Phox2b (paired like homeobox 2B) - Rat Genome Database

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Gene: Phox2b (paired like homeobox 2B) Chinchilla lanigera
Analyze
Symbol: Phox2b
Name: paired like homeobox 2B
RGD ID: 8774894
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN autonomic nervous system development (ortholog); brainstem development (ortholog); cell development (ortholog); ASSOCIATED WITH colorectal cancer (ortholog); congenital central hypoventilation syndrome (ortholog); Congenital Central Hypoventilation Syndrome 1 (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: paired mesoderm homeobox protein 2B; paired-like homeobox 2b
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554435,935,975 - 5,938,747 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554435,935,975 - 5,938,747 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autonomic nervous system development  (ISO)
brainstem development  (ISO)
cell development  (ISO)
cell differentiation in hindbrain  (ISO)
cell population proliferation  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to carbon dioxide  (ISO)
dopaminergic neuron differentiation  (ISO)
efferent axon development in a lateral line nerve  (ISO)
enteric nervous system development  (ISO)
glial cell differentiation  (ISO)
hindbrain tangential cell migration  (ISO)
inner ear development  (ISO)
medullary reticular formation development  (ISO)
membrane depolarization  (ISO)
motor neuron migration  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of type B pancreatic cell proliferation  (ISO)
neural crest cell migration involved in autonomic nervous system development  (ISO)
neuron differentiation  (ISO)
noradrenergic neuron development  (ISO)
noradrenergic neuron differentiation  (ISO)
parasympathetic nervous system development  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of gene expression  (ISO)
regulation of respiratory gaseous exchange by nervous system process  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
respiratory system development  (ISO)
response to activity  (ISO)
retrotrapezoid nucleus neuron differentiation  (ISO)
skeletal muscle cell differentiation  (ISO)
sympathetic ganglion development  (ISO)
sympathetic nervous system development  (ISO)
type B pancreatic cell proliferation  (ISO)

Cellular Component
chromatin  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Phox2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554435,935,975 - 5,938,747 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554435,935,975 - 5,938,747 (+)NCBIChiLan1.0ChiLan1.0
PHOX2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38441,744,082 - 41,748,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl441,744,082 - 41,748,725 (-)EnsemblGRCh38hg38GRCh38
GRCh37441,746,099 - 41,750,742 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36441,440,857 - 41,445,744 (-)NCBINCBI36Build 36hg18NCBI36
Build 34441,587,027 - 41,591,915NCBI
Celera442,190,119 - 42,195,007 (-)NCBICelera
Cytogenetic Map4p13NCBI
HuRef441,068,497 - 41,073,385 (-)NCBIHuRef
CHM1_1441,746,637 - 41,751,525 (-)NCBICHM1_1
T2T-CHM13v2.0441,717,855 - 41,722,498 (-)NCBIT2T-CHM13v2.0
Phox2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39567,251,751 - 67,256,399 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl567,251,742 - 67,256,644 (-)EnsemblGRCm39 Ensembl
GRCm38567,094,397 - 67,099,126 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl567,094,399 - 67,099,301 (-)EnsemblGRCm38mm10GRCm38
MGSCv37567,485,636 - 67,490,365 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36567,373,532 - 67,378,261 (-)NCBIMGSCv36mm8
Celera564,399,184 - 64,403,936 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map535.95NCBI
Phox2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81441,420,011 - 41,424,527 (+)NCBIGRCr8
mRatBN7.21441,066,012 - 41,069,202 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1441,066,264 - 41,068,978 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01442,711,169 - 42,718,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1442,714,315 - 42,717,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01442,510,540 - 42,514,526 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41443,675,180 - 43,677,970 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1440,218,744 - 40,226,258 (+)NCBICelera
Cytogenetic Map14p11NCBI
PHOX2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2341,930,596 - 41,933,522 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1442,123,959 - 42,126,885 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0436,070,924 - 36,074,532 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1441,918,047 - 41,922,449 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl441,919,742 - 41,922,449 (-)Ensemblpanpan1.1panPan2
PHOX2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,865,963 - 38,869,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,865,995 - 38,869,854 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,841,873 - 38,845,270 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01339,356,028 - 39,359,380 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1339,356,056 - 39,359,022 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11339,045,848 - 39,049,183 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01339,156,421 - 39,159,820 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,631,094 - 39,634,496 (-)NCBIUU_Cfam_GSD_1.0
Phox2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528537,322,562 - 37,326,296 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364828,972,433 - 8,975,284 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364828,972,433 - 8,975,284 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHOX2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl832,842,145 - 32,846,127 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1832,841,425 - 32,846,133 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PHOX2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1278,602,764 - 8,608,052 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl278,603,484 - 8,606,299 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604754,920,668 - 54,926,074 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phox2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476125,234,372 - 25,237,102 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476125,234,048 - 25,238,725 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000002823   ⟹   ENSCLAP00000002767
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554435,935,975 - 5,938,747 (+)Ensembl
RefSeq Acc Id: XM_013518031   ⟹   XP_013373485
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554435,935,975 - 5,938,747 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013373485 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000002767
  ENSCLAP00000002767.1
Reference Protein Sequences
RefSeq Acc Id: XP_013373485   ⟸   XM_013518031
- UniProtKB: A0A8C2ULR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000002767   ⟸   ENSCLAT00000002823
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001994 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002823 ENTREZGENE
  ENSCLAT00000002823.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
NCBI Gene Phox2b ENTREZGENE
PANTHER HOMEOBOX PROTEIN ARISTALESS UniProtKB/TrEMBL
  PAIRED MESODERM HOMEOBOX PROTEIN 2B UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8C2ULR5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-24 Phox2b  paired like homeobox 2B    paired like homeobox 2b  Symbol and/or name change 5135510 APPROVED
2016-08-03 Phox2b  paired like homeobox 2b    paired-like homeobox 2b  Symbol and/or name change 5135510 APPROVED