Fcgr3a (Fc gamma receptor 3A) - Rat Genome Database

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Gene: Fcgr3a (Fc gamma receptor 3A) Rattus norvegicus
Analyze
Symbol: Fcgr3a
Name: Fc gamma receptor 3A
RGD ID: 1303067
Description: Predicted to enable IgE receptor activity and low-affinity IgG receptor activity. Involved in cellular response to lipopolysaccharide. Located in cell surface. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); glomerulonephritis (multiple); graft-versus-host disease; and hematologic cancer (multiple). Orthologous to several human genes including FCGR3A (Fc gamma receptor IIIa); PARTICIPATES IN Leishmaniasis pathway; phagocytosis pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD16-2; Fc fragment of IgG intermediate affinity IV receptor; Fc fragment of IgG receptor IIIa; Fc fragment of IgG, low affinity IIIa, receptor; Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc gamma receptor IIIa; fcgammaRIV; Fcgr4; IgG Fc receptor III-A; LOC304966; low affinity immunoglobulin gamma Fc region receptor III-A; transmembrane receptor FcgammaRIII-X
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,782,636 - 85,792,656 (+)NCBIGRCr8
mRatBN7.21383,249,905 - 83,259,921 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,249,872 - 83,259,921 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,869,672 - 85,879,670 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,163,159 - 87,173,157 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,401,088 - 84,411,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,385,775 - 89,396,047 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,385,859 - 89,396,051 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,025,150 - 94,035,170 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,867,641 - 86,877,665 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11386,881,828 - 86,891,853 (+)NCBI
Celera1382,902,506 - 82,912,524 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
Cuprizon  (EXP)
curcumin  (ISO)
D-glucose  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
Echimidine  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fructose  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
Heliotrine  (EXP)
indoles  (EXP)
indometacin  (EXP)
isoprenaline  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mercaptopurine  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methylmercury chloride  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (EXP)
sevoflurane  (EXP)
silicon dioxide  (EXP)
succimer  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice. Abboud G, etal., J Immunol. 2009 May 15;182(10):6517-26.
2. FcgammaRIIa, IIIa and IIIb gene polymorphisms in Behcet's disease: do they have any clinical implications? Aksu K, etal., Clin Exp Rheumatol. 2008 Jul-Aug;26(4 Suppl 50):S77-83.
3. Serious pulmonary toxicity in patients with Hodgkin's lymphoma with SGN-30, gemcitabine, vinorelbine, and liposomal doxorubicin is associated with an FcgammaRIIIa-158 V/F polymorphism. Blum KA, etal., Ann Oncol. 2010 Nov;21(11):2246-54. doi: 10.1093/annonc/mdq211. Epub 2010 Apr 27.
4. Association of the leukocyte immunoglobulin G (Fcgamma) receptor IIIa-158V/F polymorphism with inflammatory myopathies in Dutch patients. Bronner IM, etal., Tissue Antigens. 2009 Jun;73(6):586-9.
5. Association of FCGR3A and FCGR3B copy number variations with systemic lupus erythematosus and rheumatoid arthritis in Taiwanese patients. Chen JY, etal., Arthritis Rheumatol. 2014 Nov;66(11):3113-21. doi: 10.1002/art.38813.
6. Correlation of specialized CD16(+) gammadelta T cells with disease course and severity in multiple sclerosis. Chen Z and Freedman MS, J Neuroimmunol. 2008 Feb;194(1-2):147-52. Epub 2007 Dec 26.
7. Platelet-associated antibodies, cellular immunity and FCGR3a genotype influence the response to rituximab in immune thrombocytopenia. Cooper N, etal., Br J Haematol. 2012 Aug;158(4):539-47. doi: 10.1111/j.1365-2141.2012.09184.x. Epub 2012 Jul 6.
8. Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections. de Vries E, etal., Blood. 1996 Oct 15;88(8):3022-7.
9. FcgammaRIIa and FcgammaRIIIa genetic polymorphisms in a group of pediatric immune thrombocytopenic purpura in Egypt. Eyada TK, etal., Blood Coagul Fibrinolysis. 2012 Jan;23(1):64-8. doi: 10.1097/MBC.0b013e32834ddf2f.
10. Fc gamma RIIIa and Fc gamma RIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia. Farag SS, etal., Blood. 2004 Feb 15;103(4):1472-4. Epub 2003 Oct 16.
11. Nonclinical evaluation of GMA161--an antihuman CD16 (FcgammaRIII) monoclonal antibody for treatment of autoimmune disorders in CD16 transgenic mice. Flaherty MM, etal., Toxicol Sci. 2012 Jan;125(1):299-309. doi: 10.1093/toxsci/kfr278. Epub 2011 Oct 24.
12. Polymorphisms in inflammatory cytokines and Fcgamma receptors in childhood chronic immune thrombocytopenic purpura: a pilot study. Foster CB, etal., Br J Haematol. 2001 Jun;113(3):596-9.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Fcgamma receptor IIIA polymorphism as a risk-factor for coronary artery disease. Gavasso S, etal., Atherosclerosis. 2005 Jun;180(2):277-82. Epub 2005 Jan 25.
15. FCGR3A/2A polymorphisms and diffuse large B-cell lymphoma outcome treated with immunochemotherapy: a meta-analysis on 1134 patients from two prospective cohorts. Ghesquieres H, etal., Hematol Oncol. 2016 Jun 10. doi: 10.1002/hon.2305.
16. Fc gamma RIII and Fc gamma RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies. Giorgini A, etal., J Immunol. 2008 Dec 15;181(12):8745-52.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Genetic determinants in hepatitis C virus-associated mixed cryoglobulinemia: role of polymorphic variants of BAFF promoter and Fcgamma receptors. Gragnani L, etal., Arthritis Rheum. 2011 May;63(5):1446-51. doi: 10.1002/art.30274.
19. The homozygous FcgammaRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes. Gruel Y, etal., Blood. 2004 Nov 1;104(9):2791-3. Epub 2004 Jun 10.
20. Phenotype and function of natural killer cells in systemic lupus erythematosus: excess interferon-gamma production in patients with active disease. Hervier B, etal., Arthritis Rheum. 2011 Jun;63(6):1698-706. doi: 10.1002/art.30313.
21. Hyperhomocysteinemia and Related Genetic Polymorphisms Correlate with Ulcerative Colitis in Southeast China. Jiang Y, etal., Cell Biochem Biophys. 2011 Sep 24.
22. Association between SLE nephritis and polymorphic variants of the CRP and FcgammaRIIIa genes. Jonsen A, etal., Rheumatology (Oxford). 2007 Sep;46(9):1417-21. Epub 2007 Jun 27.
23. Expression of complement receptors (CR1 and CR3) and Fc gamma RIII on polymorphonuclears from patients with spondylarthropathies. Kahan A, etal., Clin Exp Rheumatol. 1993 Jan-Feb;11(1):27-34.
24. Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors. Kaneko Y, etal., J Exp Med. 2006 Mar 20;203(3):789-97. Epub 2006 Mar 6.
25. Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma. Keane C, etal., Intern Med J. 2012 Oct;42(10):1113-9. doi: 10.1111/j.1445-5994.2011.02587.x.
26. Knockdown of Fcgamma receptor III in an arthritic temporomandibular joint reduces the nociceptive response in rats. Kramer PR, etal., Arthritis Rheum. 2010 Oct;62(10):3109-18.
27. Rituximab-induced late-onset neutropenia in newly diagnosed B-cell lymphoma correlates with Fc receptor FcgammaRIIIa 158(V/F) polymorphism. Li SC, etal., Am J Hematol. 2010 Oct;85(10):810-2. doi: 10.1002/ajh.21818.
28. FCGR3A and FCGR2A polymorphisms may not correlate with response to alemtuzumab in chronic lymphocytic leukemia. Lin TS, etal., Blood. 2005 Jan 1;105(1):289-91. Epub 2004 Jun 24.
29. Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease. Louis E, etal., Aliment Pharmacol Ther 2004 Mar 1;19(5):511-9.
30. Specific plasma autoantibody reactivity in myelodysplastic syndromes. Mias GI, etal., Sci Rep. 2013 Nov 22;3:3311. doi: 10.1038/srep03311.
31. Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis. Morgan AW, etal., Arthritis Res Ther. 2006;8(4):R109.
32. Polymorphisms in the Fc gamma receptor IIIA and Toll-like receptor 9 are associated with protection against severe malarial anemia and changes in circulating gamma interferon levels. Munde EO, etal., Infect Immun. 2012 Dec;80(12):4435-43. doi: 10.1128/IAI.00945-12. Epub 2012 Oct 8.
33. The levels of CD16/Fc gamma receptor IIIA on CD14+ CD16+ monocytes are higher in children with severe Plasmodium falciparum anemia than in children with cerebral or uncomplicated malaria. Ogonda LA, etal., Infect Immun. 2010 May;78(5):2173-81. doi: 10.1128/IAI.01078-09. Epub 2010 Mar 15.
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils. Ory PA, etal., J Clin Invest. 1989 Nov;84(5):1688-91.
36. Genetic susceptibility and haplotype analysis between Fcgamma receptor IIB and IIIA gene with systemic lupus erythematosus in Chinese population. Pan F, etal., Lupus. 2008 Aug;17(8):733-8.
37. Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination. Pedotti R, etal., Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1867-72. Epub 2003 Feb 7.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. High affinity allele for the gene of FCGR3A is risk factor for HIV infection and progression. Poonia B, etal., PLoS One. 2010 Dec 20;5(12):e15562.
40. GOA pipeline RGD automated data pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Comprehensive gene review and curation RGD comprehensive gene curation
44. Monoclonal antibodies that mimic the action of anti-D in the amelioration of murine ITP act by a mechanism distinct from that of IVIg. Song S, etal., Blood. 2005 Feb 15;105(4):1546-8. Epub 2004 Oct 12.
45. Fc gamma R expression on NK cells influences disease severity in rheumatoid arthritis. Stewart-Akers AM, etal., Genes Immun. 2004 Nov;5(7):521-9.
46. Fcgamma receptor IIIA genotype is associated with rituximab response in antimyelin-associated glycoprotein neuropathy. Stork AC, etal., J Neurol Neurosurg Psychiatry. 2014 Aug;85(8):918-20. doi: 10.1136/jnnp-2013-306958. Epub 2014 Jan 31.
47. A single-nucleotide polymorphism of the Fcgamma receptor type IIIA gene in the recipient predicts transplant outcomes after HLA fully matched unrelated BMT for myeloid malignancies. Takami A, etal., Bone Marrow Transplant. 2011 Feb;46(2):238-43. doi: 10.1038/bmt.2010.88. Epub 2010 Apr 19.
48. FcgammaRIIa-131R allele and FcgammaRIIIa-176V/V genotype are risk factors for progression of IgA nephropathy. Tanaka Y, etal., Nephrol Dial Transplant. 2005 Nov;20(11):2439-45.
49. Identification of a novel FcgammaRIII receptor that is up-regulated in fetal wound healing. Teusner JT, etal., Wound Repair Regen. 2006 Jul-Aug;14(4):405-12.
50. Contribution of Fcgamma receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis. Thabet MM, etal., Ann Rheum Dis. 2009 Nov;68(11):1775-80. Epub 2008 Nov 19.
51. Attainment of complete/very good partial response following rituximab-based therapy is an important determinant to progression-free survival, and is impacted by polymorphisms in FCGR3A in Waldenstrom macroglobulinaemia. Treon SP, etal., Br J Haematol. 2011 Jul;154(2):223-8. doi: 10.1111/j.1365-2141.2011.08726.x. Epub 2011 May 12.
52. Polymorphisms in FcgammaRIIIA (CD16) receptor expression are associated with clinical response to rituximab in Waldenstrom's macroglobulinemia. Treon SP, etal., J Clin Oncol. 2005 Jan 20;23(3):474-81.
53. A polymorphism in the gene encoding the Fcgamma IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis. Tsukahara S, etal., Ann Rheum Dis. 2008 Dec;67(12):1791-2.
54. Immunoglobulin G Fc receptor FcgammaRIIIa 158 V/F polymorphism correlates with rituximab-induced neutropenia after autologous transplantation in patients with non-Hodgkin's lymphoma. Weng WK, etal., J Clin Oncol. 2010 Jan 10;28(2):279-84. doi: 10.1200/JCO.2009.25.0274. Epub 2009 Nov 23.
55. Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent. Wu CL, etal., Shock. 2009 Sep;32(3):276-85.
56. FcgammaRIIIa-V/F 158 polymorphism in Turkish children with asthma bronchiale and allergic rhinitis. Zeyrek D, etal., Pediatr Allergy Immunol. 2008 Feb;19(1):20-4.
57. Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease. Zhou XJ, etal., Int Immunol. 2010 Jan;22(1):45-51. Epub 2009 Nov 27.
58. FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese. Zhou XJ, etal., Nephrol Dial Transplant. 2010 Jan;25(1):97-101. Epub 2009 Jul 29.
59. [Polymorphisms of FcgammaRIIA, FcgammaRIIIA and FcgammaRIIB in patients with immune thrombocytopenia and their clinical significance]. Zhu Y, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Feb;21(1):135-9. doi: 10.7534/j.issn.1009-2137.2013.01.028.
Additional References at PubMed
PMID:10706735   PMID:12477932   PMID:16039578   PMID:17558411   PMID:18097064   PMID:18949059   PMID:23376485   PMID:23533145   PMID:24942581   PMID:25824719  


Genomics

Comparative Map Data
Fcgr3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,782,636 - 85,792,656 (+)NCBIGRCr8
mRatBN7.21383,249,905 - 83,259,921 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,249,872 - 83,259,921 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,869,672 - 85,879,670 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,163,159 - 87,173,157 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,401,088 - 84,411,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,385,775 - 89,396,047 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,385,859 - 89,396,051 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,025,150 - 94,035,170 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,867,641 - 86,877,665 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11386,881,828 - 86,891,853 (+)NCBI
Celera1382,902,506 - 82,912,524 (+)NCBICelera
Cytogenetic Map13q24NCBI
FCGR3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,541,759 - 161,550,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,541,759 - 161,550,968 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,511,549 - 161,520,527 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,778,173 - 159,786,442 (-)NCBINCBI36Build 36hg18NCBI36
Build 341158,324,607 - 158,332,873NCBI
Cytogenetic Map1q23.3NCBI
HuRef1132,836,941 - 132,843,979 (-)NCBIHuRef
CHM1_11162,933,382 - 162,942,246 (-)NCBICHM1_1
T2T-CHM13v2.01160,804,385 - 160,813,363 (-)NCBIT2T-CHM13v2.0
Fcgr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,846,495 - 170,857,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,846,489 - 170,857,330 (+)EnsemblGRCm39 Ensembl
GRCm381171,018,926 - 171,029,761 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,018,920 - 171,029,761 (+)EnsemblGRCm38mm10GRCm38
MGSCv371172,949,057 - 172,959,892 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,855,614 - 172,866,426 (+)NCBIMGSCv36mm8
Celera1173,467,124 - 173,477,978 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map178.53NCBI
FCGR3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,237,392 - 88,246,168 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1187,906,573 - 87,914,574 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01137,027,943 - 137,036,738 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC478984
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,054,870 - 21,060,948 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,106,055 - 21,115,738 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,137,358 - 21,146,800 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13821,108,977 - 21,118,860 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,462,756 - 21,472,195 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,738,473 - 21,748,157 (+)NCBIUU_Cfam_GSD_1.0
LOC101955076
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,523,130 - 7,530,183 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493713142,523 - 49,533 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCGR3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1488,948,357 - 88,956,513 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FCGR3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,466,492 - 2,475,579 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,524,719 - 1,533,773 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcgr3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462482651,387 - 59,117 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fcgr3a
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:129
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000047434
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH134088  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,259,606 - 83,259,799 (+)MAPPERmRatBN7.2
Rnor_6.01389,395,729 - 89,395,921NCBIRnor6.0
Rnor_5.01394,034,856 - 94,035,048UniSTSRnor5.0
RGSC_v3.41386,877,351 - 86,877,543UniSTSRGSC3.4
Celera1382,912,210 - 82,912,402UniSTS
RH 3.4 Map13555.0UniSTS
Cytogenetic Map13q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 1 12 1 7 4 10
Low 3 23 52 40 7 40 1 1 72 26 37 1 1
Below cutoff 16 7 10 2 2 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047434   ⟹   ENSRNOP00000043183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,249,872 - 83,259,913 (+)Ensembl
Rnor_6.0 Ensembl1389,385,859 - 89,396,051 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086223   ⟹   ENSRNOP00000074744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,250,312 - 83,259,921 (+)Ensembl
Rnor_6.0 Ensembl1389,386,023 - 89,396,043 (+)Ensembl
RefSeq Acc Id: NM_207603   ⟹   NP_997486
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,782,636 - 85,792,656 (+)NCBI
mRatBN7.21383,249,905 - 83,259,921 (+)NCBI
Rnor_6.01389,386,019 - 89,396,043 (+)NCBI
Rnor_5.01394,025,150 - 94,035,170 (+)NCBI
RGSC_v3.41386,867,641 - 86,877,665 (+)RGD
Celera1382,902,506 - 82,912,524 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_997486 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66877 (Get FASTA)   NCBI Sequence Viewer  
  AAP44530 (Get FASTA)   NCBI Sequence Viewer  
  ABO70343 (Get FASTA)   NCBI Sequence Viewer  
  EDM09232 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043183
  ENSRNOP00000043183.2
  ENSRNOP00000074744.2
GenBank Protein Q6XPU4 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_997486   ⟸   NM_207603
- Peptide Label: precursor
- UniProtKB: Q6XPU4 (UniProtKB/Swiss-Prot),   A0A0B4J2J1 (UniProtKB/Swiss-Prot),   A0A8L2QKY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043183   ⟸   ENSRNOT00000047434
RefSeq Acc Id: ENSRNOP00000074744   ⟸   ENSRNOT00000086223
Protein Domains
Ig-like   Ig-like C2-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699004
Promoter ID:EPDNEW_R9516
Type:initiation region
Name:Fcgr3a_1
Description:Fc fragment of IgG receptor IIIa
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,386,025 - 89,386,085EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303067 AgrOrtholog
BioCyc Gene G2FUF-17457 BioCyc
Ensembl Genes ENSRNOG00000024382 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047434 ENTREZGENE
  ENSRNOT00000047434.4 UniProtKB/TrEMBL
  ENSRNOT00000086223.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6921627 IMAGE-MGC_LOAD
InterPro Ig-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304966 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188806 IMAGE-MGC_LOAD
NCBI Gene 304966 ENTREZGENE
PANTHER IMMUNOGLOBULIN FC RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR III-A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB FCGR3A RGD
PhenoGen Fcgr3a PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024382 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0B4J2J1 ENTREZGENE
  A0A0G2K8U8_RAT UniProtKB/TrEMBL
  A0A8L2QKY4 ENTREZGENE, UniProtKB/TrEMBL
  FCG3A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0B4J2J1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-05 Fcgr3a  Fc gamma receptor 3A  Fcgr3a  Fc gamma receptor IIIa  Name changed 629549 APPROVED
2021-11-11 Fcgr3a  Fc gamma receptor IIIa  Fcgr3a  Fc fragment of IgG receptor IIIa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-01-17 Fcgr3a  Fc fragment of IgG receptor IIIa  Fcgr3a  Fc fragment of IgG, low affinity IIIa, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Fcgr3a  Fc fragment of IgG, low affinity IIIa, receptor    Fc fragment of IgG, low affinity IIIa, receptor for (CD16)  Name updated 1299863 APPROVED
2005-01-11 Fcgr3a  Fc fragment of IgG, low affinity IIIa, receptor for (CD16)  LOC304966  transmembrane receptor FcgammaRIII-X  Symbol and Name updated 1299863 APPROVED