Eef1a1l2 (eukaryotic translation elongation factor 1 alpha 1 like 2) - Rat Genome Database

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Gene: Eef1a1l2 (eukaryotic translation elongation factor 1 alpha 1 like 2) Rattus norvegicus
Analyze
Symbol: Eef1a1l2
Name: eukaryotic translation elongation factor 1 alpha 1 like 2
RGD ID: 9202998
Description: Predicted to enable GTP binding activity.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: elongation factor 1-alpha 1 pseudogene; elongation factor 1-alpha 1-like; eukaryotic translation elongation factor 1 alpha 2; LOC100360150; LOC103691939
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,598,531 - 163,601,027 (-)NCBIGRCr8
mRatBN7.23143,138,360 - 143,139,773 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.03150,154,373 - 150,155,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03156,526,192 - 156,527,614 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,106,442 - 145,114,354 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Eef1a1l2
28 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_039106696   ⟹   XP_038962624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,598,531 - 163,601,027 (-)NCBI
mRatBN7.23143,138,360 - 143,139,773 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038962624 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038718.4
Reference Protein Sequences
RefSeq Acc Id: XP_038962624   ⟸   XM_039106696
- UniProtKB: F1M6C2 (UniProtKB/TrEMBL)
Protein Domains
tr-type G

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-47164 BioCyc
Ensembl Genes ENSRNOG00000029996 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036217.4 UniProtKB/TrEMBL
Gene3D-CATH P-loop containing nucleotide triphosphate hydrolases UniProtKB/TrEMBL
  Translation factors UniProtKB/TrEMBL
InterPro EFTu-like_2 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  T_Tr_GTP-bd_dom UniProtKB/TrEMBL
  Transl_B-barrel_sf UniProtKB/TrEMBL
  Transl_elong_EF1A/Init_IF2_C UniProtKB/TrEMBL
  Transl_elong_EF1A_euk/arc UniProtKB/TrEMBL
  Transl_elong_EFTu/EF1A_C UniProtKB/TrEMBL
NCBI Gene LOC103691939 ENTREZGENE
PANTHER ELONGATION FACTOR 1-ALPHA 1-RELATED UniProtKB/TrEMBL
  TRANSLATION FACTOR UniProtKB/TrEMBL
Pfam GTP_EFTU UniProtKB/TrEMBL
  GTP_EFTU_D2 UniProtKB/TrEMBL
  GTP_EFTU_D3 UniProtKB/TrEMBL
PhenoGen Eef1a1l2 PhenoGen
PRINTS ELONGATNFCT UniProtKB/TrEMBL
PROSITE G_TR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029996 RatGTEx
Superfamily-SCOP EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain UniProtKB/TrEMBL
  P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL
  Translation proteins UniProtKB/TrEMBL
UniProt F1M6C2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Eef1a1l2  eukaryotic translation elongation factor 1 alpha 1 like 2  LOC103691939  elongation factor 1-alpha 1 pseudogene  Symbol and Name Changed 1299863 APPROVED
2015-07-29 LOC103691939  elongation factor 1-alpha 1 pseudogene  LOC100360150  eukaryotic translation elongation factor 1 alpha 2  Data merged from RGD:2322699 737654 PROVISIONAL
2014-08-25 LOC103691939  elongation factor 1-alpha 1 pseudogene      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-06 LOC100360150  eukaryotic translation elongation factor 1 alpha 2      Symbol and Name status set to provisional 70820 PROVISIONAL