Akap7 (A-kinase anchoring protein 7)

Gene: Akap7 (A-kinase anchoring protein 7) Chinchilla lanigera

Analyze

Symbol:

Akap7

Name:

A-kinase anchoring protein 7

RGD ID:

8804376

Description:

ENCODES a protein that exhibits AMP binding (ortholog); protein domain specific binding (ortholog); protein kinase A binding (ortholog); INVOLVED IN cellular response to cAMP (ortholog); modulation of chemical synaptic transmission (ortholog); positive regulation of potassium ion transmembrane transport (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; ASSOCIATED WITH genetic disease (ortholog); substance-related disorder (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

A kinase (PRKA) anchor protein 7; A-kinase anchor protein 7 isoform gamma

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955436	11,884,433 - 12,004,013 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955436	11,883,840 - 12,002,668 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

substance-related disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to cAMP (ISO)

modulation of chemical synaptic transmission (ISO)

positive regulation of potassium ion transmembrane transport (ISO)

regulation of membrane repolarization (ISO)

regulation of protein kinase A signaling (ISO)

Cellular Component

apical plasma membrane (ISO)

cytoplasm (ISO)

cytosol (ISO)

exocytic vesicle (ISO)

hippocampal mossy fiber to CA3 synapse (ISO)

lateral plasma membrane (ISO)

nucleus (ISO)

protein-containing complex (ISO)

sarcoplasmic reticulum (ISO)

T-tubule (ISO)

Molecular Function

AMP binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

protein kinase A binding (ISO)

protein kinase A regulatory subunit binding (ISO)

protein kinase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

protein kinase A (PKA) signaling pathway (ISO)

vasopressin signaling pathway (ISO)

vasopressin signaling pathway via receptor type 2 (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Akap7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955436	11,884,433 - 12,004,013 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955436	11,883,840 - 12,002,668 (+)	NCBI	ChiLan1.0	ChiLan1.0

AKAP7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	131,125,627 - 131,283,532 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	131,135,467 - 131,283,535 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	131,456,607 - 131,604,672 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	131,508,154 - 131,646,366 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	131,613,196 - 131,646,366	NCBI
Celera	6	132,213,109 - 132,351,308 (+)	NCBI		Celera
Cytogenetic Map	6	q23.2	NCBI
HuRef	6	129,038,098 - 129,185,928 (+)	NCBI		HuRef
CHM1_1	6	131,720,231 - 131,868,081 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	132,320,223 - 132,477,983 (+)	NCBI		T2T-CHM13v2.0

Akap7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	25,044,988 - 25,175,115 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	25,044,988 - 25,183,768 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	25,169,090 - 25,299,217 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	25,169,090 - 25,307,870 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	24,888,896 - 25,018,969 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	24,859,538 - 24,988,579 (-)	NCBI		MGSCv36	mm8
Celera	10	26,111,351 - 26,240,604 (-)	NCBI		Celera
Cytogenetic Map	10	A4	NCBI
cM Map	10	12.26	NCBI

Akap7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	21,906,503 - 22,168,663 (+)	NCBI		GRCr8
mRatBN7.2	1	20,087,190 - 20,217,799 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	20,087,373 - 20,217,797 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	19,864,239 - 19,992,689 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	25,857,412 - 25,985,488 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	20,064,071 - 20,192,538 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	21,129,213 - 21,263,850 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	21,141,970 - 21,263,850 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	22,621,908 - 22,742,822 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	20,573,215 - 20,704,564 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	20,573,194 - 20,706,460 (+)	NCBI
Celera	1	18,857,712 - 18,969,798 (+)	NCBI		Celera
Cytogenetic Map	1	p12	NCBI

AKAP7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	151,140,808 - 151,289,973 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	149,049,175 - 149,196,706 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	128,936,583 - 129,084,018 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	133,043,403 - 133,190,745 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	133,043,403 - 133,190,745 (+)	Ensembl	panpan1.1		panPan2

AKAP7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	69,360,664 - 69,483,102 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	69,360,781 - 69,483,113 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	70,103,473 - 70,230,654 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	69,581,946 - 69,709,298 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	1	69,500,153 - 69,627,658 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	69,272,793 - 69,400,276 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	69,932,193 - 70,059,519 (+)	NCBI		UU_Cfam_GSD_1.0

Akap7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	119,623,429 - 119,740,215 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936790	223,218 - 339,713 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936790	223,080 - 339,078 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AKAP7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	32,221,066 - 32,362,149 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	32,221,061 - 32,362,153 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	35,795,817 - 35,828,693 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AKAP7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	42,270,160 - 42,418,728 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	14,418,317 - 14,563,356 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Akap7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624753	5,303,234 - 5,436,636 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624753	5,297,268 - 5,436,631 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013516678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01033822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01033823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01033824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01106984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01089361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000013002 ⟹ ENSCLAP00000012854

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955436	11,884,433 - 12,004,013 (+)	Ensembl

RefSeq Acc Id:

XM_013516678 ⟹ XP_013372132

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955436	11,883,840 - 12,002,668 (+)	NCBI

Sequence:

show sequence

CGCTGTCAACGCTCTGCGTGCAAGTCCCCGCGGGCGCTCGGCGGACTCCAGGCTCGGGGCCGCC
CGGCTAAGGCGAGGCGCGCTCCCGGGCGCGGGGACGCGCTCCCGGGCGCGCGGCCGGCCATGCT
GGGTGTGCGCGCGCCGCGGCTGCTCGCCGGGCTGCGGCTCCGGGGGCTCCTCGCCTCCGCAGGC
CCCGCCCCCGGGCGCGCCCCCGGCCCGGGCCGCCGCGCGCCGCCGCCGCCGTGGAGCCCCGGAG
CGGGGGCACCAAGTTCCAACATGTGCGACAGTGGGTCCGGAGAAGAGGAAGCGTCTATGGACTG
TGCCGCCAGCACTGTGGATTCCCTGATCAGCTTGCCGTTTGCCACTATAGATATTGAAGATGCT
TACGGAGTCACTGATGGGCCTCAGATTAACTCGAAGAGGAGTAAAGAAAAGGAAACAGTCAAGA
GCAAGCAAATAAAGAAGAGGAAGAAGAAGCGCAAGGACTATCAGCCCAACTACTTCCTGTCCAT
TCCCATCACCAACAAAAAGATTACAGGCGGAATTAAGACTCTGCAAAGCACGATAATAGAGCAA
GATCAGCGCCTGGCTAAAGCCATGGTTGGTGATGGCTCCTTCCACGTTACCTTGCTAGTGATGC
AGCTGTTAAATGCAGATGAAGTGAACATCGGTGTGGATGCACTTTTGCAGTTGAAGCCGTCGGT
AGAAGATGTCCTCCAGGGCCGGCAGCTGACGTTACCCTTCCAAGGGACTGACACCTTCGGAAAT
CAGGTTGGCTTCGTGAAGCTGGCGGATGGAGACCACATCCCCCCACTTTTAGAGATTGCAGAGA
TTGCAAAGAGAACGTTTCAAGAAAAAGGTGTCCTGGCAGGAGAAAGCAGAAGTTTTAAGCCTCA
CTTGACCTTTATGAAGTTGTCCAAAGCCCCCTGGCTCTGGAAGCACGGAGTGAAAAAGATAGAT
CCCAAGTGGTATGAAAAATTTATCAACCACAGATTTGGAGAAGAAACCCTGTACCGCATAGATC
TTTGTTCCATGGAGAAGAAAAAACAAAGTAATGGTTACTATCACTGTGAGTCTTCAATTGTGGT
TGGTGACAAGAATGGAGGGGAGCCGGATGACGCTGAGCTAGTAAGACTGAGTAAGAGGCTGGTG
GAGAATGCGGTGCTCAAGGCTGTGCAGCAGTACCTGGAAGAAACCCAGAACAAAAAGCAGCCAG
GGGAGGGCAGCTCTGTGACAGCCGAAGAGGCCGATCGCATCGGCAATGACAGTGATAACAGGAA
ATGAGACCGGAAGTGGGGTCCAGCCGCTCTGTGCAGTGCATCCCGCCCTCCCTCTGCTAAGCCT
GGACGCTGACTTGCCGTGTGCTCTTTAAATGTCTCTTGTCTTGCCCAAGGAGACGGCCTAACAC
TCACGATCGATGTGTTTGCGCTTCTGAAACACAACAGAAGTGAAGCAGAATGCTTGGGACTAGC
AGAGGAAATCAGTTTATGGAAGAAGAATGGGCCCTGTTTCCCTTGCCTTCAACCATGAACAGGG
AGGGGACTCAGGTTCCGCCTGCCTCCTGGAACCAGCGGCTGGGAGAGGCCTGGCCCTGAGCGCA
ACACTGCCGCTTCTATTACATGGGGCATTCGACTACTTTACCTGAGGCCAAACTCACACACAGC
TATCAAGTGCAAAGTTCAGTTCATCACTGTCAAAATTATCGTGGTCCTTAATATTTCGTGTTTG
ACCTCCGCCTGCTGTCACTATGCACTGATCTTCATTTCCAGTAATTTATGTTCTATGTAAATGA
TATATTTTTGGCAAAATGCAATCTTTTCTATAAAATGTGGGCAACATTTTAAAGGTTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_013372132	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000012854.1

RefSeq Acc Id:

XP_013372132 ⟸ XM_013516678

- Sequence:

show sequence

MLGVRAPRLLAGLRLRGLLASAGPAPGRAPGPGRRAPPPPWSPGAGAPSSNMCDSGSGEEEASM
DCAASTVDSLISLPFATIDIEDAYGVTDGPQINSKRSKEKETVKSKQIKKRKKKRKDYQPNYFL
SIPITNKKITGGIKTLQSTIIEQDQRLAKAMVGDGSFHVTLLVMQLLNADEVNIGVDALLQLKP
SVEDVLQGRQLTLPFQGTDTFGNQVGFVKLADGDHIPPLLEIAEIAKRTFQEKGVLAGESRSFK
PHLTFMKLSKAPWLWKHGVKKIDPKWYEKFINHRFGEETLYRIDLCSMEKKKQSNGYYHCESSI
VVGDKNGGEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGSSVTAEEADRIGNDSDN
RK

hide sequence

RefSeq Acc Id:

ENSCLAP00000012854 ⟸ ENSCLAT00000013002

Protein Domains

A-kinase anchor protein 7-like phosphoesterase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008875	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000013002.1	UniProtKB/TrEMBL
Gene3D-CATH	Cyclic phosphodiesterase	UniProtKB/TrEMBL
InterPro	Cyclic_Pdiesterase	UniProtKB/TrEMBL
	Kinase-A_anchor_nucl_local_sig	UniProtKB/TrEMBL
NCBI Gene	Akap7	ENTREZGENE
PANTHER	A-KINASE ANCHOR PROTEIN 7 ISOFORM GAMMA	UniProtKB/TrEMBL
	RNA 2',3'-CYCLIC PHOSPHODIESTERASE	UniProtKB/TrEMBL
Pfam	AKAP7_NLS	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55144	UniProtKB/TrEMBL
UniProt	A0A8C2YP28_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Akap7	A-kinase anchoring protein 7		A kinase (PRKA) anchor protein 7	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations