Ace2 (angiotensin converting enzyme 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ace2 (angiotensin converting enzyme 2) Chinchilla lanigera
Analyze
Symbol: Ace2
Name: angiotensin converting enzyme 2 (Ensembl:angiotensin I converting enzyme 2)
RGD ID: 8973203
Description: ENCODES a protein that exhibits carboxypeptidase activity (ortholog); endopeptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN angiotensin-mediated drinking behavior (ortholog); entry receptor-mediated virion attachment to host cell (ortholog); maternal process involved in female pregnancy (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Lung Injury (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: angiotensin I converting enzyme 2; angiotensin-converting enzyme 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
Alveolar Bone Loss  (ISO)
anxiety disorder  (ISO)
autistic disorder  (ISO)
avian influenza  (ISO)
bacterial pneumonia  (ISO)
Cardiac Fibrosis  (ISO)
cardiomyopathy  (ISO)
Cardiovirus Infections  (ISO)
cerebral malaria  (ISO)
chemical colitis  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
endomyocardial fibrosis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fanconi anemia  (ISO)
focal segmental glomerulosclerosis  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
hypertension  (ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
middle cerebral artery infarction  (ISO)
multiple congenital anomalies-hypotonia-seizures syndrome 2  (ISO)
myocardial infarction  (ISO)
Neurodevelopmental Disorders  (ISO)
pancreatic ductal carcinoma  (ISO)
Pleural Effusion  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (ISO)
severe acute respiratory syndrome  (ISO)
Spontaneous Abortions  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
thrombosis  (ISO)
Ventricular Remodeling  (ISO)
Weight Loss  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBIChiLan1.0ChiLan1.0
ACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,518,197 - 15,607,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,494,566 - 15,607,236 (-)EnsemblGRCh38hg38GRCh38
GRCh37X15,536,320 - 15,625,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
T2T-CHM13v2.0X15,101,170 - 15,190,203 (-)NCBIT2T-CHM13v2.0
Ace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,922,328 - 162,971,416 (+)EnsemblGRCm39 Ensembl
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBIMGSCv36mm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
Ace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,925,458 - 33,972,851 (-)NCBIGRCr8
mRatBN7.2X30,293,597 - 30,340,961 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,293,589 - 30,340,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX31,326,034 - 31,372,619 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,763,480 - 34,809,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,950,895 - 30,996,838 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
ACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,358,905 - 17,402,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,362,290 - 17,405,412 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X8,189,267 - 8,229,415 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,470,896 - 15,510,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,470,896 - 15,510,891 (-)Ensemblpanpan1.1panPan2
ACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,798,839 - 11,839,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,798,839 - 11,900,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,706,330 - 11,745,360 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,760,479 - 11,822,897 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,759,554 - 11,789,618 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,824,224 - 11,862,960 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,818,311 - 11,856,868 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,843,799 - 11,882,613 (-)NCBIUU_Cfam_GSD_1.0
Ace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,964,502 - 5,012,706 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,965,332 - 5,011,702 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,093,242 - 12,151,286 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,099,849 - 12,152,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,061,317 - 13,089,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,866,608 - 15,915,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ace2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829344,933 - 391,527 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624829344,823 - 391,451 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000001401   ⟹   ENSCLAP00000001359
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)Ensembl
RefSeq Acc Id: NM_001282361   ⟹   NP_001269290
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555192,592,171 - 2,633,470 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013506974   ⟹   XP_013362428
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555192,591,229 - 2,636,000 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013506975   ⟹   XP_013362429
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001269290 (Get FASTA)   NCBI Sequence Viewer  
  XP_013362428 (Get FASTA)   NCBI Sequence Viewer  
  XP_013362429 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACT66267 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000001359
  ENSCLAP00000001359.1
RefSeq Acc Id: XP_013362429   ⟸   XM_013506975
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UPB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362428   ⟸   XM_013506974
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UPB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269290   ⟸   NM_001282361
- Peptide Label: precursor
- UniProtKB: C7ECU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000001359   ⟸   ENSCLAT00000001401
Protein Domains
Collectrin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001034 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000001401 ENTREZGENE
  ENSCLAT00000001401.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1370.30 UniProtKB/TrEMBL
InterPro Collectrin_dom UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/TrEMBL
NCBI Gene Ace2 ENTREZGENE
PANTHER ANGIOTENSIN-CONVERTING ENZYME 2 UniProtKB/TrEMBL
  PTHR10514 UniProtKB/TrEMBL
Pfam Collectrin UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/TrEMBL
PRINTS PEPDIPTASEA UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0A8C2UPB0 ENTREZGENE, UniProtKB/TrEMBL
  C7ECU0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-19 Ace2  angiotensin converting enzyme 2  Ace2  angiotensin I converting enzyme 2  Symbol and/or name change 5135510 APPROVED