Plch2 (phospholipase C eta 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Plch2 (phospholipase C eta 2) Chinchilla lanigera
Analyze
Symbol: Plch2
Name: phospholipase C eta 2
RGD ID: 8782728
Description: ENCODES a protein that exhibits phosphatidylinositol phospholipase C activity (ortholog); phospholipase C activity (ortholog); INVOLVED IN phosphatidylinositol metabolic process (ortholog); phospholipase C-activating G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); dilated cardiomyopathy 1LL (ortholog); Ehlers-Danlos syndrome spondylodysplastic type 2 (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; phospholipase C, eta 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,718,155 - 8,775,228 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,717,799 - 8,785,144 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Plch2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,718,155 - 8,775,228 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,717,799 - 8,785,144 (-)NCBIChiLan1.0ChiLan1.0
PLCH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,415,943 - 2,505,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12,425,980 - 2,505,532 (+)EnsemblGRCh38hg38GRCh38
GRCh3712,398,890 - 2,436,971 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,397,614 - 2,426,824 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412,431,059 - 2,469,127NCBI
Celera1149,336 - 178,536 (-)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef11,686,028 - 1,715,412 (+)NCBIHuRef
CHM1_112,394,552 - 2,423,710 (+)NCBICHM1_1
T2T-CHM13v2.011,855,498 - 1,946,621 (+)NCBIT2T-CHM13v2.0
Plch2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,067,572 - 155,148,548 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,067,572 - 155,141,241 (-)EnsemblGRCm39 Ensembl
GRCm384154,983,115 - 155,064,091 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,983,115 - 155,056,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,357,224 - 154,385,093 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,827,177 - 153,854,782 (-)NCBIMGSCv36mm8
Celera4157,255,205 - 157,283,081 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.13NCBI
Plch2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,826,543 - 170,885,012 (-)NCBIGRCr8
mRatBN7.25165,544,209 - 165,613,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,544,200 - 165,602,356 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05172,386,400 - 172,455,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,388,598 - 172,424,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,842,358 - 175,871,763 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,786,340 - 171,815,148 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15171,796,834 - 171,825,402 (-)NCBI
Celera5163,750,666 - 163,780,119 (-)NCBICelera
Cytogenetic Map5q36NCBI
PLCH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,744,862 - 225,809,029 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11224,405,747 - 224,469,453 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011,171,623 - 1,235,592 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112,336,856 - 2,375,012 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12,337,005 - 2,374,695 (+)Ensemblpanpan1.1panPan2
PLCH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,303,160 - 57,368,568 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,302,996 - 57,371,468 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0557,507,893 - 57,572,778 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,507,843 - 57,572,778 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,498,906 - 57,564,121 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,391,247 - 57,456,451 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,781,026 - 57,846,156 (+)NCBIUU_Cfam_GSD_1.0
Plch2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,332,866 - 28,399,090 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,066,825 - 1,133,216 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367371,066,860 - 1,131,627 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,325,952 - 64,392,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,325,918 - 64,392,070 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2658,630,240 - 58,696,137 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLCH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,053,571 - 129,127,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605433,399,537 - 33,461,491 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plch2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,534,265 - 7,588,288 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,533,889 - 7,595,887 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000021321   ⟹   ENSCLAP00000021120
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554868,718,155 - 8,740,342 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000021322   ⟹   ENSCLAP00000021121
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554868,719,792 - 8,748,979 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000021323   ⟹   ENSCLAP00000021122
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554868,720,342 - 8,775,228 (-)Ensembl
RefSeq Acc Id: XM_013504169   ⟹   XP_013359623
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554868,717,799 - 8,776,679 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013504170   ⟹   XP_013359624
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554868,717,799 - 8,777,415 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013504172   ⟹   XP_013359626
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554868,717,799 - 8,785,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013504173   ⟹   XP_013359627
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554868,717,799 - 8,783,139 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013504174   ⟹   XP_013359628
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554868,717,799 - 8,749,138 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013359626   ⟸   XM_013504172
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VXW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359627   ⟸   XM_013504173
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VXW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359624   ⟸   XM_013504170
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VXW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359623   ⟸   XM_013504169
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VXW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359628   ⟸   XM_013504174
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VXW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021120   ⟸   ENSCLAT00000021321
RefSeq Acc Id: ENSCLAP00000021122   ⟸   ENSCLAT00000021323
RefSeq Acc Id: ENSCLAP00000021121   ⟸   ENSCLAT00000021322
Protein Domains
C2   EF-hand   PH   PI-PLC Y-box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014474 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021321 ENTREZGENE
  ENSCLAT00000021321.1 UniProtKB/TrEMBL
  ENSCLAT00000021322.1 UniProtKB/TrEMBL
  ENSCLAT00000021323.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/TrEMBL
  PLC-eta2 UniProtKB/TrEMBL
  PLC-eta2_EFh UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/TrEMBL
NCBI Gene Plch2 ENTREZGENE
PANTHER PTHR10336 UniProtKB/TrEMBL
  PTHR10336:SF166 UniProtKB/TrEMBL
Pfam EF-hand_like UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PH_12 UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PIPLC_X_DOMAIN UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
  PLCXc UniProtKB/TrEMBL
  PLCYc UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF51695 UniProtKB/TrEMBL
UniProt A0A8C2VV57_CHILA UniProtKB/TrEMBL
  A0A8C2VXW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W099_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Plch2  phospholipase C eta 2    phospholipase C, eta 2  Symbol and/or name change 5135510 APPROVED