Muc20 (mucin 20, cell surface associated) - Rat Genome Database

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Gene: Muc20 (mucin 20, cell surface associated) Rattus norvegicus
Analyze
Symbol: Muc20
Name: mucin 20, cell surface associated
RGD ID: 1304865
Description: Predicted to enable identical protein binding activity. Predicted to be involved in hepatocyte growth factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be located in basal plasma membrane. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human MUC20 (mucin 20, cell surface associated); INTERACTS WITH 3-chloropropane-1,2-diol; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC303886; mucin 20 ; mucin-20
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,492,844 - 81,506,571 (+)NCBIGRCr8
mRatBN7.21167,987,816 - 68,001,496 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,987,800 - 68,001,495 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,824,894 - 76,838,574 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,486,670 - 69,500,396 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,513,992 - 68,527,674 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,222,602 - 71,236,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,222,600 - 71,236,223 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,307,686 - 74,321,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,808,275 - 69,823,526 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11169,865,866 - 69,877,598 (+)NCBI
Celera1167,431,777 - 67,446,455 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney. Higuchi T, etal., J Biol Chem. 2004 Jan 16;279(3):1968-79. Epub 2003 Oct 17.
4. Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy. Li G, etal., Am J Nephrol. 2006;26(1):43-9. Epub 2006 Feb 24.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Effect of all-trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis. Qin YH, etal., Pediatr Nephrol. 2009 Aug;24(8):1477-86. Epub 2009 Apr 9.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:15314156  


Genomics

Comparative Map Data
Muc20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,492,844 - 81,506,571 (+)NCBIGRCr8
mRatBN7.21167,987,816 - 68,001,496 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,987,800 - 68,001,495 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,824,894 - 76,838,574 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,486,670 - 69,500,396 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,513,992 - 68,527,674 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,222,602 - 71,236,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,222,600 - 71,236,223 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,307,686 - 74,321,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,808,275 - 69,823,526 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11169,865,866 - 69,877,598 (+)NCBI
Celera1167,431,777 - 67,446,455 (+)NCBICelera
Cytogenetic Map11q22NCBI
MUC20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383195,720,978 - 195,733,551 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3195,720,884 - 195,741,123 (+)EnsemblGRCh38hg38GRCh38
GRCh373195,447,849 - 195,460,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363196,933,424 - 196,950,211 (+)NCBINCBI36Build 36hg18NCBI36
Build 343196,937,432 - 196,950,007NCBI
Celera3193,751,858 - 193,757,111 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3192,723,348 - 192,736,280 (+)NCBIHuRef
CHM1_13195,411,955 - 195,428,236 (+)NCBICHM1_1
T2T-CHM13v2.03198,633,304 - 198,645,342 (-)NCBIT2T-CHM13v2.0
Muc20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,597,793 - 32,617,805 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,597,793 - 32,617,805 (-)EnsemblGRCm39 Ensembl
GRCm381632,777,419 - 32,797,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,777,419 - 32,797,435 (-)EnsemblGRCm38mm10GRCm38
MGSCv371632,777,505 - 32,797,521 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,705,790 - 32,717,155 (-)NCBIMGSCv36mm8
Celera1633,256,163 - 33,276,159 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1623.34NCBI
Muc20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542012,212,666 - 12,234,213 (+)NCBIChiLan1.0ChiLan1.0
MUC20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,044,104 - 29,055,583 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,045,880 - 29,055,479 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,065,336 - 29,076,755 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,275,196 - 29,286,650 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13329,071,399 - 29,082,854 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,119,488 - 29,128,886 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03329,737,671 - 29,749,037 (+)NCBIUU_Cfam_GSD_1.0
Muc20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602125,373,162 - 125,406,455 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936784482,605 - 511,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113134,254,978 - 134,265,950 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,848,948 - 143,859,806 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MUC20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11591,354,233 - 91,369,553 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1591,357,841 - 91,369,482 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604165,298,547 - 65,309,871 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473061,124,764 - 61,149,993 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Muc20
104 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:149
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000002418
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

Markers in Region
RH141535  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,001,271 - 68,001,462 (+)MAPPERmRatBN7.2
Rnor_6.01171,235,999 - 71,236,189NCBIRnor6.0
Rnor_5.01174,320,803 - 74,320,993UniSTSRnor5.0
RGSC_v3.41169,823,302 - 69,823,492UniSTSRGSC3.4
Celera1167,446,231 - 67,446,421UniSTS
RH 3.4 Map11373.03UniSTS
Cytogenetic Map11q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 27 3
Low 1 16 14 11 14 2 8 24 11
Below cutoff 2 34 24 17 4 17 5 6 27 11 5

Sequence


RefSeq Acc Id: ENSRNOT00000002418   ⟹   ENSRNOP00000002418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,987,819 - 68,001,495 (+)Ensembl
Rnor_6.0 Ensembl1171,222,600 - 71,236,223 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111599   ⟹   ENSRNOP00000088906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,987,800 - 68,001,495 (+)Ensembl
RefSeq Acc Id: NM_001107089   ⟹   NP_001100559
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,492,891 - 81,506,571 (+)NCBI
mRatBN7.21167,987,816 - 68,001,496 (+)NCBI
Rnor_6.01171,222,621 - 71,236,223 (+)NCBI
Rnor_5.01174,307,686 - 74,321,027 (+)NCBI
RGSC_v3.41169,808,275 - 69,823,526 (+)RGD
Celera1167,431,777 - 67,446,455 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401397   ⟹   NP_001388326
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,492,891 - 81,506,571 (+)NCBI
mRatBN7.21167,987,816 - 68,001,496 (+)NCBI
RefSeq Acc Id: XM_063270512   ⟹   XP_063126582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,492,844 - 81,506,571 (+)NCBI
RefSeq Acc Id: NP_001100559   ⟸   NM_001107089
- Peptide Label: isoform 2 precursor
- UniProtKB: B2RZ35 (UniProtKB/TrEMBL),   F7FPW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002418   ⟸   ENSRNOT00000002418
RefSeq Acc Id: ENSRNOP00000088906   ⟸   ENSRNOT00000111599
RefSeq Acc Id: NP_001388326   ⟸   NM_001401397
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A8I6AAU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126582   ⟸   XM_063270512
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ35-F1-model_v2 AlphaFold B2RZ35 1-415 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698206
Promoter ID:EPDNEW_R8731
Type:multiple initiation site
Name:Muc20_1
Description:mucin 20, cell surface associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,222,610 - 71,222,670EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304865 AgrOrtholog
BioCyc Gene G2FUF-21114 BioCyc
Ensembl Genes ENSRNOG00000001776 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002418 ENTREZGENE
  ENSRNOT00000002418.7 UniProtKB/TrEMBL
  ENSRNOT00000111599 ENTREZGENE
  ENSRNOT00000111599.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128599 IMAGE-MGC_LOAD
InterPro MUC20 UniProtKB/TrEMBL
KEGG Report rno:303886 UniProtKB/TrEMBL
MGC_CLONE MGC:189200 IMAGE-MGC_LOAD
NCBI Gene 303886 ENTREZGENE
PANTHER MUCIN-20 UniProtKB/TrEMBL
  PTHR37358 UniProtKB/TrEMBL
PhenoGen Muc20 PhenoGen
RatGTEx ENSRNOG00000001776 RatGTEx
UniProt A0A8I6AAU0 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ35 ENTREZGENE, UniProtKB/TrEMBL
  F7FPW8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Muc20  mucin 20, cell surface associated  Muc20  mucin 20   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Muc20  mucin 20   Muc20_predicted  mucin 20 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Muc20_predicted  mucin 20 (predicted)      Symbol and Name status set to approved 70820 APPROVED