Cebpa (CCAAT enhancer binding protein alpha) - Rat Genome Database

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Pathways
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Gene: Cebpa (CCAAT enhancer binding protein alpha) Chinchilla lanigera
Analyze
Symbol: Cebpa
Name: CCAAT enhancer binding protein alpha
RGD ID: 8951649
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer binding protein alpha; CCAAT/enhancer-binding protein alpha; CCAAT/enhancer-binding protein alpha-like; LOC102019683
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554683,047,931 - 3,049,080 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554683,046,544 - 3,049,217 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
animal organ regeneration  (ISO)
brown fat cell differentiation  (ISO)
cell differentiation  (ISO)
cell population proliferation  (ISO)
cellular response to lithium ion  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cholesterol metabolic process  (ISO)
embryonic placenta development  (ISO)
energy homeostasis  (ISO)
epithelial cell maturation  (ISO)
fat cell differentiation  (ISO)
glucose homeostasis  (ISO)
granulocyte differentiation  (ISO)
hematopoietic stem cell proliferation  (ISO)
inner ear development  (ISO)
interleukin-6-mediated signaling pathway  (ISO)
lipid homeostasis  (ISO)
liver development  (ISO)
lung development  (ISO)
macrophage differentiation  (ISO)
memory  (ISO)
mitochondrion organization  (ISO)
myeloid cell differentiation  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of hematopoietic stem cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
Notch signaling pathway  (ISO)
osteoblast development  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of DNA-templated transcription initiation  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to dexamethasone  (ISO)
response to nutrient  (ISO)
response to phenylpropanoid  (ISO)
response to vitamin B2  (ISO)
transcription by RNA polymerase I  (ISO)
urea cycle  (ISO)
white fat cell differentiation  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Cebpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554683,047,931 - 3,049,080 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554683,046,544 - 3,049,217 (-)NCBIChiLan1.0ChiLan1.0
CEBPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381933,299,934 - 33,302,534 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1933,299,934 - 33,302,534 (-)EnsemblGRCh38hg38GRCh38
GRCh371933,790,840 - 33,793,440 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361938,482,776 - 38,485,160 (-)NCBINCBI36Build 36hg18NCBI36
Build 341938,482,775 - 38,485,160NCBI
Celera1930,484,405 - 30,486,995 (-)NCBICelera
Cytogenetic Map19q13.11NCBI
HuRef1930,291,676 - 30,294,205 (-)NCBIHuRef
CHM1_11933,791,795 - 33,794,385 (-)NCBICHM1_1
T2T-CHM13v2.01935,819,706 - 35,822,306 (-)NCBIT2T-CHM13v2.0
Cebpa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39734,818,718 - 34,821,353 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl734,818,718 - 34,821,353 (+)EnsemblGRCm39 Ensembl
GRCm38735,119,293 - 35,121,928 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl735,119,293 - 35,121,928 (+)EnsemblGRCm38mm10GRCm38
MGSCv37735,904,312 - 35,906,947 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36734,828,063 - 34,830,688 (+)NCBIMGSCv36mm8
Celera730,255,122 - 30,257,756 (+)NCBICelera
Cytogenetic Map7B2NCBI
cM Map721.02NCBI
Cebpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8196,896,584 - 96,899,256 (+)NCBIGRCr8
mRatBN7.2187,759,631 - 87,762,303 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl187,759,433 - 87,762,412 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx193,165,821 - 93,168,493 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01101,631,805 - 101,634,477 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0194,924,121 - 94,926,793 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0191,363,492 - 91,366,164 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl191,363,492 - 91,366,164 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0192,493,857 - 92,495,245 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4187,626,111 - 87,627,499 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1187,704,351 - 87,705,428 (+)NCBI
Celera182,110,797 - 82,113,472 (+)NCBICelera
Cytogenetic Map1q21NCBI
CEBPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22039,273,129 - 39,275,654 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11941,273,099 - 41,275,733 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01930,223,567 - 30,226,204 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11938,969,065 - 38,971,031 (-)NCBIpanpan1.1PanPan1.1panPan2
CEBPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11118,846,252 - 118,851,045 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1118,249,214 - 118,251,848 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01119,446,691 - 119,449,313 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11119,007,283 - 119,009,910 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01118,633,880 - 118,636,501 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01119,692,609 - 119,695,231 (+)NCBIUU_Cfam_GSD_1.0
Cebpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093499,129,664 - 9,132,348 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365702,513,561 - 2,516,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEBPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl643,083,207 - 43,085,836 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1643,083,200 - 43,085,884 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2638,632,195 - 38,634,910 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CEBPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1628,342,506 - 28,345,759 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl628,343,907 - 28,344,977 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660736,065,215 - 6,067,832 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cebpa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247949,809,007 - 9,813,418 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000015866   ⟹   ENSCLAP00000015704
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554683,047,931 - 3,049,080 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000015867   ⟹   ENSCLAP00000015705
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554683,048,056 - 3,049,080 (-)Ensembl
RefSeq Acc Id: XM_013522540   ⟹   XP_013377994
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554683,046,544 - 3,049,217 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013377994 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000015704.1
  ENSCLAP00000015705.1
Reference Protein Sequences
RefSeq Acc Id: XP_013377994   ⟸   XM_013522540
- UniProtKB: A0A8C2VJR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000015705   ⟸   ENSCLAT00000015867
RefSeq Acc Id: ENSCLAP00000015704   ⟸   ENSCLAT00000015866
Protein Domains
bZIP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010794 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015866.1 UniProtKB/TrEMBL
  ENSCLAT00000015867.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
InterPro bZIP UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
  C/EBP UniProtKB/TrEMBL
  C/EBP_chordates UniProtKB/TrEMBL
NCBI Gene LOC102019379 ENTREZGENE
PANTHER CCAAT/ENHANCER BINDING PROTEIN UniProtKB/TrEMBL
  CCAAT/ENHANCER-BINDING PROTEIN ALPHA UniProtKB/TrEMBL
Pfam bZIP_2 UniProtKB/TrEMBL
PIRSF CCAAT/enhancer-binding UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/TrEMBL
UniProt A0A8C2VJR9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VMZ6_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-27 Cebpa  CCAAT enhancer binding protein alpha    CCAAT/enhancer binding protein alpha  Symbol and/or name change 5135510 APPROVED
2017-11-21 Cebpa  CCAAT/enhancer binding protein alpha  LOC102019683  CCAAT/enhancer-binding protein alpha-like  Data merged from RGD:8917597 737654 PROVISIONAL
2016-08-03 Cebpa  CCAAT/enhancer binding protein alpha    CCAAT/enhancer binding protein (C/EBP), alpha  Symbol and/or name change 5135510 APPROVED
2015-08-25 Cebpa  CCAAT/enhancer binding protein (C/EBP), alpha  LOC102019379  CCAAT/enhancer-binding protein alpha-like  Symbol and/or name change 5135510 APPROVED