Vav2 (vav guanine nucleotide exchange factor 2) - Rat Genome Database

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Gene: Vav2 (vav guanine nucleotide exchange factor 2) Rattus norvegicus
Analyze
Symbol: Vav2
Name: vav guanine nucleotide exchange factor 2
RGD ID: 1306285
Description: Predicted to enable epidermal growth factor receptor binding activity; guanyl-nucleotide exchange factor activity; and phosphotyrosine residue binding activity. Predicted to be involved in cell migration and regulation of cell size. Predicted to act upstream of or within lamellipodium assembly; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and small GTPase-mediated signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Orthologous to human VAV2 (vav guanine nucleotide exchange factor 2); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; erythropoietin signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: guanine nucleotide exchange factor VAV2; LOC108350342; LOC296603; uncharacterized LOC108350342; vav 2 guanine nucleotide exchange factor; Vav2 oncogene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,982,754 - 31,152,116 (-)NCBIGRCr8
mRatBN7.2310,584,688 - 10,754,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,584,688 - 10,754,052 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,651,677 - 13,821,126 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,237,080 - 22,406,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,492,356 - 20,661,812 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,811,504 - 5,976,311 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,811,504 - 5,976,244 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,173,752 - 11,337,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,153,681 - 6,347,676 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.136,155,986 - 6,347,501 (-)NCBI
Celera35,380,148 - 5,548,591 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetohydrazide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
choline  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
doxorubicin  (ISO)
fenthion  (ISO)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
indole-3-methanol  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
permethrin  (EXP)
phenobarbital  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
selenic acid  (ISO)
sodium arsenite  (ISO)
superoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Tubeimoside II  (ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
plasma membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8990121   PMID:15728722   PMID:19029489   PMID:19755152   PMID:20335460   PMID:20624904   PMID:21810271   PMID:22467863   PMID:26224100  


Genomics

Comparative Map Data
Vav2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,982,754 - 31,152,116 (-)NCBIGRCr8
mRatBN7.2310,584,688 - 10,754,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,584,688 - 10,754,052 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,651,677 - 13,821,126 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,237,080 - 22,406,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,492,356 - 20,661,812 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,811,504 - 5,976,311 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,811,504 - 5,976,244 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,173,752 - 11,337,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,153,681 - 6,347,676 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.136,155,986 - 6,347,501 (-)NCBI
Celera35,380,148 - 5,548,591 (-)NCBICelera
Cytogenetic Map3p12NCBI
VAV2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,761,894 - 133,992,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,761,894 - 133,992,604 (-)EnsemblGRCh38hg38GRCh38
GRCh379136,627,016 - 136,857,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,616,837 - 135,847,226 (-)NCBINCBI36Build 36hg18NCBI36
Build 349133,656,570 - 133,886,959NCBI
Celera9107,174,789 - 107,404,640 (-)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9106,127,910 - 106,303,677 (-)NCBIHuRef
CHM1_19136,775,446 - 137,005,937 (-)NCBICHM1_1
T2T-CHM13v2.09145,977,670 - 146,207,128 (-)NCBIT2T-CHM13v2.0
Vav2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,152,116 - 27,317,620 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl227,152,116 - 27,317,045 (-)EnsemblGRCm39 Ensembl
GRCm38227,262,104 - 27,427,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,262,104 - 27,427,033 (-)EnsemblGRCm38mm10GRCm38
MGSCv37227,119,155 - 27,282,345 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36227,085,644 - 27,248,836 (-)NCBIMGSCv36mm8
Celera226,966,692 - 27,129,427 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.36NCBI
Vav2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,985,246 - 3,121,324 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,985,246 - 3,121,324 (-)NCBIChiLan1.0ChiLan1.0
VAV2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,361,720 - 5,593,549 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,364,289 - 5,595,883 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,883,197 - 105,115,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,492,314 - 133,690,708 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,494,481 - 133,668,036 (-)Ensemblpanpan1.1panPan2
VAV2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,103,004 - 50,232,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,094,447 - 50,230,954 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,384,008 - 49,543,991 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,977,087 - 51,137,042 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,977,257 - 51,137,583 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,738,436 - 49,898,214 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0950,081,036 - 50,241,047 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0950,158,900 - 50,319,194 (-)NCBIUU_Cfam_GSD_1.0
Vav2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947200,140,891 - 200,272,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,112,499 - 3,232,212 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,062,538 - 3,234,167 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAV2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,303,144 - 273,476,207 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,303,142 - 273,476,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,276,069 - 307,449,195 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VAV2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,142,966 - 4,377,849 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,143,139 - 4,377,852 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058616,999 - 702,000 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vav2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247602,081,796 - 2,201,934 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247602,081,796 - 2,201,520 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vav2
574 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:342
Count of miRNA genes:188
Interacting mature miRNAs:238
Transcripts:ENSRNOT00000009893
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat

Markers in Region
U37017  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,586,484 - 10,586,678 (+)MAPPERmRatBN7.2
Rnor_6.035,813,301 - 5,813,494NCBIRnor6.0
Rnor_5.0311,175,549 - 11,175,742UniSTSRnor5.0
RGSC_v3.436,155,478 - 6,155,671UniSTSRGSC3.4
Celera35,381,945 - 5,382,138UniSTS
Cytogenetic Map3p12UniSTS
AI847175  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,584,718 - 10,584,820 (+)MAPPERmRatBN7.2
Rnor_6.035,811,535 - 5,811,636NCBIRnor6.0
Rnor_5.0311,173,783 - 11,173,884UniSTSRnor5.0
RGSC_v3.436,153,712 - 6,153,813UniSTSRGSC3.4
Celera35,380,179 - 5,380,280UniSTS
Cytogenetic Map3p12UniSTS
BF387160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,673,325 - 10,673,527 (+)MAPPERmRatBN7.2
Rnor_6.035,898,709 - 5,898,910NCBIRnor6.0
Rnor_5.0311,260,353 - 11,260,554UniSTSRnor5.0
RGSC_v3.436,242,415 - 6,242,616UniSTSRGSC3.4
Celera35,468,720 - 5,468,921UniSTS
Cytogenetic Map3p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 30 28 25 14 25 59 35 31 11
Low 1 13 29 16 5 16 8 11 15 10 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009893   ⟹   ENSRNOP00000009893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,584,688 - 10,754,052 (-)Ensembl
Rnor_6.0 Ensembl35,811,504 - 5,976,244 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081376   ⟹   ENSRNOP00000075062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,588,762 - 10,754,052 (-)Ensembl
Rnor_6.0 Ensembl35,813,388 - 5,975,734 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116151   ⟹   ENSRNOP00000089811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,584,688 - 10,754,052 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118858   ⟹   ENSRNOP00000091131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,584,688 - 10,754,052 (-)Ensembl
RefSeq Acc Id: NM_001106563   ⟹   NP_001100033
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,982,754 - 31,152,116 (-)NCBI
mRatBN7.2310,584,688 - 10,754,052 (-)NCBI
Rnor_6.035,811,504 - 5,976,244 (-)NCBI
Rnor_5.0311,173,752 - 11,337,325 (-)NCBI
RGSC_v3.436,153,681 - 6,347,676 (-)RGD
Celera35,380,148 - 5,548,591 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233761   ⟹   XP_006233823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,982,754 - 31,151,641 (-)NCBI
mRatBN7.2310,584,688 - 10,753,577 (-)NCBI
Rnor_6.035,811,504 - 5,976,310 (-)NCBI
Rnor_5.0311,173,752 - 11,337,325 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104731   ⟹   XP_038960659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,982,754 - 31,151,641 (-)NCBI
mRatBN7.2310,584,688 - 10,754,126 (-)NCBI
RefSeq Acc Id: XM_063283478   ⟹   XP_063139548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,982,754 - 31,151,641 (-)NCBI
RefSeq Acc Id: XM_063283479   ⟹   XP_063139549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,998,256 - 31,151,641 (-)NCBI
RefSeq Acc Id: XR_010064602
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,987,155 - 31,151,641 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001100033   ⟸   NM_001106563
- UniProtKB: D3ZYG0 (UniProtKB/TrEMBL),   A0A8I6APU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233823   ⟸   XM_006233761
- Peptide Label: isoform X3
- UniProtKB: A0A8I6APU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075062   ⟸   ENSRNOT00000081376
RefSeq Acc Id: ENSRNOP00000009893   ⟸   ENSRNOT00000009893
RefSeq Acc Id: XP_038960659   ⟸   XM_039104731
- Peptide Label: isoform X1
- UniProtKB: A0A8I6APU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091131   ⟸   ENSRNOT00000118858
RefSeq Acc Id: ENSRNOP00000089811   ⟸   ENSRNOT00000116151
RefSeq Acc Id: XP_063139548   ⟸   XM_063283478
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139549   ⟸   XM_063283479
- Peptide Label: isoform X4
Protein Domains
Calponin-homology (CH)   DH   PH   Phorbol-ester/DAG-type   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYG0-F1-model_v2 AlphaFold D3ZYG0 1-868 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691928
Promoter ID:EPDNEW_R2449
Type:initiation region
Name:Vav2_2
Description:vav guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2450  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.035,975,817 - 5,975,877EPDNEW
RGD ID:13691925
Promoter ID:EPDNEW_R2450
Type:multiple initiation site
Name:Vav2_1
Description:vav guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2449  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.035,976,292 - 5,976,352EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306285 AgrOrtholog
BioCyc Gene G2FUF-50301 BioCyc
Ensembl Genes ENSRNOG00000007422 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009893 ENTREZGENE
  ENSRNOT00000009893.7 UniProtKB/TrEMBL
  ENSRNOT00000081376.2 UniProtKB/TrEMBL
  ENSRNOT00000116151.1 UniProtKB/TrEMBL
  ENSRNOT00000118858.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Calponin-like_dom_sf UniProtKB/TrEMBL
  Calponin_act-bd UniProtKB/TrEMBL
  CAMSAP_CH UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  PH_Vav UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  VAV2_SH2 UniProtKB/TrEMBL
  VAV2_SH3_1 UniProtKB/TrEMBL
  VAV2_SH3_2 UniProtKB/TrEMBL
KEGG Report rno:296603 UniProtKB/TrEMBL
NCBI Gene 296603 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2 UniProtKB/TrEMBL
  PROTEIN VAV UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  CAMSAP_CH UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PhenoGen Vav2 PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
  PUA UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007422 RatGTEx
SMART RhoGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0G2K9N2_RAT UniProtKB/TrEMBL
  A0A8I6ALS8_RAT UniProtKB/TrEMBL
  A0A8I6APU5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYG0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Vav2  vav guanine nucleotide exchange factor 2  LOC108350342  uncharacterized LOC108350342  Data merged from RGD:11400024 737654 PROVISIONAL
2016-08-02 LOC108350342  uncharacterized LOC108350342      Symbol and Name status set to provisional 70820 PROVISIONAL
2015-12-02 Vav2  vav guanine nucleotide exchange factor 2  Vav2  vav 2 guanine nucleotide exchange factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Vav2  vav 2 guanine nucleotide exchange factor  Vav2  Vav2 oncogene   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Vav2  Vav2 oncogene   Vav2_predicted  Vav2 oncogene (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Vav2_predicted  Vav2 oncogene (predicted)      Symbol and Name status set to approved 70820 APPROVED