of AKR1C1 protein CTD PMID:8573067 1,8-Dinitropyrene multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein results in increased degradation of 1 and 8-dinitropyrene] which results in increased abundance of 1-amino-8-nitropyrene CTD PMID:36399404 1-Aminopyrene multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene CTD PMID:36399404 1-chloro-2,4-dinitrobenzene increases expression ISO AKR1C1 (Homo sapiens) 6480464 Dinitrochlorobenzene results in increased expression of AKR1C1 mRNA CTD PMID:20566472 1-naphthyl isothiocyanate decreases expression ISO Akr1c6 (Mus musculus) 6480464 1-Naphthylisothiocyanate results in decreased expression of AKR1C6 mRNA CTD PMID:15913567 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of AKR1C1 mRNA CTD PMID:25380136 1-nitropyrene multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene CTD PMID:36399404 17beta-estradiol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Estradiol results in increased expression of AKR1C1 mRNA CTD PMID:19619570 17beta-estradiol multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C1 mRNA CTD PMID:19619570 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 Flufenamic Acid inhibits the reaction [AKR1C1 protein results in increased metabolism of Dihydrotestosterone] CTD PMID:14672942 17beta-hydroxy-5alpha-androstan-3-one increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of Dihydrotestosterone CTD PMID:14672942 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Akr1c6 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C6 mRNA CTD PMID:21354282 and PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1C1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C1 mRNA and Tetrachlorodibenzodioxin results in decreased expression of AKR1C6 mRNA CTD PMID:18796159 and PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Akr1c6 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1C6 mRNA CTD PMID:26377647 2,3-dimethoxynaphthalene-1,4-dione increases expression ISO AKR1C1 (Homo sapiens) 6480464 2 more ... CTD PMID:9973208 2,6-dinitrotoluene affects expression EXP 6480464 2 and 6-dinitrotoluene affects the expression of AKR1C6 mRNA CTD PMID:21346803 2-hydroxypropanoic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 Lactic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20566472 and PMID:30851411 2-tert-butylhydroquinone increases expression ISO AKR1C1 (Homo sapiens) 6480464 2-tert-butylhydroquinone results in increased expression of AKR1C1 mRNA CTD PMID:30806763 and PMID:9973208 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:30744511 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO Akr1c6 (Mus musculus) 6480464 3 more ... CTD PMID:19467301 3,3',5-triiodo-L-thyronine increases expression ISO AKR1C1 (Homo sapiens) 6480464 Triiodothyronine results in increased expression of AKR1C1 mRNA CTD PMID:15507505 3,4,5,3',4',5'-Hexachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:30744511 3,4-dichloroaniline increases expression ISO AKR1C1 (Homo sapiens) 6480464 3 and 4-dichloroaniline results in increased expression of AKR1C1 mRNA CTD PMID:24172598 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA CTD PMID:28628672 3-methylcholanthrene increases expression ISO AKR1C1 (Homo sapiens) 6480464 Methylcholanthrene results in increased expression of AKR1C1 mRNA CTD PMID:9973208 3-Nitrobenzanthrone increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone CTD PMID:30406992 3-Nitrobenzanthrone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone and [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone CTD PMID:30406992 3-phenylprop-2-enal increases expression ISO AKR1C1 (Homo sapiens) 6480464 cinnamaldehyde results in increased expression of AKR1C1 mRNA CTD PMID:19524605 3alpha-hydroxy-5beta-pregnan-20-one affects metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the metabolism of Pregnanolone CTD PMID:12604236 3alpha-hydroxy-5beta-pregnan-20-one increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of Pregnanolone CTD PMID:11995921 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of AKR1C1 mRNA CTD PMID:25380136 4,4'-sulfonyldiphenol multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol increases expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol S results in increased expression of AKR1C1 protein CTD PMID:34186270 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:11306090 4-hydroxybenzoic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 4-hydroxybenzoic acid analog results in decreased activity of AKR1C1 protein CTD PMID:27163852 4-hydroxyphenyl retinamide increases expression ISO AKR1C1 (Homo sapiens) 6480464 Fenretinide results in increased expression of AKR1C1 mRNA CTD PMID:16671099 4-phenylbutyric acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 4-phenylbutyric acid results in increased expression of AKR1C1 mRNA CTD PMID:14583596 5-alpha-THDOC affects oxidation ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the oxidation of tetrahydrodeoxycorticosterone CTD PMID:12604236 5-fluorouracil affects expression ISO AKR1C1 (Homo sapiens) 6480464 Fluorouracil affects the expression of AKR1C1 mRNA CTD PMID:16584549 5-fluorouracil affects response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 5alpha-pregnane-3,20-dione affects reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the reduction of 5-alpha-Dihydroprogesterone CTD PMID:12604236 5alpha-pregnane-3,20-dione increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of 5-alpha-Dihydroprogesterone CTD PMID:11995921 7-hydroxyflavone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 7-hydroxyflavone binds to and results in decreased activity of AKR1C1 protein CTD PMID:16962702 9,10-phenanthroquinone increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of 9 and 10-phenanthrenequinone CTD PMID:17950253 9,10-phenanthroquinone increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of 9 and 10-phenanthrenequinone CTD PMID:21851338 and PMID:23261716 9,10-phenanthroquinone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of and affects the activity of 9 and 10-phenanthrenequinone CTD PMID:21910479 9-cis-retinal increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of 9-cis-retinal CTD PMID:21851338 acetylsalicylic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Aspirin results in decreased activity of AKR1C1 protein CTD PMID:19010312 aflatoxin B1 decreases expression ISO Akr1c6 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of AKR1C6 mRNA CTD PMID:19770486 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of AKR1C1 mRNA CTD PMID:22484513 aflatoxin B1 decreases methylation ISO AKR1C1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of AKR1C1 gene CTD PMID:27153756 aldehydo-D-glucose multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of AKR1C6 mRNA CTD PMID:37567420 alpha-hexylcinnamaldehyde increases expression ISO AKR1C1 (Homo sapiens) 6480464 hexyl cinnamic aldehyde results in increased expression of AKR1C1 mRNA CTD PMID:20566472 amiodarone increases expression ISO AKR1C1 (Homo sapiens) 6480464 Amiodarone results in increased expression of AKR1C1 mRNA CTD PMID:21163907 anthranilic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 anthranilic acid analog results in decreased activity of AKR1C1 protein CTD PMID:19007763 arsane increases expression ISO AKR1C1 (Homo sapiens) 6480464 Arsenic results in increased expression of AKR1C1 mRNA CTD PMID:36861143 arsenic atom increases expression ISO AKR1C1 (Homo sapiens) 6480464 Arsenic results in increased expression of AKR1C1 mRNA CTD PMID:36861143 arsenite(3-) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA and SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA] CTD PMID:31781319 arsenous acid decreases response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 arsenous acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA and Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C1 protein] CTD PMID:25913414 and PMID:26598702 astilbin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 avobenzone increases expression ISO AKR1C1 (Homo sapiens) 6480464 avobenzone results in increased expression of AKR1C1 mRNA CTD PMID:31016361 azathioprine increases expression ISO AKR1C1 (Homo sapiens) 6480464 Azathioprine results in increased expression of AKR1C1 mRNA CTD PMID:22623647 Bandrowski's base increases expression ISO AKR1C1 (Homo sapiens) 6480464 Bandrowski's base results in increased expression of AKR1C1 mRNA CTD PMID:20566472 benzbromarone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 Benzbromarone binds to and results in decreased activity of AKR1C1 protein CTD PMID:12604236 Benzo[a]fluorene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzo(a)fluorene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 benzo[a]pyrene decreases expression ISO Akr1c6 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of AKR1C6 mRNA CTD PMID:19770486 benzo[a]pyrene multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Butyric Acid co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA more ... CTD PMID:17612574 more ... benzo[a]pyrene decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of AKR1C1 mRNA CTD PMID:16545412 benzo[a]pyrene increases expression ISO AKR1C1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of AKR1C1 mRNA CTD PMID:15735009 more ... benzo[a]pyrene affects response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the susceptibility to Benzo(a)pyrene CTD PMID:19800895 Benzo[a]pyrene-7,8-diol multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 and 8-dihydrodiol CTD PMID:21910479 benzo[a]pyrene-7,8-dione increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzo(a)pyrene-7 and 8-dione results in increased expression of AKR1C1 mRNA CTD PMID:9973208 benzo[a]pyrene-7,8-dione multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7 and 8-dione CTD PMID:21910479 benzo[b]fluoranthene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzo(b)fluoranthene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 Benzo[b]fluorene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzo(b)fluorene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 Benzo[k]fluoranthene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzo(k)fluoranthene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 benzoic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 Benzoic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20566472 beta-naphthoflavone increases expression ISO AKR1C1 (Homo sapiens) 6480464 beta-Naphthoflavone results in increased expression of AKR1C1 mRNA CTD PMID:17253728 and PMID:32151702 bexarotene increases expression ISO AKR1C1 (Homo sapiens) 6480464 Bexarotene results in increased expression of AKR1C1 mRNA CTD PMID:17178900 bis(2-ethylhexyl) phthalate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of AKR1C1 mRNA CTD PMID:28412506 bisphenol A increases expression ISO Akr1c6 (Mus musculus) 6480464 bisphenol A results in increased expression of AKR1C6 mRNA CTD PMID:30245210 bisphenol A increases expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol A results in increased expression of AKR1C1 protein CTD PMID:34186270 bisphenol A decreases methylation ISO AKR1C1 (Homo sapiens) 6480464 bisphenol A results in decreased methylation of AKR1C1 gene CTD PMID:31601247 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of AKR1C1 mRNA CTD PMID:30903817 bisphenol A affects expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol A affects the expression of AKR1C1 mRNA CTD PMID:30903817 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of AKR1C1 mRNA CTD PMID:32145629 Bisphenol B increases expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol B results in increased expression of AKR1C1 protein CTD PMID:34186270 bisphenol F increases expression ISO AKR1C1 (Homo sapiens) 6480464 bisphenol F results in increased expression of AKR1C1 protein CTD PMID:34186270 bortezomib increases expression ISO AKR1C1 (Homo sapiens) 6480464 Bortezomib results in increased expression of AKR1C1 mRNA CTD PMID:21215737 bortezomib multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA CTD PMID:25913414 butyric acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Butyric Acid co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA CTD PMID:30439556 cadmium atom increases expression ISO AKR1C1 (Homo sapiens) 6480464 Cadmium results in increased expression of AKR1C1 mRNA CTD PMID:21172416 cadmium atom multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AKR1C1 mRNA CTD PMID:29741670 and PMID:31738976 cadmium dichloride multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AKR1C1 mRNA CTD PMID:29741670 and PMID:31738976 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of AKR1C1 mRNA CTD PMID:25993096 cadmium sulfate multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA CTD PMID:18654764 calcitriol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Calcitriol results in increased expression of AKR1C1 mRNA CTD PMID:12040012 and PMID:21592394 calcitriol multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of AKR1C1 mRNA CTD PMID:21592394 carbon nanotube decreases expression ISO Akr1c6 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25620056 carmustine affects response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 mRNA affects the susceptibility to Carmustine CTD PMID:16365179 celastrol increases expression ISO AKR1C1 (Homo sapiens) 6480464 celastrol results in increased expression of AKR1C1 mRNA CTD PMID:17010675 CGP 52608 multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to AKR1C1 gene] CTD PMID:28238834 chenodeoxycholic acid decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Chenodeoxycholic Acid results in decreased expression of AKR1C1 mRNA CTD PMID:27174168 chlorohydrocarbon multiple interactions EXP 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in decreased expression of AKR1C1 mRNA CTD PMID:30744511 chrysene increases expression ISO AKR1C1 (Homo sapiens) 6480464 chrysene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 ciglitazone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [ciglitazone binds to PPARG protein alternative form] which results in increased expression of AKR1C1 mRNA and [ciglitazone binds to PPARG protein] which results in increased expression of AKR1C1 mRNA CTD PMID:16197558 cinnamyl alcohol increases expression ISO AKR1C1 (Homo sapiens) 6480464 cinnamyl alcohol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 cisplatin increases expression ISO AKR1C1 (Homo sapiens) 6480464 Cisplatin results in increased expression of AKR1C1 mRNA CTD PMID:23165153 and PMID:27392435 cisplatin decreases response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in decreased susceptibility to Cisplatin CTD PMID:20953859 and PMID:23165153 cisplatin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA more ... CTD PMID:23165153 more ... clofibrate multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of AKR1C6 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AKR1C6 mRNA] CTD PMID:17585979 Clofop increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of fenofibric acid CTD PMID:27599626 cloxazolam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 cloxazolam results in decreased activity of AKR1C1 protein CTD PMID:12604236 cobalt atom multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA CTD PMID:20105288 cobalt dichloride multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA CTD PMID:18654764 cobalt dichloride increases expression ISO AKR1C1 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of AKR1C1 mRNA CTD PMID:20105288 coniferyl aldehyde increases expression ISO AKR1C1 (Homo sapiens) 6480464 coniferaldehyde results in increased expression of AKR1C1 mRNA and coniferaldehyde results in increased expression of AKR1C1 protein CTD PMID:26275128 coniferyl aldehyde multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein] CTD PMID:26275128 copper atom multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1C1 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1C1 mRNA CTD PMID:20971185 copper(II) sulfate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of AKR1C1 mRNA CTD PMID:19549813 coumarin decreases expression EXP 6480464 coumarin results in decreased expression of AKR1C6 mRNA CTD PMID:18480146 crotonaldehyde increases expression ISO AKR1C1 (Homo sapiens) 6480464 2-butenal results in increased expression of AKR1C1 mRNA CTD PMID:20471460 cyclopentanol increases oxidation ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased oxidation of cyclopentanol CTD PMID:23261716 cyclopentanone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 NADP promotes the reaction [AKR1C1 protein results in increased reduction of cyclopentanone] CTD PMID:23261716 cyclopentanone increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of cyclopentanone CTD PMID:23261716 cyclosporin A increases expression ISO AKR1C1 (Homo sapiens) 6480464 Cyclosporine results in increased expression of AKR1C1 mRNA CTD PMID:25562108 cylindrospermopsin decreases expression ISO Akr1c6 (Mus musculus) 6480464 cylindrospermopsin results in decreased expression of AKR1C6 mRNA CTD PMID:20936652 D-glucose multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of AKR1C6 mRNA CTD PMID:37567420 dexamethasone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA CTD PMID:28628672 dexamethasone increases expression ISO AKR1C1 (Homo sapiens) 6480464 Dexamethasone results in increased expression of AKR1C1 mRNA CTD PMID:25047013 diallyl trisulfide increases expression ISO AKR1C1 (Homo sapiens) 6480464 diallyl trisulfide results in increased expression of AKR1C1 mRNA CTD PMID:34995734 diarsenic trioxide multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA and Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C1 protein] CTD PMID:25913414 and PMID:26598702 diarsenic trioxide decreases response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 diazepam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Diazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 and PMID:12604236 Dibenz[a,c]anthracene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzotriphenylene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 dibenz[a,h]anthracene increases expression ISO AKR1C1 (Homo sapiens) 6480464 1 more ... CTD PMID:17253728 dibenzo[a,l]pyrene multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Particulate Matter co-treated with dibenzo(a more ... CTD PMID:17612574 dibutyl phthalate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Dibutyl Phthalate results in increased expression of AKR1C1 mRNA CTD PMID:18214805 dicoumarol decreases activity EXP 6480464 Dicumarol results in decreased activity of AKR1C6 protein CTD PMID:16788056 dienogest decreases expression ISO AKR1C1 (Homo sapiens) 6480464 dienogest results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 dimethylarsinous acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 dimethylarsinous acid results in increased expression of AKR1C1 mRNA CTD PMID:23487506 diquat increases expression ISO AKR1C1 (Homo sapiens) 6480464 Diquat results in increased expression of AKR1C1 mRNA CTD PMID:21172416 disulfiram increases expression ISO AKR1C1 (Homo sapiens) 6480464 Disulfiram results in increased expression of AKR1C1 mRNA CTD PMID:20566472 diuron increases expression ISO AKR1C1 (Homo sapiens) 6480464 Diuron metabolite results in increased expression of AKR1C1 mRNA CTD PMID:24172598 dorsomorphin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 dutasteride increases expression ISO AKR1C1 (Homo sapiens) 6480464 Dutasteride results in increased expression of AKR1C1 mRNA CTD PMID:16806904 dydrogesterone increases expression ISO AKR1C1 (Homo sapiens) 6480464 Dydrogesterone results in increased expression of AKR1C1 mRNA CTD PMID:23183084 dydrogesterone increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of Dydrogesterone CTD PMID:21182831 dydrogesterone decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Dydrogesterone results in decreased activity of AKR1C1 protein CTD PMID:21182831 dydrogesterone decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Dydrogesterone results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 entinostat decreases expression ISO AKR1C1 (Homo sapiens) 6480464 entinostat results in decreased expression of AKR1C1 mRNA CTD PMID:27188386 estazolam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Estazolam results in decreased activity of AKR1C1 protein CTD PMID:11995921 etacrynic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 Ethacrynic Acid results in increased expression of AKR1C1 mRNA CTD PMID:9973208 ethyl methanesulfonate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of AKR1C1 mRNA CTD PMID:23649840 eugenol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Eugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 farnesol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Farnesol results in increased expression of AKR1C1 mRNA CTD PMID:30806763 fenamic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 fenamic acid analog results in decreased activity of AKR1C1 protein CTD PMID:19010312 flufenamic acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 Flufenamic Acid inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin] and Flufenamic Acid inhibits the reaction [AKR1C1 protein results in increased metabolism of Dihydrotestosterone] CTD PMID:14672942 and PMID:23933386 flufenamic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Flufenamic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 flunitrazepam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Flunitrazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 flurbiprofen decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Flurbiprofen results in decreased activity of AKR1C1 protein CTD PMID:19010312 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 fructose multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of AKR1C6 mRNA CTD PMID:37567420 furan decreases expression EXP 6480464 furan results in decreased expression of AKR1C1 mRNA CTD PMID:25539665 gamma-linolenic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 gamma-Linolenic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20664735 gedunin increases expression ISO AKR1C1 (Homo sapiens) 6480464 gedunin results in increased expression of AKR1C1 mRNA CTD PMID:17010675 genistein decreases activity EXP 6480464 Genistein results in decreased activity of AKR1C6 protein CTD PMID:16788056 geraniol increases expression ISO AKR1C1 (Homo sapiens) 6480464 geraniol results in increased expression of AKR1C1 mRNA CTD PMID:30806763 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 glimepiride decreases activity ISO AKR1C1 (Homo sapiens) 6480464 glimepiride results in decreased activity of AKR1C1 protein CTD PMID:26362498 glipizide decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Glipizide results in decreased activity of AKR1C1 protein CTD PMID:26362498 glucose multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of AKR1C6 mRNA CTD PMID:37567420 glyburide decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Glyburide results in decreased activity of AKR1C1 protein CTD PMID:26362498 glycidyl methacrylate decreases expression ISO AKR1C1 (Homo sapiens) 6480464 glycidyl methacrylate results in decreased expression of AKR1C1 protein CTD PMID:36641056 glycyrrhetinate decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 glycyrrhetinic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 glyphosate multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose co-treated with Glyphosate] results in decreased expression of AKR1C6 mRNA CTD PMID:37567420 hexane increases expression ISO AKR1C1 (Homo sapiens) 6480464 n-hexane results in increased expression of AKR1C1 mRNA CTD PMID:20566472 hexestrol decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Hexestrol results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 hydrogen peroxide decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of AKR1C1 protein CTD PMID:34581912 hydrogen peroxide multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 mRNA and [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 protein CTD PMID:19320734 hydrogen peroxide increases expression ISO AKR1C1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of AKR1C1 mRNA CTD PMID:9973208 ibuprofen decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Ibuprofen results in decreased activity of AKR1C1 protein CTD PMID:19010312 Indeno[1,2,3-cd]pyrene increases expression ISO AKR1C1 (Homo sapiens) 6480464 indeno(1 more ... CTD PMID:17253728 indometacin decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Indomethacin results in decreased activity of AKR1C1 protein CTD PMID:12604236 more ... indometacin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA CTD PMID:28628672 isoeugenol increases expression ISO AKR1C1 (Homo sapiens) 6480464 isoeugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 ivermectin decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of AKR1C1 protein CTD PMID:32959892 lead diacetate increases expression ISO AKR1C1 (Homo sapiens) 6480464 lead acetate results in increased expression of AKR1C1 mRNA CTD PMID:22839698 lead(0) affects splicing ISO AKR1C1 (Homo sapiens) 6480464 Lead affects the splicing of AKR1C1 mRNA CTD PMID:28903495 lead(II) chloride increases expression ISO AKR1C1 (Homo sapiens) 6480464 lead chloride results in increased expression of AKR1C1 mRNA CTD PMID:18654764 lead(II) chloride multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA CTD PMID:18654764 leflunomide decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Leflunomide results in decreased expression of AKR1C1 mRNA CTD PMID:28988120 leflunomide decreases expression EXP 6480464 Leflunomide results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 lipopolysaccharide multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [S-(1 more ... CTD PMID:35811015 lithocholic acid affects binding ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein binds to Lithocholic Acid CTD PMID:8573067 lithocholic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Lithocholic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 malathion increases expression ISO AKR1C1 (Homo sapiens) 6480464 Malathion results in increased expression of AKR1C1 mRNA CTD PMID:16079077 and PMID:18214805 meclofenamic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Meclofenamic Acid results in decreased activity of AKR1C1 protein CTD PMID:19010312 more ... Medazepam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Medazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 and PMID:12604236 medroxyprogesterone acetate decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Medroxyprogesterone Acetate results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:21182831 medroxyprogesterone acetate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Medroxyprogesterone Acetate results in increased expression of AKR1C1 mRNA CTD PMID:18497975 and PMID:23183084 medroxyprogesterone acetate decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Medroxyprogesterone Acetate results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 mefenamic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Mefenamic Acid analog results in decreased activity of AKR1C1 protein CTD PMID:19010312 menadione affects expression ISO AKR1C1 (Homo sapiens) 6480464 Vitamin K 3 affects the expression of AKR1C1 mRNA CTD PMID:20044591 mercury dibromide multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 mercury dibromide increases expression ISO AKR1C1 (Homo sapiens) 6480464 mercuric bromide results in increased expression of AKR1C1 mRNA CTD PMID:26272509 methidathion decreases expression ISO Akr1c6 (Mus musculus) 6480464 methidathion results in decreased expression of AKR1C6 mRNA CTD PMID:34813904 methyl methanesulfonate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of AKR1C1 mRNA CTD PMID:23649840 methyl salicylate increases expression ISO AKR1C1 (Homo sapiens) 6480464 methyl salicylate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 methylmercury chloride multiple interactions EXP 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in decreased expression of AKR1C1 mRNA CTD PMID:30744511 methylmercury chloride increases expression ISO AKR1C1 (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of AKR1C1 mRNA CTD PMID:28001369 monosodium L-glutamate increases expression ISO Akr1c6 (Mus musculus) 6480464 Sodium Glutamate results in increased expression of AKR1C6 mRNA CTD PMID:25473020 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] CTD PMID:23165153 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO AKR1C1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1C1 mRNA CTD PMID:21215737 and PMID:23165153 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AKR1C6 mRNA CTD PMID:28943392 N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of AKR1C1 mRNA CTD PMID:25380136 NAD zwitterion multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol more ... CTD PMID:25446855 NAD(+) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol more ... CTD PMID:25446855 NADP zwitterion multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:21910479 and PMID:23261716 NADP(+) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:21910479 and PMID:23261716 naproxen decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Naproxen results in decreased activity of AKR1C1 protein CTD PMID:19010312 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 neoastilbin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 nickel sulfate increases expression ISO AKR1C1 (Homo sapiens) 6480464 nickel sulfate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 nitrazepam decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Nitrazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 norethisterone decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Norethindrone results in decreased activity of AKR1C1 protein CTD PMID:21182831 ochratoxin A decreases expression ISO AKR1C1 (Homo sapiens) 6480464 ochratoxin A results in decreased expression of AKR1C1 mRNA CTD PMID:19287073 and PMID:32905824 octadecanoic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 stearic acid results in increased expression of AKR1C1 mRNA CTD PMID:32347412 octyl gallate decreases activity ISO AKR1C1 (Homo sapiens) 6480464 octyl gallate results in decreased activity of AKR1C1 protein CTD PMID:27163852 oxaliplatin multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 alpha-methylcinnamic acid inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin] more ... CTD PMID:23933386 oxaliplatin affects response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the susceptibility to Oxaliplatin CTD PMID:23933386 oxcarbazepine increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of Oxcarbazepine CTD PMID:25063510 p-chloromercuribenzoic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in increased expression of AKR1C1 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 paracetamol affects expression ISO Akr1c6 (Mus musculus) 6480464 Acetaminophen affects the expression of AKR1C6 mRNA CTD PMID:17562736 paracetamol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of AKR1C1 mRNA CTD PMID:21420995 paracetamol decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of AKR1C1 mRNA CTD PMID:26690555 paracetamol decreases expression ISO Akr1c6 (Mus musculus) 6480464 Acetaminophen results in decreased expression of AKR1C6 mRNA CTD PMID:11264010 and PMID:17585979 paracetamol multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of AKR1C6 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AKR1C6 mRNA] CTD PMID:17585979 Paraoxon-methyl multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon] CTD PMID:19800895 Paraoxon-methyl increases expression ISO AKR1C1 (Homo sapiens) 6480464 methylparaoxon results in increased expression of AKR1C1 mRNA CTD PMID:19800895 parathion-methyl increases activity ISO AKR1C1 (Homo sapiens) 6480464 Methyl Parathion results in increased activity of AKR1C1 protein CTD PMID:19800895 parathion-methyl increases expression ISO AKR1C1 (Homo sapiens) 6480464 Methyl Parathion results in increased expression of AKR1C1 mRNA CTD PMID:19800895 parathion-methyl multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion] more ... CTD PMID:19800895 perfluorooctane-1-sulfonic acid affects expression ISO Akr1c6 (Mus musculus) 6480464 perfluorooctane sulfonic acid affects the expression of AKR1C6 mRNA CTD PMID:19429403 perfluorooctane-1-sulfonic acid multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of AKR1C6 mRNA CTD PMID:36331819 perfluorooctanoic acid affects expression ISO Akr1c6 (Mus musculus) 6480464 perfluorooctanoic acid affects the expression of AKR1C6 mRNA CTD PMID:19429403 perfluorooctanoic acid decreases expression ISO AKR1C1 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of AKR1C1 mRNA CTD PMID:23978341 phenethyl caffeate decreases activity ISO AKR1C1 (Homo sapiens) 6480464 caffeic acid phenethyl ester results in decreased activity of AKR1C1 protein CTD PMID:27163852 phenobarbital decreases expression ISO Akr1c6 (Mus musculus) 6480464 Phenobarbital results in decreased expression of AKR1C6 protein CTD PMID:35881160 phenolphthalein decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Phenolphthalein results in decreased activity of AKR1C1 protein CTD PMID:12604236 phenolphthalein multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 Phenolphthalein inhibits the reaction [AKR1C1 protein affects the susceptibility to Oxaliplatin] CTD PMID:23933386 phenylmercury acetate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of AKR1C1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 pirinixic acid multiple interactions ISO Akr1c6 (Mus musculus) 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of AKR1C6 mRNA CTD PMID:20813756 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of AKR1C1 mRNA CTD PMID:22484513 pirinixic acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AKR1C1 mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO Akr1c6 (Mus musculus) 6480464 pirinixic acid results in decreased expression of AKR1C6 mRNA CTD PMID:20813756 potassium dichromate affects expression ISO Akr1c6 (Mus musculus) 6480464 Potassium Dichromate affects the expression of AKR1C6 mRNA CTD PMID:23608068 pregnenolone 16alpha-carbonitrile decreases expression ISO Akr1c6 (Mus musculus) 6480464 Pregnenolone Carbonitrile results in decreased expression of AKR1C6 mRNA CTD PMID:28903501 progesterone affects reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the reduction of Progesterone CTD PMID:12604236 and PMID:16338060 progesterone increases reduction ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased reduction of Progesterone CTD PMID:11995921 and PMID:22245609 progesterone decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Progesterone results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 progesterone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein affects the metabolism of and results in decreased activity of Progesterone CTD PMID:16962702 propan-2-ol increases expression ISO AKR1C1 (Homo sapiens) 6480464 2-Propanol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 prostaglandin G2 increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of prostaglandin G2 CTD PMID:8573067 pyrimidine decreases activity ISO AKR1C1 (Homo sapiens) 6480464 pyrimidine analog results in decreased activity of AKR1C1 protein CTD PMID:19007763 quercetin decreases activity EXP 6480464 Quercetin results in decreased activity of AKR1C6 protein CTD PMID:16788056 quinolin-8-ol increases expression ISO AKR1C1 (Homo sapiens) 6480464 Oxyquinoline results in increased expression of AKR1C1 mRNA CTD PMID:21632981 quinomethionate affects expression ISO AKR1C1 (Homo sapiens) 6480464 quinomethionate affects the expression of AKR1C1 mRNA CTD PMID:15387888 quinomethionate increases expression ISO AKR1C1 (Homo sapiens) 6480464 quinomethionate results in increased expression of AKR1C1 mRNA CTD PMID:18214805 rac-lactic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 Lactic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20566472 and PMID:30851411 reactive oxygen species increases expression ISO AKR1C1 (Homo sapiens) 6480464 Reactive Oxygen Species results in increased expression of AKR1C1 mRNA CTD PMID:9973208 reactive oxygen species multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 mRNA and [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 protein CTD PMID:19320734 resorcinol increases expression ISO AKR1C1 (Homo sapiens) 6480464 resorcinol results in increased expression of AKR1C1 mRNA CTD PMID:30806763 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of AKR1C1 mRNA CTD PMID:28374803 S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [S-(1 more ... CTD PMID:35811015 S-(1,2-dichlorovinyl)-L-cysteine increases expression ISO AKR1C1 (Homo sapiens) 6480464 S-(1 and 2-dichlorovinyl)cysteine results in increased expression of AKR1C1 mRNA CTD PMID:35811015 salicylic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Salicylic Acid results in decreased activity of AKR1C1 protein CTD PMID:19010312 and PMID:23165153 salicylic acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] and Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin] CTD PMID:23165153 SB 431542 multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of AKR1C1 mRNA CTD PMID:25895662 silver atom multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 NFE2L2 protein promotes the reaction [Silver results in increased expression of AKR1C1 mRNA] CTD PMID:22036727 silver atom increases expression ISO AKR1C1 (Homo sapiens) 6480464 Silver results in increased expression of AKR1C1 mRNA CTD PMID:22036727 silver(0) increases expression ISO AKR1C1 (Homo sapiens) 6480464 Silver results in increased expression of AKR1C1 mRNA CTD PMID:22036727 silver(0) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 NFE2L2 protein promotes the reaction [Silver results in increased expression of AKR1C1 mRNA] CTD PMID:22036727 simvastatin increases expression ISO AKR1C1 (Homo sapiens) 6480464 Simvastatin results in increased expression of AKR1C1 mRNA CTD PMID:17428261 sodium arsenate increases expression ISO AKR1C1 (Homo sapiens) 6480464 sodium arsenate results in increased expression of AKR1C1 mRNA CTD PMID:12727804 sodium arsenite increases expression ISO Akr1c6 (Mus musculus) 6480464 sodium arsenite results in increased expression of AKR1C6 mRNA and sodium arsenite results in increased expression of AKR1C6 protein CTD PMID:17077188 and PMID:29044176 sodium arsenite affects expression ISO AKR1C1 (Homo sapiens) 6480464 sodium arsenite affects the expression of AKR1C1 mRNA CTD PMID:29319823 sodium arsenite multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA and SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA] CTD PMID:31781319 sodium arsenite increases expression ISO AKR1C1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of AKR1C1 mRNA and sodium arsenite results in increased expression of AKR1C1 protein CTD PMID:19696165 more ... sodium arsenite decreases expression ISO Akr1c6 (Mus musculus) 6480464 sodium arsenite results in decreased expression of AKR1C6 mRNA CTD PMID:17350061 and PMID:17451858 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of AKR1C1 mRNA CTD PMID:25993096 sodium dodecyl sulfate increases expression ISO AKR1C1 (Homo sapiens) 6480464 Sodium Dodecyl Sulfate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 sulforaphane increases expression ISO AKR1C1 (Homo sapiens) 6480464 sulforaphane results in increased expression of AKR1C1 mRNA CTD PMID:24383545 more ... sulforaphane multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 NFE2L2 protein affects the reaction [sulforaphane results in increased expression of AKR1C1 mRNA] CTD PMID:31518892 sulindac decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Sulindac results in decreased activity of AKR1C1 protein CTD PMID:19010312 sulindac sulfide increases expression ISO AKR1C1 (Homo sapiens) 6480464 sulindac sulfide results in increased expression of AKR1C1 mRNA CTD PMID:16184548 sunitinib decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Sunitinib results in decreased expression of AKR1C1 mRNA CTD PMID:31533062 temozolomide affects response to substance ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 mRNA affects the susceptibility to Temozolomide CTD PMID:16365179 tert-butyl hydroperoxide increases expression ISO AKR1C1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of AKR1C1 mRNA CTD PMID:15336504 testosterone increases oxidation EXP 6480464 AKR1C6 protein results in increased oxidation of Testosterone CTD PMID:16788056 testosterone multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of AKR1C1 mRNA CTD PMID:21592394 testosterone increases expression ISO AKR1C1 (Homo sapiens) 6480464 Testosterone results in increased expression of AKR1C1 mRNA CTD PMID:21592394 testosterone enanthate affects expression ISO AKR1C1 (Homo sapiens) 6480464 testosterone enanthate affects the expression of AKR1C1 mRNA CTD PMID:17440010 tetrachloromethane decreases expression ISO Akr1c6 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of AKR1C6 mRNA CTD PMID:31919559 tetraphene increases expression ISO AKR1C1 (Homo sapiens) 6480464 benz(a)anthracene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 and PMID:22236718 thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AKR1C6 mRNA CTD PMID:28943392 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of AKR1C1 mRNA CTD PMID:23411599 more ... titanium dioxide affects expression ISO Akr1c6 (Mus musculus) 6480464 titanium dioxide affects the expression of AKR1C6 mRNA CTD PMID:23557971 tofacitinib increases metabolic processing ISO AKR1C1 (Homo sapiens) 6480464 AKR1C1 protein results in increased metabolism of tofacitinib metabolite CTD PMID:27117606 tolcapone affects binding EXP 6480464 Tolcapone binds to AKR1C1 protein CTD PMID:19783845 trans-isoeugenol increases expression ISO AKR1C1 (Homo sapiens) 6480464 isoeugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of AKR1C1 gene CTD PMID:27618143 trichostatin A multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 trichostatin A increases expression ISO AKR1C1 (Homo sapiens) 6480464 trichostatin A results in increased expression of AKR1C1 mRNA CTD PMID:24935251 and PMID:26272509 triclosan decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Triclosan results in decreased expression of AKR1C1 mRNA CTD PMID:30510588 Triptolide decreases expression ISO Akr1c6 (Mus musculus) 6480464 triptolide results in decreased expression of AKR1C6 mRNA CTD PMID:32835833 tris(2-butoxyethyl) phosphate decreases expression ISO AKR1C1 (Homo sapiens) 6480464 tris(2-butoxyethyl) phosphate results in decreased expression of AKR1C1 mRNA CTD PMID:29024780 Tungsten carbide multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA CTD PMID:20105288 Tungsten carbide decreases expression ISO AKR1C1 (Homo sapiens) 6480464 tungsten carbide results in decreased expression of AKR1C1 mRNA CTD PMID:20105288 urethane decreases expression ISO AKR1C1 (Homo sapiens) 6480464 Urethane results in decreased expression of AKR1C1 mRNA CTD PMID:28818685 ursodeoxycholic acid decreases activity ISO AKR1C1 (Homo sapiens) 6480464 Ursodeoxycholic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 valdecoxib decreases expression EXP 6480464 valdecoxib results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 valproic acid affects expression ISO Akr1c6 (Mus musculus) 6480464 Valproic Acid affects the expression of AKR1C6 mRNA CTD PMID:17292431 valproic acid multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 valproic acid increases expression ISO AKR1C1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of AKR1C1 mRNA CTD PMID:23179753 more ... vitamin D increases expression ISO AKR1C1 (Homo sapiens) 6480464 Vitamin D results in increased expression of AKR1C1 mRNA and Vitamin D results in increased expression of AKR1C1 protein CTD PMID:30698894 vorinostat increases expression ISO AKR1C1 (Homo sapiens) 6480464 Vorinostat results in increased expression of AKR1C1 mRNA CTD PMID:26272509 vorinostat multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 zinc atom multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [PCI 5002 co-treated with Zinc] results in decreased expression of AKR1C1 mRNA CTD PMID:18593933 zinc(0) multiple interactions ISO AKR1C1 (Homo sapiens) 6480464 [PCI 5002 co-treated with Zinc] results in decreased expression of AKR1C1 mRNA CTD PMID:18593933 zomepirac decreases activity ISO AKR1C1 (Homo sapiens) 6480464 zomepirac results in decreased activity of AKR1C1 protein CTD PMID:19010312