Sirt2 (sirtuin 2) - Rat Genome Database

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Pathways
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Gene: Sirt2 (sirtuin 2) Chinchilla lanigera
Analyze
Symbol: Sirt2
Name: sirtuin 2
RGD ID: 8963181
Description: ENCODES a protein that exhibits beta-tubulin binding (ortholog); chromatin binding (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN cellular lipid catabolic process (ortholog); cellular response to caloric restriction (ortholog); cellular response to epinephrine stimulus (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); cocaine dependence (ortholog); genetic disease (ortholog); FOUND IN centriole (ortholog); centrosome (ortholog); chromosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NAD-dependent protein deacetylase sirtuin-2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468626,365 - 644,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468626,365 - 644,441 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular lipid catabolic process  (ISO)
cellular response to caloric restriction  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to oxidative stress  (ISO)
chromatin organization  (ISO)
epigenetic regulation of gene expression  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of NLRP3 inflammasome complex assembly  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of oligodendrocyte progenitor proliferation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
NLRP3 inflammasome complex assembly  (ISO)
positive regulation of attachment of spindle microtubules to kinetochore  (ISO)
positive regulation of cell division  (ISO)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of meiotic nuclear division  (ISO)
positive regulation of oocyte maturation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
regulation of cell cycle  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of myelination  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
response to cocaine  (ISO)
substantia nigra development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Sirt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468626,365 - 644,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468626,365 - 644,441 (+)NCBIChiLan1.0ChiLan1.0
SIRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,878,555 - 38,899,618 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,878,555 - 38,899,862 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,369,195 - 39,390,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,061,040 - 44,082,201 (-)NCBINCBI36Build 36hg18NCBI36
Build 341944,061,039 - 44,082,193NCBI
Celera1936,171,632 - 36,192,939 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,815,856 - 35,837,294 (-)NCBIHuRef
CHM1_11939,369,665 - 39,390,970 (-)NCBICHM1_1
T2T-CHM13v2.01941,682,611 - 41,703,673 (-)NCBIT2T-CHM13v2.0
Sirt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,466,192 - 28,488,086 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,466,160 - 28,488,086 (+)EnsemblGRCm39 Ensembl
GRCm38728,766,752 - 28,788,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,766,735 - 28,788,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,551,771 - 29,573,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,475,543 - 28,497,420 (+)NCBIMGSCv36mm8
Celera723,327,529 - 23,349,457 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.92NCBI
Sirt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,181,472 - 93,204,499 (+)NCBIGRCr8
mRatBN7.2184,053,883 - 84,076,975 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,052,903 - 84,076,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,463,787 - 89,486,870 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,922,897 - 97,945,932 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,219,644 - 91,242,728 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,948,918 - 86,971,952 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBICelera
Cytogenetic Map1q21NCBI
SIRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,181,332 - 45,202,521 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,051,896 - 47,073,091 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,984,453 - 36,005,582 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,533,965 - 44,554,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,533,965 - 44,554,799 (-)Ensemblpanpan1.1panPan2
SIRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,224,922 - 114,235,041 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,224,900 - 114,234,583 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,618,889 - 113,636,581 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,817,111 - 114,834,816 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,817,428 - 114,834,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,375,328 - 114,392,089 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,008,029 - 114,025,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,003,788 - 115,021,492 (+)NCBIUU_Cfam_GSD_1.0
Sirt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,400,802 - 13,421,980 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,828,831 - 1,850,000 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366611,828,868 - 1,849,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,682,429 - 47,703,384 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,682,427 - 47,703,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,218,298 - 43,228,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,493,106 - 33,518,793 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,493,079 - 33,518,647 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,514,410 - 11,540,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,235,263 - 12,259,276 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,239,363 - 12,259,561 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000019963   ⟹   ENSCLAP00000019770
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955468626,365 - 644,441 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000019964   ⟹   ENSCLAP00000019771
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955468626,460 - 643,884 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000019965   ⟹   ENSCLAP00000019772
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955468628,415 - 644,441 (+)Ensembl
RefSeq Acc Id: XM_005399813   ⟹   XP_005399870
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468628,415 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399815   ⟹   XP_005399872
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468628,416 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399816   ⟹   XP_005399873
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468629,332 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399817   ⟹   XP_005399874
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468626,365 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399818   ⟹   XP_005399875
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468626,368 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399819   ⟹   XP_005399876
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468626,525 - 644,441 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399820   ⟹   XP_005399877
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955468629,588 - 644,441 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005399874   ⟸   XM_005399817
- Peptide Label: isoform X4
- UniProtKB: A0A8C2YSC8 (UniProtKB/TrEMBL),   A0A8C2VS91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005399875   ⟸   XM_005399818
- Peptide Label: isoform X5
- UniProtKB: A0A8C2VZI5 (UniProtKB/TrEMBL),   A0A8C2VS91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005399876   ⟸   XM_005399819
- Peptide Label: isoform X5
- UniProtKB: A0A8C2VZI5 (UniProtKB/TrEMBL),   A0A8C2VS91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005399872   ⟸   XM_005399815
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005399870   ⟸   XM_005399813
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005399873   ⟸   XM_005399816
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005399877   ⟸   XM_005399820
- Peptide Label: isoform X5
- UniProtKB: A0A8C2VZI5 (UniProtKB/TrEMBL),   A0A8C2VS91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000019772   ⟸   ENSCLAT00000019965
RefSeq Acc Id: ENSCLAP00000019771   ⟸   ENSCLAT00000019964
RefSeq Acc Id: ENSCLAP00000019770   ⟸   ENSCLAT00000019963
Protein Domains
Deacetylase sirtuin-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013560 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019963 ENTREZGENE
  ENSCLAT00000019963.1 UniProtKB/TrEMBL
  ENSCLAT00000019964 ENTREZGENE
  ENSCLAT00000019964.1 UniProtKB/TrEMBL
  ENSCLAT00000019965 ENTREZGENE
  ENSCLAT00000019965.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  Sirtuin UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/TrEMBL
  Sirtuin_class_I UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
NCBI Gene Sirt2 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PIRSF SIR2_euk UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt A0A8C2VS91 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VZI5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YSC8 ENTREZGENE, UniProtKB/TrEMBL