Prtn3 (proteinase 3) - Rat Genome Database

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Gene: Prtn3 (proteinase 3) Rattus norvegicus
Analyze
Symbol: Prtn3
Name: proteinase 3
RGD ID: 1304898
Description: Predicted to enable enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including mature conventional dendritic cell differentiation; membrane protein ectodomain proteolysis; and neutrophil extravasation. Predicted to be located in azurophil granule lumen; cytosol; and plasma membrane raft. Predicted to be active in extracellular space. Predicted to colocalize with plasma membrane. Orthologous to human PRTN3 (proteinase 3); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314615; myeloblastin
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,472,750 - 10,482,037 (-)NCBIGRCr8
mRatBN7.279,822,123 - 9,831,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,822,122 - 9,831,944 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,702,828 - 12,706,274 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,580,909 - 14,584,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,440,584 - 12,444,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,643,712 - 12,646,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,643,516 - 12,646,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,813,238 - 12,822,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,334,722 - 11,338,559 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,334,722 - 11,338,559 (-)NCBI
Celera77,997,078 - 8,000,317 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11389039   PMID:16478888   PMID:16502470   PMID:17244676   PMID:17712045   PMID:18462208   PMID:19056867   PMID:20551380   PMID:20828556   PMID:21193407   PMID:21821719   PMID:22266279  
PMID:23202369   PMID:23533145   PMID:28240246  


Genomics

Comparative Map Data
Prtn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,472,750 - 10,482,037 (-)NCBIGRCr8
mRatBN7.279,822,123 - 9,831,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,822,122 - 9,831,944 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,702,828 - 12,706,274 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,580,909 - 14,584,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,440,584 - 12,444,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,643,712 - 12,646,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,643,516 - 12,646,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,813,238 - 12,822,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,334,722 - 11,338,559 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,334,722 - 11,338,559 (-)NCBI
Celera77,997,078 - 8,000,317 (-)NCBICelera
Cytogenetic Map7q11NCBI
PRTN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819840,999 - 848,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19840,999 - 848,175 (+)EnsemblGRCh38hg38GRCh38
GRCh3719840,999 - 848,175 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619791,985 - 799,175 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419791,964 - 799,051NCBI
Celera19766,135 - 773,326 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19610,181 - 617,038 (+)NCBIHuRef
CHM1_119840,583 - 847,665 (+)NCBICHM1_1
T2T-CHM13v2.019796,963 - 804,283 (+)NCBIT2T-CHM13v2.0
Prtn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,715,499 - 79,719,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,710,310 - 79,719,008 (+)EnsemblGRCm39 Ensembl
GRCm381079,879,667 - 79,883,174 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,874,476 - 79,883,174 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,342,412 - 79,345,919 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,282,796 - 79,286,303 (+)NCBIMGSCv36mm8
Celera1080,894,480 - 80,897,987 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
PRTN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,171,167 - 5,180,414 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,409,659 - 4,418,867 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019283,314 - 291,504 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119810,237 - 817,588 (+)NCBIpanpan1.1PanPan1.1panPan2
PRTN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,520,314 - 77,523,563 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,520,314 - 77,526,303 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,472,358 - 77,477,327 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRTN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16590,193 - 598,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660818,318,743 - 8,324,146 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prtn3
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000014687
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat

Markers in Region
AW531576  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,822,143 - 9,822,357 (+)MAPPERmRatBN7.2
Rnor_6.0712,643,537 - 12,643,750NCBIRnor6.0
Rnor_5.0712,813,259 - 12,813,472UniSTSRnor5.0
RGSC_v3.4711,334,547 - 11,334,760UniSTSRGSC3.4
Celera77,996,903 - 7,997,116UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 12 2 12
Low 14 8 15 8 68 18 36 6
Below cutoff 22 10 6 2 6 1 2 6 2 4 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014687   ⟹   ENSRNOP00000014687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,822,122 - 9,825,588 (-)Ensembl
Rnor_6.0 Ensembl712,643,516 - 12,646,960 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101903   ⟹   ENSRNOP00000097376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,822,122 - 9,831,944 (-)Ensembl
RefSeq Acc Id: NM_001024264   ⟹   NP_001019435
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,472,750 - 10,476,196 (-)NCBI
mRatBN7.279,822,123 - 9,825,569 (-)NCBI
Rnor_6.0712,643,712 - 12,646,951 (-)NCBI
Rnor_5.0712,813,238 - 12,822,399 (-)NCBI
RGSC_v3.4711,334,722 - 11,338,559 (-)RGD
Celera77,997,078 - 8,000,317 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078973   ⟹   XP_038934901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,472,750 - 10,482,037 (-)NCBI
mRatBN7.279,822,123 - 9,831,300 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001019435 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934901 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM27444 (Get FASTA)   NCBI Sequence Viewer  
  EDL89379 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014687
  ENSRNOP00000014687.5
  ENSRNOP00000097376
  ENSRNOP00000097376.1
Reference Protein Sequences
RefSeq Acc Id: NP_001019435   ⟸   NM_001024264
- Peptide Label: precursor
- UniProtKB: Q8K597 (UniProtKB/TrEMBL),   A6K8V9 (UniProtKB/TrEMBL),   F7FNG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014687   ⟸   ENSRNOT00000014687
RefSeq Acc Id: XP_038934901   ⟸   XM_039078973
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000097376   ⟸   ENSRNOT00000101903
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FNG0-F1-model_v2 AlphaFold F7FNG0 1-256 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304898 AgrOrtholog
BioCyc Gene G2FUF-34894 BioCyc
Ensembl Genes ENSRNOG00000029814 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014687 ENTREZGENE
  ENSRNOT00000014687.6 UniProtKB/TrEMBL
  ENSRNOT00000101903.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:314615 UniProtKB/TrEMBL
NCBI Gene 314615 ENTREZGENE
PANTHER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER UniProtKB/TrEMBL
  MYELOBLASTIN UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prtn3 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029814 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A0A8I6ARE6 ENTREZGENE, UniProtKB/TrEMBL
  A6K8V9 ENTREZGENE, UniProtKB/TrEMBL
  F7FNG0 ENTREZGENE, UniProtKB/TrEMBL
  Q8K597 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Prtn3  proteinase 3   Prtn3_predicted  proteinase 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Prtn3_predicted  proteinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED