Tsc22d3 (TSC22 domain family member 3)

Gene: Tsc22d3 (TSC22 domain family member 3) Chinchilla lanigera

Analyze

Symbol:

Tsc22d3

Name:

TSC22 domain family member 3

RGD ID:

8819676

Description:

INVOLVED IN body fluid secretion (ortholog); negative regulation of activation-induced cell death of T cells (ortholog); response to osmotic stress (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Charcot-Marie-Tooth disease type X (ortholog); COVID-19 (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

TSC22 domain family protein 3; TSC22 domain family, member 3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955490	8,177,356 - 8,238,373 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955490	8,177,356 - 8,238,373 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Charcot-Marie-Tooth disease type X (ISO)

COVID-19 (ISO)

genetic disease (ISO)

hyperinsulinism (ISO)

male infertility (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

testicular disease (ISO)

Weight Loss (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

body fluid secretion (ISO)

negative regulation of activation-induced cell death of T cells (ISO)

response to osmotic stress (ISO)

Cellular Component

nucleus (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Tsc22d3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955490	8,177,356 - 8,238,373 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955490	8,177,356 - 8,238,373 (+)	NCBI	ChiLan1.0	ChiLan1.0

TSC22D3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	107,713,221 - 107,775,988 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	107,713,221 - 107,777,342 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	106,956,451 - 107,019,218 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	106,843,107 - 106,905,673 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	107,427,403 - 107,489,966 (-)	NCBI		Celera
Cytogenetic Map	X	q22.3	NCBI
HuRef	X	96,580,831 - 96,643,067 (-)	NCBI		HuRef
CHM1_1	X	106,867,386 - 106,929,923 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	106,149,979 - 106,212,727 (-)	NCBI		T2T-CHM13v2.0

Tsc22d3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	139,440,277 - 139,501,257 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	139,440,277 - 139,501,408 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	140,539,528 - 140,600,522 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	140,539,528 - 140,600,659 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	137,074,067 - 137,135,061 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	135,885,892 - 135,889,531 (-)	NCBI		MGSCv36	mm8
Celera	X	123,798,019 - 123,859,465 (-)	NCBI		Celera
Cytogenetic Map	X	F1	NCBI
cM Map	X	61.35	NCBI

Tsc22d3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	109,006,410 - 109,066,389 (-)	NCBI		GRCr8
mRatBN7.2	X	104,217,898 - 104,277,886 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	104,217,925 - 104,276,861 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	106,347,240 - 106,407,215 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	109,845,976 - 109,905,951 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	107,401,045 - 107,460,983 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	111,884,285 - 111,944,693 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	111,884,295 - 111,887,906 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	52,655,031 - 52,715,433 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	128,336,408 - 128,340,027 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	128,409,842 - 128,413,460 (-)	NCBI
Celera	3	43,710,349 - 43,713,973 (+)	NCBI		Celera
Cytogenetic Map	X	q32	NCBI

TSC22D3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	107,189,525 - 107,253,711 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	107,193,129 - 107,257,315 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	96,806,179 - 96,870,020 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	107,179,077 - 107,242,902 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	107,179,077 - 107,242,902 (-)	Ensembl	panpan1.1		panPan2

TSC22D3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	81,235,489 - 81,298,290 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	81,235,809 - 81,298,192 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	67,355,142 - 67,417,939 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	82,882,231 - 82,945,043 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	82,882,234 - 82,944,500 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	80,342,439 - 80,405,260 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	82,054,298 - 82,117,113 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	81,846,235 - 81,908,809 (-)	NCBI		UU_Cfam_GSD_1.0

Tsc22d3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	80,613,791 - 80,680,477 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936499	6,977,686 - 7,045,294 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936499	6,977,924 - 7,044,173 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TSC22D3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	88,230,048 - 88,233,098 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	88,171,325 - 88,233,583 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	102,611,634 - 102,673,219 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TSC22D3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	95,535,798 - 95,606,309 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	95,535,783 - 95,539,669 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	20,659,327 - 20,723,753 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tsc22d3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624803	8,701,221 - 8,763,529 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624803	8,701,348 - 8,762,194 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005404695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01060277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01115007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01157293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000002232 ⟹ ENSCLAP00000002186

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955490	8,177,356 - 8,238,373 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000002233 ⟹ ENSCLAP00000002187

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955490	8,230,287 - 8,237,069 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000002234 ⟹ ENSCLAP00000002188

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955490	8,235,043 - 8,237,069 (+)	Ensembl

RefSeq Acc Id:

XM_005404695 ⟹ XP_005404752

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955490	8,177,356 - 8,238,373 (+)	NCBI

Sequence:

show sequence

CGCGCGTGGGTGGGCGGCGGAGCGGGCAGCGCCGAGCCCGCCCGGCCCGCGCCCGCCGGGGAAG
CGGCGCGTCGTCCGCCCGCCCCTGGGGGGAATTCGCCGCTGTCACCGCCCGGTGCCGGTGCCGG
TGCCGGCGGGGAGGCGTGCGGCGCGCCCCTCGCTCTCGGCTCCTGCCGCCCCCGCCGGCACGGC
CCAGGGGAGCCGAGCGCCGGGAGGGAGGGGGCGGAGGAGGGAAGGAGGGAGCCCGGGCGCGCCT
CAGCCTTCCCTCTGCCCTGCTGCCCGCCCTCCCCTCGGCCTCGGGTCCGCCTCGGCCCCGCTCG
CCGCTGCCAAACTTAGGCACCCTGGAGTCCTCTCAGACCGGCCCGGCTGGCGCACACCTGCCAG
CCTTCCCCGACCGTGCAGGCCCGGCAGCTCCCGCCTCCGAGGAGATGGCCCAGTCCAAGCTCGA
CTGCCGCTCCACTGTGGGCCTCGACTGCTGCAACTGCTGCCTGGACCTGGCGAGCCGGAGCGGT
CCGCAGCAAGCCAGCGGCGGGGCCGACAGCAACGCGGGCAGCCCCACCGTGAACAACTTTAAGC
AGCTGCAGGAGAAGTTGGTCTTTGAGAACCTCAATACTGACAAGCTCAACAGCATCATGCGGCA
GGATTCGCTAGAGCCCGTGCTGCGGGACCCCTGCTACCTCATTAACGAAGGCATCTGCAGTCCC
AACATCGACCAAACCATGCTATCCATCCTGCTCTTCTTCCACAGTGCCTCAGGAGCCAGCGTGG
TGGCCATTGACAACAAGATTGAACAGGCCATGGATCTGGTGAAGAATCATCTGATGTATGCTGT
GAGAGAGGAGGTGGAGATCCTGAAGGAGCAAATTCGTGAGCTGGTGGAGAAGAACTCCCAGCTG
GAGCGTGAGAACACCCTGCTGAAGACACTGGCAAGCCCCGAGCAGCTTGAGAAGTTCCAGTCCA
GGCTGAGCCCTGAAGAGCCAGCAACTGAATCCCCACAAGCGCTTGAGGCCCCTGGTGGCTCTGC
GGTGTAAGTGGCTCTGTCCTTCAGGGTGGGCAGAGCCACTAAACTTGTTCTACCTAGTTCTTTC
CAGTTTGTTTTTGGCTCCCCAAGCGTCATCTCACGTGGAGAACTTTACACCTAGCATAGCTGGT
GCCAAGAGATGTCCCAAGGACGTGGCCACCTGGGTCCACTCCAGTGACAGACCCCTGACAAAGA
GCAGCCAGGTCTCTGGAGGCTGAGTTGCATGGGGTTTAGTAACCCCAAGCCAGTGAGCCTCTAA
TGCCACCATGTCCTAGAGACTCCCAGGGCCTGGGCAACTTATCTGCACCTGGCAATGGAGAAAG
GTAGTTTGAGATGTAACACCAGTTTGCTCCAGAAAATAGAAGGGGTCTGTTTTCATTTCCATGG
ACATCTTCTACAGCTTCACCTGACAAAGACCGTTCCTATGAAGAAGCCACTTGTGTTTTAAGCA
GAGGTAGCCTCTCTTCTCCCCTGCCTCACCAAAGCAGGGGGCACAGATGAGAGAGATTGAGCCA
AGTCAGCCTTCTGTTGGTTAATATGGTATAATGCATGGCTTTGTGCACAGCCCAGTGTGGGATT
ACAGCTTTGGGATGACCGCTTACAAAGTTCTGTTTGGTTAGTATTGGCATAGTTTATTATATAG
CCATAAATGCATATATATACCCATAGGGCTAGATCTATATCTTAGTGTAGCAATGTATACATAT
ACATATACACCTGTGTGTCCAAGGGCCTAACCAGCTTTGGGAGTACTGACTGGTCCCTTACATC
TTAAAGCTAATTCTTTGACTGTGTTCATTTATCAGCTTGATCCAGTTTGTCCTTTAGGTTAAGT
AAGACTCAAGAGTAAAGAAAGAGAGAGGGGAGCCAGCCTCAGAACGTGGCCACCGATGCCTTGC
TGCTGTAGCCCTTTCCCCATCTGTCCACTGAAGACAAGTGAAGTCCTTTTTCGAATGCCAAACC
CACCATTCACTGGTGCTGACTACATAGAATGGGGTTGAGAGAAGATCAGTTTGGACTTCACATT
GCTGTTTGAGAACTTTTTTAAAAAAATTTTTTTGTGGAAAATTTTCAGGTGACTAGAAGGATAG
CATCCTACTGTGGATGAGGGTTGGGGGAGGGCATGGCTTTGATCCATGGAGTCTGGGGGATGTA
CCCTGGGAGCTTGTCTCGGGCGGGGGGGATCCTGTGACAGTGAATACTTTCCACTTTCTGACAG
CTTATCCTGATGTATGTCTCCAGGATTTGAATTTTGATTTTTCAAATGTAGCTTGAAATTTCAA
TAAAACTTTGCTTCATTTTTCTAAAAATATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005404752	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000002186
	ENSCLAP00000002186.1
	ENSCLAP00000002187.1
	ENSCLAP00000002188.1

RefSeq Acc Id:

XP_005404752 ⟸ XM_005404695

- UniProtKB:

A0A8C2UNY0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAQSKLDCRSTVGLDCCNCCLDLASRSGPQQASGGADSNAGSPTVNNFKQLQEKLVFENLNTDK
LNSIMRQDSLEPVLRDPCYLINEGICSPNIDQTMLSILLFFHSASGASVVAIDNKIEQAMDLVK
NHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSRLSPEEPATESPQAL
EAPGGSAV

hide sequence

RefSeq Acc Id:

ENSCLAP00000002186 ⟸ ENSCLAT00000002232

RefSeq Acc Id:

ENSCLAP00000002188 ⟸ ENSCLAT00000002234

RefSeq Acc Id:

ENSCLAP00000002187 ⟸ ENSCLAT00000002233

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000001579	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000002232	ENTREZGENE
	ENSCLAT00000002232.1	UniProtKB/TrEMBL
	ENSCLAT00000002233.1	UniProtKB/TrEMBL
	ENSCLAT00000002234.1	UniProtKB/TrEMBL
Gene3D-CATH	Single helix bin	UniProtKB/TrEMBL
InterPro	TSC-22_Dip_Bun	UniProtKB/TrEMBL
	TSC22/BUN_CS	UniProtKB/TrEMBL
NCBI Gene	Tsc22d3	ENTREZGENE
PANTHER	TSC22	UniProtKB/TrEMBL
	TSC22 DOMAIN FAMILY PROTEIN 3	UniProtKB/TrEMBL
Pfam	TSC22	UniProtKB/TrEMBL
PROSITE	TSC22	UniProtKB/TrEMBL
Superfamily-SCOP	Delta-sleep-inducing peptide immunoreactive peptide	UniProtKB/TrEMBL
UniProt	A0A8C2UN35_CHILA	UniProtKB/TrEMBL
	A0A8C2UNY0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2URA0_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Tsc22d3	TSC22 domain family member 3		TSC22 domain family, member 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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