Csnk2a2 (casein kinase 2 alpha 2)

Gene: Csnk2a2 (casein kinase 2 alpha 2) Chinchilla lanigera

Analyze

Symbol:

Csnk2a2

Name:

casein kinase 2 alpha 2

RGD ID:

8934619

Description:

ENCODES a protein that exhibits protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cerebral cortex development (ortholog); double-strand break repair (ortholog); liver regeneration (ortholog); PARTICIPATES IN E-cadherin signaling pathway; mitochondrial autophagy pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN acrosomal vesicle (ortholog); chromatin (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

casein kinase 2, alpha prime polypeptide; casein kinase II subunit alpha'

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	15,674,116 - 15,718,894 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	15,677,788 - 15,718,894 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bardet-Biedl syndrome (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

genetic disease (ISO)

male infertility (ISO)

Oxygen-Induced Retinopathy (ISO)

Skin Neoplasms (ISO)

squamous cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cerebral cortex development (ISO)

double-strand break repair (ISO)

liver regeneration (ISO)

negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

positive regulation of protein targeting to mitochondrion (ISO)

regulation of cell cycle (ISO)

regulation of chromosome separation (ISO)

regulation of mitophagy (ISO)

spermatogenesis (ISO)

Cellular Component

acrosomal vesicle (ISO)

chromatin (ISO)

nucleus (ISO)

PcG protein complex (ISO)

Molecular Function

protein binding (ISO)

protein kinase activity (ISO)

protein serine/threonine kinase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

E-cadherin signaling pathway (ISO)

mitochondrial autophagy pathway (ISO)

nuclear factor kappa B signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Csnk2a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	15,674,116 - 15,718,894 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	15,677,788 - 15,718,894 (-)	NCBI	ChiLan1.0	ChiLan1.0

CSNK2A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	58,157,907 - 58,198,106 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	58,157,907 - 58,198,106 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	58,191,811 - 58,232,010 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	56,749,312 - 56,789,283 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	56,749,314 - 56,789,283	NCBI
Celera	16	42,691,263 - 42,731,230 (-)	NCBI		Celera
Cytogenetic Map	16	q21	NCBI
HuRef	16	44,059,729 - 44,099,930 (-)	NCBI		HuRef
CHM1_1	16	59,598,846 - 59,638,724 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	63,953,540 - 63,993,732 (-)	NCBI		T2T-CHM13v2.0

Csnk2a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	96,172,724 - 96,215,505 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	96,172,724 - 96,216,667 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	95,446,096 - 95,488,868 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	95,446,096 - 95,490,039 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	97,969,996 - 98,012,720 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	98,337,101 - 98,377,919 (-)	NCBI		MGSCv36	mm8
Celera	8	99,760,768 - 99,802,427 (-)	NCBI		Celera
Cytogenetic Map	8	C5- D1	NCBI
cM Map	8	47.12	NCBI

Csnk2a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	9,562,340 - 9,602,136 (+)	NCBI		GRCr8
mRatBN7.2	19	9,556,443 - 9,596,080 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	9,556,260 - 9,596,080 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	9,521,860 - 9,561,150 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	10,288,686 - 10,327,976 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	9,575,016 - 9,614,306 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	9,972,537 - 10,012,043 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	9,972,537 - 10,012,043 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	9,956,494 - 9,996,397 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	10,015,369 - 10,054,662 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	10,020,174 - 10,054,722 (+)	NCBI
Celera	19	9,448,494 - 9,487,786 (+)	NCBI		Celera
Cytogenetic Map	19	p13	NCBI

CSNK2A2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	67,620,768 - 67,660,961 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	73,541,651 - 73,581,859 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	38,426,399 - 38,466,575 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	57,557,262 - 57,596,218 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	57,557,270 - 57,596,218 (-)	Ensembl	panpan1.1		panPan2

CSNK2A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	58,361,328 - 58,441,701 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	58,360,838 - 58,432,371 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	54,991,254 - 55,071,046 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	58,899,781 - 58,979,588 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	58,899,298 - 58,971,571 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	55,731,413 - 55,811,164 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	56,739,015 - 56,818,751 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	57,631,725 - 57,711,511 (+)	NCBI		UU_Cfam_GSD_1.0

Csnk2a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	49,513,855 - 49,558,667 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	10,033,717 - 10,075,511 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	10,030,408 - 10,073,576 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CSNK2A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	19,976,930 - 20,016,923 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	19,975,030 - 20,016,768 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	17,998,939 - 18,074,082 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CSNK2A2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	44,093,320 - 44,133,352 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	44,093,215 - 44,133,335 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	32,045,388 - 32,085,772 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Csnk2a2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	28,012,556 - 28,060,413 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	28,012,543 - 28,064,610 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005388434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01031761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01031762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01031942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01352606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000008703 ⟹ ENSCLAP00000008576

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955433	15,674,116 - 15,718,894 (-)	Ensembl

RefSeq Acc Id:

ENSCLAT00000008704 ⟹ ENSCLAP00000008577

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955433	15,683,645 - 15,718,854 (-)	Ensembl

RefSeq Acc Id:

ENSCLAT00000008705 ⟹ ENSCLAP00000008578

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955433	15,683,699 - 15,717,961 (-)	Ensembl

RefSeq Acc Id:

XM_005388434 ⟹ XP_005388491

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955433	15,677,788 - 15,718,894 (-)	NCBI

Sequence:

show sequence

TCCTCCGCCTCCTCCTCCTCCTTCTTCGCCGCCGCCGCCGCCGCTGTCCCTTTCCCGGCCCGTG
GCTGCAGCGGCCGCTGCCGCCGCCTCCTGGGGCTGCGAGCCGAGCACCGCCCGCCCGTCGCCCC
GCCGGCAGCCTCAGGGCCGGGCAGGCTCGGCCGGCGCCCCCCGCGCCCCCTGCCCGCCGCCCGC
CCCCGCGGGCCCGGCCTGGCGCGGACGCCCGCCGCCGCGCTCCTCCTCCTGCTCCGGCGCCCCG
CGGCCCGCAGCCTCCTCCGCCCGCCGCCCCGCGCCCCCCGCCGCGCCGCCCTCTGCACCCCGCG
GTGCCCCCCGGTCCCGCCCGCCATGCCCGGCCCGGCCGCGGGCAGTAGGGCCCGGGTCTACGCC
GAGGTGAACAGCCTGAGGAGCCGCGAGTACTGGGACTACGAGTCTCACGTCCCGAGCTGGGGTA
ATCAGGATGATTACCAACTGGTTCGAAAACTTGGTCGGGGAAAATATAGTGAAGTATTTGAGGC
CATTAACATCACTAACAACGAAAGAGTGGTTGTGAAAATTCTCAAGCCAGTGAAGAAAAAGAAG
ATAAAACGAGAGGTTAAGATTCTGGAGAATCTTCGTGGTGGAACAAATATCATTAAGCTGATTG
ACACTGTAAAGGACCCTGTGTCAAAGACACCAGCTTTGGTATTTGAATATATCAATAATACAGA
TTTTAAGCAACTGTACCAGATCCTGACAGACTTTGATATTCGGTTTTATATGTATGAACTACTT
AAAGCTCTGGATTACTGCCACAGCAAGGGAATCATGCACAGGGATGTGAAACCTCACAATGTCA
TGATAGATCACCAACAAAAAAAGCTGCGACTGATAGATTGGGGCTTGGCAGAGTTCTATCATCC
TGCACAGGAGTACAATGTTCGCGTAGCCTCGAGGTACTTCAAGGGACCAGAGCTCCTTGTGGAC
TATCAGATGTATGATTACAGCTTGGACATGTGGAGTTTGGGCTGTATGTTAGCAAGCATGATCT
TTCGAAAGGAACCCTTTTTCCATGGGCAGGACAACTACGACCAGCTTGTTCGCATTGCCAAGGT
TCTGGGTACAGATGAGCTGTATGGCTATCTGAAGAAATATCACATAGACCTAGATCCACACTTC
AACGATATCTTGGGACAGCATTCAAGGAAACGCTGGGAAAACTTTATCCATAGTGAGAACAGAC
ACCTTGTCAGCCCTGAGGCCCTAGATCTTCTGGACAAACTTCTGCGATATGACCATCAACAGAG
ACTGACTGCCAAAGAGGCCATGGAACACCCATACTTCTACCCCGTGGTGAAGGAGCAGTCCCAG
CCTTGTGCAGAGAACGCCGTGCTCTCCAGTGGCCTCACCGCAGCGCGATGAAGACTGGAAAGCG
ACGGTCTGTTGCGGTTCCTCCCACTTTTCCATAAGCAGAACAAGAACCAAATCAAACGTCTTAA
CGTGTGTAGAGAGATCACGTTCCGTGAGCAGACACAAAACGGTGGCAGGTTTGGCGAGCATGAA
CTAGACCAACTGAAGGGCAGCCCACTACCGTGTATCAAACCTCACTTCCGAATGTAAAAGGTTC
ACATGCCTTTGGCTTCCTGTTGACTTCCTCCTGACCCAGAAAGCATGGGAAATGTGAAGGGTAT
GCAAATGGTTGTTGGTTACTGTTGCTCCCCGCGTCCCTTGACTCGTCCGTGGCCGCCTGTTTTT
CCAGCGAACCACGTTGACTAGCTGACCAGATTCCAGTGGGGAGAGGGGACAATATATAGCATGA
CGGGCAGTTACATATTATTATTTTAAAAGTATATATTATTGAATAAAAGGTTTTAAAAGACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005388491	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000008576
	ENSCLAP00000008576.1
	ENSCLAP00000008577.1
	ENSCLAP00000008578.1

RefSeq Acc Id:

XP_005388491 ⟸ XM_005388434

- UniProtKB:

A0A8C2V5V5 (UniProtKB/TrEMBL), A0A8C2V0S2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPGPAAGSRARVYAEVNSLRSREYWDYESHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE
RVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI
LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR
VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELY
GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM
EHPYFYPVVKEQSQPCAENAVLSSGLTAAR

hide sequence

RefSeq Acc Id:

ENSCLAP00000008576 ⟸ ENSCLAT00000008703

RefSeq Acc Id:

ENSCLAP00000008577 ⟸ ENSCLAT00000008704

RefSeq Acc Id:

ENSCLAP00000008578 ⟸ ENSCLAT00000008705

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000005997	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000008703	ENTREZGENE
	ENSCLAT00000008703.1	UniProtKB/TrEMBL
	ENSCLAT00000008704.1	UniProtKB/TrEMBL
	ENSCLAT00000008705.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	CK2_alpha	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	Csnk2a2	ENTREZGENE
PANTHER	CASEIN KINASE II SUBUNIT ALPHA	UniProtKB/TrEMBL
	PTHR24054	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C2V0S2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2V0S6_CHILA	UniProtKB/TrEMBL
	A0A8C2V5V5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Csnk2a2	casein kinase 2 alpha 2		casein kinase 2, alpha prime polypeptide	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - PID (archival)