Dsp (desmoplakin) - Rat Genome Database

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Gene: Dsp (desmoplakin) Rattus norvegicus
Analyze
Symbol: Dsp
Name: desmoplakin
RGD ID: 1305794
Description: Predicted to enable protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Predicted to be involved in several processes, including intermediate filament organization; regulation of heart contraction; and ventricular compact myocardium morphogenesis. Predicted to act upstream of or within adherens junction organization; desmosome organization; and epithelial cell-cell adhesion. Located in desmosome and fascia adherens. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; dilated cardiomyopathy; and keratosis palmoplantaris striata 2. Orthologous to human DSP (desmoplakin); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DP; LOC306871
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81726,829,153 - 26,877,419 (-)NCBIGRCr8
mRatBN7.21726,623,602 - 26,671,692 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1726,623,588 - 26,671,800 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01727,286,811 - 27,334,453 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1727,286,796 - 27,334,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01729,201,872 - 29,249,490 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41732,848,313 - 32,896,044 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11732,851,800 - 32,898,885 (-)NCBI
Celera1726,257,726 - 26,305,766 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amyloidosis  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
arrhythmogenic right ventricular dysplasia 8  (ISO,ISS)
arrhythmogenic right ventricular dysplasia 9  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2J  (ISO)
Brugada syndrome  (ISO)
cardiac arrest  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Conduction Defect  (ISO)
cardiomyopathy  (ISO)
Carvajal syndrome  (ISO,ISS)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
chronic obstructive pulmonary disease  (ISO)
Developmental Disabilities  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1S  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Dilated Cardiomyopathy with Woolly Hair, Keratoderma, and Tooth Agenesis  (ISO)
Ectodermal Dysplasia-Skin Fragility Syndrome  (ISO)
Epidermolysis Bullosa, Lethal Acantholytic  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
hemiplegia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
idiopathic pulmonary fibrosis  (ISO)
keratosis palmoplantaris striata 2  (ISO)
Left Ventricular Hypertrophy  (ISO)
left ventricular noncompaction  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
lung disease  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
migraine  (ISO)
myocarditis  (ISO)
PALMOPLANTAR KERATODERMA AND WOOLLY HAIR  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
progressive familial heart block  (ISO)
pulmonary fibrosis  (ISO)
restrictive cardiomyopathy  (ISO)
subvalvular aortic stenosis  (ISO)
Subvalvular Aortic Stenosis, Eisenberg Type  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Syncope  (ISO)
systolic heart failure  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Fibrillation, Paroxysmal Familial, 1  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
glafenine  (EXP)
indometacin  (ISO)
lasalocid  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
nitrofen  (EXP)
Nonylphenol  (EXP)
okadaic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
topotecan  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair. Alcalai R, etal., J Am Coll Cardiol. 2003 Jul 16;42(2):319-27.
2. Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium. Angst BD, etal., Circ Res. 1997 Jan;80(1):88-94.
3. Assembly and remodelling of myofibrils and intercalated discs in cultured neonatal rat heart cells. Atherton BT, etal., J Cell Sci. 1986 Dec;86:233-48.
4. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Ben-Ze'ev A, etal., Proc Natl Acad Sci U S A. 1988 Apr;85(7):2161-5.
5. The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules in the intercalated disk. Borrmann CM, etal., Eur J Cell Biol. 2006 Jun;85(6):469-85. Epub 2006 Apr 4.
6. The complement of desmosomal plaque proteins in different cell types. Cowin P, etal., J Cell Biol. 1985 Oct;101(4):1442-54.
7. Lumen formation and redistribution of inframembranous proteins during differentiation of ducts in the rat mammary gland. Dulbecco R, etal., Proc Natl Acad Sci U S A. 1984 Sep;81(18):5763-6.
8. The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins. Franke WW, etal., Eur J Cell Biol. 2006 Feb;85(2):69-82. Epub 2006 Jan 9.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Desmoplakin expression and distribution in cultured rat bladder epithelial cells of varying tumorigenic potential. Green KJ, etal., Exp Cell Res. 1991 Mar;193(1):134-43.
12. Contact-inhibitory factor induces alterations in the distribution and content of specific cytoskeletal elements in an established line of rat hepatic tumor cells. Higgins PJ, etal., Int J Cancer. 1987 Dec 15;40(6):792-801.
13. Intermediate filament-co-localized molecules with myosin heavy chain epitopes define distinct cellular domains in hair follicles and epidermis. Jazwinska A, etal., BMC Cell Biol. 2003 Aug 4;4:10.
14. Specific attachment of desmin filaments to desmosomal plaques in cardiac myocytes. Kartenbeck J, etal., EMBO J. 1983;2(5):735-42.
15. Changes in cytokeratin, vimentin and desmoplakin distribution during the repair of irradiation-induced lung injury in adult rats. Kasper M, etal., Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;64(5):271-9.
16. Spatiotemporal development and distribution of intercellular junctions in adult rat cardiomyocytes in culture. Kostin S, etal., Circ Res. 1999 Jul 23;85(2):154-67.
17. Remodeling of cell-cell and cell-extracellular matrix interactions at the border zone of rat myocardial infarcts. Matsushita T, etal., Circ Res. 1999 Nov 26;85(11):1046-55.
18. Formation of cell junctions between grafted and host cardiomyocytes at the border zone of rat myocardial infarction. Matsushita T, etal., Circulation. 1999 Nov 9;100(19 Suppl):II262-8.
19. Expression of desmosomal proteins in rat keratinocytes during in vitro differentiation. Mochizuki R, etal., J Vet Med Sci. 2002 Feb;64(2):123-7.
20. Formation of the tooth enamel rod pattern and the cytoskeletal organization in secretory ameloblasts of the rat incisor. Nishikawa S, etal., Eur J Cell Biol. 1988 Dec;47(2):222-32.
21. Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma. Norgett EE, etal., Hum Mol Genet. 2000 Nov 1;9(18):2761-6.
22. Disappearance of desmosomal components in rat corneal epithelium during wound healing. Okada Y, etal., Ophthalmologica. 2001 Jan-Feb;215(1):61-5.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Cytoskeletons of retinal pigment epithelial cells: interspecies differences of expression patterns indicate independence of cell function from the specific complement of cytoskeletal proteins. Owaribe K, etal., Cell Tissue Res. 1988 Nov;254(2):301-15.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Progesterone treatment and the progress of early pregnancy reduce desmoglein 1&2 staining along the lateral plasma membrane in rat uterine epithelial cells. Preston AM, etal., Acta Histochem. 2004;106(5):345-51.
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. Savagner P, etal., J Cell Biol 1997 Jun 16;137(6):1403-19.
30. A novel type of adhering junction in an epithelioid tumorigenic rat cell culture line. Schmelz M, etal., Cell Tissue Res. 1998 Oct;294(1):11-25.
31. Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: II. Different types of lymphatic vessels. Schmelz M, etal., Differentiation. 1994 Aug;57(2):97-117.
32. Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy. Sepp R, etal., Heart. 1996 Nov;76(5):412-7.
33. Cytoplasmic desmosomes and intermediate filament disturbance following acrylamide treatment in cultured rat keratinocytes. Shabana AH, etal., Tissue Cell. 1994 Feb;26(1):43-55.
34. The cytoplasmic domain of CEACAM1-L controls its lateral localization and the organization of desmosomes in polarized epithelial cells. Sundberg U, etal., J Cell Sci. 2004 Mar 1;117(Pt 7):1091-104. Epub 2004 Feb 17.
35. Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments. Toivola DM, etal., J Cell Sci. 1997 Jan;110 ( Pt 1):23-33.
36. Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage. Troyanovsky SM, etal., Cell. 1993 Feb 26;72(4):561-74.
37. Isolation of cell-to-cell adherens junctions from rat liver. Tsukita S and Tsukita S, J Cell Biol. 1989 Jan;108(1):31-41.
38. Remodeling of gap junctional coupling in hypertrophied right ventricles of rats with monocrotaline-induced pulmonary hypertension. Uzzaman M, etal., Circ Res. 2000 Apr 28;86(8):871-8.
39. Blood-testis barrier dynamics are regulated by an engagement/disengagement mechanism between tight and adherens junctions via peripheral adaptors. Yan HH and Cheng CY, Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11722-7. Epub 2005 Aug 5.
40. Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat. Yoo S, etal., Circulation. 2006 Sep 26;114(13):1360-71. Epub 2006 Sep 11.
Additional References at PubMed
PMID:9864371   PMID:10852826   PMID:10908733   PMID:11781569   PMID:12373648   PMID:12477932   PMID:12951053   PMID:14673151   PMID:16418220   PMID:16917092   PMID:17535849   PMID:18474624  
PMID:18496566   PMID:19001636   PMID:19056867   PMID:19199708   PMID:19723622   PMID:20458337   PMID:20859650   PMID:21630459   PMID:21700703   PMID:22152112   PMID:22658674   PMID:22781308  
PMID:22889254   PMID:23376485   PMID:23381804   PMID:23979707   PMID:25617501   PMID:26296893   PMID:26403541   PMID:27892606   PMID:29959233   PMID:35352799  


Genomics

Comparative Map Data
Dsp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81726,829,153 - 26,877,419 (-)NCBIGRCr8
mRatBN7.21726,623,602 - 26,671,692 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1726,623,588 - 26,671,800 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01727,286,811 - 27,334,453 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1727,286,796 - 27,334,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01729,201,872 - 29,249,490 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41732,848,313 - 32,896,044 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11732,851,800 - 32,898,885 (-)NCBI
Celera1726,257,726 - 26,305,766 (-)NCBICelera
Cytogenetic Map17p12NCBI
DSP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3867,541,671 - 7,586,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl67,541,338 - 7,586,714 (+)EnsemblGRCh38hg38GRCh38
GRCh3767,541,904 - 7,586,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3667,486,869 - 7,531,945 (+)NCBINCBI36Build 36hg18NCBI36
Build 3467,486,868 - 7,531,945NCBI
Celera68,771,623 - 8,816,711 (+)NCBICelera
Cytogenetic Map6p24.3NCBI
HuRef67,419,476 - 7,464,417 (+)NCBIHuRef
CHM1_167,544,023 - 7,589,106 (+)NCBICHM1_1
T2T-CHM13v2.067,410,711 - 7,455,759 (+)NCBIT2T-CHM13v2.0
Dsp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391338,335,357 - 38,382,553 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1338,335,270 - 38,382,553 (+)EnsemblGRCm39 Ensembl
GRCm381338,151,294 - 38,198,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1338,151,294 - 38,198,577 (+)EnsemblGRCm38mm10GRCm38
MGSCv371338,243,163 - 38,290,446 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361338,158,760 - 38,206,043 (+)NCBIMGSCv36mm8
Celera1339,265,897 - 39,313,259 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1318.0NCBI
Dsp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554656,356,863 - 6,392,207 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554656,356,970 - 6,391,206 (-)NCBIChiLan1.0ChiLan1.0
DSP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2522,183,206 - 22,228,587 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1618,180,000 - 18,225,467 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v067,381,046 - 7,426,408 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.167,664,399 - 7,709,391 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl67,664,211 - 7,709,391 (+)Ensemblpanpan1.1panPan2
DSP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,479,628 - 7,524,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,479,643 - 7,524,044 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha357,483,107 - 7,528,345 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0357,562,265 - 7,607,463 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,562,020 - 7,607,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,415,316 - 7,460,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,441,523 - 7,486,395 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,773,585 - 8,819,012 (+)NCBIUU_Cfam_GSD_1.0
Dsp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494616,760,022 - 16,807,481 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365345,028,911 - 5,077,199 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365345,029,008 - 5,076,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl74,862,649 - 4,915,623 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.174,862,649 - 4,915,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.274,968,344 - 5,021,222 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DSP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11764,611,243 - 64,656,297 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1764,611,103 - 64,656,366 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660447,495,774 - 7,541,054 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dsp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475618,035,892 - 18,083,336 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475618,036,103 - 18,083,379 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dsp
223 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:16
Count of miRNA genes:16
Interacting mature miRNAs:16
Transcripts:ENSRNOT00000018649
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat

Markers in Region
RH130644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21726,623,710 - 26,623,906 (+)MAPPERmRatBN7.2
Rnor_6.01727,286,920 - 27,287,115NCBIRnor6.0
Rnor_5.01729,201,981 - 29,202,176UniSTSRnor5.0
RGSC_v3.41732,848,422 - 32,848,617UniSTSRGSC3.4
Celera1726,257,835 - 26,258,030UniSTS
RH 3.4 Map17341.4UniSTS
Cytogenetic Map17p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 41 25 8 25 35 23 11
Low 16 16 11 16 8 8 50 17 8
Below cutoff 3 24 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018649   ⟹   ENSRNOP00000018649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1726,623,588 - 26,671,800 (-)Ensembl
Rnor_6.0 Ensembl1727,286,796 - 27,334,379 (-)Ensembl
RefSeq Acc Id: NM_001419598   ⟹   NP_001406527
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81726,829,153 - 26,877,121 (-)NCBI
mRatBN7.21726,623,602 - 26,671,566 (-)NCBI
RefSeq Acc Id: XM_017600713   ⟹   XP_017456202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81726,829,153 - 26,877,419 (-)NCBI
mRatBN7.21726,623,602 - 26,671,692 (-)NCBI
Rnor_6.01727,286,811 - 27,334,452 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001406527 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456202 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98071 (Get FASTA)   NCBI Sequence Viewer  
  EDL98260 (Get FASTA)   NCBI Sequence Viewer  
  EDL98261 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018649
  ENSRNOP00000018649.5
GenBank Protein F1LMV6 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_017456202   ⟸   XM_017600713
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000018649   ⟸   ENSRNOT00000018649
RefSeq Acc Id: NP_001406527   ⟸   NM_001419598
- UniProtKB: F1LMV6 (UniProtKB/Swiss-Prot),   Q4QQR7 (UniProtKB/Swiss-Prot)
Protein Domains
SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700401
Promoter ID:EPDNEW_R10917
Type:initiation region
Name:Dsp_1
Description:desmoplakin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01727,334,318 - 27,334,378EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305794 AgrOrtholog
BioCyc Gene G2FUF-9681 BioCyc
Ensembl Genes ENSRNOG00000013928 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018649 ENTREZGENE
  ENSRNOT00000018649.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.1060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.160.780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1290.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7459514 IMAGE-MGC_LOAD
InterPro Desmoplakin_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Desmoplakin_Spectrin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plakin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plakin_repeat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plectin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:116287 IMAGE-MGC_LOAD
NCBI Gene 306871 ENTREZGENE
PANTHER DESMOPLAKIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENVOPLAKIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Plectin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DSP RGD
PhenoGen Dsp PhenoGen
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013928 RatGTEx
SMART PLEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Plakin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6J7B0_RAT UniProtKB/TrEMBL
  A6J7B1_RAT UniProtKB/TrEMBL
  DESP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4QQR7 ENTREZGENE
UniProt Secondary Q4QQR7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Dsp  desmoplakin  Dsp_predicted  desmoplakin (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dsp_predicted  desmoplakin (predicted)      Symbol and Name status set to approved 70820 APPROVED