Zfp281 (zinc finger protein 281) - Rat Genome Database

Name: Zfp281
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Zfp281 (zinc finger protein 281) Rattus norvegicus

Analyze

Symbol:

Zfp281

Name:

zinc finger protein 281

RGD ID:

1305139

Description:

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic body morphogenesis; regulation of gene expression; and stem cell differentiation. Predicted to be located in nucleoplasm. Orthologous to human ZNF281 (zinc finger protein 281); INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC305083

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ZNF281 (zinc finger protein 281)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Zfp281 (zinc finger protein 281)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Znf281 (zinc finger protein 281)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ZNF281 (zinc finger protein 281)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ZNF281 (zinc finger protein 281)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Znf281 (zinc finger protein 281)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ZNF281 (zinc finger protein 281)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ZNF281 (zinc finger protein 281)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Znf281 (zinc finger protein 281)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CCDC62 (coiled-coil domain containing 62)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ZNF281 (zinc finger protein 281)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Zfp281 (zinc finger protein 281)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	znf281a (zinc finger protein 281a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	znf281b (zinc finger protein 281b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MIG2	Alliance	DIOPT (Hieranoid\|InParanoid)
Caenorhabditis elegans (roundworm):	F26A10.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	MIG3	Alliance	DIOPT (Hieranoid\|InParanoid)
Xenopus tropicalis (tropical clawed frog):	znf281	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	50,647,750 - 50,655,912 (+)	NCBI		GRCr8
mRatBN7.2	13	48,096,103 - 48,104,265 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	48,037,286 - 48,104,888 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	50,704,215 - 50,707,529 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	51,992,300 - 51,995,614 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	49,259,175 - 49,262,489 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	53,531,080 - 53,534,399 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	53,506,925 - 53,534,353 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	58,554,859 - 58,577,429 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	49,700,599 - 49,704,316 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	49,714,678 - 49,718,388 (+)	NCBI
Celera	13	48,405,634 - 48,408,556 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (EXP)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

finasteride (EXP)

FR900359 (ISO)

geraniol (ISO)

indometacin (ISO)

lidocaine (EXP)

mitomycin C (ISO)

paracetamol (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

rotenone (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulindac (EXP)

sunitinib (ISO)

testosterone (ISO)

tributylstannane (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

embryonic body morphogenesis (ISO)

negative regulation of DNA-templated transcription (ISO,ISS)

negative regulation of gene expression (ISO,ISS)

negative regulation of transcription by RNA polymerase II (ISO)

positive regulation of DNA-templated transcription (ISO,ISS)

regulation of transcription by RNA polymerase II (IBA)

stem cell differentiation (ISO)

Cellular Component

nucleoplasm (IEA,ISO)

nucleus (ISO,ISS)

Molecular Function

DNA-binding transcription factor activity (IBA,ISO,ISS)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

sequence-specific DNA binding (ISO,ISS)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10405178	PMID:10448078	PMID:12477932	PMID:12771217	PMID:21915945	PMID:22988117

Genomics

Comparative Map Data

Zfp281
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	50,647,750 - 50,655,912 (+)	NCBI		GRCr8
mRatBN7.2	13	48,096,103 - 48,104,265 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	48,037,286 - 48,104,888 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	50,704,215 - 50,707,529 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	51,992,300 - 51,995,614 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	49,259,175 - 49,262,489 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	53,531,080 - 53,534,399 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	53,506,925 - 53,534,353 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	58,554,859 - 58,577,429 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	49,700,599 - 49,704,316 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	49,714,678 - 49,718,388 (+)	NCBI
Celera	13	48,405,634 - 48,408,556 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

ZNF281
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	200,404,951 - 200,410,036 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	200,404,940 - 200,410,056 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	200,374,079 - 200,379,164 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	198,642,043 - 198,645,789 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	197,107,078 - 197,110,823	NCBI
Celera	1	173,498,045 - 173,501,791 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	171,540,348 - 171,545,460 (-)	NCBI		HuRef
CHM1_1	1	201,796,720 - 201,801,832 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	199,661,900 - 199,740,523 (-)	NCBI		T2T-CHM13v2.0

Zfp281
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	136,552,639 - 136,558,129 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	136,552,639 - 136,557,791 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	136,624,901 - 136,630,391 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	136,624,901 - 136,630,053 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	138,521,478 - 138,526,968 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	138,441,356 - 138,444,700 (+)	NCBI		MGSCv36	mm8
Celera	1	139,267,739 - 139,273,257 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	59.93	NCBI

Znf281
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	36,592,771 - 36,599,543 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	36,592,771 - 36,599,543 (-)	NCBI	ChiLan1.0	ChiLan1.0

ZNF281
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	48,970,235 - 48,976,222 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	48,933,807 - 48,939,796 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	176,004,142 - 176,009,291 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	180,312,596 - 180,317,701 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

ZNF281
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	2,716,575 - 2,721,524 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	2,716,974 - 2,719,613 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	2,401,615 - 2,406,904 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	2,364,849 - 2,370,157 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	2,364,811 - 2,432,792 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	2,347,748 - 2,353,041 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	2,449,104 - 2,454,307 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	2,480,583 - 2,485,879 (+)	NCBI		UU_Cfam_GSD_1.0

Znf281
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	74,647,672 - 74,653,803 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936567	3,882,406 - 3,885,732 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936567	3,882,391 - 3,885,744 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZNF281
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	23,036,146 - 23,038,758 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	23,033,629 - 23,039,121 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	27,510,758 - 27,515,911 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZNF281
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	29,011,153 - 29,016,298 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	29,011,516 - 29,014,215 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	29,839,230 - 29,844,549 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Znf281
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624798	154,980 - 158,287 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624798	154,949 - 158,292 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Zfp281
18 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	36
Count of miRNA genes:	26
Interacting mature miRNAs:	35
Transcripts:	ENSRNOT00000012085
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	32284471	77284471	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
6893344	Cm79	Cardiac mass QTL 79	1.5	0.04	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	43720770	62022792	Rat
12879444	Bp397	Blood pressure QTL 397			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45049404	90049404	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45514719	90514719	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	46088046	91088046	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	46197976	84753113	Rat

Markers in Region

RH138778

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	48,103,902 - 48,104,149 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	53,538,813 - 53,539,059	NCBI	Rnor6.0
Rnor_5.0	13	58,581,843 - 58,582,089	UniSTS	Rnor5.0
Rnor_5.0	13	58,574,119 - 58,574,365	UniSTS	Rnor5.0
RGSC_v3.4	13	49,708,730 - 49,708,976	UniSTS	RGSC3.4
RGSC_v3.4	13	49,701,006 - 49,701,252	UniSTS	RGSC3.4
Celera	13	48,412,970 - 48,413,216	UniSTS
RH 3.4 Map	13	147.3	UniSTS
Cytogenetic Map	13	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	42	26	19	26	1	1	74	29	38	11	1
Low	1	17	15	15		15	7	10		6	3		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000088133 ⟹ ENSRNOP00000072700

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	48,037,286 - 48,104,888 (+)	Ensembl
Rnor_6.0 Ensembl	13	53,506,925 - 53,534,353 (+)	Ensembl

RefSeq Acc Id:

NM_001012030 ⟹ NP_001012030

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	50,647,822 - 50,651,136 (+)	NCBI
mRatBN7.2	13	48,096,175 - 48,099,489 (+)	NCBI
Rnor_6.0	13	53,531,080 - 53,534,399 (+)	NCBI
Rnor_5.0	13	58,554,859 - 58,577,429 (+)	NCBI
RGSC_v3.4	13	49,700,599 - 49,704,316 (+)	RGD
Celera	13	48,405,634 - 48,408,556 (+)	RGD

Sequence:

show sequence

GGCTTTTAATTCCATTGTGGAGAGGACGGCGTTATTTTTATTAACTGGAGGCGACGGCGGCTGC
GGCGGCGGCGGAACCCGCCTCCTCCGGGGTATGAAAATCGGCAGCGGGTTCCTCAGCGGCGGCG
GCGGTCCCGGCAGTAGCGGTGGTAGCGGCTCCAGCGGCAGCTCCGGCAGCGGCGGCAGCAGGAG
AGCTGAGATGGAGCCCACCTTCCCCCAGAGTATGGTTATGTTCAACCACCGGCTCCCCCCGGTC
ACCAGCTTCACCCGGCCTGCGGGGACGGCCGCCCCTCCCCCGCAGTGCGTGTTATCCTCCTCTA
CCTCCGCAGCCCCGGCCGCTGAGCCCCCCCCTCCACCAGCCCCGGACATGACTTTCAAGAAGGA
GCCGGCGGCGTCAGCCGCGGCCTTCCCTTCGCAGAGGACCTCCTGGGGATTCTTGCAGTCCTTG
GTGAGCATCAAGCAGGAGAAACCTGCGGATCCTGAGGAGCAGCAGTCCCACCACCATCATCACC
ACCACCACTATGGGGGGCTGTTCGCTGGGGCTGAAGAGAGATCACCAGGCCTAGGAGGAGGGGA
AGGGGGGAGCCACGGCGTCATCCAAGACCTCAGTATTCTCCACCAGCATGTCCAGCAGCAACCA
GCCCAGCATCACCGCGATGTATTACTGAGCAGCAGCGGTAGCAGGACTGATGACCATGGCAACG
AGGAGCCAAAGCAGGACACTAACGTCAAAAAGGCAAAGAGGCCAAAGCCAGAATCTCAGGGAAT
CAAAGCCAAGAGGAAGCCAAGTGCATCTTCCAAACCTTTGGTTGGAGAGGGAGAAGGTGCCGTC
CTGTCCCCAAGTCAGAAACCTCATATCTGTGATCACTGTAGTGCTGCTTTCAGGAGCTCCTACC
ACCTGCGGAGACATGTCCTCATTCACACAGGAGAAAGGCCGTTCCAGTGCAGCCAGTGTAGTAT
GGGTTTCATTCAGAAATACCTACTGCAGAGACACGAGAAAATTCACAGCAGAGAGAAGCCCTTT
GGGTGCGATCAGTGCAGCATGAAGTTTATTCAGAAGTACCATATGGAGAGACACAAGAGGACAC
ATAGTGGAGAAAAGCCATATAAGTGTGACACTTGCCAACAGTATTTTTCAAGGACTGACAGATT
GTTGAAGCACAGGCGCACGTGTGGTGAAGCCATAGCAAAAGGGGCCGCTAGTGCAGAACCTGGG
TCATCAAACCATAATAATATGGGTAATCTGGCTGTGTTGTCTCAGGGAAATACAAGTTCTTCAC
GGAGAAAATCGAAGTCAAAAAGCATAGCTGTTGAAAATAAGGAACACAAGACTGGCAAAACAAA
CGAATCACAGATGTCAAACAATATAAACATGCAGAGTTACTCAGTAGAAATGCCTACTGTGTCC
ACCAGTGGCGGCATCATCGGCACGGGGCTCGATGAGCTACAGAAAAGGGTGCCAAAACTGATCT
TTAAGAAAGGAAGCAGAAAGAATACAGATAAAAGCTACCTTAATTTTGTGTCACCGTTACCAGA
TGTAGCTGGGCAGAAATCCTTGTCTGGTAAACCAAGTGGCTCGCTTGGCATCGTATCGAACAAT
AGCGTGGAGACCATTAGTCTTCTCCAAAGTGCAAGCGGCAAACCAGGCCCGATAAGTAGTAATT
ATGATGATGCCATGCAGTTCTCAAAGAAGAGAAGATACTTACCAACTGCCAGCAGCAACAGTGC
CTTTTCTATCAATGTAGGACACATGGTCTCCCAGCAGTCAGTCATTCAGTCTGCAGGGGTCAGT
GTTTTGGACAATGAGGCGCCATTGTCACTTATTGACTCCTCAGCTCTAAATGCTGAAATTAAGT
CTTGTCACGACAAGTCTGGAATTCCTGATGAGGTTCTACAAAGTATTTTGGATCAGTACTCTAG
CAAGTCAGAACCACAGAAGGAGGATCCCTTCAACTTAACAGAACCACGAGTGGATTTACACACC
TCAGGAGAACACTCTGAATTGGTTCAAGAAGAGCATTTGAGCCCAGGCACCCAGACACCTTCAA
ATGACAAAGCAAGCGTGTTGCAGGAGTACTCCAAATACCTCCAGCAGGCTTTTGAGAAGTCCAC
GAATGCAGGTTTTACCCTCGGACATGGTTTCCAGTTTGTCAGCTTATCTTCACCTCTCCACAAC
CACACTTTGTTTCCAGAAAAACAGATATACACTACATCTCCTTTGGAGTGTGGTTTTGGCCAAT
CTGTTACCTCAGTGTTGCCATCTTCATTGCCAAAGCCTCCTTTTGGGATGTTGTTTGGATCTCA
ACCAGGTCTTTATTTATCTGCTTTGGATGCTACACATCAGCAGTTGACACCTTCCCAGGAGCTG
GATGATCTGATAGATTCTCAGAAGAACTTAGAGACATCATCAGCCTTCCAGTCCTCATCTCAGA
AATTGACTAGCCAGAAGGAACAACAGAAAAATTTAGAGTCCTCAACAAGCTTTCAGATTCCATC
TCAGGAGTTAGCTAGCCAGATTGATCCTCAGAAAGACATAGAGCCTAGAACAACGTACCAGATT
GAGAACTTTGCACAAGCATTCGGTTCTCAGTTTAAGTCGGGCAGCAGGGTGCCAATGACCTTTA
TCACTAACTCTAATGGAGAAGTGGACCATAGAGTAAGGACTTCAGTGTCAGATTTCTCAGGGTA
TACAAATATGATGTCTGATGTAAGTGAGCCATGTAGTACAAGAGTAAAGACACCCACCAGCCAG
AGTTACAGGTAAGGTCTCGAGAGTGACCAGGCTGGGAGTCTAATGTAATTTTGTTTTATTTTGA
GAACACTGCCATTGGAATGTTTCTACACGATCCTATTAAGAATAATGTAATGCCCTTTCAATGC
AACTTTTCATATTTAGTTTATTTTGTTAGTGTGATTTTAGCTCTGTTTGTATTATGATTTTTAA
TCAAAATCAATAGATTAAAAATAGTTTGACATTCAAAGTGACAATGTTTAGCAATCAAATTTAC
ATGTACAGATTGTCAGGGAATAGCCCAAAAGTTTTAAATGCAAAAACAAAAAAATTTTAAAAAA
GCAAAAAAAGTACAGAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039090831 ⟹ XP_038946759

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	50,647,750 - 50,655,912 (+)	NCBI
mRatBN7.2	13	48,096,103 - 48,104,265 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012030	(Get FASTA)	NCBI Sequence Viewer
	XP_038946759	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83844	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072700
	ENSRNOP00000072700.2

RefSeq Acc Id:

NP_001012030 ⟸ NM_001012030

- UniProtKB:

Q5XI48 (UniProtKB/TrEMBL), A0A0G2K3M5 (UniProtKB/TrEMBL), A6ICJ2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKIGSGFLSGGGGPGSSGGSGSSGSSGSGGSRRAEMEPTFPQSMVMFNHRLPPVTSFTRPAGTA
APPPQCVLSSSTSAAPAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSWGFLQSLVSIKQEKPAD
PEEQQSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSILHQHVQQQPAQHHRDVLLS
SSGSRTDDHGNEEPKQDTNVKKAKRPKPESQGIKAKRKPSASSKPLVGEGEGAVLSPSQKPHIC
DHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFI
QKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEAIAKGAASAEPGSSNHNNMGNL
AVLSQGNTSSSRRKSKSKSIAVENKEHKTGKTNESQMSNNINMQSYSVEMPTVSTSGGIIGTGL
DELQKRVPKLIFKKGSRKNTDKSYLNFVSPLPDVAGQKSLSGKPSGSLGIVSNNSVETISLLQS
ASGKPGPISSNYDDAMQFSKKRRYLPTASSNSAFSINVGHMVSQQSVIQSAGVSVLDNEAPLSL
IDSSALNAEIKSCHDKSGIPDEVLQSILDQYSSKSEPQKEDPFNLTEPRVDLHTSGEHSELVQE
EHLSPGTQTPSNDKASVLQEYSKYLQQAFEKSTNAGFTLGHGFQFVSLSSPLHNHTLFPEKQIY
TTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNL
ETSSAFQSSSQKLTSQKEQQKNLESSTSFQIPSQELASQIDPQKDIEPRTTYQIENFAQAFGSQ
FKSGSRVPMTFITNSNGEVDHRVRTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR

hide sequence

RefSeq Acc Id:

ENSRNOP00000072700 ⟸ ENSRNOT00000088133

RefSeq Acc Id:	XP_038946759 ⟸ XM_039090831
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K3M5 (UniProtKB/TrEMBL), Q5XI48 (UniProtKB/TrEMBL), A6ICJ2 (UniProtKB/TrEMBL)

Protein Domains

C2H2-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K3M5-F1-model_v2	AlphaFold	A0A0G2K3M5	1-890	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305139	AgrOrtholog
BioCyc Gene	G2FUF-18167	BioCyc
Ensembl Genes	ENSRNOG00000058643	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000088133	ENTREZGENE
	ENSRNOT00000088133.2	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7121097	IMAGE-MGC_LOAD
InterPro	Znf_C2H2/integrase_DNA-bd	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
KEGG Report	rno:305083	UniProtKB/TrEMBL
MGC_CLONE	MGC:95002	IMAGE-MGC_LOAD
NCBI Gene	305083	ENTREZGENE
PANTHER	ZINC FINGER PROTEIN	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN 281A	UniProtKB/TrEMBL
Pfam	zf-C2H2	UniProtKB/TrEMBL
PhenoGen	Zfp281	PhenoGen
PROSITE	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000058643	RatGTEx
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/TrEMBL
UniProt	A0A0G2K3M5	ENTREZGENE
	A6ICJ2	ENTREZGENE, UniProtKB/TrEMBL
	Q5XI48	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A0G2K3M5	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Zfp281	zinc finger protein 281	Zfp281_predicted	zinc finger protein 281 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Zfp281_predicted	zinc finger protein 281 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar