Cnr1 (cannabinoid receptor 1) - Rat Genome Database

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Gene: Cnr1 (cannabinoid receptor 1) Chinchilla lanigera
Analyze
Symbol: Cnr1
Name: cannabinoid receptor 1
RGD ID: 8945552
Description: ENCODES a protein that exhibits cannabinoid receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); axonal fasciculation (ortholog); cannabinoid signaling pathway (ortholog); PARTICIPATES IN N-cadherin signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol Withdrawal Delirium (ortholog); Animal Disease Models (ortholog); FOUND IN actin cytoskeleton (ortholog); axon (ortholog); GABA-ergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cannabinoid receptor 1 (brain)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541115,052,163 - 15,077,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541115,052,151 - 15,077,320 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (ISO)
Alcohol Withdrawal Delirium  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
Ascites  (ISO)
attention deficit hyperactivity disorder  (ISO)
Binge-Eating Disorder  (ISO)
cannabis abuse  (ISO)
Catalepsy  (ISO)
cholestasis  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
developmental coordination disorder  (ISO)
diabetic neuropathy  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fever  (ISO)
focal epilepsy  (ISO)
genetic disease  (ISO)
glucose intolerance  (ISO)
Hemorrhagic Shock  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Hypotension  (ISO)
Hypothermia  (ISO)
impotence  (ISO)
Insulin Resistance  (ISO)
Intravenous Substance Abuse  (ISO)
liver cirrhosis  (ISO)
Memory Disorders  (ISO)
morphine dependence  (ISO)
movement disease  (ISO)
multiple sclerosis  (ISO)
Muscle Spasticity  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (ISO)
obesity  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
Parkinsonism  (ISO)
peptic ulcer disease  (ISO)
post-traumatic stress disorder  (ISO)
Reperfusion Injury  (ISO)
rhabdomyosarcoma  (ISO)
schizophrenia  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
stress-related disorder  (ISO)
substance-related disorder  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
type 2 diabetes mellitus  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
axonal fasciculation  (ISO)
cannabinoid signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucose homeostasis  (ISO)
learning or memory  (ISO)
maternal process involved in female pregnancy  (ISO)
memory  (ISO)
negative regulation of action potential  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of dopamine secretion  (ISO)
negative regulation of fatty acid beta-oxidation  (ISO)
negative regulation of mast cell activation  (ISO)
negative regulation of monoatomic ion transport  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of serotonin secretion  (ISO)
positive regulation of acute inflammatory response to antigenic stimulus  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of fever generation  (ISO)
positive regulation of neuron projection development  (ISO)
regulation of feeding behavior  (ISO)
regulation of insulin secretion  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of penile erection  (ISO)
regulation of presynaptic cytosolic calcium ion concentration  (ISO)
regulation of synaptic transmission, GABAergic  (ISO)
regulation of synaptic transmission, glutamatergic  (ISO)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
retrograde trans-synaptic signaling by endocannabinoid  (ISO)
spermatogenesis  (ISO)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Cnr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541115,052,163 - 15,077,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541115,052,151 - 15,077,320 (-)NCBIChiLan1.0ChiLan1.0
CNR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38688,139,864 - 88,167,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl688,139,864 - 88,166,347 (-)EnsemblGRCh38hg38GRCh38
GRCh37688,849,583 - 88,877,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36688,906,302 - 88,911,775 (-)NCBINCBI36Build 36hg18NCBI36
Build 34688,906,301 - 88,911,775NCBI
Celera689,267,475 - 89,293,659 (-)NCBICelera
Cytogenetic Map6q15NCBI
HuRef686,064,928 - 86,090,983 (-)NCBIHuRef
CHM1_1688,947,341 - 88,973,526 (-)NCBICHM1_1
T2T-CHM13v2.0689,348,358 - 89,375,841 (-)NCBIT2T-CHM13v2.0
Cnr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39433,923,171 - 33,948,831 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl433,924,593 - 33,948,831 (+)EnsemblGRCm39 Ensembl
GRCm38433,923,171 - 33,948,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl433,924,593 - 33,948,831 (+)EnsemblGRCm38mm10GRCm38
MGSCv37434,011,607 - 34,035,806 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36434,253,245 - 34,277,444 (+)NCBIMGSCv36mm8
Celera433,679,304 - 33,703,476 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map416.28NCBI
Cnr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8553,204,867 - 53,230,396 (+)NCBIGRCr8
mRatBN7.2548,408,543 - 48,436,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl548,408,574 - 48,435,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx550,575,033 - 50,597,155 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0552,174,251 - 52,196,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0552,110,881 - 52,132,920 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0549,307,584 - 49,333,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl549,311,030 - 49,333,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0553,878,619 - 53,904,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4550,427,173 - 50,445,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1550,427,351 - 50,445,650 (+)NCBI
Celera547,168,709 - 47,190,724 (+)NCBICelera
Cytogenetic Map5q21NCBI
CNR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25108,222,001 - 108,249,883 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16106,115,872 - 106,143,699 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0686,017,141 - 86,044,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1689,289,102 - 89,315,174 (-)NCBIpanpan1.1PanPan1.1panPan2
CNR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11247,537,240 - 47,560,723 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1247,509,583 - 47,560,983 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1247,344,588 - 47,368,064 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01248,342,012 - 48,365,459 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11247,639,694 - 47,663,171 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01247,561,070 - 47,584,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01247,752,753 - 47,776,234 (-)NCBIUU_Cfam_GSD_1.0
Cnr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494682,664,248 - 82,691,073 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365103,781,210 - 3,802,693 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365103,779,930 - 3,806,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl156,467,835 - 56,492,602 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1156,466,022 - 56,493,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2163,201,796 - 63,224,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11312,626,259 - 12,653,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1312,630,270 - 12,631,688 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040188,875,655 - 188,902,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247996,101,728 - 6,126,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247996,100,709 - 6,126,530 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000019768   ⟹   ENSCLAP00000019575
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541115,052,163 - 15,077,320 (-)Ensembl
RefSeq Acc Id: XM_005377738   ⟹   XP_005377795
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541115,052,151 - 15,077,320 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013510704   ⟹   XP_013366158
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541115,052,151 - 15,077,320 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013510705   ⟹   XP_013366159
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541115,052,151 - 15,077,320 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005377795 (Get FASTA)   NCBI Sequence Viewer  
  XP_013366158 (Get FASTA)   NCBI Sequence Viewer  
  XP_013366159 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ76976 (Get FASTA)   NCBI Sequence Viewer  
  AEO94875 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000019575
  ENSCLAP00000019575.1
RefSeq Acc Id: XP_005377795   ⟸   XM_005377738
- UniProtKB: A0A8C2VRI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013366159   ⟸   XM_013510705
- UniProtKB: A0A8C2VRI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013366158   ⟸   XM_013510704
- UniProtKB: A0A8C2VRI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000019575   ⟸   ENSCLAT00000019768

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013432 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019768 ENTREZGENE
  ENSCLAT00000019768.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Canbinoid_rcpt_1 UniProtKB/TrEMBL
  Cnbnoid_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene Cnr1 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR22750:SF47 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PIRSF Cnoid_rcpt_1 UniProtKB/TrEMBL
PRINTS CANABINOID1R UniProtKB/TrEMBL
  CANNABINOIDR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C2VRI3 ENTREZGENE, UniProtKB/TrEMBL
  G3M6G8_CHILA UniProtKB/TrEMBL
  Q6W9C9_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Cnr1  cannabinoid receptor 1    cannabinoid receptor 1 (brain)  Symbol and/or name change 5135510 APPROVED