Tmtc2 (transmembrane O-mannosyltransferase targeting cadherins 2) - Rat Genome Database

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Gene: Tmtc2 (transmembrane O-mannosyltransferase targeting cadherins 2) Chinchilla lanigera
Analyze
Symbol: Tmtc2
Name: transmembrane O-mannosyltransferase targeting cadherins 2
RGD ID: 8925291
Description: ENCODES a protein that exhibits dolichyl-phosphate-mannose-protein mannosyltransferase activity (ortholog); INVOLVED IN calcium ion homeostasis (ortholog); protein O-linked mannosylation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Deafness (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transmembrane and tetratricopeptide repeat containing 2; transmembrane and TPR repeat-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540520,969,952 - 21,359,783 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540520,969,836 - 21,357,939 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tmtc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540520,969,952 - 21,359,783 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540520,969,836 - 21,357,939 (+)NCBIChiLan1.0ChiLan1.0
TMTC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381282,686,906 - 83,134,866 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1282,686,880 - 83,134,870 (+)EnsemblGRCh38hg38GRCh38
GRCh371283,080,685 - 83,528,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361281,605,065 - 82,052,196 (+)NCBINCBI36Build 36hg18NCBI36
Celera1282,748,495 - 83,195,421 (+)NCBICelera
Cytogenetic Map12q21.31NCBI
HuRef1280,139,235 - 80,586,094 (+)NCBIHuRef
CHM1_11283,046,833 - 83,493,575 (+)NCBICHM1_1
T2T-CHM13v2.01282,666,441 - 83,114,534 (+)NCBIT2T-CHM13v2.0
Tmtc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910105,023,524 - 105,410,340 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10105,023,524 - 105,410,312 (-)EnsemblGRCm39 Ensembl
GRCm3810105,187,663 - 105,574,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10105,187,663 - 105,574,451 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710104,624,719 - 105,011,535 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610104,591,773 - 104,978,561 (-)NCBIMGSCv36mm8
Celera10107,116,217 - 107,505,137 (-)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1054.72NCBI
Tmtc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8742,280,746 - 42,695,651 (-)NCBIGRCr8
mRatBN7.2740,392,377 - 40,806,685 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl740,394,220 - 40,807,298 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx742,297,607 - 42,708,576 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0744,500,689 - 44,911,641 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0744,275,578 - 44,686,535 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0747,179,596 - 47,586,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl747,181,981 - 47,586,137 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0747,197,110 - 47,603,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4743,667,983 - 44,133,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1743,688,792 - 44,154,492 (-)NCBI
Celera737,294,447 - 37,702,308 (-)NCBICelera
Cytogenetic Map7q21NCBI
TMTC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21090,738,676 - 91,185,559 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11290,735,094 - 91,186,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01280,209,070 - 80,660,058 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11283,316,647 - 83,761,761 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1283,317,358 - 83,759,281 (+)Ensemblpanpan1.1panPan2
TMTC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11524,629,610 - 25,017,936 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1524,629,157 - 25,016,555 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1525,060,632 - 25,448,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01525,377,180 - 25,529,388 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1525,008,752 - 25,526,997 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11524,585,728 - 24,973,537 (+)NCBIUMICH_Zoey_3.1
Tmtc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494535,255,207 - 35,632,245 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936507603,868 - 980,230 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936507603,222 - 980,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMTC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl598,697,035 - 99,229,550 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1598,695,404 - 99,085,243 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25103,474,951 - 103,667,323 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMTC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11178,130,490 - 78,569,546 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1178,296,438 - 78,569,740 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037166,791,023 - 167,244,956 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmtc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248371,998,083 - 2,398,451 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248371,998,443 - 2,398,290 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000012476   ⟹   ENSCLAP00000012333
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540520,969,952 - 21,359,783 (+)Ensembl
RefSeq Acc Id: XM_005374399   ⟹   XP_005374456
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540520,969,836 - 21,357,939 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005374456 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000012333
  ENSCLAP00000012333.1
Reference Protein Sequences
RefSeq Acc Id: XP_005374456   ⟸   XM_005374399
- UniProtKB: A0A8C2V9P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000012333   ⟸   ENSCLAT00000012476
Protein Domains
DUF1736


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008519 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000012476 ENTREZGENE
  ENSCLAT00000012476.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro TMTC_DUF1736 UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_1 UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
NCBI Gene Tmtc2 ENTREZGENE
PANTHER PROTEIN O-MANNOSYL-TRANSFERASE TMTC2 UniProtKB/TrEMBL
  PROTEIN O-MANNOSYL-TRANSFERASE TMTC2 UniProtKB/TrEMBL
Pfam DUF1736 UniProtKB/TrEMBL
  TPR_1 UniProtKB/TrEMBL
  TPR_12 UniProtKB/TrEMBL
  TPR_16 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PROSITE TPR UniProtKB/TrEMBL
  TPR_REGION UniProtKB/TrEMBL
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A8C2V9P3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-11 Tmtc2  transmembrane O-mannosyltransferase targeting cadherins 2  Tmtc2  transmembrane and tetratricopeptide repeat containing 2  Symbol and/or name change 5135510 APPROVED