Casp6 (caspase 6) - Rat Genome Database

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Gene: Casp6 (caspase 6) Chinchilla lanigera
Analyze
Symbol: Casp6
Name: caspase 6
RGD ID: 8986610
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); cysteine-type endopeptidase activity involved in apoptotic process (ortholog); cysteine-type endopeptidase activity involved in execution phase of apoptosis (ortholog); INVOLVED IN activation of innate immune response (ortholog); acute inflammatory response to non-antigenic stimulus (ortholog); axonal fasciculation (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Breast Neoplasms (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caspase 6, apoptosis-related cysteine peptidase; caspase-6
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496577,832 - 584,287 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955496575,839 - 584,287 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
cytoplasm  (ISO)
cytosol  (ISO)
neuronal cell body  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Casp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496577,832 - 584,287 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955496575,839 - 584,287 (+)NCBIChiLan1.0ChiLan1.0
CASP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384109,664,388 - 109,709,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4109,688,622 - 109,703,583 (-)EnsemblGRCh38hg38GRCh38
GRCh374110,609,784 - 110,624,601 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364110,829,234 - 110,844,078 (-)NCBINCBI36Build 36hg18NCBI36
Build 344110,967,388 - 110,982,233NCBI
Celera4107,903,448 - 107,918,292 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4106,342,777 - 106,357,627 (-)NCBIHuRef
CHM1_14110,586,394 - 110,601,238 (-)NCBICHM1_1
T2T-CHM13v2.04112,966,324 - 113,010,471 (-)NCBIT2T-CHM13v2.0
Casp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,695,064 - 129,707,761 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,695,074 - 129,707,752 (+)EnsemblGRCm39 Ensembl
GRCm383129,901,415 - 129,914,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,901,425 - 129,914,103 (+)EnsemblGRCm38mm10GRCm38
MGSCv373129,604,343 - 129,617,020 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,893,486 - 129,905,973 (+)NCBIMGSCv36mm8
Celera3136,415,853 - 136,428,433 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map359.5NCBI
Casp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82221,140,287 - 221,152,727 (+)NCBIGRCr8
mRatBN7.22218,466,063 - 218,478,503 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,466,076 - 218,478,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2226,144,507 - 226,156,834 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02224,044,202 - 224,056,533 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,901,851 - 218,914,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02235,341,326 - 235,353,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2235,341,365 - 235,353,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2230,186,198 - 230,198,555 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02249,539,649 - 249,552,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,361,538 - 227,373,844 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12227,348,217 - 227,360,523 (+)NCBI
Celera2210,748,422 - 210,760,763 (+)NCBICelera
Cytogenetic Map2q43NCBI
CASP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23107,781,319 - 107,798,789 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,075,317 - 108,092,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,186,215 - 102,201,992 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14112,753,988 - 112,768,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,753,988 - 112,768,836 (-)Ensemblpanpan1.1panPan2
CASP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13229,897,706 - 29,910,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3229,897,823 - 29,911,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3212,119,155 - 12,132,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,117,004 - 30,130,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,117,008 - 30,130,778 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,111,494 - 30,124,567 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03229,855,989 - 29,869,067 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,980,365 - 9,993,491 (+)NCBIUU_Cfam_GSD_1.0
Casp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530111,030,886 - 11,038,493 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936563911,304 - 919,119 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936563912,502 - 920,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,520,629 - 112,537,045 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,519,450 - 112,534,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,664,346 - 120,678,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,592,632 - 57,616,094 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl757,593,342 - 57,607,489 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603736,243,873 - 36,268,826 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624830171,427 - 184,814 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624830170,392 - 179,883 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000004713   ⟹   ENSCLAP00000004627
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955496577,832 - 584,287 (+)Ensembl
RefSeq Acc Id: XM_005406189   ⟹   XP_005406246
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955496575,839 - 584,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013505399   ⟹   XP_013360853
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955496575,843 - 584,287 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005406246 (Get FASTA)   NCBI Sequence Viewer  
  XP_013360853 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000004627
  ENSCLAP00000004627.1
RefSeq Acc Id: XP_005406246   ⟸   XM_005406189
- UniProtKB: A0A8C2UR54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013360853   ⟸   XM_013505399
- UniProtKB: A0A8C2UR54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000004627   ⟸   ENSCLAT00000004713

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003293 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004713 ENTREZGENE
  ENSCLAT00000004713.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1460 UniProtKB/TrEMBL
InterPro Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
NCBI Gene Casp6 ENTREZGENE
PANTHER PTHR10454 UniProtKB/TrEMBL
  PTHR10454:SF206 UniProtKB/TrEMBL
Pfam Peptidase_C14 UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
Superfamily-SCOP SSF52129 UniProtKB/TrEMBL
UniProt A0A8C2UR54 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Casp6  caspase 6    caspase 6, apoptosis-related cysteine peptidase  Symbol and/or name change 5135510 APPROVED