Tp53 (tumor protein p53) - Rat Genome Database

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Gene: Tp53 (tumor protein p53) Chinchilla lanigera
Analyze
Symbol: Tp53
Name: tumor protein p53
RGD ID: 8924440
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); ATP-dependent DNA/DNA annealing activity (ortholog); chromatin binding (ortholog); INVOLVED IN positive regulation of outer hair cell apoptotic process; apoptotic process (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN centrosome (ortholog); chromatin (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cellular tumor antigen p53
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,252,130 - 9,255,928 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,241,391 - 9,256,716 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Erythroleukemia  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute megakaryocytic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adenoma  (ISO)
adenosine deaminase deficiency  (ISO)
Adrenal Cortex Neoplasms  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anaplastic astrocytoma  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
Arsenic Poisoning  (ISO)
atherosclerosis  (ISO)
atypical teratoid rhabdoid tumor  (ISO)
Autosomal Recessive Dyskeratosis Congenita  (ISO)
autosomal recessive dyskeratosis congenita 3  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Balkan nephropathy  (ISO)
basal cell carcinoma  (ISO)
bone development disease  (ISO)
Bone Marrow Failure Syndrome 5  (ISO)
Bone Marrow Neoplasms  (ISO)
bone osteosarcoma  (ISO)
brain ischemia  (ISO)
Brain Neoplasms  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
bronchopulmonary dysplasia  (ISO)
Calcification of Aortic Valve  (ISO)
calcinosis  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
carotid artery disease  (ISO)
cataract  (ISO)
Cecal Neoplasms  (ISO)
Central Nervous System Neoplasms  (ISO)
cervical adenocarcinoma  (ISO)
cervical cancer  (ISO)
cervical squamous cell carcinoma  (ISO)
CHARGE syndrome  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
choroid plexus carcinoma  (ISO)
choroid plexus papilloma  (ISO)
Chromosome 17 Deletion  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell adenocarcinoma  (ISO)
clear cell renal cell carcinoma  (ISO)
Cognitive Dysfunction  (ISO)
colon carcinoma  (ISO)
Colon Diverticulum  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
combined oxidative phosphorylation deficiency 11  (ISO)
common variable immunodeficiency  (ISO)
congenital fibrosarcoma  (ISO)
congenital merosin-deficient muscular dystrophy 1A  (ISO)
congenital myasthenic syndrome 2A  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Craniofacial Abnormalities  (ISO)
demyelinating disease  (ISO)
Diabetic Nephropathies  (ISO)
Diamond-Blackfan anemia  (ISO)
diffuse large B-cell lymphoma  (ISO)
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  (ISO)
DiGeorge syndrome  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Ductal Carcinoma  (ISO)
ductal carcinoma in situ  (ISO)
Dwarfism  (ISO)
dyskeratosis congenita  (ISO)
Emphysema  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
Endometrial Intraepithelial Neoplasia  (ISO)
Endometrial Neoplasms  (ISO)
esophageal cancer  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Eye Neoplasms  (ISO)
familial melanoma  (ISO)
Female Infertility  (ISO)
Funnel Chest  (ISO)
gallbladder cancer  (ISO)
gallbladder carcinoma  (ISO)
Gallbladder Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
glioblastoma  (ISO)
graft-versus-host disease  (ISO)
Graves' disease  (ISO)
head and neck cancer  (ISO)
Head and Neck Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematologic cancer  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Adrenocortical Carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypogonadism and Testicular Atrophy  (ISO)
ischemia  (ISO)
keratosis  (ISO)
Leber hereditary optic neuropathy  (ISO)
leukemia  (ISO)
Li-Fraumeni syndrome  (ISO)
Li-Fraumeni syndrome 1  (ISO)
Li-Fraumeni-Like Syndrome  (ISO)
Lip Neoplasms  (ISO)
Liver Neoplasms  (ISO)
low tension glaucoma  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung sarcomatoid carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
male infertility  (ISO)
malignant astrocytoma  (ISO)
malignant mesothelioma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
meninges sarcoma  (ISO)
Mesothelioma  (ISO)
mismatch repair cancer syndrome  (ISO)
mitochondrial metabolism disease  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myelofibrosis  (ISO)
myeloid leukemia associated with Down Syndrome  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nasal cavity cancer  (ISO)
Nasopharyngeal Neoplasms  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
Nerve Sheath Neoplasms  (ISO)
nervous system disease  (ISO)
neuroblastoma  (ISO)
non-Hodgkin lymphoma  (ISO)
Odontogenic Myxoma  (ISO)
Oral Lichen Planus  (ISO)
oral mucosa leukoplakia  (ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
Oropharyngeal Neoplasms  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
ovarian small cell carcinoma  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatic intraductal papillary-mucinous neoplasm  (ISO)
pancytopenia  (ISO)
papillary renal cell carcinoma  (ISO)
paranasal sinus benign neoplasm  (ISO)
Paraproteinemias  (ISO)
Parasitic Liver Diseases  (ISO)
Pediatric Adrenocortical Carcinoma  (ISO)
Penile Neoplasms  (ISO)
Phyllodes Tumor  (ISO)
plasma cell neoplasm  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Polyploidy  (ISO)
pre-malignant neoplasm  (ISO)
Premature Aging  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
primary open angle glaucoma  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pterygium  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Reperfusion Injury  (ISO)
rhabdomyosarcoma  (ISO)
SAPHO syndrome  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
serous cystadenocarcinoma  (ISO)
Sezary's disease  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Injuries  (ISO)
spondyloarthropathy  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
thymoma  (ISO)
Thymus Neoplasms  (ISO)
thyroid gland anaplastic carcinoma  (ISO)
thyroid gland papillary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
transthyretin amyloidosis  (ISO)
traumatic brain injury  (ISO)
Trigeminal Nerve Injuries  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
Urogenital Neoplasms  (ISO)
Urologic Neoplasms  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)
very long chain acyl-CoA dehydrogenase deficiency  (ISO)
Vulvar Lichen Sclerosus  (ISO)
Vulvar Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
apoptotic signaling pathway  (ISO)
autophagy  (ISO)
B cell lineage commitment  (ISO)
bone marrow development  (ISO)
cardiac muscle cell apoptotic process  (ISO)
cardiac septum morphogenesis  (ISO)
cell population proliferation  (ISO)
cellular response to actinomycin D  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to heat  (ISO)
cellular response to hypoxia  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to organonitrogen compound  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to triglyceride  (ISO)
cellular response to UV  (ISO)
cellular response to UV-C  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cellular senescence  (ISO)
central nervous system development  (ISO)
cerebellum development  (ISO)
chromosome organization  (ISO)
circadian behavior  (ISO)
circadian rhythm  (ISO)
determination of adult lifespan  (ISO)
DNA damage response  (ISO)
DNA damage response, signal transduction by p53 class mediator  (ISO)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  (ISO)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  (ISO)
double-strand break repair  (ISO)
embryo development ending in birth or egg hatching  (ISO)
embryonic organ development  (ISO)
entrainment of circadian clock by photoperiod  (ISO)
ER overload response  (ISO)
fibroblast proliferation  (ISO)
gastrulation  (ISO)
glial cell proliferation  (ISO)
glucose catabolic process to lactate via pyruvate  (ISO)
heart development  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
hematopoietic stem cell differentiation  (ISO)
in utero embryonic development  (ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
intrinsic apoptotic signaling pathway in response to hypoxia  (ISO)
mitochondrial DNA repair  (ISO)
mitophagy  (ISO)
mitotic G1 DNA damage checkpoint signaling  (ISO)
mRNA transcription  (ISO)
multicellular organism growth  (ISO)
necroptotic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of DNA replication  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of G1 to G0 transition  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of glucose catabolic process to lactate via pyruvate  (ISO)
negative regulation of miRNA processing  (ISO)
negative regulation of mitophagy  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of pentose-phosphate shunt  (ISO)
negative regulation of progesterone secretion  (ISO)
negative regulation of proteolysis  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of stem cell proliferation  (ISO)
negative regulation of telomere maintenance via telomerase  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuroblast proliferation  (ISO)
neuron apoptotic process  (ISO)
nucleotide-excision repair  (ISO)
oligodendrocyte apoptotic process  (ISO)
oxidative stress-induced premature senescence  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of mitochondrial membrane permeability  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of outer hair cell apoptotic process  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of programmed necrotic cell death  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
positive regulation of thymocyte apoptotic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein import into nucleus  (ISO)
protein localization  (ISO)
protein stabilization  (ISO)
protein-containing complex assembly  (ISO)
Ras protein signal transduction  (ISO)
reactive oxygen species metabolic process  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell cycle  (ISO)
regulation of cell cycle G2/M phase transition  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cellular senescence  (ISO)
regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of fibroblast apoptotic process  (ISO)
regulation of intracellular pH  (ISO)
regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
regulation of mitotic cell cycle  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of peptide hormone secretion  (ISO)
regulation of prostaglandin secretion  (ISO)
regulation of thymocyte apoptotic process  (ISO)
regulation of tissue remodeling  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
release of cytochrome c from mitochondria  (ISO)
replicative senescence  (ISO)
response to amino acid  (ISO)
response to antibiotic  (ISO)
response to caffeine  (ISO)
response to cytokine  (ISO)
response to ethanol  (ISO)
response to gamma radiation  (ISO)
response to hyperoxia  (ISO)
response to inorganic substance  (ISO)
response to ischemia  (ISO)
response to metal ion  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to oxidative stress  (ISO)
response to retinoic acid  (ISO)
response to salt stress  (ISO)
response to UV  (ISO)
response to UV-B  (ISO)
response to vitamin B3  (ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
rRNA transcription  (ISO)
signal transduction by p53 class mediator  (ISO)
somitogenesis  (ISO)
spermatogenesis  (ISO)
stem cell proliferation  (ISO)
T cell differentiation in thymus  (ISO)
T cell lineage commitment  (ISO)
T cell proliferation involved in immune response  (ISO)
thymocyte apoptotic process  (ISO)
transcription initiation-coupled chromatin remodeling  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)
type II interferon-mediated signaling pathway  (ISO)
viral process  (ISO)

Molecular Function
14-3-3 protein binding  (ISO)
ATP-dependent DNA/DNA annealing activity  (ISO)
chromatin binding  (ISO)
cis-regulatory region sequence-specific DNA binding  (ISO)
copper ion binding  (ISO)
core promoter sequence-specific DNA binding  (ISO)
disordered domain specific binding  (ISO)
DNA binding  (ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific  (ISO)
DNA-binding transcription factor activity  (ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific  (ISO)
DNA-binding transcription repressor activity, RNA polymerase II-specific  (ISO)
enzyme binding  (ISO)
general transcription initiation factor binding  (ISO)
histone deacetylase binding  (ISO)
histone deacetylase regulator activity  (ISO)
identical protein binding  (ISO)
MDM2/MDM4 family protein binding  (ISO)
molecular function activator activity  (ISO)
mRNA 3'-UTR binding  (ISO)
p53 binding  (ISO)
promoter-specific chromatin binding  (ISO)
protease binding  (ISO)
protein binding  (ISO)
protein heterodimerization activity  (ISO)
protein phosphatase 2A binding  (ISO)
protein-folding chaperone binding  (ISO)
receptor tyrosine kinase binding  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (ISO)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (ISO)
sequence-specific DNA binding  (ISO)
TFIID-class transcription factor complex binding  (ISO)
transcription cis-regulatory region binding  (ISO)
transcription coregulator binding  (ISO)
transmembrane transporter binding  (ISO)
ubiquitin protein ligase binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor. Fetoni AR, etal., Neurosci Res. 2014 Apr-May;81-82:30-7. doi: 10.1016/j.neures.2014.01.006. Epub 2014 Jan 25.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tp53
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,252,130 - 9,255,928 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,241,391 - 9,256,716 (+)NCBIChiLan1.0ChiLan1.0
TP53
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,668,421 - 7,687,490 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,661,779 - 7,687,538 (-)EnsemblGRCh38hg38GRCh38
GRCh37177,571,739 - 7,590,808 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,512,445 - 7,531,642 (-)NCBINCBI36Build 36hg18NCBI36
Build 34177,512,463 - 7,531,642NCBI
Celera177,598,099 - 7,617,224 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,465,169 - 7,484,283 (-)NCBIHuRef
CHM1_1177,580,866 - 7,600,003 (-)NCBICHM1_1
T2T-CHM13v2.0177,572,544 - 7,591,594 (-)NCBIT2T-CHM13v2.0
Trp53
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,471,174 - 69,482,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,471,185 - 69,482,699 (+)EnsemblGRCm39 Ensembl
GRCm381169,580,348 - 69,591,873 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,580,359 - 69,591,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,393,861 - 69,405,375 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,396,176 - 69,408,066 (+)NCBIMGSCv36mm8
Celera1176,543,319 - 76,554,788 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.83NCBI
Tp53
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,798,871 - 54,810,300 (+)NCBIGRCr8
mRatBN7.21054,300,070 - 54,311,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,300,048 - 54,311,524 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,962,496 - 58,973,951 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,451,039 - 58,462,496 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,958,739 - 53,970,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,186,299 - 56,198,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,187,020 - 56,198,449 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,932,658 - 55,944,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,399,721 - 56,411,150 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,413,290 - 56,424,751 (+)NCBI
Celera1053,454,375 - 53,465,803 (+)NCBICelera
Cytogenetic Map10q24NCBI
TP53
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,262,550 - 15,280,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,217,636 - 17,246,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,699,449 - 7,717,812 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,687,132 - 7,706,120 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,684,922 - 7,706,120 (-)Ensemblpanpan1.1panPan2
TP53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,561,406 - 32,565,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,560,598 - 32,574,109 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,699,559 - 32,713,071 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,665,395 - 32,678,721 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,665,394 - 32,678,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,633,092 - 32,646,601 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,589,339 - 32,602,824 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,768,467 - 32,781,775 (-)NCBIUU_Cfam_GSD_1.0
Tp53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,445,372 - 47,461,208 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595919,428 - 925,425 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595919,807 - 935,367 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP53
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,939,644 - 52,953,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,939,643 - 52,953,786 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,220,545 - 55,234,668 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12q12-q14NCBI
TP53
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,047,686 - 7,065,567 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,045,146 - 7,066,223 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,343,255 - 14,361,299 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp53
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,263,518 - 10,271,218 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,266,316 - 10,282,664 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000010534   ⟹   ENSCLAP00000010404
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554679,252,130 - 9,255,928 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000010535   ⟹   ENSCLAP00000010405
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554679,252,150 - 9,255,928 (+)Ensembl
RefSeq Acc Id: XM_005399463   ⟹   XP_005399520
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554679,241,391 - 9,256,716 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005399464   ⟹   XP_005399521
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554679,241,391 - 9,256,716 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005399520 (Get FASTA)   NCBI Sequence Viewer  
  XP_005399521 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000010404
  ENSCLAP00000010404.1
  ENSCLAP00000010405
  ENSCLAP00000010405.1
Reference Protein Sequences
RefSeq Acc Id: XP_005399520   ⟸   XM_005399463
- UniProtKB: A0A8C2YMX2 (UniProtKB/TrEMBL),   A0A8C2YMW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005399521   ⟸   XM_005399464
- UniProtKB: A0A8C2YMX2 (UniProtKB/TrEMBL),   A0A8C2YMW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000010405   ⟸   ENSCLAT00000010535
RefSeq Acc Id: ENSCLAP00000010404   ⟸   ENSCLAT00000010534
Protein Domains
p53 DNA-binding   p53 tetramerisation   p53 transactivation


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000007189 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000010534 ENTREZGENE
  ENSCLAT00000010534.1 UniProtKB/TrEMBL
  ENSCLAT00000010535 ENTREZGENE
  ENSCLAT00000010535.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.720 UniProtKB/TrEMBL
  4.10.170.10 UniProtKB/TrEMBL
  6.10.50.20 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/TrEMBL
  p53_DNA-bd UniProtKB/TrEMBL
  p53_tetramer_sf UniProtKB/TrEMBL
  p53_tetrameristn UniProtKB/TrEMBL
  p53_transactivation_domain UniProtKB/TrEMBL
  p53_tumour_suppressor UniProtKB/TrEMBL
NCBI Gene Tp53 ENTREZGENE
PANTHER CELLULAR TUMOR ANTIGEN P53 UniProtKB/TrEMBL
  PTHR11447 UniProtKB/TrEMBL
Pfam P53 UniProtKB/TrEMBL
  P53_TAD UniProtKB/TrEMBL
  P53_tetramer UniProtKB/TrEMBL
PRINTS P53SUPPRESSR UniProtKB/TrEMBL
PROSITE P53 UniProtKB/TrEMBL
Superfamily-SCOP SSF47719 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
UniProt A0A8C2YMW9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YMX2 ENTREZGENE, UniProtKB/TrEMBL