Wrn (WRN RecQ like helicase) - Rat Genome Database

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Gene: Wrn (WRN RecQ like helicase) Chinchilla lanigera
Analyze
Symbol: Wrn
Name: WRN RecQ like helicase
RGD ID: 8962398
Description: ENCODES a protein that exhibits 3'-5' DNA helicase activity (ortholog); 3'-5' exonuclease activity (ortholog); 3'-flap-structured DNA binding (ortholog); INVOLVED IN base-excision repair (ortholog); cellular response to gamma radiation (ortholog); cellular response to starvation (ortholog); ASSOCIATED WITH breast cancer (ortholog); coronary artery disease (ortholog); diffuse scleroderma (ortholog); FOUND IN centrosome (ortholog); chromosome, telomeric region (ortholog); nuclear speck (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Werner syndrome ATP-dependent helicase; Werner syndrome RecQ like helicase; Werner syndrome, RecQ helicase-like
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554637,525,100 - 7,633,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554637,495,243 - 7,633,532 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wrn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554637,525,100 - 7,633,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554637,495,243 - 7,633,532 (+)NCBIChiLan1.0ChiLan1.0
WRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38831,033,810 - 31,176,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl831,033,788 - 31,176,138 (+)EnsemblGRCh38hg38GRCh38
GRCh37830,891,326 - 31,033,654 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36831,010,320 - 31,150,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 34831,010,319 - 31,150,818NCBI
Celera829,850,819 - 29,989,925 (+)NCBICelera
Cytogenetic Map8p12NCBI
HuRef829,435,610 - 29,576,278 (+)NCBIHuRef
CHM1_1831,092,222 - 31,232,737 (+)NCBICHM1_1
T2T-CHM13v2.0831,314,935 - 31,457,266 (+)NCBIT2T-CHM13v2.0
Wrn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39833,724,400 - 33,875,591 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl833,724,412 - 33,875,555 (-)EnsemblGRCm39 Ensembl
GRCm38833,234,372 - 33,385,543 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl833,234,384 - 33,385,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv37834,344,845 - 34,495,999 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36834,700,308 - 34,851,437 (-)NCBIMGSCv36mm8
Celera835,829,900 - 36,023,160 (-)NCBICelera
Cytogenetic Map8A3NCBI
cM Map820.3NCBI
Wrn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,466,552 - 65,602,951 (+)NCBIGRCr8
mRatBN7.21658,763,517 - 58,898,604 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,763,504 - 58,895,450 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01662,483,773 - 62,619,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,483,761 - 62,615,375 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01662,148,560 - 62,283,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,535,144 - 62,668,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1656,796,927 - 56,929,877 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
WRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2749,612,933 - 49,764,582 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1825,329,155 - 25,486,021 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0830,353,643 - 30,492,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1827,541,145 - 27,679,855 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl827,541,145 - 27,679,855 (+)Ensemblpanpan1.1panPan2
WRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11633,164,662 - 33,304,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1633,167,364 - 33,304,625 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1633,688,179 - 33,763,508 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01635,190,440 - 35,330,557 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1635,190,442 - 35,331,243 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11633,288,917 - 33,429,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01633,863,786 - 34,003,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01633,981,929 - 34,122,272 (-)NCBIUU_Cfam_GSD_1.0
Wrn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494356,358,222 - 56,501,123 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936792862,383 - 1,005,755 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936792862,659 - 1,005,065 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1553,966,986 - 54,094,587 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11553,966,968 - 54,094,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21561,329,196 - 61,464,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1829,150,256 - 29,288,830 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl829,174,229 - 29,289,129 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605212,803,116 - 12,942,546 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wrn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478012,876,093 - 13,025,739 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478012,875,747 - 13,051,492 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000001100   ⟹   ENSCLAP00000001060
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554637,525,100 - 7,633,596 (+)Ensembl
RefSeq Acc Id: XM_005398387   ⟹   XP_005398444
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554637,495,244 - 7,633,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005398388   ⟹   XP_005398445
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554637,495,244 - 7,633,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005398389   ⟹   XP_005398446
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554637,495,244 - 7,633,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005398390   ⟹   XP_005398447
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554637,495,243 - 7,633,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013521530   ⟹   XP_013376984
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554637,495,245 - 7,633,532 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005398444   ⟸   XM_005398387
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005398447   ⟸   XM_005398390
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005398445   ⟸   XM_005398388
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UKG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005398446   ⟸   XM_005398389
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013376984   ⟸   XM_013521530
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSCLAP00000001060   ⟸   ENSCLAT00000001100
Protein Domains
Helicase ATP-binding   Helicase C-terminal   HRDC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000000817 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000001100 ENTREZGENE
  ENSCLAT00000001100.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.150.80 UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro 3'-5'_exonuclease_dom UniProtKB/TrEMBL
  DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  DNA_helicase_ATP-dep_RecQ UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  Helicase_HTH UniProtKB/TrEMBL
  HRDC-like_sf UniProtKB/TrEMBL
  HRDC_dom UniProtKB/TrEMBL
  HRDC_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RecQ_Zn-bd UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
  RQC_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene Wrn ENTREZGENE
PANTHER DNA HELICASE RECQ FAMILY MEMBER UniProtKB/TrEMBL
  WERNER SYNDROME ATP-DEPENDENT HELICASE UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  DNA_pol_A_exo1 UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
  HTH_40 UniProtKB/TrEMBL
  RecQ_Zn_bind UniProtKB/TrEMBL
  RQC UniProtKB/TrEMBL
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
SMART 35EXOc UniProtKB/TrEMBL
  DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
  RQC UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF47819 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF53098 UniProtKB/TrEMBL
UniProt A0A8C2UKG7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-23 Wrn  WRN RecQ like helicase    Werner syndrome RecQ like helicase  Symbol and/or name change 5135510 APPROVED
2016-08-03 Wrn  Werner syndrome RecQ like helicase    Werner syndrome, RecQ helicase-like  Symbol and/or name change 5135510 APPROVED