Scn4a (sodium voltage-gated channel alpha subunit 4) - Rat Genome Database

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Gene: Scn4a (sodium voltage-gated channel alpha subunit 4) Chinchilla lanigera
Analyze
Symbol: Scn4a
Name: sodium voltage-gated channel alpha subunit 4
RGD ID: 9036237
Description: ENCODES a protein that exhibits voltage-gated sodium channel activity (ortholog); INVOLVED IN choline transport (ortholog); monoatomic cation transport (ortholog); potassium ion transport (ortholog); ASSOCIATED WITH congenital myasthenic syndrome (ortholog); congenital myasthenic syndrome 16 (ortholog); congenital myopathy (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated sodium channel complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium channel protein type 4 subunit alpha; sodium channel, voltage gated, type IV alpha subunit; sodium channel, voltage-gated, type IV, alpha subunit
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,861,585 - 7,906,192 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554787,861,585 - 7,906,192 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Scn4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,861,585 - 7,906,192 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554787,861,585 - 7,906,192 (+)NCBIChiLan1.0ChiLan1.0
SCN4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,938,554 - 63,972,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,938,554 - 63,972,918 (-)EnsemblGRCh38hg38GRCh38
GRCh371762,015,914 - 62,050,278 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,369,646 - 59,404,010 (-)NCBINCBI36Build 36hg18NCBI36
Build 341759,369,645 - 59,404,010NCBI
Celera1756,403,975 - 56,438,354 (-)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,383,629 - 57,417,946 (-)NCBIHuRef
CHM1_11762,079,833 - 62,114,196 (-)NCBICHM1_1
T2T-CHM13v2.01764,809,317 - 64,843,693 (-)NCBIT2T-CHM13v2.0
Scn4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,208,374 - 106,256,385 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,209,418 - 106,244,114 (-)EnsemblGRCm39 Ensembl
GRCm3811106,317,545 - 106,365,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,318,592 - 106,353,288 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,179,907 - 106,210,704 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,135,394 - 106,165,480 (-)NCBIMGSCv36mm8
Celera11118,049,260 - 118,080,125 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.91NCBI
Scn4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,745,459 - 91,796,452 (-)NCBIGRCr8
mRatBN7.21091,246,936 - 91,296,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,246,936 - 91,296,545 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,301,564 - 96,351,302 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,764,729 - 95,814,463 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,175,309 - 91,225,142 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,505,026 - 94,557,803 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,505,026 - 94,557,764 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,256,140 - 94,305,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,710,710 - 95,760,323 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11095,725,079 - 95,774,693 (-)NCBI
Celera1089,922,418 - 89,970,101 (-)NCBICelera
RH 3.4 Map10988.7RGD
Cytogenetic Map10q32.1NCBI
SCN4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,119,592 - 80,155,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,939,899 - 84,975,867 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,034,146 - 58,066,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,128,550 - 63,161,043 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,128,550 - 63,161,043 (-)Ensemblpanpan1.1panPan2
SCN4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,849,066 - 11,893,689 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,851,347 - 11,877,767 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0913,510,606 - 13,554,819 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,510,606 - 13,539,011 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,457,351 - 12,500,840 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,030,745 - 15,074,957 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,032,962 - 15,077,426 (+)NCBIUU_Cfam_GSD_1.0
Scn4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,610,329 - 14,653,543 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,543,102 - 4,569,862 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,541,061 - 4,570,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,002,175 - 15,047,582 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,001,356 - 15,048,092 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21214,992,881 - 15,039,475 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCN4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,273,143 - 57,331,677 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,282,252 - 57,331,035 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607727,910,000 - 27,944,696 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scn4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,436,047 - 1,483,531 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248491,436,372 - 1,483,531 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000011271   ⟹   ENSCLAP00000011135
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554787,861,585 - 7,906,192 (+)Ensembl
RefSeq Acc Id: XM_005402177   ⟹   XP_005402234
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554787,861,585 - 7,904,126 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013503233   ⟹   XP_013358687
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554787,876,286 - 7,906,192 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005402234 (Get FASTA)   NCBI Sequence Viewer  
  XP_013358687 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000011135
  ENSCLAP00000011135.1
Reference Protein Sequences
RefSeq Acc Id: XP_005402234   ⟸   XM_005402177
- UniProtKB: A0A8C2V745 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358687   ⟸   XM_013503233
- UniProtKB: A0A8C2V745 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000011135   ⟸   ENSCLAT00000011271
Protein Domains
Ion transport   Sodium ion transport-associated


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000007693 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000011271 ENTREZGENE
  ENSCLAT00000011271.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  iswi atpase UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Na_channel_a4su_mammal UniProtKB/TrEMBL
  Na_channel_asu UniProtKB/TrEMBL
  Na_chnl_inactivation_gate UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  VGCC_Ca_Na UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene Scn4a ENTREZGENE
PANTHER PTHR10037 UniProtKB/TrEMBL
  SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
PRINTS NACHANNEL UniProtKB/TrEMBL
  NACHANNEL4 UniProtKB/TrEMBL
PROSITE PS50096 UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8C2V745 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Scn4a  sodium voltage-gated channel alpha subunit 4    sodium channel, voltage gated, type IV alpha subunit  Symbol and/or name change 5135510 APPROVED
2015-08-25 Scn4a  sodium channel, voltage gated, type IV alpha subunit    sodium channel, voltage-gated, type IV, alpha subunit  Symbol and/or name change 5135510 APPROVED