Fam237a (family with sequence similarity 237 member A) - Rat Genome Database

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Gene: Fam237a (family with sequence similarity 237 member A) Rattus norvegicus
Analyze
Symbol: Fam237a
Name: family with sequence similarity 237 member A
RGD ID: 9235481
Description: Orthologous to human FAM237A (family with sequence similarity 237 member A); INTERACTS WITH benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC689663; LOC103690541; LOC689663; neurosecretory protein GL; NPGL; uncharacterized LOC103690541; uncharacterized protein LOC103690541
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8972,521,779 - 72,528,795 (+)NCBIGRCr8
mRatBN7.2965,024,312 - 65,035,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,028,251 - 65,034,525 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx973,531,929 - 73,538,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0978,685,219 - 78,691,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0977,070,281 - 77,076,826 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0970,310,919 - 70,318,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl970,310,932 - 70,317,992 (+)EnsemblRnor6.0rn6Rnor6.0
RGSC_v3.4962,273,693 - 62,277,843 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera962,439,284 - 62,447,171 (+)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:25708449   PMID:28323972   PMID:28799896  


Genomics

Comparative Map Data
Fam237a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8972,521,779 - 72,528,795 (+)NCBIGRCr8
mRatBN7.2965,024,312 - 65,035,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,028,251 - 65,034,525 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx973,531,929 - 73,538,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0978,685,219 - 78,691,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0977,070,281 - 77,076,826 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0970,310,919 - 70,318,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl970,310,932 - 70,317,992 (+)EnsemblRnor6.0rn6Rnor6.0
RGSC_v3.4962,273,693 - 62,277,843 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera962,439,284 - 62,447,171 (+)NCBICelera
Cytogenetic Map9q32NCBI
FAM237A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382206,642,487 - 206,649,365 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2206,642,487 - 206,649,365 (+)EnsemblGRCh38hg38GRCh38
GRCh372207,507,211 - 207,514,089 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362207,215,387 - 207,222,418 (+)NCBINCBI36Build 36hg18NCBI36
Celera2201,268,569 - 201,275,600 (+)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2199,356,677 - 199,363,708 (+)NCBIHuRef
CHM1_12207,512,976 - 207,520,006 (+)NCBICHM1_1
T2T-CHM13v2.02207,124,596 - 207,131,470 (+)NCBIT2T-CHM13v2.0
Fam237a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,655,127 - 63,659,980 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,655,127 - 63,659,978 (+)EnsemblGRCm39 Ensembl
GRCm38163,615,968 - 63,620,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl163,615,968 - 63,620,819 (+)EnsemblGRCm38mm10GRCm38
Celera164,138,496 - 64,145,142 (+)NCBICelera
Cytogenetic Map1C2NCBI
Fam237a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554578,335,357 - 8,340,060 (-)NCBIChiLan1.0ChiLan1.0
FAM237A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213109,230,567 - 109,257,776 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B109,245,546 - 109,272,755 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B93,876,816 - 93,883,882 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B212,006,961 - 212,012,088 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B212,005,146 - 212,012,183 (+)Ensemblpanpan1.1panPan2
FAM237A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13715,177,567 - 15,193,117 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3715,185,950 - 15,193,125 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3716,065,468 - 16,070,581 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03715,124,612 - 15,129,725 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3715,124,626 - 15,129,187 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13715,075,630 - 15,080,738 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03715,049,231 - 15,054,342 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03715,047,114 - 15,052,225 (+)NCBIUU_Cfam_GSD_1.0
Fam237a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303163,331,180 - 163,337,883 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366312,968,088 - 2,972,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM237A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15109,907,835 - 109,914,834 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115109,909,766 - 109,914,892 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FAM237A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11092,411,483 - 92,420,021 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040106,961,422 - 106,966,187 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam237a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247659,363,756 - 9,370,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fam237a
58 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1578659Tspe1Trichinella spiralis expulsion QTL 14.8parasite quantity (VT:0010441)logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024)96138143465691299Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system
High
Medium
Low 7
Below cutoff 45 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000088268   ⟹   ENSRNOP00000068896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,028,251 - 65,034,525 (+)Ensembl
Rnor_6.0 Ensembl970,310,932 - 70,317,992 (+)Ensembl
RefSeq Acc Id: NM_001401946   ⟹   NP_001388875
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,522,278 - 72,528,795 (+)NCBI
mRatBN7.2965,028,454 - 65,034,971 (+)NCBI
RefSeq Acc Id: XM_008767160   ⟹   XP_008765382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,522,516 - 72,528,795 (+)NCBI
mRatBN7.2965,028,537 - 65,035,051 (+)NCBI
Rnor_6.0970,311,585 - 70,318,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767161   ⟹   XP_008765383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,521,779 - 72,528,795 (+)NCBI
mRatBN7.2965,024,312 - 65,035,051 (+)NCBI
Rnor_6.0970,310,919 - 70,318,018 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001388875 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765382 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765383 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BBA46262 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068896
  ENSRNOP00000068896.1
Reference Protein Sequences
RefSeq Acc Id: XP_008765383   ⟸   XM_008767161
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765382   ⟸   XM_008767160
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068896   ⟸   ENSRNOT00000088268
RefSeq Acc Id: NP_001388875   ⟸   NM_001401946
- UniProtKB: A0A0G2JTZ0 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTZ0-F1-model_v2 AlphaFold A0A0G2JTZ0 1-183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:9235481 AgrOrtholog
BioCyc Gene G2FUF-27341 BioCyc
Ensembl Genes ENSRNOG00000054699 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088268 ENTREZGENE
  ENSRNOT00000088268.2 UniProtKB/TrEMBL
InterPro FAM237A UniProtKB/TrEMBL
KEGG Report rno:103690541 UniProtKB/TrEMBL
NCBI Gene LOC103690541 ENTREZGENE
PANTHER PROTEIN FAM237A UniProtKB/TrEMBL
  PTHR36690 UniProtKB/TrEMBL
PhenoGen Fam237a PhenoGen
RatGTEx ENSRNOG00000054699 RatGTEx
UniProt A0A0G2JTZ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-21 Fam237a  family with sequence similarity 237 member A  LOC103690541  uncharacterized LOC103690541  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 LOC103690541  uncharacterized LOC103690541  LOC689663  hypothetical protein LOC689663  Data merged from RGD:1589915 737654 PROVISIONAL
2014-08-25 LOC103690541  uncharacterized LOC103690541      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC689663  hypothetical protein LOC689663  LOC684651  hypothetical protein LOC684651  Data merged from RGD:1587923 1643240 APPROVED
2006-11-20 LOC689663  hypothetical protein LOC689663      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684651  hypothetical protein LOC684651      Symbol and Name status set to provisional 70820 PROVISIONAL