Symbol:
Slc22a1
Name:
solute carrier family 22 member 1
RGD ID:
3224
Description:
Enables several functions, including dopamine:sodium symporter activity; identical protein binding activity; and organic cation transmembrane transporter activity. Involved in several processes, including metanephric proximal tubule development; monoamine transport; and monoatomic ion transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Used to study acute kidney failure. Biomarker of asthma; extrahepatic cholestasis; and intrahepatic cholestasis. Orthologous to human SLC22A1 (solute carrier family 22 member 1); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; tramadol pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; (R)-carnitine; 17alpha-ethynylestradiol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
MGC93570; Oct1; Orct1; organic cation transporter; organic cation transporter 1; Roct1; solute carrier family 22 (organic cation transporter), member 1; solute carrier family 22, member 1
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SLC22A1 (solute carrier family 22 member 1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):
Slc22a1 (solute carrier family 22 (organic cation transporter), member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SLC22A1 (solute carrier family 22 member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SLC22A1 (solute carrier family 22 member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Slc22a1 (solute carrier family 22 member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SLC22A1 (solute carrier family 22 member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
SLC22A1 (solute carrier family 22 member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SLC22A2 (solute carrier family 22 member 2) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
SLC22A1 (solute carrier family 22 member 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Slc22a1 (solute carrier family 22 (organic cation transporter), member 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
slc22a2 (solute carrier family 22 member 2)
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
Balat
Alliance
DIOPT (Ensembl Compara|Hieranoid|PANTHER)
Caenorhabditis elegans (roundworm):
oct-1
Alliance
DIOPT (Ensembl Compara|Hieranoid|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
CG14855
Alliance
DIOPT (Ensembl Compara|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
CG14856
Alliance
DIOPT (Ensembl Compara|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
CG16727
Alliance
DIOPT (Ensembl Compara|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
CG17751
Alliance
DIOPT (Ensembl Compara|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
CG17752
Alliance
DIOPT (Ensembl Compara|OMA|PANTHER)
Saccharomyces cerevisiae (baker's yeast):
GIT1
Alliance
DIOPT (Ensembl Compara|Hieranoid)
Drosophila melanogaster (fruit fly):
CarT
Alliance
DIOPT (Ensembl Compara|Hieranoid|PANTHER)
Drosophila melanogaster (fruit fly):
CG42269
Alliance
DIOPT (Ensembl Compara|Hieranoid|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
CG6006
Alliance
DIOPT (Ensembl Compara|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
CG7084
Alliance
DIOPT (Ensembl Compara|Hieranoid|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
CG7342
Alliance
DIOPT (Ensembl Compara|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
CG6356
Alliance
DIOPT (Ensembl Compara|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
CG6231
Alliance
DIOPT (Ensembl Compara|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
CG7333
Alliance
DIOPT (Ensembl Compara|OMA|PANTHER)
Drosophila melanogaster (fruit fly):
Orct
Alliance
DIOPT (Ensembl Compara|InParanoid|OrthoFinder|OrthoInspector|PANTHER|SonicParanoid)
Drosophila melanogaster (fruit fly):
Orct2
Alliance
DIOPT (Ensembl Compara|InParanoid|OrthoFinder|OrthoInspector|PANTHER|SonicParanoid)
Drosophila melanogaster (fruit fly):
CG4630
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER)
Drosophila melanogaster (fruit fly):
CG7458
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER)
Drosophila melanogaster (fruit fly):
CG6126
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|PANTHER)
Drosophila melanogaster (fruit fly):
SLC22A
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER)
Allele / Splice:
Slc22a1em1Sage
Genetic Models:
SD-Slc22a1em1Sage
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 1 50,624,339 - 50,651,437 (+) NCBI GRCr8 mRatBN7.2 1 48,076,657 - 48,103,679 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 48,076,666 - 48,103,678 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 1 48,768,287 - 48,795,288 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 1 54,754,091 - 54,781,071 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 1 48,843,810 - 48,870,799 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 1 48,273,639 - 48,300,645 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 48,273,611 - 48,300,655 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 1 51,452,604 - 51,479,610 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 1 42,351,239 - 42,378,295 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 1 42,354,183 - 42,381,239 (+) NCBI Celera 1 43,876,335 - 43,903,290 (+) NCBI Celera Cytogenetic Map 1 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Slc22a1 Rat (+)-artemisinin multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 artemisinin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 Slc22a1 Rat (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SLC22A1 mRNA] CTD PMID:31150632 Slc22a1 Rat (1->4)-beta-D-glucan multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SLC22A1 mRNA CTD PMID:36331819 Slc22a1 Rat (R)-carnitine decreases expression EXP 6480464 Carnitine results in decreased expression of SLC22A1 protein CTD PMID:25669660 Slc22a1 Rat (S)-nicotine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Nicotine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] CTD PMID:27450509 Slc22a1 Rat 1,1'-diethyl-2,2'-cyanine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 pseudoisocyanine affects the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] and pseudoisocyanine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:11388889 and PMID:12110607 Slc22a1 Rat 1,1'-diethyl-2,2'-cyanine decreases activity ISO SLC22A1 (Homo sapiens) 6480464 pseudoisocyanine results in decreased activity of SLC22A1 protein CTD PMID:12110607 Slc22a1 Rat 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expression ISO SLC22A1 (Homo sapiens) 6480464 o and p'-DDT results in decreased expression of SLC22A1 mRNA CTD PMID:24464585 Slc22a1 Rat 1,1-dichloroethene decreases expression ISO Slc22a1 (Mus musculus) 6480464 vinylidene chloride results in decreased expression of SLC22A1 mRNA CTD PMID:26682919 Slc22a1 Rat 1,2-dimethylhydrazine multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SLC22A1 mRNA CTD PMID:22206623 Slc22a1 Rat 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases response to substance ISO Slc22a1 (Mus musculus) 6480464 SLC22A1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:25248837 Slc22a1 Rat 1-methylnicotinamide increases import ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 results in increased import of N(1)-methylnicotinamide CTD PMID:9260930 Slc22a1 Rat 1-naphthyl isothiocyanate decreases expression ISO Slc22a1 (Mus musculus) 6480464 1-Naphthylisothiocyanate results in decreased expression of SLC22A1 mRNA CTD PMID:15913567 Slc22a1 Rat 17alpha-ethynylestradiol multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SLC22A1 mRNA CTD PMID:17942748 Slc22a1 Rat 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of SLC22A1 mRNA and Ethinyl Estradiol results in decreased expression of SLC22A1 protein CTD PMID:17108234 and PMID:19002567 Slc22a1 Rat 17beta-estradiol decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Estradiol results in decreased expression of SLC22A1 mRNA CTD PMID:20106945 Slc22a1 Rat 17beta-estradiol decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Estradiol results in decreased activity of SLC22A1 protein CTD PMID:12110607 Slc22a1 Rat 17beta-estradiol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Estradiol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12110607 Slc22a1 Rat 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:31826744 and PMID:32679240 Slc22a1 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SLC22A1 mRNA CTD PMID:17942748 Slc22a1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of SLC22A1 mRNA CTD PMID:20106945 more ... Slc22a1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Slc22a1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SLC22A1 mRNA CTD PMID:21570461 Slc22a1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SLC22A1 mRNA CTD PMID:16054898 and PMID:21215274 Slc22a1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SLC22A1 mRNA CTD PMID:22298810 Slc22a1 Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Slc22a1 (Mus musculus) 6480464 2 more ... CTD PMID:38648751 Slc22a1 Rat 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Verapamil inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] more ... CTD PMID:21641380 more ... Slc22a1 Rat 3,3',5,5'-tetrabromobisphenol A decreases activity ISO SLC22A1 (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased activity of SLC22A1 protein CTD PMID:27989701 Slc22a1 Rat 3,3',5,5'-tetrabromobisphenol A multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 tetrabromobisphenol A inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:27989701 Slc22a1 Rat 3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 3 more ... CTD PMID:30189235 Slc22a1 Rat 3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine decreases activity ISO SLC22A1 (Homo sapiens) 6480464 3 more ... CTD PMID:30189235 Slc22a1 Rat 3-[2-(ethylamino)-1-hydroxyethyl]phenol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Etilefrine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 Slc22a1 Rat 3-Amino-1-methyl-5H-pyrido[4,3-b]indole multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 3-amino-1-methyl-5H-pyrido(4 more ... CTD PMID:30189235 Slc22a1 Rat 3-Amino-1-methyl-5H-pyrido[4,3-b]indole decreases activity ISO SLC22A1 (Homo sapiens) 6480464 3-amino-1-methyl-5H-pyrido(4 and 3-b)indole results in decreased activity of SLC22A1 protein CTD PMID:30189235 Slc22a1 Rat 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of SLC22A1 mRNA CTD PMID:28522335 Slc22a1 Rat 4,4'-diaminodiphenylmethane decreases expression ISO Slc22a1 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of SLC22A1 mRNA CTD PMID:18648102 Slc22a1 Rat 4,4'-sulfonyldiphenol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 bisphenol S promotes the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:27989701 Slc22a1 Rat 4-hydroxyphenyl retinamide increases expression ISO Slc22a1 (Mus musculus) 6480464 Fenretinide results in increased expression of SLC22A1 mRNA CTD PMID:28973697 Slc22a1 Rat 5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Nadolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of SLC22A1 mRNA CTD PMID:19483382 Slc22a1 Rat 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of SLC22A1 mRNA CTD PMID:19483382 Slc22a1 Rat [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Mefloquine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 Slc22a1 Rat abacavir multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir CTD PMID:25844889 Slc22a1 Rat acetamide decreases expression EXP 6480464 acetamide results in decreased expression of SLC22A1 mRNA CTD PMID:31881176 Slc22a1 Rat acetamiprid increases activity ISO SLC22A1 (Homo sapiens) 6480464 acetamiprid results in increased activity of SLC22A1 protein CTD PMID:31364238 Slc22a1 Rat acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of SLC22A1 mRNA CTD PMID:28959563 Slc22a1 Rat aflatoxin B1 affects expression ISO SLC22A1 (Homo sapiens) 6480464 Aflatoxin B1 affects the expression of SLC22A1 protein CTD PMID:20106945 Slc22a1 Rat aflatoxin B1 decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of SLC22A1 mRNA CTD PMID:27153756 Slc22a1 Rat all-trans-retinoic acid increases expression ISO SLC22A1 (Homo sapiens) 6480464 Tretinoin results in increased expression of SLC22A1 mRNA CTD PMID:33167477 Slc22a1 Rat allopurinol multiple interactions ISO Slc22a1 (Mus musculus) 6480464 Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA] and Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein] CTD PMID:21909718 and PMID:22865646 Slc22a1 Rat allopurinol multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA] and Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein] CTD PMID:19605544 Slc22a1 Rat amiodarone affects expression EXP 6480464 Amiodarone affects the expression of SLC22A1 mRNA CTD PMID:19483382 Slc22a1 Rat amiodarone multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Amiodarone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat amitriptyline multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Amitriptyline inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] CTD PMID:30189235 Slc22a1 Rat amitriptyline decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Amitriptyline results in decreased activity of SLC22A1 protein CTD PMID:31364238 Slc22a1 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SLC22A1 mRNA CTD PMID:16483693 Slc22a1 Rat angelicin decreases expression ISO Slc22a1 (Mus musculus) 6480464 angelicin results in decreased expression of SLC22A1 mRNA CTD PMID:22173200 Slc22a1 Rat angelicin increases expression ISO Slc22a1 (Mus musculus) 6480464 angelicin results in increased expression of SLC22A1 protein CTD PMID:22173200 Slc22a1 Rat aristolochic acid A increases expression ISO SLC22A1 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of SLC22A1 mRNA CTD PMID:33212167 Slc22a1 Rat aristolochic acids decreases expression EXP 6480464 Aristolochic Acids results in decreased expression of SLC22A1 mRNA CTD PMID:21167265 Slc22a1 Rat atazanavir sulfate multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of SLC22A1 mRNA CTD PMID:33819548 Slc22a1 Rat atenolol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Atenolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat atorvastatin calcium multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Atorvastatin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat atorvastatin calcium increases expression ISO Slc22a1 (Mus musculus) 6480464 Atorvastatin results in increased expression of SLC22A1 mRNA CTD PMID:25278499 Slc22a1 Rat atropine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] and Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 and PMID:21641380 Slc22a1 Rat Azoxymethane multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC22A1 mRNA CTD PMID:29950665 Slc22a1 Rat bacitracin decreases expression EXP 6480464 Bacitracin results in decreased expression of SLC22A1 mRNA CTD PMID:18289764 Slc22a1 Rat benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of SLC22A1 mRNA CTD PMID:19483382 Slc22a1 Rat benzo[a]pyrene multiple interactions ISO Slc22a1 (Mus musculus) 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to SLC22A1 promoter] CTD PMID:19654925 Slc22a1 Rat benzo[a]pyrene affects methylation ISO SLC22A1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of SLC22A1 promoter CTD PMID:27901495 Slc22a1 Rat benzo[a]pyrene decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased activity of SLC22A1 protein CTD PMID:31830554 Slc22a1 Rat benzo[a]pyrene increases expression ISO Slc22a1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of SLC22A1 mRNA CTD PMID:22228805 Slc22a1 Rat benzo[a]pyrene decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of SLC22A1 mRNA CTD PMID:20106945 and PMID:32234424 Slc22a1 Rat beta-carboline multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 norharman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] CTD PMID:30189235 Slc22a1 Rat beta-carboline decreases activity ISO SLC22A1 (Homo sapiens) 6480464 norharman results in decreased activity of SLC22A1 protein CTD PMID:30189235 Slc22a1 Rat beta-naphthoflavone decreases expression ISO SLC22A1 (Homo sapiens) 6480464 beta-Naphthoflavone results in decreased expression of SLC22A1 mRNA CTD PMID:22258563 Slc22a1 Rat biphenyl-4-amine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 4-biphenylamine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] CTD PMID:27450509 Slc22a1 Rat bisoprolol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Bisoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SLC22A1 mRNA CTD PMID:25181051 Slc22a1 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SLC22A1 mRNA CTD PMID:32145629 Slc22a1 Rat bisphenol A decreases activity ISO SLC22A1 (Homo sapiens) 6480464 bisphenol A results in decreased activity of SLC22A1 protein CTD PMID:27989701 Slc22a1 Rat bisphenol A multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 bisphenol A inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:27989701 Slc22a1 Rat bisphenol F multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 bisphenol F inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:27989701 Slc22a1 Rat bisphenol F increases expression ISO Slc22a1 (Mus musculus) 6480464 bisphenol F results in increased expression of SLC22A1 mRNA CTD PMID:38685157 Slc22a1 Rat buta-1,3-diene decreases expression ISO Slc22a1 (Mus musculus) 6480464 1 and 3-butadiene results in decreased expression of SLC22A1 mRNA CTD PMID:29038090 Slc22a1 Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of SLC22A1 mRNA and Cadmium Chloride results in decreased expression of SLC22A1 protein CTD PMID:25588984 Slc22a1 Rat carvedilol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 carvedilol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat CGP 52608 multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to SLC22A1 gene] CTD PMID:28238834 Slc22a1 Rat chenodeoxycholic acid decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Chenodeoxycholic Acid results in decreased expression of SLC22A1 mRNA CTD PMID:27174168 Slc22a1 Rat chenodeoxycholic acid multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of SLC22A1 mRNA more ... CTD PMID:33819548 Slc22a1 Rat chlordecone decreases expression ISO Slc22a1 (Mus musculus) 6480464 Chlordecone results in decreased expression of SLC22A1 mRNA CTD PMID:33711761 Slc22a1 Rat chloroquine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Chloroquine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 Slc22a1 Rat chlorphenamine multiple interactions EXP 6480464 Chlorpheniramine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:12440152 Slc22a1 Rat cimetidine increases uptake EXP 6480464 SLC22A1 protein results in increased uptake of Cimetidine CTD PMID:16006492 Slc22a1 Rat cimetidine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium] CTD PMID:19357179 Slc22a1 Rat cisplatin affects response to substance ISO Slc22a1 (Mus musculus) 6480464 SLC22A1 protein affects the susceptibility to Cisplatin CTD PMID:31493026 Slc22a1 Rat cisplatin multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [SLC22A1 protein affects the susceptibility to Cisplatin] which affects the expression of TYSND1 protein CTD PMID:31493026 Slc22a1 Rat clofibrate affects expression EXP 6480464 Clofibrate affects the expression of SLC22A1 mRNA CTD PMID:19483382 Slc22a1 Rat clonidine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 Slc22a1 Rat clonidine (amino form) multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 Slc22a1 Rat clonidine (imino form) multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 Slc22a1 Rat cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of SLC22A1 mRNA CTD PMID:24386269 Slc22a1 Rat cyclosporin A decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of SLC22A1 mRNA CTD PMID:20106945 Slc22a1 Rat cyclosporin A multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of SLC22A1 mRNA CTD PMID:33819548 Slc22a1 Rat deoxycholic acid decreases expression ISO Slc22a1 (Mus musculus) 6480464 Deoxycholic Acid results in decreased expression of SLC22A1 mRNA CTD PMID:21914718 Slc22a1 Rat deoxycholic acid multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of SLC22A1 mRNA more ... CTD PMID:33819548 Slc22a1 Rat dexamethasone multiple interactions EXP 6480464 Dexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC22A1 mRNA] CTD PMID:15205389 Slc22a1 Rat dexamethasone increases expression ISO SLC22A1 (Homo sapiens) 6480464 Dexamethasone results in increased expression of SLC22A1 mRNA and Dexamethasone results in increased expression of SLC22A1 protein CTD PMID:24399729 Slc22a1 Rat dextran sulfate multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC22A1 mRNA CTD PMID:29950665 Slc22a1 Rat dibenzofurans increases expression ISO Slc22a1 (Mus musculus) 6480464 Dibenzofurans results in increased expression of SLC22A1 mRNA CTD PMID:34254344 Slc22a1 Rat dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of SLC22A1 mRNA CTD PMID:18636392 Slc22a1 Rat diclofenac decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Diclofenac results in decreased activity of SLC22A1 protein CTD PMID:12388633 Slc22a1 Rat dieldrin decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Dieldrin results in decreased activity of SLC22A1 protein CTD PMID:24464585 Slc22a1 Rat diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of SLC22A1 mRNA CTD PMID:21658437 Slc22a1 Rat digoxin multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Digoxin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat diltiazem multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Diltiazem inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat diosmetin multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:28867436 Slc22a1 Rat diphenhydramine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Diphenhydramine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 Slc22a1 Rat disopyramide multiple interactions EXP 6480464 Disopyramide affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:12440152 Slc22a1 Rat dopamine multiple interactions EXP 6480464 Dopamine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:12440152 Slc22a1 Rat doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of SLC22A1 mRNA CTD PMID:19915844 Slc22a1 Rat endosulfan decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Endosulfan results in decreased activity of SLC22A1 protein CTD PMID:24464585 Slc22a1 Rat endosulfan decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Endosulfan results in decreased expression of SLC22A1 mRNA CTD PMID:24464585 Slc22a1 Rat ethidium multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium] more ... CTD PMID:19357179 Slc22a1 Rat ethidium increases uptake ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased uptake of Ethidium CTD PMID:19357179 Slc22a1 Rat ethidium affects uptake ISO Slc22a1 (Mus musculus) 6480464 SLC22A1 protein affects the uptake of Ethidium CTD PMID:19357179 Slc22a1 Rat famotidine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Famotidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 Slc22a1 Rat famotidine increases uptake EXP 6480464 SLC22A1 protein results in increased uptake of Famotidine CTD PMID:16006492 Slc22a1 Rat famotidine affects transport ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein affects the transport of Famotidine CTD PMID:16141367 Slc22a1 Rat fenthion decreases expression ISO Slc22a1 (Mus musculus) 6480464 Fenthion results in decreased expression of SLC22A1 mRNA CTD PMID:34813904 Slc22a1 Rat finasteride increases expression EXP 6480464 Finasteride results in increased expression of SLC22A1 mRNA CTD PMID:24136188 Slc22a1 Rat flecainide multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Flecainide inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat flutamide increases expression EXP 6480464 Flutamide results in increased expression of SLC22A1 mRNA CTD PMID:24136188 Slc22a1 Rat folic acid decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Folic Acid deficiency results in decreased expression of SLC22A1 mRNA CTD PMID:20465997 Slc22a1 Rat folic acid decreases expression ISO Slc22a1 (Mus musculus) 6480464 Folic Acid results in decreased expression of SLC22A1 protein CTD PMID:38272249 Slc22a1 Rat folic acid multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [1 more ... CTD PMID:22206623 and PMID:38272249 Slc22a1 Rat fonofos increases methylation ISO SLC22A1 (Homo sapiens) 6480464 Fonofos results in increased methylation of SLC22A1 promoter CTD PMID:22847954 Slc22a1 Rat fructose multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA] more ... CTD PMID:19605544 Slc22a1 Rat fructose decreases expression EXP 6480464 Fructose results in decreased expression of SLC22A1 mRNA and Fructose results in decreased expression of SLC22A1 protein CTD PMID:19605544 Slc22a1 Rat fumonisin B1 decreases expression ISO Slc22a1 (Mus musculus) 6480464 fumonisin B1 results in decreased expression of SLC22A1 mRNA CTD PMID:16221962 Slc22a1 Rat gamma-hexachlorocyclohexane decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Hexachlorocyclohexane results in decreased activity of SLC22A1 protein CTD PMID:24464585 Slc22a1 Rat genistein decreases expression ISO Slc22a1 (Mus musculus) 6480464 Genistein results in decreased expression of SLC22A1 mRNA CTD PMID:32186404 Slc22a1 Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of SLC22A1 protein CTD PMID:29460972 Slc22a1 Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of SLC22A1 mRNA CTD PMID:18289764 Slc22a1 Rat glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of SLC22A1 mRNA CTD PMID:24136188 Slc22a1 Rat glycochenodeoxycholic acid multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of SLC22A1 mRNA more ... CTD PMID:33819548 Slc22a1 Rat glycocholic acid multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of SLC22A1 mRNA more ... CTD PMID:33819548 Slc22a1 Rat glycodeoxycholic acid multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of SLC22A1 mRNA more ... CTD PMID:33819548 Slc22a1 Rat graphite affects expression EXP 6480464 Graphite affects the expression of SLC22A1 mRNA CTD PMID:29933104 Slc22a1 Rat harman decreases activity ISO SLC22A1 (Homo sapiens) 6480464 harman results in decreased activity of SLC22A1 protein CTD PMID:30189235 Slc22a1 Rat harman multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] CTD PMID:30189235 Slc22a1 Rat heptachlor decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Heptachlor results in decreased activity of SLC22A1 protein CTD PMID:24464585 Slc22a1 Rat hyperforin decreases expression ISO SLC22A1 (Homo sapiens) 6480464 hyperforin results in decreased expression of SLC22A1 protein CTD PMID:26920453 Slc22a1 Rat hyperforin multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA more ... CTD PMID:26920453 Slc22a1 Rat ibuprofen decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Ibuprofen results in decreased activity of SLC22A1 protein CTD PMID:12388633 Slc22a1 Rat icariin multiple interactions ISO Slc22a1 (Mus musculus) 6480464 icariin inhibits the reaction [Folic Acid results in decreased expression of SLC22A1 protein] CTD PMID:38272249 Slc22a1 Rat imidacloprid increases activity ISO SLC22A1 (Homo sapiens) 6480464 imidacloprid results in increased activity of SLC22A1 protein CTD PMID:31364238 Slc22a1 Rat imipramine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin] more ... CTD PMID:24947867 and PMID:25106415 Slc22a1 Rat imperatorin increases expression ISO Slc22a1 (Mus musculus) 6480464 imperatorin results in increased expression of SLC22A1 mRNA and imperatorin results in increased expression of SLC22A1 protein CTD PMID:22173200 Slc22a1 Rat indometacin decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Indomethacin results in decreased activity of SLC22A1 protein CTD PMID:12388633 Slc22a1 Rat ipratropium multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Ipratropium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat isoimperatorin increases expression ISO Slc22a1 (Mus musculus) 6480464 isoimperatorin results in increased expression of SLC22A1 protein CTD PMID:22173200 Slc22a1 Rat ketoprofen decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Ketoprofen results in decreased activity of SLC22A1 protein CTD PMID:12388633 Slc22a1 Rat L-ethionine affects expression EXP 6480464 Ethionine affects the expression of SLC22A1 mRNA CTD PMID:19483382 Slc22a1 Rat lamivudine increases uptake ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased uptake of Lamivudine CTD PMID:19141712 Slc22a1 Rat lidocaine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Lidocaine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat lipopolysaccharide multiple interactions EXP 6480464 Dexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC22A1 mRNA] CTD PMID:15205389 Slc22a1 Rat lipopolysaccharide increases expression ISO SLC22A1 (Homo sapiens) 6480464 Lipopolysaccharides results in increased expression of SLC22A1 mRNA CTD PMID:35811015 Slc22a1 Rat lipopolysaccharide multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of SLC22A1 mRNA CTD PMID:35811015 Slc22a1 Rat lipopolysaccharide decreases expression EXP 6480464 Lipopolysaccharides results in decreased expression of SLC22A1 mRNA CTD PMID:15205389 Slc22a1 Rat manganese(II) chloride increases methylation EXP 6480464 manganese chloride results in increased methylation of SLC22A1 gene CTD PMID:28801915 Slc22a1 Rat manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of SLC22A1 mRNA CTD PMID:28801915 Slc22a1 Rat mangiferin increases expression ISO Slc22a1 (Mus musculus) 6480464 mangiferin results in increased expression of SLC22A1 mRNA CTD PMID:21348301 Slc22a1 Rat mefenamic acid decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Mefenamic Acid results in decreased activity of SLC22A1 protein CTD PMID:12388633 Slc22a1 Rat mefloquine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Mefloquine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 Slc22a1 Rat MeIQ multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 2-amino-3 more ... CTD PMID:30189235 Slc22a1 Rat MeIQ decreases activity ISO SLC22A1 (Homo sapiens) 6480464 2-amino-3 more ... CTD PMID:30189235 Slc22a1 Rat mercury atom increases expression EXP 6480464 Mercury results in increased expression of SLC22A1 mRNA CTD PMID:12730625 Slc22a1 Rat mercury(0) increases expression EXP 6480464 Mercury results in increased expression of SLC22A1 mRNA CTD PMID:12730625 Slc22a1 Rat metformin multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin] and Metformin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 and PMID:25106415 Slc22a1 Rat metformin increases uptake ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased uptake of Metformin CTD PMID:25106415 Slc22a1 Rat metformin increases response to substance ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased susceptibility to Metformin CTD PMID:20956498 Slc22a1 Rat methoxsalen increases expression ISO Slc22a1 (Mus musculus) 6480464 Methoxsalen results in increased expression of SLC22A1 protein CTD PMID:22173200 Slc22a1 Rat metoprolol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Metoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat molsidomine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Molsidomine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat monocrotaline multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Monocrotaline inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] more ... CTD PMID:23831208 Slc22a1 Rat monocrotaline increases uptake ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased uptake of Monocrotaline CTD PMID:23831208 Slc22a1 Rat monosodium L-glutamate multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [Sodium Glutamate co-treated with Trans Fatty Acids] results in increased expression of SLC22A1 mRNA CTD PMID:19001666 Slc22a1 Rat N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in increased methylation of SLC22A1 gene CTD PMID:33148267 Slc22a1 Rat N-methyl-4-phenylpyridinium increases import ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased import of 1-Methyl-4-phenylpyridinium and SLC22A1 results in increased import of 1-Methyl-4-phenylpyridinium CTD PMID:22394605 and PMID:9260930 Slc22a1 Rat N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SLC22A1 mRNA CTD PMID:28801915 Slc22a1 Rat N-methyl-4-phenylpyridinium increases transport ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium CTD PMID:16263091 and PMID:25466967 Slc22a1 Rat N-methyl-4-phenylpyridinium increases uptake ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium CTD PMID:11388889 more ... Slc22a1 Rat N-methyl-4-phenylpyridinium increases uptake EXP 6480464 SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium CTD PMID:16142924 Slc22a1 Rat N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 1-Methyl-4-phenylpyridinium affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] more ... CTD PMID:12440152 and PMID:16142924 Slc22a1 Rat N-methyl-4-phenylpyridinium multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium] more ... CTD PMID:11388889 more ... Slc22a1 Rat N-Nitrosopyrrolidine decreases expression ISO SLC22A1 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in decreased expression of SLC22A1 mRNA CTD PMID:32234424 Slc22a1 Rat N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Ranitidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] and Ranitidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 and PMID:16263091 Slc22a1 Rat N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine increases uptake EXP 6480464 SLC22A1 protein results in increased uptake of Ranitidine CTD PMID:16006492 Slc22a1 Rat N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine affects transport ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein affects the transport of Ranitidine CTD PMID:16141367 Slc22a1 Rat nadolol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Nadolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat nefazodone increases expression EXP 6480464 nefazodone results in increased expression of SLC22A1 mRNA CTD PMID:24136188 Slc22a1 Rat nefazodone multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone] results in decreased expression of SLC22A1 mRNA CTD PMID:33819548 Slc22a1 Rat nicotine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Nicotine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] CTD PMID:27450509 Slc22a1 Rat nifedipine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Nifedipine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat nimesulide increases expression EXP 6480464 nimesulide results in increased expression of SLC22A1 mRNA CTD PMID:24136188 Slc22a1 Rat nitenpyram increases activity ISO SLC22A1 (Homo sapiens) 6480464 nitenpyram results in increased activity of SLC22A1 protein CTD PMID:31364238 Slc22a1 Rat O-methyleugenol decreases expression ISO SLC22A1 (Homo sapiens) 6480464 methyleugenol results in decreased expression of SLC22A1 mRNA CTD PMID:32234424 Slc22a1 Rat ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of SLC22A1 mRNA and ochratoxin A results in decreased expression of SLC22A1 protein CTD PMID:16251485 more ... Slc22a1 Rat ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of SLC22A1 mRNA CTD PMID:30120945 Slc22a1 Rat omeprazole affects expression EXP 6480464 Omeprazole affects the expression of SLC22A1 mRNA CTD PMID:19483382 Slc22a1 Rat ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of SLC22A1 mRNA CTD PMID:18636392 Slc22a1 Rat ozone multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Air Pollutants results in increased abundance of Ozone] which affects the expression of SLC22A1 mRNA CTD PMID:35430440 Slc22a1 Rat paracetamol affects expression ISO Slc22a1 (Mus musculus) 6480464 Acetaminophen affects the expression of SLC22A1 mRNA CTD PMID:17562736 Slc22a1 Rat paracetamol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of SLC22A1 mRNA CTD PMID:33819548 Slc22a1 Rat paracetamol decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of SLC22A1 mRNA CTD PMID:29067470 Slc22a1 Rat paraquat increases expression EXP 6480464 Paraquat results in increased expression of SLC22A1 mRNA CTD PMID:32680482 Slc22a1 Rat parathion increases methylation ISO SLC22A1 (Homo sapiens) 6480464 Parathion results in increased methylation of SLC22A1 promoter CTD PMID:22847954 Slc22a1 Rat perfluorobutanesulfonic acid increases expression ISO SLC22A1 (Homo sapiens) 6480464 perfluorobutanesulfonic acid results in increased expression of SLC22A1 mRNA CTD PMID:33772556 Slc22a1 Rat perfluorononanoic acid decreases expression ISO SLC22A1 (Homo sapiens) 6480464 perfluoro-n-nonanoic acid results in decreased expression of SLC22A1 mRNA CTD PMID:32588087 Slc22a1 Rat perfluorooctane-1-sulfonic acid decreases expression ISO SLC22A1 (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in decreased expression of SLC22A1 mRNA CTD PMID:32588087 Slc22a1 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SLC22A1 mRNA CTD PMID:36331819 Slc22a1 Rat perfluorooctane-1-sulfonic acid increases expression ISO SLC22A1 (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in increased expression of SLC22A1 mRNA CTD PMID:33772556 Slc22a1 Rat perfluorooctanoic acid increases expression ISO SLC22A1 (Homo sapiens) 6480464 perfluorooctanoic acid results in increased expression of SLC22A1 mRNA CTD PMID:33772556 Slc22a1 Rat permethrin multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in increased methylation of SLC22A1 gene CTD PMID:33148267 Slc22a1 Rat phenobarbital multiple interactions ISO Slc22a1 (Mus musculus) 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC22A1 mRNA] CTD PMID:19482888 Slc22a1 Rat phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of SLC22A1 mRNA CTD PMID:16510358 and PMID:19162173 Slc22a1 Rat phenobarbital increases expression ISO Slc22a1 (Mus musculus) 6480464 Phenobarbital results in increased expression of SLC22A1 mRNA CTD PMID:19482888 Slc22a1 Rat Phenoxybenzamine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Phenoxybenzamine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12110607 Slc22a1 Rat Phenoxybenzamine decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Phenoxybenzamine results in decreased activity of SLC22A1 protein CTD PMID:12110607 Slc22a1 Rat phenylephrine multiple interactions EXP 6480464 [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine CTD PMID:21140131 Slc22a1 Rat PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of SLC22A1 mRNA CTD PMID:15059925 Slc22a1 Rat pirinixic acid multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC22A1 mRNA CTD PMID:19710929 Slc22a1 Rat pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of SLC22A1 mRNA CTD PMID:19483382 Slc22a1 Rat pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of SLC22A1 mRNA CTD PMID:16940010 and PMID:19162173 Slc22a1 Rat Potassium 2,6-dihydroxytriazinecarboxylate decreases expression ISO Slc22a1 (Mus musculus) 6480464 potassium oxonate results in decreased expression of SLC22A1 mRNA and potassium oxonate results in decreased expression of SLC22A1 protein CTD PMID:21909718 more ... Slc22a1 Rat Potassium 2,6-dihydroxytriazinecarboxylate multiple interactions ISO Slc22a1 (Mus musculus) 6480464 Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA] more ... CTD PMID:21909718 more ... Slc22a1 Rat potassium dichromate increases expression ISO Slc22a1 (Mus musculus) 6480464 Potassium Dichromate results in increased expression of SLC22A1 mRNA CTD PMID:23608068 Slc22a1 Rat prazosin multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Prazosin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12110607 Slc22a1 Rat prazosin decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Prazosin results in decreased activity of SLC22A1 protein CTD PMID:12110607 Slc22a1 Rat probenecid multiple interactions ISO Slc22a1 (Mus musculus) 6480464 Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA] and Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein] CTD PMID:22865646 and PMID:22967667 Slc22a1 Rat prochloraz increases expression ISO Slc22a1 (Mus musculus) 6480464 prochloraz results in increased expression of SLC22A1 mRNA CTD PMID:27028005 Slc22a1 Rat progesterone multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Progesterone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12110607 Slc22a1 Rat progesterone multiple interactions EXP 6480464 Progesterone inhibits the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:9830022 Slc22a1 Rat progesterone decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Progesterone results in decreased activity of SLC22A1 protein CTD PMID:12110607 Slc22a1 Rat propafenone multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Propafenone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat propranolol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Propranolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat psoralen increases expression ISO Slc22a1 (Mus musculus) 6480464 Ficusin results in increased expression of SLC22A1 protein CTD PMID:22173200 Slc22a1 Rat psoralen decreases expression ISO Slc22a1 (Mus musculus) 6480464 Ficusin results in decreased expression of SLC22A1 mRNA CTD PMID:22173200 Slc22a1 Rat pyrimethamine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Pyrimethamine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 Slc22a1 Rat quercetin multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin] more ... CTD PMID:24947867 Slc22a1 Rat quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA] and Quercetin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein] CTD PMID:19605544 Slc22a1 Rat quercetin multiple interactions ISO Slc22a1 (Mus musculus) 6480464 Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA] and Quercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein] CTD PMID:21909718 Slc22a1 Rat quercetin increases uptake ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased uptake of Quercetin CTD PMID:24947867 Slc22a1 Rat quinidine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] more ... CTD PMID:16141367 more ... Slc22a1 Rat quinidine multiple interactions EXP 6480464 [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine and [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine CTD PMID:21140131 Slc22a1 Rat quinine multiple interactions EXP 6480464 Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16142924 Slc22a1 Rat quinine increases uptake ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased uptake of Quinine CTD PMID:27504015 Slc22a1 Rat quinine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir more ... CTD PMID:16263091 more ... Slc22a1 Rat quinine decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Quinine results in decreased activity of SLC22A1 and Quinine results in decreased activity of SLC22A1 protein CTD PMID:25844889 and PMID:31830554 Slc22a1 Rat ranitidine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Ranitidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] and Ranitidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 and PMID:16263091 Slc22a1 Rat ranitidine affects transport ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein affects the transport of Ranitidine CTD PMID:16141367 Slc22a1 Rat ranitidine increases uptake EXP 6480464 SLC22A1 protein results in increased uptake of Ranitidine CTD PMID:16006492 Slc22a1 Rat resveratrol multiple interactions ISO Slc22a1 (Mus musculus) 6480464 resveratrol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein] CTD PMID:22865646 Slc22a1 Rat Retrorsine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 4-(4-dimethylaminostyryl)-1-methylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine] more ... CTD PMID:24799337 Slc22a1 Rat Retrorsine increases uptake ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased uptake of retrorsine CTD PMID:24799337 Slc22a1 Rat rifampicin multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [NR1I2 protein co-treated with Rifampin] results in decreased expression of SLC22A1 mRNA more ... CTD PMID:26920453 Slc22a1 Rat rifampicin decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Rifampin results in decreased expression of SLC22A1 mRNA and Rifampin results in decreased expression of SLC22A1 protein CTD PMID:26920453 and PMID:27199754 Slc22a1 Rat rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA] and Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein] CTD PMID:19605544 Slc22a1 Rat S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of SLC22A1 mRNA CTD PMID:35811015 Slc22a1 Rat senecionine decreases expression ISO Slc22a1 (Mus musculus) 6480464 senecionine results in decreased expression of SLC22A1 mRNA CTD PMID:31606820 Slc22a1 Rat silicon dioxide increases expression ISO SLC22A1 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of SLC22A1 mRNA CTD PMID:23806026 Slc22a1 Rat sodium arsenite decreases expression ISO SLC22A1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of SLC22A1 mRNA CTD PMID:29301061 Slc22a1 Rat sodium arsenite increases expression ISO SLC22A1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of SLC22A1 mRNA CTD PMID:38568856 Slc22a1 Rat sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of SLC22A1 mRNA CTD PMID:12325037 Slc22a1 Rat soybean oil affects expression EXP 6480464 Soybean Oil affects the expression of SLC22A1 mRNA CTD PMID:15770074 Slc22a1 Rat spironolactone multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Spironolactone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of SLC22A1 protein CTD PMID:19605544 Slc22a1 Rat sulindac decreases activity ISO SLC22A1 (Homo sapiens) 6480464 Sulindac results in decreased activity of SLC22A1 protein CTD PMID:12388633 Slc22a1 Rat Sunset Yellow FCF multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of SLC22A1 mRNA CTD PMID:33819548 Slc22a1 Rat synephrine multiple interactions EXP 6480464 [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine CTD PMID:21140131 Slc22a1 Rat talinolol multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 talinolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 Slc22a1 Rat tartrazine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in decreased expression of SLC22A1 mRNA CTD PMID:33819548 Slc22a1 Rat terbufos increases methylation ISO SLC22A1 (Homo sapiens) 6480464 terbufos results in increased methylation of SLC22A1 promoter CTD PMID:22847954 Slc22a1 Rat tetrabutylammonium multiple interactions EXP 6480464 tetrabutylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16142924 Slc22a1 Rat tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of SLC22A1 mRNA and Carbon Tetrachloride results in decreased expression of SLC22A1 protein CTD PMID:17544377 and PMID:31150632 Slc22a1 Rat tetrachloromethane decreases expression ISO Slc22a1 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of SLC22A1 mRNA CTD PMID:31919559 Slc22a1 Rat tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SLC22A1 mRNA] CTD PMID:31150632 Slc22a1 Rat tetraethylammonium multiple interactions EXP 6480464 1-Methyl-4-phenylpyridinium affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] more ... CTD PMID:12440152 more ... Slc22a1 Rat tetraethylammonium increases import ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased import of Tetraethylammonium and SLC22A1 results in increased import of Tetraethylammonium CTD PMID:25862123 more ... Slc22a1 Rat tetraethylammonium multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 3-amino-1 more ... CTD PMID:16141367 more ... Slc22a1 Rat tetraethylammonium increases uptake ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased uptake of Tetraethylammonium CTD PMID:21256917 more ... Slc22a1 Rat tetraethylammonium increases uptake EXP 6480464 SLC22A1 protein results in increased uptake of Tetraethylammonium CTD PMID:12440152 more ... Slc22a1 Rat tetraethylammonium affects transport ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein affects the transport of Tetraethylammonium CTD PMID:16141367 Slc22a1 Rat tetrahydropalmatine multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline] and tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine] CTD PMID:23831208 and PMID:24799337 Slc22a1 Rat tetrapentylammonium multiple interactions EXP 6480464 tetrapentylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16142924 Slc22a1 Rat thiacloprid increases activity ISO SLC22A1 (Homo sapiens) 6480464 thiacloprid metabolite results in increased activity of SLC22A1 protein and thiacloprid results in increased activity of SLC22A1 protein CTD PMID:31364238 Slc22a1 Rat thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of SLC22A1 mRNA CTD PMID:19483382 Slc22a1 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of SLC22A1 mRNA CTD PMID:23411599 and PMID:26222700 Slc22a1 Rat titanium dioxide decreases expression ISO Slc22a1 (Mus musculus) 6480464 titanium dioxide results in decreased expression of SLC22A1 mRNA CTD PMID:23557971 and PMID:35295148 Slc22a1 Rat titanium dioxide multiple interactions ISO Slc22a1 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC22A1 mRNA CTD PMID:29950665 Slc22a1 Rat trans-piceid multiple interactions ISO Slc22a1 (Mus musculus) 6480464 polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein] CTD PMID:22865646 Slc22a1 Rat trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of SLC22A1 gene CTD PMID:27618143 Slc22a1 Rat trimethoprim multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Trimethoprim inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin] CTD PMID:24947867 Slc22a1 Rat troglitazone decreases expression ISO SLC22A1 (Homo sapiens) 6480464 troglitazone results in decreased expression of SLC22A1 mRNA CTD PMID:25572481 Slc22a1 Rat tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] and Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 and PMID:21641380 Slc22a1 Rat trospium chloride increases metabolic processing ISO SLC22A1 (Homo sapiens) 6480464 SLC22A1 protein results in increased metabolism of trospium chloride CTD PMID:25466967 Slc22a1 Rat trospium chloride decreases activity ISO SLC22A1 (Homo sapiens) 6480464 trospium chloride results in decreased activity of SLC22A1 protein CTD PMID:25466967 Slc22a1 Rat trovafloxacin decreases expression EXP 6480464 trovafloxacin results in decreased expression of SLC22A1 mRNA CTD PMID:24136188 Slc22a1 Rat urethane increases expression ISO SLC22A1 (Homo sapiens) 6480464 Urethane results in increased expression of SLC22A1 mRNA CTD PMID:28818685 Slc22a1 Rat valproic acid affects expression ISO Slc22a1 (Mus musculus) 6480464 Valproic Acid affects the expression of SLC22A1 mRNA CTD PMID:17292431 Slc22a1 Rat valproic acid decreases expression ISO SLC22A1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of SLC22A1 mRNA CTD PMID:29154799 Slc22a1 Rat verapamil multiple interactions ISO SLC22A1 (Homo sapiens) 6480464 Verapamil inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] more ... CTD PMID:21641380 more ... Slc22a1 Rat vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of SLC22A1 mRNA CTD PMID:23034163
Imported Annotations - SMPDB
Imported Annotations - KEGG (archival)
(+)-artemisinin (ISO) (+)-schisandrin B (EXP) (1->4)-beta-D-glucan (ISO) (R)-carnitine (EXP) (S)-nicotine (ISO) 1,1'-diethyl-2,2'-cyanine (ISO) 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO) 1,1-dichloroethene (ISO) 1,2-dimethylhydrazine (ISO) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO) 1-methylnicotinamide (ISO) 1-naphthyl isothiocyanate (ISO) 17alpha-ethynylestradiol (EXP,ISO) 17beta-estradiol (ISO) 2,2',4,4'-Tetrabromodiphenyl ether (EXP) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO) 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile (ISO) 3,3',5,5'-tetrabromobisphenol A (ISO) 3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine (ISO) 3-[2-(ethylamino)-1-hydroxyethyl]phenol (ISO) 3-Amino-1-methyl-5H-pyrido[4,3-b]indole (ISO) 3-chloropropane-1,2-diol (EXP) 4,4'-diaminodiphenylmethane (ISO) 4,4'-sulfonyldiphenol (ISO) 4-hydroxyphenyl retinamide (ISO) 5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol (ISO) 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP) 6-propyl-2-thiouracil (EXP) [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol (ISO) abacavir (ISO) acetamide (EXP) acetamiprid (ISO) acrylamide (EXP) aflatoxin B1 (ISO) all-trans-retinoic acid (ISO) allopurinol (EXP,ISO) amiodarone (EXP,ISO) amitriptyline (ISO) ammonium chloride (EXP) angelicin (ISO) aristolochic acid A (ISO) aristolochic acids (EXP) atazanavir sulfate (ISO) atenolol (ISO) atorvastatin calcium (ISO) atropine (ISO) Azoxymethane (ISO) bacitracin (EXP) benzbromarone (EXP) benzo[a]pyrene (ISO) beta-carboline (ISO) beta-naphthoflavone (ISO) biphenyl-4-amine (ISO) bisoprolol (ISO) bisphenol A (EXP,ISO) bisphenol F (ISO) buta-1,3-diene (ISO) cadmium dichloride (EXP) carvedilol (ISO) CGP 52608 (ISO) chenodeoxycholic acid (ISO) chlordecone (ISO) chloroquine (ISO) chlorphenamine (EXP) cimetidine (EXP,ISO) cisplatin (ISO) clofibrate (EXP) clonidine (ISO) clonidine (amino form) (ISO) clonidine (imino form) (ISO) cobalt dichloride (EXP) cyclosporin A (ISO) deoxycholic acid (ISO) dexamethasone (EXP,ISO) dextran sulfate (ISO) dibenzofurans (ISO) dichlorine (EXP) diclofenac (ISO) dieldrin (ISO) diethylstilbestrol (EXP) digoxin (ISO) diltiazem (ISO) diosmetin (ISO) diphenhydramine (ISO) disopyramide (EXP) dopamine (EXP) doxorubicin (EXP) endosulfan (ISO) ethidium (ISO) famotidine (EXP,ISO) fenthion (ISO) finasteride (EXP) flecainide (ISO) flutamide (EXP) folic acid (ISO) fonofos (ISO) fructose (EXP) fumonisin B1 (ISO) gamma-hexachlorocyclohexane (ISO) genistein (ISO) gentamycin (EXP) glafenine (EXP) glycochenodeoxycholic acid (ISO) glycocholic acid (ISO) glycodeoxycholic acid (ISO) graphite (EXP) harman (ISO) heptachlor (ISO) hyperforin (ISO) ibuprofen (ISO) icariin (ISO) imidacloprid (ISO) imipramine (ISO) imperatorin (ISO) indometacin (ISO) ipratropium (ISO) isoimperatorin (ISO) ketoprofen (ISO) L-ethionine (EXP) lamivudine (ISO) lidocaine (ISO) lipopolysaccharide (EXP,ISO) manganese(II) chloride (EXP) mangiferin (ISO) mefenamic acid (ISO) mefloquine (ISO) MeIQ (ISO) mercury atom (EXP) mercury(0) (EXP) metformin (ISO) methoxsalen (ISO) metoprolol (ISO) molsidomine (ISO) monocrotaline (ISO) monosodium L-glutamate (ISO) N,N-diethyl-m-toluamide (EXP) N-methyl-4-phenylpyridinium (EXP,ISO) N-Nitrosopyrrolidine (ISO) N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine (EXP,ISO) nadolol (ISO) nefazodone (EXP,ISO) nicotine (ISO) nifedipine (ISO) nimesulide (EXP) nitenpyram (ISO) O-methyleugenol (ISO) ochratoxin A (EXP) omeprazole (EXP) ozone (EXP,ISO) paracetamol (ISO) paraquat (EXP) parathion (ISO) perfluorobutanesulfonic acid (ISO) perfluorononanoic acid (ISO) perfluorooctane-1-sulfonic acid (ISO) perfluorooctanoic acid (ISO) permethrin (EXP) phenobarbital (EXP,ISO) Phenoxybenzamine (ISO) phenylephrine (EXP) PhIP (EXP) pirinixic acid (EXP,ISO) Potassium 2,6-dihydroxytriazinecarboxylate (ISO) potassium dichromate (ISO) prazosin (ISO) probenecid (ISO) prochloraz (ISO) progesterone (EXP,ISO) propafenone (ISO) propranolol (ISO) psoralen (ISO) pyrimethamine (ISO) quercetin (EXP,ISO) quinidine (EXP,ISO) quinine (EXP,ISO) ranitidine (EXP,ISO) resveratrol (ISO) Retrorsine (ISO) rifampicin (ISO) rutin (EXP) S-(1,2-dichlorovinyl)-L-cysteine (ISO) senecionine (ISO) silicon dioxide (ISO) sodium arsenite (ISO) sodium dichromate (EXP) soybean oil (EXP) spironolactone (ISO) streptozocin (EXP) sulindac (ISO) Sunset Yellow FCF (ISO) synephrine (EXP) talinolol (ISO) tartrazine (ISO) terbufos (ISO) tetrabutylammonium (EXP) tetrachloromethane (EXP,ISO) tetraethylammonium (EXP,ISO) tetrahydropalmatine (ISO) tetrapentylammonium (EXP) thiacloprid (ISO) thioacetamide (EXP) titanium dioxide (ISO) trans-piceid (ISO) trichloroethene (EXP) trimethoprim (ISO) troglitazone (ISO) tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate (ISO) trospium chloride (ISO) trovafloxacin (EXP) urethane (ISO) valproic acid (ISO) verapamil (ISO) vinclozolin (EXP)
Biological Process
(R)-carnitine transmembrane transport (ISO,ISS) acetylcholine transport (IDA,ISO) cellular detoxification (IMP,ISO) dopamine transport (IDA,ISO) dopamine uptake (ISO) epinephrine transport (IDA,ISO) establishment or maintenance of transmembrane electrochemical gradient (IDA) metanephric proximal tubule development (IEP) monoamine transport (IDA,ISO) monoatomic cation transmembrane transport (IDA) monoatomic cation transport (ISO) neurotransmitter transport (ISO) norepinephrine transport (IDA,ISO) norepinephrine uptake (IEA) O-acyl-L-carnitine transmembrane transport (ISO,ISS) organic cation transport (IBA,IDA,ISO) prostaglandin transport (ISO,ISS) putrescine transport (ISO,ISS) quaternary ammonium group transport (IDA,ISO) serotonin transport (IDA,ISO) serotonin uptake (ISO) spermidine transmembrane transport (IEA) spermidine transport (ISO,ISS) thiamine transmembrane transport (ISO,ISS) thiamine transport (ISO,ISS) xenobiotic transport (IDA,IMP,ISO) xenobiotic transport across blood-brain barrier (NAS)
Molecular Function
(R)-carnitine transmembrane transporter activity (ISO,ISS) acetylcholine transmembrane transporter activity (IDA,ISO) dopamine:sodium symporter activity (IDA) identical protein binding (IPI) monoamine transmembrane transporter activity (IDA,ISO) neurotransmitter transmembrane transporter activity (IDA,ISO) norepinephrine:sodium symporter activity (IDA) organic anion transmembrane transporter activity (ISO,ISS) organic cation transmembrane transporter activity (IBA,IDA,ISO) prostaglandin transmembrane transporter activity (ISO,ISS) protein binding (ISO) putrescine transmembrane transporter activity (ISO,ISS) pyrimidine nucleoside transmembrane transporter activity (ISO) quaternary ammonium group transmembrane transporter activity (IDA,ISO) spermidine transmembrane transporter activity (ISO,ISS) thiamine transmembrane transporter activity (ISO) toxin transmembrane transporter activity (IMP,ISO) xenobiotic transmembrane transporter activity (IDA,IMP,ISO)
1.
Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain.
Amphoux A, etal., Neuropharmacology. 2006 Jun;50(8):941-52. doi: 10.1016/j.neuropharm.2006.01.005. Epub 2006 Mar 31.
2.
Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.
Arndt P, etal., Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. doi: 10.1152/ajprenal.2001.281.3.F454.
3.
Catecholamine transport by the organic cation transporter type 1 (OCT1).
Breidert T, etal., Br J Pharmacol. 1998 Sep;125(1):218-24.
4.
Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1.
Busch AE, etal., J Biol Chem. 1996 Dec 20;271(51):32599-604. doi: 10.1074/jbc.271.51.32599.
5.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.
Metformin pathways: pharmacokinetics and pharmacodynamics.
Gong L, etal., Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22.
7.
Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate.
Gorboulev V, etal., Mol Pharmacol. 1999 Dec;56(6):1254-61. doi: 10.1124/mol.56.6.1254.
8.
Reduced expression of organic cation transporters rOCT1 and rOCT2 in experimental diabetes.
Grover B, etal., J Pharmacol Exp Ther. 2004 Mar;308(3):949-56. Epub 2004 Jan 8.
9.
Drug excretion mediated by a new prototype of polyspecific transporter.
Grundemann D, etal., Nature 1994 Dec 8;372(6506):549-52.
10.
Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia.
Heemskerk S, etal., Eur J Pharmacol. 2008 Apr 28;584(2-3):390-7. doi: 10.1016/j.ejphar.2008.02.006. Epub 2008 Feb 12.
11.
Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice.
Hu QH, etal., Eur J Nutr. 2012 Aug;51(5):593-606. doi: 10.1007/s00394-011-0243-y. Epub 2011 Sep 10.
12.
Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis.
Jin HE, etal., Pharm Res. 2009 Mar;26(3):549-59. doi: 10.1007/s11095-008-9770-5. Epub 2008 Nov 11.
13.
Functional characterization of mouse cation transporter mOCT2 compared with mOCT1.
Kakehi M, etal., Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50.
14.
Localization of organic cation transporters OCT1 and OCT2 in rat kidney.
Karbach U, etal., Am J Physiol Renal Physiol. 2000 Oct;279(4):F679-87.
15.
Cell free expression and functional reconstitution of eukaryotic drug transporters.
Keller T, etal., Biochemistry. 2008 Apr 15;47(15):4552-64. doi: 10.1021/bi800060w. Epub 2008 Mar 25.
16.
The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization.
Keller T, etal., J Biol Chem. 2011 Oct 28;286(43):37874-86. doi: 10.1074/jbc.M111.289330. Epub 2011 Sep 6.
17.
Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2.
Kurata T, etal., Drug Metab Pharmacokinet. 2010;25(4):328-34.
18.
Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents.
Lin CJ, etal., J Neurochem. 2010 Aug;114(3):717-27. doi: 10.1111/j.1471-4159.2010.06801.x. Epub 2010 May 6.
19.
Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium.
Lips KS, etal., Am J Respir Cell Mol Biol. 2005 Jul;33(1):79-88. Epub 2005 Apr 7.
20.
Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse.
Lips KS, etal., Life Sci. 2007 May 30;80(24-25):2263-9. Epub 2007 Jan 23.
21.
Transport of organic cations across the blood-testis barrier.
Maeda T, etal., Mol Pharm. 2007 Jul-Aug;4(4):600-7. Epub 2007 Jul 7.
22.
The affinity of the organic cation transporter rOCT1 is increased by protein kinase C-dependent phosphorylation.
Mehrens T, etal., J Am Soc Nephrol. 2000 Jul;11(7):1216-1224. doi: 10.1681/ASN.V1171216.
23.
Membrane localization of the electrogenic cation transporter rOCT1 in rat liver.
Meyer-Wentrup F, etal.
24.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
25.
Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells.
Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
26.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
27.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
28.
SMPDB Annotation Import Pipeline
Pipeline to import SMPDB annotations from SMPDB into RGD
29.
Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease.
Popp C, etal., Mol Pharmacol. 2005 May;67(5):1600-11. doi: 10.1124/mol.104.008839. Epub 2005 Jan 20.
30.
GOA pipeline
RGD automated data pipeline
31.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
32.
The organic cation transporters rOCT1 and hOCT2 are inhibited by cGMP.
Schlatter E, etal., J Membr Biol. 2002 Oct 1;189(3):237-44. doi: 10.1007/s00232-002-1023-7.
33.
Nitric oxide-induced regulation of renal organic cation transport after renal ischemia-reperfusion injury.
Schneider R, etal., Am J Physiol Renal Physiol. 2011 Nov;301(5):F997-F1004. doi: 10.1152/ajprenal.00264.2011. Epub 2011 Aug 10.
34.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
35.
Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.
Sturm A, etal., Am J Physiol Renal Physiol. 2007 Sep;293(3):F767-79. doi: 10.1152/ajprenal.00106.2007. Epub 2007 Jun 13.
36.
Differential localization of organic cation transporters rOCT1 and rOCT2 in the basolateral membrane of rat kidney proximal tubules.
Sugawara-Yokoo M, etal., Histochem Cell Biol. 2000 Sep;114(3):175-80. doi: 10.1007/s004180000186.
37.
Tentative Sequence Identification Numbers
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
38.
Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury.
Ulu R, etal., Food Chem Toxicol. 2012 May;50(5):1675-9. doi: 10.1016/j.fct.2012.02.082. Epub 2012 Mar 3.
39.
Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.
Urakami Y, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):800-5.
40.
Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides.
van Montfoort JE, etal., J Pharmacol Exp Ther. 2001 Jul;298(1):110-5.
41.
Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice.
Wang CP, etal., Planta Med. 2011 May;77(8):786-94. doi: 10.1055/s-0030-1250599. Epub 2010 Dec 10.
42.
Renal tumours in a Tsc1(+)/(-) mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.
Yang J, etal., Eur J Cancer. 2013 Apr;49(6):1479-90. doi: 10.1016/j.ejca.2012.10.027. Epub 2012 Dec 7.
43.
Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).
Zhang L, etal., J Biol Chem 1997 Jun 27;272(26):16548-54.
Slc22a1 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 1 50,624,339 - 50,651,437 (+) NCBI GRCr8 mRatBN7.2 1 48,076,657 - 48,103,679 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 48,076,666 - 48,103,678 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 1 48,768,287 - 48,795,288 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 1 54,754,091 - 54,781,071 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 1 48,843,810 - 48,870,799 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 1 48,273,639 - 48,300,645 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 48,273,611 - 48,300,655 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 1 51,452,604 - 51,479,610 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 1 42,351,239 - 42,378,295 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 1 42,354,183 - 42,381,239 (+) NCBI Celera 1 43,876,335 - 43,903,290 (+) NCBI Celera Cytogenetic Map 1 q11 NCBI
SLC22A1 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 6 160,121,815 - 160,158,718 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 6 160,121,815 - 160,158,718 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 6 160,542,847 - 160,579,750 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 6 160,462,853 - 160,499,740 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 6 160,513,273 - 160,550,159 NCBI Celera 6 161,188,634 - 161,224,539 (+) NCBI Celera Cytogenetic Map 6 q25.3 NCBI HuRef 6 158,013,550 - 158,049,540 (+) NCBI HuRef CHM1_1 6 160,805,108 - 160,841,995 (+) NCBI CHM1_1 T2T-CHM13v2.0 6 161,367,910 - 161,404,908 (+) NCBI T2T-CHM13v2.0
Slc22a1 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 17 12,867,761 - 12,894,725 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 17 12,867,756 - 12,894,716 (-) Ensembl GRCm39 Ensembl GRCm38 17 12,648,874 - 12,675,838 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 17 12,648,869 - 12,675,829 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 17 12,841,740 - 12,868,704 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 17 12,492,232 - 12,519,196 (-) NCBI MGSCv36 mm8 Celera 17 12,680,587 - 12,707,864 (-) NCBI Celera Cytogenetic Map 17 A1 NCBI cM Map 17 8.63 NCBI
SLC22A1 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 5 180,216,337 - 180,263,051 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 6 178,125,295 - 178,169,671 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 6 158,004,545 - 158,046,428 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 6 163,014,522 - 163,054,818 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 6 163,014,663 - 163,054,681 (+) Ensembl panpan1.1 panPan2
SLC22A1 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 1 49,268,978 - 49,296,522 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 1 50,109,085 - 50,138,635 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 1 49,451,887 - 49,481,466 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 1 49,451,182 - 49,482,182 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 1 49,334,247 - 49,363,803 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 1 49,205,883 - 49,235,453 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 1 49,820,796 - 49,850,348 (+) NCBI UU_Cfam_GSD_1.0
Slc22a1 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024404946 144,281,749 - 144,305,075 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936489 11,534,095 - 11,556,745 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936489 11,534,095 - 11,556,759 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
SLC22A1 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 1 7,340,126 - 7,365,520 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 1 7,340,442 - 7,365,543 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 1 9,139,435 - 9,164,369 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
SLC22A1 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 13 87,744,600 - 87,780,846 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 13 87,745,023 - 87,781,073 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666040 60,132,123 - 60,167,647 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
.
Predicted Target Of
Count of predictions: 210 Count of miRNA genes: 89 Interacting mature miRNAs: 95 Transcripts: ENSRNOT00000022068, ENSRNOT00000022254 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
1331732 Srn4 Serum renin concentration QTL 4 4.467 renin activity (VT:0005581) plasma renin activity level (CMO:0000116) 1 35239598 78430678 Rat 2313059 Bss55 Bone structure and strength QTL 55 3.2 0.0001 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) 1 43284731 118944897 Rat 631688 Hcas2 Hepatocarcinoma susceptibility QTL 2 3 0.0001 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) 1 5925874 115540829 Rat 1357397 Bw41 Body weight QTL 41 4.19 0.0001 body mass (VT:0001259) body weight (CMO:0000012) 1 22340647 49361612 Rat 1358359 Sradr1 Stress Responsive Adrenal Weight QTL 1 4.74 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 1 30882023 123479925 Rat 1331792 Rf29 Renal function QTL 29 4.589 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) 1 35239598 78430678 Rat 2313062 Bmd73 Bone mineral density QTL 73 3.9 0.0001 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) 1 11481312 82174945 Rat 8552900 Pigfal1 Plasma insulin-like growth factor 1 level QTL 1 7.4 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 1 34836858 79836858 Rat 1554320 Bmd1 Bone mineral density QTL 1 12.2 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 1 509108 86060548 Rat 1354643 Foco2 Food consumption QTL 2 7.17 0.0001 eating behavior trait (VT:0001431) food intake rate (CMO:0000427) 1 33449848 78449848 Rat 2302059 Pia36 Pristane induced arthritis QTL 36 3.8 0.001 blood immunoglobulin amount (VT:0002460) serum immunoglobulin G1 level (CMO:0002115) 1 43333002 88333002 Rat 2313065 Bss67 Bone structure and strength QTL 67 3.1 0.0001 tibia area (VT:1000281) tibia total energy absorbed before break (CMO:0001736) 1 11481312 82174945 Rat 7421626 Bp360 Blood pressure QTL 360 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 4393289 49393289 Rat 1357400 Bw62 Body weight QTL62 4.05 inguinal fat pad mass (VT:0010424) inguinal fat pad weight to body weight ratio (CMO:0001253) 1 22340647 67340647 Rat 1357401 Bw43 Body weight QTL 43 3.75 body mass (VT:0001259) body weight (CMO:0000012) 1 22340647 49361612 Rat 2313069 Bss68 Bone structure and strength QTL 68 2.9 0.0001 tibia size trait (VT:0100001) tibia total energy absorbed before break (CMO:0001736) 1 11481312 82174945 Rat 631495 Bp96 Blood pressure QTL 96 4.52 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 22340647 102268831 Rat 631494 Bp95 Blood pressure QTL 95 40 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 16206210 49268520 Rat 2313075 Bss66 Bone structure and strength QTL 66 3.4 0.0001 tibia length (VT:0004357) tibia length (CMO:0000450) 1 11481312 82174945 Rat 5684998 Bss101 Bone structure and strength QTL 101 3.6 tibia strength trait (VT:1000284) tibia ultimate force (CMO:0001734) 1 15431621 49361612 Rat 70225 Bp58 Blood pressure QTL 58 3.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 32356093 162846471 Rat 5684999 Bss102 Bone structure and strength QTL 102 5.5 7e-07 tibia strength trait (VT:1000284) tibia stiffness (CMO:0001735) 1 15431621 49361612 Rat 2313072 Bss53 Bone structure and strength QTL 53 4.3 0.0001 tibia length (VT:0004357) tibia length (CMO:0000450) 1 43284731 118944897 Rat 1300167 Hrtrt2 Heart rate QTL 2 4.35 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 1 11481312 75088344 Rat 10059597 Bp377 Blood pressure QTL 377 3.42 0.025 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 32737458 199368955 Rat 2313078 Bss54 Bone structure and strength QTL 54 3.5 0.0001 tibia area (VT:1000281) tibia midshaft cross-sectional area (CMO:0001717) 1 43284731 118944897 Rat 2313077 Bss69 Bone structure and strength QTL 69 3.5 0.0001 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) 1 11481312 82174945 Rat 1331778 Rf28 Renal function QTL 28 4.66 urine potassium amount (VT:0010539) urine potassium excretion rate (CMO:0000761) 1 45803140 78430678 Rat 1578756 Iddm22 Insulin dependent diabetes mellitus QTL 22 2.7 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 11835181 56835181 Rat 631508 Sald1 Serum aldosterone level QTL 1 3.7 blood aldosterone amount (VT:0005346) serum aldosterone level (CMO:0000487) 1 9856001 54856001 Rat 1331785 Rf27 Renal function QTL 27 4.643 urine sodium amount (VT:0006274) urine sodium level (CMO:0000129) 1 28879780 78430678 Rat 1300172 Bp172 Blood pressure QTL 172 3.56 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 1 32737273 90665040 Rat 724520 Bp145 Blood pressure QTL 145 2.1 0.0024 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 20784828 65784828 Rat 2313094 Bss58 Bone structure and strength QTL 58 3.7 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 1 43284731 118944897 Rat 2313092 Bmd72 Bone mineral density QTL 72 2.5 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 1 11481312 82174945 Rat 2313099 Bss56 Bone structure and strength QTL 56 2.4 0.0001 tibia size trait (VT:0100001) tibia midshaft endosteal cross-sectional area (CMO:0001716) 1 43284731 118944897 Rat 2313098 Bmd70 Bone mineral density QTL 70 3.6 0.0001 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) 1 43284731 118944897 Rat 2313097 Bss70 Bone structure and strength QTL 70 3.5 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 1 11481312 82174945 Rat 9589820 Insglur3 Insulin/glucose ratio QTL 3 10.75 0.001 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) 1 34836858 79836858 Rat 738020 Pia8 Pristane induced arthritis QTL 8 4.7 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 1 1 65833076 Rat 1354599 Bw29 Body weight QTL 29 3.46 0.001 body mass (VT:0001259) body weight (CMO:0000012) 1 33449848 78449848 Rat 2302038 Pia31 Pristane induced arthritis QTL 31 5.5 0.001 blood autoantibody amount (VT:0003725) serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111) 1 10992065 55992065 Rat 8552948 Pigfal11 Plasma insulin-like growth factor 1 level QTL 11 4.7 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 1 34836858 79836858 Rat 634353 Rends2 Renal damage susceptibility QTL 2 0.05 kidney blood vessel morphology trait (VT:0000530) organ lesion measurement (CMO:0000677) 1 19333571 56983283 Rat 2313051 Bss57 Bone structure and strength QTL 57 3.7 0.0001 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) 1 43284731 118944897 Rat
This gene Slc22a1 is modified in the following models/strains:
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
10
49
70
89
88
57
24
57
6
213
94
50
45
54
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000022068 ⟹ ENSRNOP00000022068
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 1 48,076,688 - 48,103,678 (+) Ensembl Rnor_6.0 Ensembl 1 48,273,639 - 48,300,495 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000022254 ⟹ ENSRNOP00000022254
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 1 48,076,666 - 48,103,678 (+) Ensembl Rnor_6.0 Ensembl 1 48,273,611 - 48,300,655 (+) Ensembl
RefSeq Acc Id:
NM_012697 ⟹ NP_036829
RefSeq Status:
PROVISIONAL
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 50,624,430 - 50,651,437 (+) NCBI mRatBN7.2 1 48,076,666 - 48,103,679 (+) NCBI Rnor_6.0 1 48,273,639 - 48,300,645 (+) NCBI Rnor_5.0 1 51,452,604 - 51,479,610 (-) NCBI RGSC_v3.4 1 42,351,239 - 42,378,295 (+) RGD Celera 1 43,876,335 - 43,903,290 (+) RGD
Sequence:
GCAGGCCTGGCTAAACTGGTGAGGGCCCTACCCAGCCATGCCCACCGTGGATGATGTCCTGGAGCAAGTTGGAGAGTTTGGCTGGTTCCAGAAACAAGCCTTCCTGTTGCTATGCCTGATCTCAGCTT
hide sequence
RefSeq Acc Id:
XM_039101083 ⟹ XP_038957011
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 50,624,339 - 50,651,437 (+) NCBI mRatBN7.2 1 48,076,657 - 48,103,679 (+) NCBI
RefSeq Acc Id:
XM_039101089 ⟹ XP_038957017
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 1 50,633,142 - 50,651,437 (+) NCBI mRatBN7.2 1 48,085,370 - 48,103,679 (+) NCBI
RefSeq Acc Id:
NP_036829 ⟸ NM_012697
- UniProtKB:
O35882 (UniProtKB/Swiss-Prot), Q6AYW1 (UniProtKB/Swiss-Prot), Q63089 (UniProtKB/Swiss-Prot), A6KJW8 (UniProtKB/TrEMBL)
- Sequence:
MPTVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVY
hide sequence
Ensembl Acc Id:
ENSRNOP00000022068 ⟸ ENSRNOT00000022068
Ensembl Acc Id:
ENSRNOP00000022254 ⟸ ENSRNOT00000022254
RefSeq Acc Id:
XP_038957011 ⟸ XM_039101083
- Peptide Label:
isoform X1
RefSeq Acc Id:
XP_038957017 ⟸ XM_039101089
- Peptide Label:
isoform X2
RGD ID: 13689619 Promoter ID: EPDNEW_R143 Type: initiation region Name: Slc22a1_1 Description: solute carrier family 22 member 1 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 1 48,273,628 - 48,273,688 EPDNEW
BioCyc Gene G2FUF-61571 BioCyc
Ensembl Genes ENSRNOG00000016337 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022068.6 UniProtKB/Swiss-Prot
ENSRNOT00000022254.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130305 IMAGE-MGC_LOAD
InterPro MFS UniProtKB/TrEMBL
MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MFS_sugar_transport-like UniProtKB/Swiss-Prot
MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Orgcat_transp/SVOP UniProtKB/Swiss-Prot
Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24904 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93570 IMAGE-MGC_LOAD
NCBI Gene 24904 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
Sugar_tr UniProtKB/Swiss-Prot
PharmGKB SLC22A1 RGD
PhenoGen Slc22a1 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016337 RatGTEx
Superfamily-SCOP MFS general substrate transporter UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC230941
UniProt A6KJW8 ENTREZGENE, UniProtKB/TrEMBL
O35882 ENTREZGENE
Q63089 ENTREZGENE
Q6AYW1 ENTREZGENE
S22A1_RAT UniProtKB/Swiss-Prot
UniProt Secondary O35882 UniProtKB/Swiss-Prot
Q6AYW1 UniProtKB/Swiss-Prot
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2016-02-25
Slc22a1
solute carrier family 22 member 1
Slc22a1
solute carrier family 22 (organic cation transporter), member 1
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2004-09-10
Slc22a1
solute carrier family 22 (organic cation transporter), member 1
solute carrier family 22, member 1
Name updated
1299863 APPROVED
2003-04-09
Slc22a1
solute carrier family 22, member 1
Solute carrier family 22, member 1
Name updated
629478 APPROVED
2001-06-22
1-Oct
Organic cation transporter
Symbol and Name withdrawn
67952 WITHDRAWN
2001-06-22
Slc22a1
Solute carrier family 22, member 1
Symbol and Name updated to reflect Human and Mouse nomenclature
67952 APPROVED
Note Type
Note
Reference
gene_function
translocates hydrophobic and hydrophilic organic cations
634159
gene_protein
556-amino-acid membrane protein
634159
