Dek (DEK proto-oncogene) - Rat Genome Database

Name: Dek
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Dek (DEK proto-oncogene) Rattus norvegicus

Analyze

Symbol:

Dek

Name:

DEK proto-oncogene

RGD ID:

1303246

Description:

Predicted to enable histone binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase III and regulation of double-strand break repair. Predicted to act upstream of or within regulation of double-strand break repair via nonhomologous end joining. Predicted to be located in contractile fiber and nucleoplasm. Predicted to be part of B-WICH complex. Predicted to be active in nucleus. Orthologous to human DEK (DEK proto-oncogene); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DEK oncogene; DEK oncogene (DNA binding); MGC94795

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DEK (DEK proto-oncogene)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Dek (DEK proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dek (DEK proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DEK (DEK proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC100688177 (protein DEK-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dek (DEK proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DEK (DEK proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DEK (DEK proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dek (DEK proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DEK (DEK proto-oncogene)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dek (DEK proto-oncogene)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dek (DEK proto-oncogene)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Dek	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dek	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	17,786,989 - 17,809,096 (+)	NCBI		GRCr8
mRatBN7.2	17	17,580,804 - 17,602,825 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	17,580,843 - 17,602,808 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	17,467,321 - 17,488,966 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	19,071,178 - 19,092,823 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	17,394,438 - 17,416,083 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	17,965,872 - 17,987,836 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	17,965,881 - 17,987,834 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	19,948,512 - 19,970,498 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	23,633,551 - 23,655,507 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	23,633,599 - 23,655,553 (+)	NCBI
Celera	17	17,292,456 - 17,314,107 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

Breast Neoplasms (ISO)

genetic disease (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-methylnicotinamide (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4-methyl-2-oxopentanoic acid (ISO)

5-oxo-L-proline (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alloxanthine (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

C60 fullerene (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chloroprene (EXP)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

creatine (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dimethylamine (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

fenthion (ISO)

folic acid (ISO)

formic acid (ISO)

FR900359 (ISO)

fructose (ISO)

fulvestrant (ISO)

furan (EXP)

gamma-poly(L-glutamic acid) macromolecule (ISO)

gentamycin (EXP)

geraniol (ISO)

glafenine (EXP)

glucose (ISO)

glutathione (ISO)

glycine (ISO)

inositol (ISO)

ivermectin (ISO)

kojic acid (ISO)

L-alanine (ISO)

Mesaconitine (EXP)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

N-nitrosodiethylamine (ISO)

NAD zwitterion (ISO)

NAD(+) (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

PCB138 (EXP)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phosphocholine (ISO)

phosphorylcholine chloride (ISO)

picoxystrobin (ISO)

progesterone (ISO)

pyrimidifen (ISO)

pyruvic acid (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

succinic acid (ISO)

tamoxifen (ISO)

taurine (ISO)

tebufenpyrad (ISO)

temozolomide (ISO)

testosterone (ISO)

thapsigargin (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin organization (IEA)

positive regulation of transcription by RNA polymerase III (IEA,ISO)

regulation of double-strand break repair (IBA,ISO)

regulation of double-strand break repair via nonhomologous end joining (IEA,ISO)

Cellular Component

B-WICH complex (IEA,ISO)

contractile muscle fiber (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

Molecular Function

DNA binding (IEA)

histone binding (IBA,IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12140263	PMID:15489334	PMID:21653549	PMID:22358842	PMID:22658674	PMID:22681889	PMID:31505169

Genomics

Comparative Map Data

Dek
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	17,786,989 - 17,809,096 (+)	NCBI		GRCr8
mRatBN7.2	17	17,580,804 - 17,602,825 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	17,580,843 - 17,602,808 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	17,467,321 - 17,488,966 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	19,071,178 - 19,092,823 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	17,394,438 - 17,416,083 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	17,965,872 - 17,987,836 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	17,965,881 - 17,987,834 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	19,948,512 - 19,970,498 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	23,633,551 - 23,655,507 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	23,633,599 - 23,655,553 (+)	NCBI
Celera	17	17,292,456 - 17,314,107 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

DEK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	18,223,860 - 18,264,530 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	18,223,860 - 18,264,548 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	18,224,091 - 18,264,761 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	18,332,379 - 18,372,778 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	18,332,391 - 18,372,750	NCBI
Celera	6	19,462,368 - 19,502,747 (-)	NCBI		Celera
Cytogenetic Map	6	p22.3	NCBI
HuRef	6	18,168,737 - 18,209,264 (-)	NCBI		HuRef
CHM1_1	6	18,226,996 - 18,267,392 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	18,096,002 - 18,136,672 (-)	NCBI		T2T-CHM13v2.0

Dek
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	47,238,243 - 47,261,134 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	47,238,251 - 47,259,677 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	47,084,767 - 47,107,530 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	47,084,775 - 47,106,201 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	47,180,136 - 47,201,589 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	47,095,757 - 47,117,082 (-)	NCBI		MGSCv36	mm8
Celera	13	48,169,343 - 48,190,333 (-)	NCBI		Celera
Cytogenetic Map	13	A5	NCBI
cM Map	13	24.5	NCBI

Dek
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955408	28,470,207 - 28,472,083 (-)	NCBI	ChiLan1.0	ChiLan1.0

DEK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	32,883,587 - 32,923,584 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	28,868,850 - 28,909,152 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	18,071,928 - 18,112,245 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	18,425,882 - 18,465,828 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	18,427,844 - 18,465,606 (-)	Ensembl	panpan1.1		panPan2

LOC100688177
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	10,279,204 - 10,280,935 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	11,622,628 - 11,624,150 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	10,169,743 - 10,171,465 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	3	10,110,427 - 10,111,962 (-)	NCBI		UMICH_Zoey_3.1

Dek
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	7,737,766 - 7,766,430 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936552	3,966,198 - 3,993,113 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936552	3,964,515 - 3,997,318 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DEK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	13,872,775 - 13,935,173 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	13,901,562 - 13,935,477 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	14,643,279 - 14,676,979 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DEK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	53,879,902 - 53,919,533 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666044	18,447,488 - 18,487,777 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dek
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	8,421,782 - 8,447,452 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624756	8,421,492 - 8,447,452 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dek
73 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	185
Count of miRNA genes:	137
Interacting mature miRNAs:	161
Transcripts:	ENSRNOT00000021751
Prediction methods:	Miranda, Pita, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22871563	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2115149	21881669	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
631499	Stl1	Serum triglyceride level QTL 1	3.6		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	3271398	27389946	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	17	4299130	21293263	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	4299130	21293263	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4354487	27028127	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4354487	27028127	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9201365	23653323	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9201365	23653323	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9201365	23653323	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9201365	23653323	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9991286	40540197	Rat
1549900	Iddm20	Insulin dependent diabetes mellitus QTL 20	3.7		pancreas integrity trait (VT:0010560)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	17	13986773	21975515	Rat
1331720	Rf43	Renal function QTL 43	2.881		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	17	15330613	23017269	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat

Markers in Region

RH139333

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	17	p13	UniSTS

RH132430

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	17,602,534 - 17,602,751 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	17,987,546 - 17,987,762	NCBI	Rnor6.0
Rnor_5.0	17	19,948,586 - 19,948,802	UniSTS	Rnor5.0
RGSC_v3.4	17	23,655,217 - 23,655,433	UniSTS	RGSC3.4
Celera	17	17,313,817 - 17,314,033	UniSTS
RH 3.4 Map	17	195.1	UniSTS
Cytogenetic Map	17	p13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	10	74	35	41	11	8
Low								1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010058862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC133492	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000021751 ⟹ ENSRNOP00000021751

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	17,580,843 - 17,602,808 (+)	Ensembl
Rnor_6.0 Ensembl	17	17,965,881 - 17,987,834 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000115805 ⟹ ENSRNOP00000089065

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	17,580,843 - 17,601,409 (+)	Ensembl

RefSeq Acc Id:

NM_001004255 ⟹ NP_001004255

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	17,787,139 - 17,809,096 (+)	NCBI
mRatBN7.2	17	17,580,866 - 17,602,825 (+)	NCBI
Rnor_6.0	17	17,965,881 - 17,987,836 (+)	NCBI
Rnor_5.0	17	19,948,512 - 19,970,498 (-)	NCBI
RGSC_v3.4	17	23,633,551 - 23,655,507 (+)	RGD
Celera	17	17,292,456 - 17,314,107 (+)	RGD

Sequence:

show sequence

GTTGATTCTGAGGAACCGAGAGCGAGCGCGCGGCTTCGCGAGGACCTCGGCCCGCGCGCCTTCC
ACTCAGCGGCGGCCTTCTCGTGCGCACCCGCGGCTCCCAGCATGTCGGCGGCGGCAGCCCCCGC
TGCGGAGGGAGAGGACACCCCCACGCCGCCCGCGTCCGAGAAGGAACCTGAGATGCCGGGTCCC
AGGGAGGAGAGTGAGGAGGAAGAGGAGGAGGACGACGACGATGAGGATGAGGAGGAAGAAAAAG
AAAAGAGCCTTATCGTGGAGGGCAAGAGAGAGAAGAGGAAAGTAGAGAGGCTGACGATGCAGGT
GTCTTCCTTACAGAGAGAGCCGTTCACAATCGCACAAGGGAAGGGTCAGAAACTTTGTGAAATT
GAAAGGATACATTTCTTTCTGAGTAAGAAAAAAACAGATGAACTTAGAAATCTACACAAACTGC
TTTACAACAGGCCGGGCACAGTGTCCTCTTTGAAGAAGAATGTGGGTCAGTTCAGTGGCTTTCC
ATTTGAAAAAGGCAGTACCCAGTATAAAAAGAAGGAAGAAATGTTGAAAAAGTATAGAAACGCC
ATGTTAAAGAGCATCTGTGAGGTTCTTGATCTAGAGAGGTCAGGTGTGAACAGTGAACTAGTGA
AGAGGATCTTGAATTTCTTAATGCATCCAAAGCCTTCTGGCAAACCATTGCCAAAATCCAAAAA
ATCTTCCAGCAAAGGTAGTAAAAAGGAACGGAACAGTTCTGGAACGACAAGGAAGTCAAAGCAA
ACTAAATGTCCTGAAATTCTGTCAGATGAGTCTAGTAGTGATGAAGATGAGAAGAAAAACAAGG
ACGAGTCTTCAGAAGATGAAGAGAAAGAAAGTGAAGAGGAGCAACCACCAAAAAAGACATCTAA
AAAAGAAAAAGCAAAACAGAAAGCTACCACTAAAAGTAAAAAATCTGTGAAGAGTGCTAATGTT
AAGAAGGCGGACAGCAGCACCACCAAGAAGAACCAAAACAGTTCCAAAAAAGAGTCTGGATCTG
AAGATAGTTCTGATGATGAACCTTTAATTAAAAAATTGAAAAAGCCACCTACAGATGAAGAACT
AAAGGAGACTGTGAAGAAGTTACTGGCTGATGCGAACCTGGAAGAAGTCACAATGAAGCAGATT
TGCAAAGAGGTATATGAAAATTATCCTGCGTATGATTTAACTGAGAGGAAAGATTTCATTAAAA
CGACTGTAAAAGAGCTAATCTCTTGAGATAGAGGACAGATGGCTTGTTCTCAGATTAGAAGATC
TGATTTATACCAGCAAAGAGAATGTATTCTTTTTTAAGTCTATTGTTGGTAGAACTTGCTGCTG
ACTCTTTTGCGTGTTACATATATTTGAGCTTGTTTTAAATTGCATTTTCTCGCAGTTTTCAGTT
TAAATCTTGCATGGCCGAAATTGTTCCTTGCTTTTTATAGTTGTACATTTTGGGTTTCTTTATT
GTAAGGTCATAGATTCCTGAACTATTGTGAATTTTAGTGAACTTAATGTTAGCTTGCTTAAGAC
ATACTTTTAATCAAAGCAAAAACTATTATAACCAGCATTTATATGTGCAAAGACGACTGCAGTA
TTTAGCATATGGATATTTTGAACACATCTTCTGTCAGTGTGGGACACGGCGGCAGTCTGTTCAT
CAGGGTGGAGCACAGCTGTGCAGACGACCGAGCTGGAACTTTCTCTGCATGTGTATATATCTCA
AGTTGTTGGCATGACAGAAGTGACAGATGTTATTTTTGTATTTTTTAAAACCAATTTGTTGTAT
ATAATTTTTTTTATTTCTTTTGTGCAAATCAATTTTTTAAATCTTGTGTCTTTAAACTTGTAAC
TAAACGTCAGTGTTCATCCAGGCAGCAATGACAGAACAGTTCAGTGATGATGACACTGAAAGGA
CTGTTGAGTTCTGCTTTGCCCTGAAAGTGTCATCAGTGTGGTTGTGTTAAAACTTTAAGTGTCA
TAGAAATTTTATGAGGATAAACACATCACAGCTTCAAACTGGGAAAGAGTAAGCACACATAGCT
TATGTATCAGTGAACTGACAGTAGCAAACCTCTGACCATATAAAAGATACAGGAAACCTGGCTA
CCTTCATAATTATGATAAAAGTATCTGGGTAAGGCCAGAGTTGGTGTGGACAACATAGGTCTCT
AAAGTATATCAAAAACCATACATTTAATATTAAAGTATTATAGAATCAAGGCTATTTGATTTTA
AATTTTGGTCAATCAAGATTTTAAGGTGATGAAACATGGAGTGCCCCTGAATTTAAATTTTGAC
TGTCCTAATAACCTATTTCTGAATTATAACATGCTGCTTGACAGAGTGACATTTGATGTACCGA
CTGAGTGTTTAATCTTCCACATCAGAGATCAGATTTGAGCATTAACAGGTATATTTTCACATAC
TTGACTTCAACATGCTTAGAGTGATATGGAACAGGCAACTAAGGGGGGACTAAAAAGTTGACCT
TTGTCATAAATCTTCGCAATAAAGAATAAATCAATGTTTTAAGTTTCTTGTATTTAAAAAAAAA
AAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039095669 ⟹ XP_038951597

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	17,787,354 - 17,809,081 (+)	NCBI
mRatBN7.2	17	17,581,069 - 17,602,825 (+)	NCBI

RefSeq Acc Id:

XM_039095670 ⟹ XP_038951598

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	17,789,012 - 17,809,081 (+)	NCBI
mRatBN7.2	17	17,582,768 - 17,602,825 (+)	NCBI

RefSeq Acc Id:

XM_063276370 ⟹ XP_063132440

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	17,786,989 - 17,809,081 (+)	NCBI

RefSeq Acc Id:

XM_063276371 ⟹ XP_063132441

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	17,787,349 - 17,809,081 (+)	NCBI

RefSeq Acc Id:

XM_063276372 ⟹ XP_063132442

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	17,788,996 - 17,809,081 (+)	NCBI

RefSeq Acc Id:

XR_010058862

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	17,786,989 - 17,805,561 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001004255	(Get FASTA)	NCBI Sequence Viewer
	XP_038951597	(Get FASTA)	NCBI Sequence Viewer
	XP_038951598	(Get FASTA)	NCBI Sequence Viewer
	XP_063132440	(Get FASTA)	NCBI Sequence Viewer
	XP_063132441	(Get FASTA)	NCBI Sequence Viewer
	XP_063132442	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79344	(Get FASTA)	NCBI Sequence Viewer
	EDL98152	(Get FASTA)	NCBI Sequence Viewer
	EDL98153	(Get FASTA)	NCBI Sequence Viewer
	EDL98154	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021751
	ENSRNOP00000021751.4
	ENSRNOP00000089065.1
	ENSRNOP00055019391
	ENSRNOP00060030272
	ENSRNOP00065012156
GenBank Protein	Q6AXS3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001004255 ⟸ NM_001004255

- UniProtKB:

Q6AXS3 (UniProtKB/Swiss-Prot), A6J702 (UniProtKB/TrEMBL), A0A8I6A9D8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSAAAAPAAEGEDTPTPPASEKEPEMPGPREESEEEEEEDDDDEDEEEEKEKSLIVEGKREKRK
VERLTMQVSSLQREPFTIAQGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTVSSLKKN
VGQFSGFPFEKGSTQYKKKEEMLKKYRNAMLKSICEVLDLERSGVNSELVKRILNFLMHPKPSG
KPLPKSKKSSSKGSKKERNSSGTTRKSKQTKCPEILSDESSSDEDEKKNKDESSEDEEKESEEE
QPPKKTSKKEKAKQKATTKSKKSVKSANVKKADSSTTKKNQNSSKKESGSEDSSDDEPLIKKLK
KPPTDEELKETVKKLLADANLEEVTMKQICKEVYENYPAYDLTERKDFIKTTVKELIS

hide sequence

RefSeq Acc Id:

ENSRNOP00000021751 ⟸ ENSRNOT00000021751

RefSeq Acc Id:	XP_038951597 ⟸ XM_039095669
- Peptide Label:	isoform X2
- UniProtKB:	Q6AXS3 (UniProtKB/Swiss-Prot), A6J702 (UniProtKB/TrEMBL), A0A8I6A9D8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038951598 ⟸ XM_039095670
- Peptide Label:	isoform X4

RefSeq Acc Id:

ENSRNOP00000089065 ⟸ ENSRNOT00000115805

RefSeq Acc Id:	XP_063132440 ⟸ XM_063276370
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063132441 ⟸ XM_063276371
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063132442 ⟸ XM_063276372
- Peptide Label:	isoform X3

Protein Domains

DEK-C SAP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AXS3-F1-model_v2	AlphaFold	Q6AXS3	1-378	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700363

Promoter ID:

EPDNEW_R10887

Type:

multiple initiation site

Name:

Dek_1

Description:

DEK proto-oncogene

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	17,965,884 - 17,965,944	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303246	AgrOrtholog
BioCyc Gene	G2FUF-9911	BioCyc
Ensembl Genes	ENSRNOG00000016152	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055013831	UniProtKB/Swiss-Prot
	ENSRNOG00060021195	UniProtKB/Swiss-Prot
	ENSRNOG00065009985	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000021751	ENTREZGENE
	ENSRNOT00000021751.5	UniProtKB/Swiss-Prot
	ENSRNOT00000115805.1	UniProtKB/TrEMBL
	ENSRNOT00055023791	UniProtKB/Swiss-Prot
	ENSRNOT00060036761	UniProtKB/Swiss-Prot
	ENSRNOT00065016057	UniProtKB/Swiss-Prot
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7107191	IMAGE-MGC_LOAD
InterPro	DEK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DEK_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAP_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:306817	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:94795	IMAGE-MGC_LOAD
NCBI Gene	306817	ENTREZGENE
PANTHER	PROTEIN DEK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR13468	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DEK_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dek	PhenoGen
PROSITE	DEK_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016152	RatGTEx
	ENSRNOG00055013831	RatGTEx
	ENSRNOG00060021195	RatGTEx
	ENSRNOG00065009985	RatGTEx
SMART	SAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	DEK C-terminal domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A9D8	ENTREZGENE, UniProtKB/TrEMBL
	A6J702	ENTREZGENE, UniProtKB/TrEMBL
	A6J703_RAT	UniProtKB/TrEMBL
	A6J704_RAT	UniProtKB/TrEMBL
	DEK_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-07-09	Dek	DEK proto-oncogene	Dek	DEK oncogene	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Dek	DEK oncogene	Dek	DEK oncogene (DNA binding)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Dek	DEK oncogene (DNA binding)			Symbol and Name status set to approved	1299863	APPROVED
2005-09-30	Dek				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD