Grk1 (G protein-coupled receptor kinase 1)

Gene: Grk1 (G protein-coupled receptor kinase 1) Chinchilla lanigera

Analyze

Symbol:

Grk1

Name:

G protein-coupled receptor kinase 1

RGD ID:

8987439

Description:

ENCODES a protein that exhibits rhodopsin kinase activity (ortholog); INVOLVED IN apoptotic process (ortholog); negative regulation of neuron apoptotic process (ortholog); photoreceptor cell morphogenesis (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH congenital stationary night blindness (ortholog); congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytoplasm (ortholog); photoreceptor outer segment (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

rhodopsin kinase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	343,009 - 353,683 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	343,009 - 353,683 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital stationary night blindness (ISO)

congestive heart failure (ISO)

Experimental Diabetes Mellitus (ISO)

factor X deficiency (ISO)

genetic disease (ISO)

hereditary night blindness (ISO)

Neuralgia (ISO)

night blindness (ISO)

Oguchi disease-2 (ISO)

retinal disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (ISO)

negative regulation of neuron apoptotic process (ISO)

photoreceptor cell morphogenesis (ISO)

positive regulation of phosphorylation (ISO)

post-embryonic retina morphogenesis in camera-type eye (ISO)

protein autophosphorylation (ISO)

regulation of opsin-mediated signaling pathway (ISO)

response to light stimulus (ISO)

response to xenobiotic stimulus (ISO)

retinal rod cell apoptotic process (ISO)

Cellular Component

cytoplasm (ISO)

photoreceptor outer segment (ISO)

Molecular Function

rhodopsin kinase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

visual phototransduction pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Grk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	343,009 - 353,683 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	343,009 - 353,683 (-)	NCBI	ChiLan1.0	ChiLan1.0

GRK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	113,648,199 - 113,737,736 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	113,667,219 - 113,737,736 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	114,321,534 - 114,440,709 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	113,369,595 - 113,373,975 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	113,369,597 - 113,373,973	NCBI
Celera	13	95,148,890 - 95,166,521 (+)	NCBI		Celera
Cytogenetic Map	13	q34	NCBI
HuRef	13	94,993,393 - 94,997,833 (-)	NCBI		HuRef
HuRef	13	94,760,843 - 94,763,381 (+)	NCBI		HuRef
CHM1_1	13	114,395,320 - 114,407,284 (+)	NCBI		CHM1_1
CHM1_1	13	114,290,923 - 114,295,255 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	112,903,498 - 112,947,029 (+)	NCBI		T2T-CHM13v2.0

Grk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	13,455,081 - 13,471,951 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	13,455,081 - 13,471,951 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	13,405,081 - 13,421,951 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	13,405,081 - 13,421,951 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	13,405,081 - 13,421,951 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	13,405,058 - 13,417,557 (+)	NCBI		MGSCv36	mm8
Celera	8	13,573,519 - 13,590,102 (+)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI
cM Map	8	5.93	NCBI

Grk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	82,821,184 - 82,837,971 (-)	NCBI		GRCr8
mRatBN7.2	16	76,122,501 - 76,135,792 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	76,123,842 - 76,135,792 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	81,404,428 - 81,416,381 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	84,857,390 - 84,869,343 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	80,106,227 - 80,118,183 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	81,153,489 - 81,165,442 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,153,489 - 81,165,442 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	80,641,991 - 80,657,693 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	80,979,323 - 80,991,796 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	80,979,589 - 80,992,061 (-)	NCBI
Celera	16	73,931,302 - 73,943,259 (-)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

GRK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	115,179,766 - 115,204,613 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	113,871,114 - 113,897,632 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	94,816,045 - 94,838,509 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	113,867,002 - 113,885,610 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	113,867,002 - 113,885,610 (+)	Ensembl	panpan1.1		panPan2

GRK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	60,911,953 - 60,929,330 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	60,911,953 - 60,926,146 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	60,622,827 - 60,638,762 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	61,596,581 - 61,612,683 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	61,596,581 - 61,609,597 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	61,035,074 - 61,051,125 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	61,037,157 - 61,053,062 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	61,068,208 - 61,084,263 (+)	NCBI		UU_Cfam_GSD_1.0

Grk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	195,787,031 - 195,800,023 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936472	151,854 - 165,281 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936472	152,202 - 165,134 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	78,793,777 - 78,804,262 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	78,793,670 - 78,803,291 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	86,527,109 - 86,537,944 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	91,633,902 - 91,655,989 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	91,636,813 - 91,653,521 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666046	48,723,661 - 48,741,396 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624793	453,125 - 462,053 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624793	453,125 - 462,053 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005373936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01003199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000004508 ⟹ ENSCLAP00000004424

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955404	343,009 - 353,683 (-)	Ensembl

RefSeq Acc Id:

XM_005373936 ⟹ XP_005373993

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955404	343,009 - 353,683 (-)	NCBI

Sequence:

show sequence

ATGGACTTCGGGGCCTTGGAGACCGTGGTGGCCAATTCTGCCTTCATCGCTGCCCGGGGCAGCT
TTGATGGGAGCAGTGTCCCATCCTCCCGGGACAAGAAGTACCTGGCCAAGCTCCGGCTGCCCCC
GCTGTCCAAGTGCGAGGGCCTCCGTGAGAGCCTCAGCCTGGGGTTTGACAGTGTGTGCTTGGAA
CAGCCCATTGGGAAGCGGCTCTTCCAGCAGTTCCTGGGGATGGACAAGAGGCACGCACCGGCCT
TGGGGCTCTGGAGGGACATCGAGGACTACGACATGGCCGACGATGACCTGCGGCCGCAGAAGGC
ACAGGCCCTCTTGGCCGAGTACCTGGACACCCGGGCGGAGCTCTTCTGTGGCTTCCTGGAGGAG
GGCGCTGTGGCGAGGGTGAGGGAGGGCCCGGCGGGGAGCCAGGATGGGCTCTTCCAGCCGCTGC
TGCAGGCCACCCTGGCGCACTTGAGCCAGGGCCCCTTCCAGGAGTTCCTGGGCAGCCTGCACTT
CTTGAGGTTCCTGCAGTGGAAGTGGCTTGAGGCACAGCCCATGGGTGAGGACTGGTTCCTGGAC
TTTAGGGTGCTGGGCAAGGGTGGTTTTGGGGAGGTGTGGGCCTGCCAGATGAAGGCCACTGGCA
AGATGTATGCCTGCAAGAAGCTCAACAAGAAGCGCCTGAAGAAGAGGAAGGGGTACCAGGGTGC
CATGGTGGAGAAGAAGATCCTGGCCAAGGTGCACAGCCGCTTCATCGTCTCCCTGGCCTACGCG
TTCGAAACCAAGACGGACCTCTGCCTGGTCATGACTATCATGAACGGAGGTGACATCAGGTACC
ACATTTACAACATGGATGAGGAGAACCCCGGCTTCCCAGAGCCCCGCGCTATCTTCTACACGGC
CCAGATCATTAGCGGCCTGGAGCATCTGCACCAGAGGCGCATCGTCTACCGCGACCTCAAGCCA
GAGAATGTGCTGCTGGACAACGATGGCAATGTGCGGATCTCTGACCTTGGGCTGGCTGTGGAGC
TGCAGGAAGGGCAGAGCAAGACCAAGGGCTACGCGGGGACCCCAGGCTTCATGGCCCCCGAGCT
CCTTCGGGGTGAAGAATATGACTTCTCCGTGGACTACTTTGCCCTGGGGGTCACACTGTATGAG
ATGATCGCAGCCAGAGGGCCCTTCCGTGCCCGTGGGGAGAAGGTGGAGAACAAGGAACTGAAGC
AGCGGATCCTCTCAGAGCCCGTCAAGTACCCCGAAAAGTTCAGCCAGGCCAGCAAAGACTTCTG
TGAGGCGCTGCTGGAGAAGGACCCCACACGGCGCCTGGGCTTTCTCGATGGGAGCTGTGATGGG
TTGCGTGTGCATGCCCTCTTCGGGAGCATCAGCTGGAGGCAGCTCGAGGCTGGGATGCTCATCC
CTCCCTTCATCCCAGACTCCAGGACCGTCTATGCCAAGAACATCCAGGACGTGGGGGCCTTTTC
CACTGTCAAAGGCGTGGTCTTTGACAAAGTGGACACGGAATTCTTTCAGGAATTTGCCTCTGGC
AACTGCCCCATTCCCTGGCAGGAGGAGATGATTGAGACAGGCATCTTTGGGGAGCTGAACGTGT
GGCGTGCTGACGGCGAGATGCCTGATGATATGAAGGGGGTTGCCACGGAGCAGGTGGCCCCTGC
ATCCAAGTCGGGAATGTGTCTGGTCTCCTAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005373993	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000004424
	ENSCLAP00000004424.1

RefSeq Acc Id:

XP_005373993 ⟸ XM_005373936

- UniProtKB:

A0A8C2UQP0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDFGALETVVANSAFIAARGSFDGSSVPSSRDKKYLAKLRLPPLSKCEGLRESLSLGFDSVCLE
QPIGKRLFQQFLGMDKRHAPALGLWRDIEDYDMADDDLRPQKAQALLAEYLDTRAELFCGFLEE
GAVARVREGPAGSQDGLFQPLLQATLAHLSQGPFQEFLGSLHFLRFLQWKWLEAQPMGEDWFLD
FRVLGKGGFGEVWACQMKATGKMYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYA
FETKTDLCLVMTIMNGGDIRYHIYNMDEENPGFPEPRAIFYTAQIISGLEHLHQRRIVYRDLKP
ENVLLDNDGNVRISDLGLAVELQEGQSKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYE
MIAARGPFRARGEKVENKELKQRILSEPVKYPEKFSQASKDFCEALLEKDPTRRLGFLDGSCDG
LRVHALFGSISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGAFSTVKGVVFDKVDTEFFQEFASG
NCPIPWQEEMIETGIFGELNVWRADGEMPDDMKGVATEQVAPASKSGMCLVS

hide sequence

RefSeq Acc Id:

ENSCLAP00000004424 ⟸ ENSCLAT00000004508

Protein Domains

AGC-kinase C-terminal Protein kinase RGS

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003146	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000004508	ENTREZGENE
	ENSCLAT00000004508.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.167.10	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	AGC-kinase_C	UniProtKB/TrEMBL
	GPCR_kinase	UniProtKB/TrEMBL
	GRK1_dom	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	RGS	UniProtKB/TrEMBL
	RGS_sf	UniProtKB/TrEMBL
	RGS_subdomain_2	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	Grk1	ENTREZGENE
PANTHER	G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE	UniProtKB/TrEMBL
	PTHR24355:SF11	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
	RGS	UniProtKB/TrEMBL
PRINTS	GPCRKINASE	UniProtKB/TrEMBL
PROSITE	AGC_KINASE_CTER	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
	RGS	UniProtKB/TrEMBL
SMART	RGS	UniProtKB/TrEMBL
	S_TK_X	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48097	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C2UQP0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations