Znf660 (zinc finger protein 660) - Rat Genome Database

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Gene: Znf660 (zinc finger protein 660) Rattus norvegicus
Analyze
Symbol: Znf660
Name: zinc finger protein 660
RGD ID: 11394460
Description: Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be located in nucleus. Orthologous to human ZNF660 (zinc finger protein 660); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-isobutyl-1-methyl-7H-xanthine (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,401,672 - 131,415,046 (+)NCBIGRCr8
mRatBN7.28122,523,881 - 122,537,581 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,524,324 - 122,536,247 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8128,127,193 - 128,140,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,326,138 - 126,339,414 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,148,206 - 124,161,620 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08131,955,636 - 131,968,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8131,965,134 - 131,966,540 (+)EnsemblRnor6.0rn6Rnor6.0
Celera8121,641,611 - 121,654,736 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Comparative Map Data
Znf660
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88131,401,672 - 131,415,046 (+)NCBIGRCr8
mRatBN7.28122,523,881 - 122,537,581 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,524,324 - 122,536,247 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8128,127,193 - 128,140,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,326,138 - 126,339,414 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,148,206 - 124,161,620 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08131,955,636 - 131,968,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8131,965,134 - 131,966,540 (+)EnsemblRnor6.0rn6Rnor6.0
Celera8121,641,611 - 121,654,736 (+)NCBICelera
Cytogenetic Map8q32NCBI
ZNF660
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38344,584,964 - 44,599,694 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl344,578,223 - 44,599,694 (+)EnsemblGRCh38hg38GRCh38
GRCh37344,626,456 - 44,641,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36344,601,460 - 44,612,561 (+)NCBINCBI36Build 36hg18NCBI36
Build 34344,601,459 - 44,612,561NCBI
Celera344,564,450 - 44,575,551 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef344,670,627 - 44,681,724 (+)NCBIHuRef
CHM1_1344,576,557 - 44,587,655 (+)NCBICHM1_1
T2T-CHM13v2.0344,600,686 - 44,615,407 (+)NCBIT2T-CHM13v2.0
Zfp660
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399122,732,313 - 122,743,223 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9122,732,311 - 122,743,219 (+)EnsemblGRCm39 Ensembl
GRCm389122,903,248 - 122,914,158 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9122,903,246 - 122,914,154 (+)EnsemblGRCm38mm10GRCm38
MGSCv379122,812,364 - 122,819,135 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369122,749,506 - 122,757,662 (+)NCBIMGSCv36mm8
Celera9123,356,498 - 123,362,985 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map973.22NCBI
ZNF660
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2244,541,385 - 44,542,791 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1344,546,151 - 44,551,831 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0344,473,151 - 44,489,731 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1345,533,245 - 45,547,392 (+)NCBIpanpan1.1PanPan1.1panPan2
ZNF660
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.120292,558 - 299,662 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2025,714 - 32,241 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02092,542 - 99,073 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2088,176 - 100,954 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.020154,723 - 161,249 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.020113,984 - 120,512 (-)NCBIUU_Cfam_GSD_1.0
ZNF660
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1327,867,553 - 27,868,533 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11327,859,251 - 27,869,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21330,702,579 - 30,710,493 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF660
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,060,305 - 6,071,867 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl226,069,819 - 6,070,814 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041161,099,167 - 161,113,844 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf660
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473075,813,208 - 75,828,134 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473075,786,740 - 75,828,031 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Znf660
67 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 4 4 37 16 25
Low 28 31 24 6 24 4 4 37 18 16 11 4
Below cutoff 3 10 13 4 13 4 4 6 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078308   ⟹   ENSRNOP00000075741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8122,524,324 - 122,536,247 (+)Ensembl
Rnor_6.0 Ensembl8131,965,134 - 131,966,540 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106615   ⟹   ENSRNOP00000094841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8122,524,324 - 122,536,247 (+)Ensembl
RefSeq Acc Id: NM_001398721   ⟹   NP_001385650
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,401,768 - 131,415,046 (+)NCBI
mRatBN7.28122,524,303 - 122,537,581 (+)NCBI
RefSeq Acc Id: XM_017596165   ⟹   XP_017451654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,401,672 - 131,415,046 (+)NCBI
mRatBN7.28122,524,204 - 122,537,581 (+)NCBI
Rnor_6.08131,955,748 - 131,968,550 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063264724   ⟹   XP_063120794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88131,401,672 - 131,415,046 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385650 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451654 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120794 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075741
  ENSRNOP00000075741.1
  ENSRNOP00000094841.1
Reference Protein Sequences
RefSeq Acc Id: XP_017451654   ⟸   XM_017596165
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KBC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075741   ⟸   ENSRNOT00000078308
RefSeq Acc Id: ENSRNOP00000094841   ⟸   ENSRNOT00000106615
RefSeq Acc Id: NP_001385650   ⟸   NM_001398721
- UniProtKB: A0A0G2KBC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120794   ⟸   XM_063264724
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KBC6 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KBC6-F1-model_v2 AlphaFold A0A0G2KBC6 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:11394460 AgrOrtholog
BioCyc Gene G2FUF-28631 BioCyc
Ensembl Genes ENSRNOG00000053687 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078308 ENTREZGENE
  ENSRNOT00000078308.2 UniProtKB/TrEMBL
  ENSRNOT00000106615.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:108351806 UniProtKB/TrEMBL
NCBI Gene Znf660 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 383-RELATED UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Znf660 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053687 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2KBC6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-02 Znf660  zinc finger protein 660      Symbol and Name status set to provisional 70820 PROVISIONAL