Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MXD4 mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | ISO | Mxd4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of MXD4 mRNA | CTD | PMID:36331819 | 1,2-dichloroethane | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of MXD4 mRNA | CTD | PMID:28189721 and PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | Mxd4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MXD4 mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of MXD4 mRNA | CTD | PMID:16474171 and PMID:31614463 | 17beta-estradiol | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Estradiol results in decreased expression of MXD4 mRNA | CTD | PMID:14664709 | 17beta-estradiol | affects expression | ISO | Mxd4 (Mus musculus) | 6480464 | Estradiol affects the expression of MXD4 mRNA | CTD | PMID:15598610 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Mxd4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of MXD4 mRNA | CTD | PMID:21570461 and PMID:24680724 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MXD4 mRNA | CTD | PMID:33387578 and PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MXD4 mRNA | CTD | PMID:32109520 | 2-palmitoylglycerol | increases expression | ISO | MXD4 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of MXD4 mRNA | CTD | PMID:37199045 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of MXD4 mRNA | CTD | PMID:25172293 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of MXD4 mRNA | CTD | PMID:20188158 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | MXD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of MXD4 mRNA | CTD | PMID:28628672 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of MXD4 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | bisphenol S results in decreased expression of MXD4 mRNA | CTD | PMID:25912373 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | MXD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of MXD4 mRNA | CTD | PMID:28628672 | aflatoxin B1 | increases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of MXD4 mRNA | CTD | PMID:19770486 | antirheumatic drug | increases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of MXD4 mRNA | CTD | PMID:24449571 | aristolochic acid A | increases expression | ISO | MXD4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of MXD4 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of MXD4 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | increases methylation | ISO | MXD4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of MXD4 promoter | CTD | PMID:27901495 | bisphenol A | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of MXD4 mRNA | CTD | PMID:16474171 | bisphenol A | affects expression | ISO | MXD4 (Homo sapiens) | 6480464 | bisphenol A affects the expression of MXD4 mRNA | CTD | PMID:30903817 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with tributyltin] results in decreased expression of MXD4 mRNA | CTD | PMID:31129395 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of MXD4 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | MXD4 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of MXD4 mRNA | CTD | PMID:20678512 and PMID:29275510 | buta-1,3-diene | increases expression | ISO | Mxd4 (Mus musculus) | 6480464 | 1 and 3-butadiene results in increased expression of MXD4 mRNA | CTD | PMID:29038090 | butan-1-ol | multiple interactions | ISO | MXD4 (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of MXD4 mRNA | CTD | PMID:29432896 | butanal | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of MXD4 mRNA | CTD | PMID:26079696 | carbon nanotube | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of MXD4 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | MXD4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to MXD4 gene] | CTD | PMID:28238834 | chloroprene | increases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Chloroprene results in increased expression of MXD4 mRNA | CTD | PMID:23125180 | cisplatin | multiple interactions | ISO | MXD4 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of MXD4 mRNA | CTD | PMID:27392435 | clofibrate | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of MXD4 mRNA | CTD | PMID:23811191 | copper(II) sulfate | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of MXD4 mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | MXD4 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MXD4 mRNA | CTD | PMID:19167446 | coumestrol | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of MXD4 mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of MXD4 mRNA | CTD | PMID:25562108 | dexamethasone | increases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Dexamethasone results in increased expression of MXD4 mRNA | CTD | PMID:22733784 | dexamethasone | multiple interactions | ISO | MXD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of MXD4 mRNA | CTD | PMID:28628672 | diazinon | increases methylation | ISO | MXD4 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of MXD4 gene | CTD | PMID:22964155 | dibutyl phthalate | increases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of MXD4 mRNA | CTD | PMID:21266533 | diethylstilbestrol | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Diethylstilbestrol results in decreased expression of MXD4 mRNA | CTD | PMID:15171707 | dioxygen | multiple interactions | ISO | MXD4 (Homo sapiens) | 6480464 | Oxygen affects the reaction [AHR protein results in decreased expression of MXD4 mRNA] | CTD | PMID:27103661 | dioxygen | multiple interactions | EXP | | 6480464 | [dan-shen root extract co-treated with Andrographis paniculata extract] inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of MXD4 mRNA] and [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of MXD4 mRNA | CTD | PMID:33729688 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of MXD4 mRNA | CTD | PMID:29391264 | Enterolactone | multiple interactions | ISO | MXD4 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MXD4 mRNA | CTD | PMID:19167446 | ethanol | affects splicing | ISO | Mxd4 (Mus musculus) | 6480464 | Ethanol affects the splicing of MXD4 mRNA | CTD | PMID:30319688 | ethanol | affects expression | ISO | Mxd4 (Mus musculus) | 6480464 | Ethanol affects the expression of MXD4 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of MXD4 mRNA | CTD | PMID:23649840 | fenthion | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Fenthion results in decreased expression of MXD4 mRNA | CTD | PMID:34813904 | folic acid | multiple interactions | ISO | Mxd4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MXD4 mRNA | CTD | PMID:22206623 | genistein | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Genistein results in decreased expression of MXD4 mRNA | CTD | PMID:16474171 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of MXD4 mRNA | CTD | PMID:33387578 | geraniol | increases expression | ISO | MXD4 (Homo sapiens) | 6480464 | geraniol results in increased expression of MXD4 mRNA | CTD | PMID:27683099 | GW 7647 | decreases expression | EXP | | 6480464 | GW 7647 results in decreased expression of MXD4 mRNA | CTD | PMID:31628012 | indometacin | multiple interactions | ISO | MXD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of MXD4 mRNA | CTD | PMID:28628672 | manganese(II) chloride | decreases expression | EXP | | 6480464 | manganese chloride results in decreased expression of MXD4 mRNA | CTD | PMID:28801915 | methamphetamine | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Methamphetamine results in decreased expression of MXD4 mRNA | CTD | PMID:36914120 | methidathion | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | methidathion results in decreased expression of MXD4 mRNA | CTD | PMID:34813904 | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of MXD4 mRNA | CTD | PMID:28801915 | ozone | multiple interactions | ISO | Mxd4 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of MXD4 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of MXD4 mRNA | CTD | PMID:34911549 | palbociclib | increases expression | ISO | MXD4 (Homo sapiens) | 6480464 | palbociclib results in increased expression of MXD4 mRNA | CTD | PMID:22869556 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of MXD4 mRNA | CTD | PMID:33387578 | paraquat | increases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Paraquat results in increased expression of MXD4 mRNA | CTD | PMID:21463325 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Mxd4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of MXD4 mRNA | CTD | PMID:36331819 | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of MXD4 mRNA | CTD | PMID:19162173 | potassium chromate | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of MXD4 mRNA | CTD | PMID:22714537 | rotenone | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of MXD4 mRNA | CTD | PMID:29955902 | silicon dioxide | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of MXD4 mRNA | CTD | PMID:25895662 | silicon dioxide | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of MXD4 mRNA | CTD | PMID:29203145 | silver atom | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Silver results in decreased expression of MXD4 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | Silver results in decreased expression of MXD4 mRNA | CTD | PMID:27131904 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of MXD4 mRNA | CTD | PMID:19281266 | succimer | multiple interactions | ISO | Mxd4 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MXD4 mRNA | CTD | PMID:21641980 | sulforaphane | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of MXD4 mRNA | CTD | PMID:31838189 | testosterone enanthate | affects expression | ISO | MXD4 (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of MXD4 mRNA | CTD | PMID:17440010 | tetrachloromethane | affects expression | ISO | Mxd4 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of MXD4 mRNA | CTD | PMID:17484886 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MXD4 mRNA] | CTD | PMID:31150632 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of MXD4 mRNA | CTD | PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of MXD4 mRNA | CTD | PMID:23411599 | tremolite asbestos | decreases expression | ISO | Mxd4 (Mus musculus) | 6480464 | tremolite results in decreased expression of MXD4 mRNA | CTD | PMID:29279043 | tributylstannane | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with tributyltin] results in decreased expression of MXD4 mRNA | CTD | PMID:31129395 | tris(2-butoxyethyl) phosphate | affects expression | ISO | MXD4 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of MXD4 mRNA | CTD | PMID:29024780 | troglitazone | increases expression | ISO | MXD4 (Homo sapiens) | 6480464 | troglitazone results in increased expression of MXD4 mRNA | CTD | PMID:19140230 | urethane | increases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Urethane results in increased expression of MXD4 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | MXD4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of MXD4 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of MXD4 mRNA | CTD | PMID:23527032 more ... | valproic acid | affects expression | ISO | Mxd4 (Mus musculus) | 6480464 | Valproic Acid affects the expression of MXD4 mRNA | CTD | PMID:17963808 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of MXD4 mRNA | CTD | PMID:19015723 | vorinostat | decreases expression | ISO | MXD4 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of MXD4 mRNA | CTD | PMID:27188386 | |