Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | ISO | Elf5 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of ELF5 mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in increased expression of ELF5 mRNA | CTD | PMID:27840820 | 17beta-estradiol | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ELF5 mRNA and EGF protein promotes the reaction [Estradiol results in decreased expression of ELF5 mRNA] | CTD | PMID:19619570 and PMID:24758408 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of ELF5 mRNA and [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of ELF5 mRNA | CTD | PMID:26496021 and PMID:32741896 | 17beta-estradiol | increases expression | ISO | Elf5 (Mus musculus) | 6480464 | Estradiol results in increased expression of ELF5 mRNA | CTD | PMID:19484750 | 17beta-estradiol | decreases expression | ISO | ELF5 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of ELF5 mRNA | CTD | PMID:24758408 | 17beta-estradiol | increases expression | ISO | ELF5 (Homo sapiens) | 6480464 | Estradiol results in increased expression of ELF5 mRNA | CTD | PMID:19619570 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of ELF5 mRNA | CTD | PMID:32741896 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Elf5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ELF5 mRNA | CTD | PMID:17035482 and PMID:24058054 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | ELF5 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ELF5 mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ELF5 mRNA | CTD | PMID:19619570 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 3,7-dihydropurine-6-thione | decreases expression | EXP | | 6480464 | Mercaptopurine results in decreased expression of ELF5 mRNA | CTD | PMID:23358152 | 4,4'-sulfonyldiphenol | increases methylation | ISO | Elf5 (Mus musculus) | 6480464 | bisphenol S results in increased methylation of ELF5 promoter | CTD | PMID:33297965 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of ELF5 mRNA | CTD | PMID:30047161 | aflatoxin B1 | increases methylation | ISO | ELF5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of ELF5 intron | CTD | PMID:30157460 | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of ELF5 mRNA | CTD | PMID:30047161 | benzo[a]pyrene | decreases methylation | ISO | ELF5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of ELF5 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | ELF5 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ELF5 5' UTR | CTD | PMID:27901495 | benzo[e]pyrene | decreases methylation | ISO | ELF5 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of ELF5 intron | CTD | PMID:30157460 | Benzo[k]fluoranthene | decreases expression | ISO | Elf5 (Mus musculus) | 6480464 | benzo(k)fluoranthene results in decreased expression of ELF5 mRNA | CTD | PMID:26377693 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Elf5 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of ELF5 mRNA | CTD | PMID:28085963 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of ELF5 mRNA | CTD | PMID:26496021 | bisphenol A | increases expression | ISO | Elf5 (Mus musculus) | 6480464 | bisphenol A results in increased expression of ELF5 mRNA | CTD | PMID:32156529 | bisphenol A | increases methylation | ISO | Elf5 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of ELF5 promoter | CTD | PMID:27312807 | bisphenol A | affects methylation | ISO | Elf5 (Mus musculus) | 6480464 | bisphenol A affects the methylation of ELF5 promoter | CTD | PMID:27334623 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of ELF5 gene | CTD | PMID:28505145 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ELF5 mRNA | CTD | PMID:25181051 | cantharidin | increases expression | ISO | Elf5 (Mus musculus) | 6480464 | Cantharidin results in increased expression of ELF5 mRNA | CTD | PMID:36907384 | carbon nanotube | decreases expression | ISO | Elf5 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ELF5 gene] | CTD | PMID:28238834 | chlordecone | increases expression | ISO | Elf5 (Mus musculus) | 6480464 | Chlordecone results in increased expression of ELF5 mRNA | CTD | PMID:33711761 | chlorpyrifos | decreases expression | ISO | Elf5 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of ELF5 mRNA | CTD | PMID:37019170 | ciglitazone | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [ciglitazone binds to PPARG protein alternative form] which results in increased expression of ELF5 mRNA and [ciglitazone binds to PPARG protein] which results in increased expression of ELF5 mRNA | CTD | PMID:16197558 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of ELF5 mRNA | CTD | PMID:24386269 | coumestrol | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ELF5 mRNA | CTD | PMID:19167446 | crocidolite asbestos | increases expression | ISO | ELF5 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in increased expression of ELF5 mRNA | CTD | PMID:25351596 | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of ELF5 mRNA | CTD | PMID:23640034 | dexamethasone | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [Dexamethasone co-treated with Genistein] results in decreased expression of ELF5 mRNA | CTD | PMID:25136773 | dexamethasone | decreases expression | ISO | ELF5 (Homo sapiens) | 6480464 | Dexamethasone results in decreased expression of ELF5 mRNA | CTD | PMID:25136773 | diethylstilbestrol | increases expression | ISO | Elf5 (Mus musculus) | 6480464 | Diethylstilbestrol results in increased expression of ELF5 mRNA | CTD | PMID:15171707 | dioxygen | multiple interactions | ISO | Elf5 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ELF5 mRNA | CTD | PMID:30529165 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of ELF5 mRNA | CTD | PMID:25152437 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of ELF5 mRNA | CTD | PMID:21551480 | dorsomorphin | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Enterolactone | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ELF5 mRNA | CTD | PMID:19167446 | ethanol | multiple interactions | ISO | Elf5 (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of ELF5 mRNA | CTD | PMID:30517762 | folic acid | decreases expression | ISO | ELF5 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of ELF5 mRNA | CTD | PMID:21867686 | genistein | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [Dexamethasone co-treated with Genistein] results in decreased expression of ELF5 mRNA | CTD | PMID:25136773 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of ELF5 mRNA | CTD | PMID:23160963 | genistein | multiple interactions | EXP | | 6480464 | [Genistein co-treated with vinclozolin] results in increased expression of ELF5 mRNA | CTD | PMID:23160963 | GW 4064 | decreases expression | ISO | Elf5 (Mus musculus) | 6480464 | GW 4064 results in decreased expression of ELF5 mRNA | CTD | PMID:26655953 | hydroquinone | increases expression | ISO | ELF5 (Homo sapiens) | 6480464 | hydroquinone results in increased expression of ELF5 mRNA | CTD | PMID:31256213 | lead diacetate | decreases expression | ISO | Elf5 (Mus musculus) | 6480464 | lead acetate results in decreased expression of ELF5 mRNA | CTD | PMID:22609695 | mercaptopurine | decreases expression | EXP | | 6480464 | Mercaptopurine results in decreased expression of ELF5 mRNA | CTD | PMID:23358152 | mercury dibromide | increases expression | ISO | ELF5 (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of ELF5 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA | CTD | PMID:27188386 | methapyrilene | decreases methylation | ISO | ELF5 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of ELF5 intron | CTD | PMID:30157460 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of ELF5 mRNA | CTD | PMID:30047161 | mifepristone | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | Mifepristone inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 and 20-dione results in increased expression of ELF5 protein] | CTD | PMID:20519331 | nickel atom | decreases expression | ISO | ELF5 (Homo sapiens) | 6480464 | Nickel results in decreased expression of ELF5 mRNA | CTD | PMID:24768652 and PMID:25583101 | panobinostat | increases expression | ISO | ELF5 (Homo sapiens) | 6480464 | panobinostat results in increased expression of ELF5 mRNA | CTD | PMID:26272509 | panobinostat | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA | CTD | PMID:27188386 | phenylmercury acetate | increases expression | ISO | ELF5 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of ELF5 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA | CTD | PMID:27188386 | promegestone | increases expression | ISO | ELF5 (Homo sapiens) | 6480464 | Promegestone results in increased expression of ELF5 protein | CTD | PMID:20519331 | purine-6-thiol | decreases expression | EXP | | 6480464 | Mercaptopurine results in decreased expression of ELF5 mRNA | CTD | PMID:23358152 | SB 431542 | decreases methylation | ISO | ELF5 (Homo sapiens) | 6480464 | 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased methylation of ELF5 promoter | CTD | PMID:25670856 | SB 431542 | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [4-(5-benzo(1 more ... | CTD | PMID:25670856 and PMID:27188386 | SB 431542 | affects expression | ISO | ELF5 (Homo sapiens) | 6480464 | 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the expression of ELF5 mRNA | CTD | PMID:25670856 | sodium arsenite | decreases expression | ISO | Elf5 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of ELF5 mRNA | CTD | PMID:37682722 | sotorasib | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ELF5 mRNA | CTD | PMID:36139627 | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of ELF5 mRNA | CTD | PMID:30047161 | tert-butyl hydroperoxide | increases expression | ISO | Elf5 (Mus musculus) | 6480464 | tert-Butylhydroperoxide results in increased expression of ELF5 mRNA | CTD | PMID:15003993 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of ELF5 mRNA | CTD | PMID:32741896 | tetrachloromethane | multiple interactions | ISO | Elf5 (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of ELF5 mRNA | CTD | PMID:30517762 | titanium dioxide | increases expression | ISO | Elf5 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of ELF5 mRNA | CTD | PMID:23557971 | trametinib | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ELF5 mRNA | CTD | PMID:36139627 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of ELF5 mRNA | CTD | PMID:33387578 | trichostatin A | increases expression | ISO | ELF5 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of ELF5 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA | CTD | PMID:27188386 | tris(2-butoxyethyl) phosphate | affects expression | ISO | ELF5 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of ELF5 mRNA | CTD | PMID:29024780 | valproic acid | increases expression | ISO | ELF5 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ELF5 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | ELF5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA | CTD | PMID:27188386 | vinclozolin | multiple interactions | EXP | | 6480464 | [Genistein co-treated with vinclozolin] results in increased expression of ELF5 mRNA | CTD | PMID:23160963 | |