Tpcn2 (two pore segment channel 2) - Rat Genome Database

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Gene: Tpcn2 (two pore segment channel 2) Chinchilla lanigera
Analyze
Symbol: Tpcn2
Name: two pore segment channel 2
RGD ID: 8994578
Description: ENCODES a protein that exhibits calcium channel activity (ortholog); identical protein binding (ortholog); intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity (ortholog); INVOLVED IN calcium-mediated signaling (ortholog); endocytosis involved in viral entry into host cell (ortholog); endosome to lysosome transport of low-density lipoprotein particle (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); brain infarction (ortholog); genetic disease (ortholog); FOUND IN endolysosome membrane (ortholog); endosome membrane (ortholog); lysosomal membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: two pore calcium channel protein 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,900,239 - 16,923,978 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,899,730 - 16,923,962 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tpcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,900,239 - 16,923,978 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,899,730 - 16,923,962 (-)NCBIChiLan1.0ChiLan1.0
TPCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,048,932 - 69,090,597 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,048,932 - 69,136,316 (+)EnsemblGRCh38hg38GRCh38
GRCh371168,816,400 - 68,858,065 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361168,572,926 - 68,614,648 (+)NCBINCBI36Build 36hg18NCBI36
Build 341168,572,940 - 68,612,568NCBI
Celera1166,156,085 - 66,198,158 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1165,155,518 - 65,197,367 (+)NCBIHuRef
CHM1_11168,700,007 - 68,741,850 (+)NCBICHM1_1
T2T-CHM13v2.01169,059,173 - 69,101,661 (+)NCBIT2T-CHM13v2.0
Tpcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,735,370 - 144,837,743 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,740,261 - 144,837,748 (-)EnsemblGRCm39 Ensembl
GRCm387145,181,633 - 145,284,011 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7145,186,524 - 145,284,011 (-)EnsemblGRCm38mm10GRCm38
MGSCv377152,439,828 - 152,469,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367145,063,313 - 145,093,317 (-)NCBIMGSCv36mm8
Celera7145,021,844 - 145,051,957 (-)NCBICelera
Cytogenetic Map7F5NCBI
Tpcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,845,827 - 209,875,561 (-)NCBIGRCr8
mRatBN7.21200,416,538 - 200,446,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,416,540 - 200,446,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,792,040 - 208,821,577 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,878,483 - 215,908,119 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,552,709 - 208,582,341 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,419,182 - 218,448,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,419,184 - 218,448,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,286,480 - 225,316,685 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,702,971 - 205,732,664 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,857,086 - 205,886,037 (-)NCBI
Celera1197,971,266 - 198,000,753 (-)NCBICelera
Cytogenetic Map1q42NCBI
TPCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2970,008,866 - 70,097,396 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11171,051,894 - 71,140,237 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01164,139,512 - 64,227,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11167,438,635 - 67,478,106 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1167,438,635 - 67,478,106 (+)Ensemblpanpan1.1panPan2
TPCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11848,956,833 - 48,984,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1848,957,249 - 48,984,564 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,525,455 - 47,591,712 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,592,807 - 49,659,116 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1849,627,141 - 49,659,100 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,039,802 - 49,105,897 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,625,233 - 48,691,444 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01849,371,799 - 49,438,088 (-)NCBIUU_Cfam_GSD_1.0
Tpcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,875,313 - 4,900,723 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365991,318,169 - 1,343,106 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365991,301,937 - 1,343,046 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,069,280 - 4,105,042 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,069,267 - 4,105,065 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.222,709,001 - 2,726,449 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115,491,476 - 5,529,015 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15,490,910 - 5,528,718 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038102,770,203 - 102,810,947 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,918,080 - 17,944,653 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,877,791 - 17,944,190 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000023814   ⟹   ENSCLAP00000023590
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542216,900,239 - 16,923,978 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000023815   ⟹   ENSCLAP00000023591
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542216,900,239 - 16,923,894 (-)Ensembl
RefSeq Acc Id: XM_005384252   ⟹   XP_005384309
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542216,899,730 - 16,923,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013514134   ⟹   XP_013369588
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542216,899,730 - 16,923,962 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013514135   ⟹   XP_013369589
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542216,899,730 - 16,923,962 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013514136   ⟹   XP_013369590
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542216,899,730 - 16,923,962 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005384309 (Get FASTA)   NCBI Sequence Viewer  
  XP_013369588 (Get FASTA)   NCBI Sequence Viewer  
  XP_013369589 (Get FASTA)   NCBI Sequence Viewer  
  XP_013369590 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000023590
  ENSCLAP00000023590.1
  ENSCLAP00000023591.1
RefSeq Acc Id: XP_005384309   ⟸   XM_005384252
- Peptide Label: isoform X4
- UniProtKB: A0A8C2W8X9 (UniProtKB/TrEMBL),   A0A8C2W380 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369589   ⟸   XM_013514135
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W380 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369590   ⟸   XM_013514136
- Peptide Label: isoform X3
- UniProtKB: A0A8C2W380 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369588   ⟸   XM_013514134
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W380 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000023591   ⟸   ENSCLAT00000023815
RefSeq Acc Id: ENSCLAP00000023590   ⟸   ENSCLAT00000023814
Protein Domains
Ion transport


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016178 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023814 ENTREZGENE
  ENSCLAT00000023814.1 UniProtKB/TrEMBL
  ENSCLAT00000023815.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  TPC2 UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene Tpcn2 ENTREZGENE
PANTHER PTHR46768 UniProtKB/TrEMBL
  TWO PORE CALCIUM CHANNEL PROTEIN 2 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8C2W380 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W8X9 ENTREZGENE, UniProtKB/TrEMBL