Ago1 (argonaute RISC component 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ago1 (argonaute RISC component 1) Rattus norvegicus
Analyze
Symbol: Ago1
Name: argonaute RISC component 1
RGD ID: 1304619
Description: Predicted to enable RNA polymerase II complex binding activity and nucleic acid binding activity. Involved in regulation of mRNA stability. Predicted to be located in P-body and cytosol. Predicted to be part of RISC complex and RISC-loading complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human AGO1 (argonaute RISC component 1); PARTICIPATES IN microRNA pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: argonaute 1, RISC catalytic component; argonaute RISC catalytic component 1; Eif2c1; eukaryotic translation initiation factor 2C, 1; LOC313594; protein argonaute-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,006,618 - 144,064,740 (-)NCBIGRCr8
mRatBN7.25138,722,111 - 138,757,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,722,111 - 138,773,546 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5141,419,895 - 141,454,732 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,189,892 - 143,224,724 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,190,669 - 143,225,508 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,444,390 - 144,479,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,448,792 - 144,479,306 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,214,328 - 148,246,407 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45145,797,436 - 145,829,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15145,806,727 - 145,840,972 (-)NCBI
Celera5137,218,551 - 137,248,255 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Argonaute proteins at a glance. Ender C and Meister G, J Cell Sci. 2010 Jun 1;123(Pt 11):1819-23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. Gedik H, etal., DNA Cell Biol. 2015 Mar;34(3):220-6. doi: 10.1089/dna.2014.2549. Epub 2014 Dec 11.
4. Non-equivalent Roles of AGO1 and AGO2 in mRNA Turnover and Translation of Cyclin D1 mRNA. Ghosh U and Adhya S, J Biol Chem. 2016 Mar 25;291(13):7119-27. doi: 10.1074/jbc.M115.696377. Epub 2016 Feb 4.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11726686   PMID:15260970   PMID:17932509   PMID:18771919   PMID:19536157   PMID:19898466   PMID:19966796   PMID:20014101   PMID:22053081   PMID:22681889   PMID:22795694   PMID:23185045  
PMID:23426184   PMID:23809764   PMID:24949972   PMID:25336585   PMID:26764146   PMID:30207314   PMID:31786333  


Genomics

Comparative Map Data
Ago1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,006,618 - 144,064,740 (-)NCBIGRCr8
mRatBN7.25138,722,111 - 138,757,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,722,111 - 138,773,546 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5141,419,895 - 141,454,732 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,189,892 - 143,224,724 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,190,669 - 143,225,508 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,444,390 - 144,479,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,448,792 - 144,479,306 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,214,328 - 148,246,407 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45145,797,436 - 145,829,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15145,806,727 - 145,840,972 (-)NCBI
Celera5137,218,551 - 137,248,255 (-)NCBICelera
Cytogenetic Map5q36NCBI
AGO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,869,761 - 35,930,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl135,869,808 - 35,930,532 (+)EnsemblGRCh38hg38GRCh38
GRCh37136,335,362 - 36,396,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,121,397 - 36,162,486 (+)NCBINCBI36Build 36hg18NCBI36
Build 34136,017,902 - 36,058,992NCBI
Celera134,623,239 - 34,664,327 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef134,466,263 - 34,506,900 (+)NCBIHuRef
CHM1_1136,465,187 - 36,506,280 (+)NCBICHM1_1
T2T-CHM13v2.0135,732,654 - 35,793,426 (+)NCBIT2T-CHM13v2.0
Ago1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,328,805 - 126,362,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,328,805 - 126,362,376 (-)EnsemblGRCm39 Ensembl
GRCm384126,435,012 - 126,468,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,435,012 - 126,468,583 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,112,256 - 126,145,665 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,941,807 - 125,970,725 (-)NCBIMGSCv36mm8
Celera4124,771,815 - 124,805,219 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map460.76NCBI
Ago1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,934,346 - 13,968,624 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545213,935,028 - 13,967,281 (+)NCBIChiLan1.0ChiLan1.0
AGO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,922,849 - 190,963,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,038,742 - 190,085,087 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,148,984 - 35,196,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1136,324,733 - 36,370,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl136,324,733 - 36,360,832 (+)Ensemblpanpan1.1panPan2
AGO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,258,359 - 6,294,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,263,882 - 6,295,338 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha156,501,590 - 6,538,192 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0156,394,522 - 6,431,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,395,742 - 6,431,512 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,247,517 - 6,284,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,321,049 - 6,352,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,330,625 - 6,367,229 (-)NCBIUU_Cfam_GSD_1.0
AGO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12096,929,985 - 96,971,074 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2096,934,659 - 96,971,014 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603319,754,613 - 19,801,453 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ago1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,904,639 - 18,940,594 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476418,904,607 - 18,940,594 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ago1
94 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat

Markers in Region
BF413651  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25138,750,307 - 138,750,436 (+)MAPPERmRatBN7.2
Rnor_6.05144,472,586 - 144,472,714NCBIRnor6.0
Rnor_5.05148,239,800 - 148,239,928UniSTSRnor5.0
RGSC_v3.45145,822,909 - 145,823,037UniSTSRGSC3.4
Celera5137,246,465 - 137,246,593UniSTS
RH 3.4 Map5919.1UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 14 20 4 19 4 74 27 34 11
Low 1 29 37 37 37 8 11 8 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087697   ⟹   ENSRNOP00000072144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5138,722,111 - 138,757,118 (-)Ensembl
Rnor_6.0 Ensembl5144,448,792 - 144,479,306 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104567   ⟹   ENSRNOP00000077744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5138,722,111 - 138,752,747 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111477   ⟹   ENSRNOP00000080864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5138,722,111 - 138,752,196 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117987   ⟹   ENSRNOP00000088339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5138,722,111 - 138,773,546 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118733   ⟹   ENSRNOP00000080113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5138,722,111 - 138,752,976 (-)Ensembl
RefSeq Acc Id: NM_001191765   ⟹   NP_001178694
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,006,618 - 144,041,624 (-)NCBI
mRatBN7.25138,722,111 - 138,757,118 (-)NCBI
Rnor_6.05144,444,390 - 144,479,396 (-)NCBI
Rnor_5.05148,214,328 - 148,246,407 (-)NCBI
Celera5137,218,551 - 137,248,255 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001317181   ⟹   NP_001304110
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,006,618 - 144,041,624 (-)NCBI
mRatBN7.25138,722,111 - 138,757,118 (-)NCBI
Rnor_6.05144,444,390 - 144,479,396 (-)NCBI
Celera5137,218,551 - 137,248,255 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764025   ⟹   XP_008762247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,006,674 - 144,041,619 (-)NCBI
mRatBN7.25138,722,167 - 138,757,113 (-)NCBI
Rnor_6.05144,444,390 - 144,479,430 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593401   ⟹   XP_017448890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,006,674 - 144,034,435 (-)NCBI
mRatBN7.25138,722,111 - 138,749,940 (-)NCBI
Rnor_6.05144,444,390 - 144,472,163 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110021   ⟹   XP_038965949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,006,674 - 144,034,442 (-)NCBI
mRatBN7.25138,722,111 - 138,749,940 (-)NCBI
RefSeq Acc Id: XM_039110022   ⟹   XP_038965950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,006,674 - 144,034,436 (-)NCBI
mRatBN7.25138,722,111 - 138,749,930 (-)NCBI
RefSeq Acc Id: XM_063287758   ⟹   XP_063143828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,006,674 - 144,064,740 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001178694   ⟸   NM_001191765
- Peptide Label: isoform 1
- UniProtKB: A0A8I5ZP12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762247   ⟸   XM_008764025
- Peptide Label: isoform X1
- UniProtKB: D4AC38 (UniProtKB/TrEMBL),   A0A8I5ZP12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304110   ⟸   NM_001317181
- Peptide Label: isoform 1x
- UniProtKB: A0A8I5ZP12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448890   ⟸   XM_017593401
- Peptide Label: isoform X3
- UniProtKB: A0A8I6G551 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072144   ⟸   ENSRNOT00000087697
RefSeq Acc Id: XP_038965949   ⟸   XM_039110021
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G551 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965950   ⟸   XM_039110022
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000080864   ⟸   ENSRNOT00000111477
RefSeq Acc Id: ENSRNOP00000080113   ⟸   ENSRNOT00000118733
RefSeq Acc Id: ENSRNOP00000077744   ⟸   ENSRNOT00000104567
RefSeq Acc Id: ENSRNOP00000088339   ⟸   ENSRNOT00000117987
RefSeq Acc Id: XP_063143828   ⟸   XM_063287758
- Peptide Label: isoform X4
- UniProtKB: A6ISA8 (UniProtKB/TrEMBL)
Protein Domains
PAZ   Piwi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AC38-F1-model_v2 AlphaFold D4AC38 1-857 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694037
Promoter ID:EPDNEW_R4562
Type:multiple initiation site
Name:Ago1_1
Description:argonaute 1, RISC catalytic component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05144,479,396 - 144,479,456EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304619 AgrOrtholog
BioCyc Gene G2FUF-39887 BioCyc
Ensembl Genes ENSRNOG00000055915 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087697 ENTREZGENE
  ENSRNOT00000087697.2 UniProtKB/TrEMBL
  ENSRNOT00000104567.1 UniProtKB/TrEMBL
  ENSRNOT00000111477.1 UniProtKB/TrEMBL
  ENSRNOT00000117987.1 UniProtKB/TrEMBL
  ENSRNOT00000118733 ENTREZGENE
  ENSRNOT00000118733.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
  paz domain UniProtKB/TrEMBL
InterPro ArgoL2 UniProtKB/TrEMBL
  Argonaute_Mid_dom UniProtKB/TrEMBL
  Argonaute_N UniProtKB/TrEMBL
  DUF1785 UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
  Piwi_ago-like UniProtKB/TrEMBL
  PolynucTfrase_RNaseH_fold UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
NCBI Gene 313594 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/TrEMBL
  PROTEIN ARGONAUTE-1 UniProtKB/TrEMBL
Pfam ArgoL2 UniProtKB/TrEMBL
  ArgoMid UniProtKB/TrEMBL
  ArgoN UniProtKB/TrEMBL
  DUF1785 UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
PhenoGen Ago1 PhenoGen
PROSITE PAZ UniProtKB/TrEMBL
  PIWI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055915 RatGTEx
SMART DUF1785 UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
Superfamily-SCOP PAZ UniProtKB/TrEMBL
  RNaseH_fold UniProtKB/TrEMBL
UniProt A0A8I5Y871_RAT UniProtKB/TrEMBL
  A0A8I5ZP12 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4X4_RAT UniProtKB/TrEMBL
  A0A8I6G551 ENTREZGENE, UniProtKB/TrEMBL
  A6ISA8 ENTREZGENE, UniProtKB/TrEMBL
  D4AC38 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-25 Ago1  argonaute RISC component 1  Ago1  argonaute RISC catalytic component 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-12-04 Ago1  argonaute RISC catalytic component 1  Ago1  argonaute 1, RISC catalytic component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Ago1  argonaute 1, RISC catalytic component  Ago1  argonaute RISC catalytic component 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-22 Ago1  argonaute RISC catalytic component 1  Eif2c1  eukaryotic translation initiation factor 2C, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Eif2c1  eukaryotic translation initiation factor 2C, 1   Eif2c1_predicted  eukaryotic translation initiation factor 2C, 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Eif2c1_predicted  eukaryotic translation initiation factor 2C, 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED