Park7 (Parkinsonism associated deglycase) - Rat Genome Database

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Gene: Park7 (Parkinsonism associated deglycase) Chinchilla lanigera
Analyze
Symbol: Park7
Name: Parkinsonism associated deglycase
RGD ID: 8892808
Description: ENCODES a protein that exhibits copper ion binding (ortholog); cupric ion binding (ortholog); cuprous ion binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); cellular detoxification of aldehyde (ortholog); cellular detoxification of methylglyoxal (ortholog); PARTICIPATES IN Parkinson's disease pathway; transforming growth factor-beta signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ortholog); cerebral infarction (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN axon (ortholog); cell body (ortholog); chromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: parkinson protein 7
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,969,497 - 4,985,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,974,130 - 4,985,927 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
cellular detoxification of aldehyde  (ISO)
cellular detoxification of methylglyoxal  (ISO)
cellular response to glyoxal  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to reactive oxygen species  (ISO)
detection of oxidative stress  (ISO)
detoxification of copper ion  (ISO)
detoxification of hydrogen peroxide  (ISO)
detoxification of mercury ion  (ISO)
DNA repair  (ISO)
dopamine uptake involved in synaptic transmission  (ISO)
glucose homeostasis  (ISO)
glutathione deglycation  (ISO)
glycolate biosynthetic process  (ISO)
glyoxal metabolic process  (ISO)
guanine deglycation  (ISO)
guanine deglycation, glyoxal removal  (ISO)
guanine deglycation, methylglyoxal removal  (ISO)
hydrogen peroxide metabolic process  (ISO)
insulin secretion  (ISO)
lactate biosynthetic process  (ISO)
maternal process involved in female pregnancy  (ISO)
membrane depolarization  (ISO)
membrane hyperpolarization  (ISO)
methylglyoxal catabolic process to lactate  (ISO)
methylglyoxal metabolic process  (ISO)
mitochondrion organization  (ISO)
negative regulation of cellular process  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of NMDA glutamate receptor activity  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
negative regulation of protein acetylation  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein export from nucleus  (ISO)
negative regulation of protein K48-linked deubiquitination  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein sumoylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of TRAIL-activated apoptotic signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of acute inflammatory response to antigenic stimulus  (ISO)
positive regulation of dopamine biosynthetic process  (ISO)
positive regulation of fertilization  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of L-dopa biosynthetic process  (ISO)
positive regulation of mitochondrial electron transport, NADH to ubiquinone  (ISO)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein stabilization  (ISO)
regulation of androgen receptor signaling pathway  (ISO)
regulation of inflammatory response  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation of TRAIL production  (ISO)
response to hydrogen peroxide  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)
synaptic transmission, dopaminergic  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Park7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,969,497 - 4,985,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,974,130 - 4,985,927 (-)NCBIChiLan1.0ChiLan1.0
PARK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3817,961,711 - 7,985,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl17,954,291 - 7,985,505 (+)EnsemblGRCh38hg38GRCh38
GRCh3718,021,771 - 8,045,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,944,380 - 7,967,926 (+)NCBINCBI36Build 36hg18NCBI36
Build 3417,956,058 - 7,979,602NCBI
Celera17,128,771 - 7,152,398 (+)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef17,169,316 - 7,193,163 (+)NCBIHuRef
CHM1_118,009,469 - 8,033,097 (+)NCBICHM1_1
T2T-CHM13v2.017,492,675 - 7,516,444 (+)NCBIT2T-CHM13v2.0
Park7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,981,590 - 150,994,378 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,981,590 - 150,998,894 (-)EnsemblGRCm39 Ensembl
GRCm384150,897,133 - 150,909,921 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,897,133 - 150,914,437 (-)EnsemblGRCm38mm10GRCm38
MGSCv374150,271,242 - 150,284,030 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364149,740,942 - 149,753,650 (-)NCBIMGSCv36mm8
Celera4153,174,297 - 153,187,100 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map481.52NCBI
Park7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85166,636,551 - 166,659,825 (-)NCBIGRCr8
mRatBN7.25161,353,718 - 161,376,993 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,353,719 - 161,376,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5164,071,138 - 164,094,398 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,887,564 - 165,910,960 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,849,775 - 165,873,035 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,982,438 - 168,004,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,982,439 - 168,004,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,559,202 - 171,582,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,050,149 - 168,061,616 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15168,060,336 - 168,071,804 (-)NCBI
Celera5159,607,648 - 159,630,713 (-)NCBICelera
Cytogenetic Map5q36NCBI
PARK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21220,243,225 - 220,268,293 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11218,884,515 - 218,908,146 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016,722,260 - 6,745,915 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.117,969,265 - 7,993,271 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17,969,280 - 7,993,271 (+)Ensemblpanpan1.1panPan2
PARK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,576,219 - 61,592,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl561,576,069 - 61,592,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,584,413 - 61,601,125 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0561,791,984 - 61,808,701 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl561,792,439 - 61,808,700 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1561,791,244 - 61,807,961 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0561,656,017 - 61,672,730 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0562,059,399 - 62,076,120 (+)NCBIUU_Cfam_GSD_1.0
Park7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505831,937,508 - 31,951,577 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366232,422,833 - 2,436,817 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366232,422,780 - 2,436,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,629,214 - 68,645,516 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,629,327 - 68,645,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,023,779 - 63,033,855 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,776,084 - 123,808,031 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20123,776,297 - 123,798,434 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605427,810,002 - 27,834,129 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Park7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248183,900,917 - 3,911,042 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248183,900,917 - 3,915,457 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000009223   ⟹   ENSCLAP00000009094
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554864,969,497 - 4,985,885 (-)Ensembl
RefSeq Acc Id: XM_005404061   ⟹   XP_005404118
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,974,130 - 4,985,107 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005404062   ⟹   XP_005404119
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,974,130 - 4,985,885 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005404063   ⟹   XP_005404120
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,974,130 - 4,985,927 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005404064   ⟹   XP_005404121
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,974,130 - 4,985,591 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005404118 (Get FASTA)   NCBI Sequence Viewer  
  XP_005404119 (Get FASTA)   NCBI Sequence Viewer  
  XP_005404120 (Get FASTA)   NCBI Sequence Viewer  
  XP_005404121 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000009094
  ENSCLAP00000009094.1
RefSeq Acc Id: XP_005404120   ⟸   XM_005404063
- UniProtKB: A0A8C2V1Y0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005404119   ⟸   XM_005404062
- UniProtKB: A0A8C2V1Y0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005404121   ⟸   XM_005404064
- UniProtKB: A0A8C2V1Y0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005404118   ⟸   XM_005404061
- UniProtKB: A0A8C2V1Y0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000009094   ⟸   ENSCLAT00000009223
Protein Domains
DJ-1/PfpI


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006345 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009223 ENTREZGENE
  ENSCLAT00000009223.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.880 UniProtKB/TrEMBL
InterPro Class_I_gatase-like UniProtKB/TrEMBL
  DJ-1 UniProtKB/TrEMBL
  DJ-1/PfpI UniProtKB/TrEMBL
NCBI Gene Park7 ENTREZGENE
PANTHER PARKINSON DISEASE PROTEIN 7 HOMOLOG UniProtKB/TrEMBL
  PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED UniProtKB/TrEMBL
Pfam DJ-1_PfpI UniProtKB/TrEMBL
Superfamily-SCOP SSF52317 UniProtKB/TrEMBL
UniProt A0A8C2V1Y0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Park7  Parkinsonism associated deglycase    parkinson protein 7  Symbol and/or name change 5135510 APPROVED