Pon3 (paraoxonase 3) - Rat Genome Database

Name: Pon3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Pon3 (paraoxonase 3) Chinchilla lanigera

Analyze

Symbol:

Pon3

Name:

paraoxonase 3

RGD ID:

8763906

Description:

ENCODES a protein that exhibits 3,4-dihydrocoumarin hydrolase activity (ortholog); arylesterase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN aromatic compound catabolic process (ortholog); carboxylic acid catabolic process (ortholog); coumarin catabolic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); atherosclerosis (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serum paraoxonase/lactonase 3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PON3 (paraoxonase 3)	NCBI	Ortholog
Mus musculus (house mouse):	Pon3 (paraoxonase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Pon3 (paraoxonase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PON3 (paraoxonase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PON3 (paraoxonase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pon3 (paraoxonase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PON3 (paraoxonase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PON3 (paraoxonase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pon3 (paraoxonase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	11,942,922 - 11,983,504 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	11,945,383 - 11,983,417 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

amyotrophic lateral sclerosis (ISO)

atherosclerosis (ISO)

autism spectrum disorder (ISO)

celiac disease (ISO)

Crohn's disease (ISO)

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

ulcerative colitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aromatic compound catabolic process (ISO)

carboxylic acid catabolic process (ISO)

coumarin catabolic process (ISO)

establishment of localization in cell (ISO)

negative regulation of superoxide anion generation (ISO)

phenylacetate catabolic process (ISO)

renal sodium ion transport (ISO)

Cellular Component

extracellular space (ISO)

Molecular Function

3,4-dihydrocoumarin hydrolase activity (ISO)

arylesterase activity (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pon3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	11,942,922 - 11,983,504 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	11,945,383 - 11,983,417 (-)	NCBI	ChiLan1.0	ChiLan1.0

PON3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	95,359,872 - 95,396,375 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	95,359,872 - 95,396,375 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	94,989,184 - 95,025,687 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	94,827,120 - 94,863,623 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	94,633,925 - 94,670,313	NCBI
Celera	7	89,687,888 - 89,724,394 (-)	NCBI		Celera
Cytogenetic Map	7	q21.3	NCBI
HuRef	7	89,596,240 - 89,632,745 (-)	NCBI		HuRef
CHM1_1	7	94,919,217 - 94,955,721 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	96,596,019 - 96,632,523 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	94,318,186 - 94,354,692 (-)	NCBI

Pon3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	5,216,253 - 5,256,236 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	5,220,852 - 5,256,286 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	5,216,256 - 5,256,285 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	5,220,852 - 5,256,286 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	5,170,852 - 5,206,233 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	5,170,852 - 5,206,233 (-)	NCBI		MGSCv36	mm8
Celera	6	5,367,370 - 5,403,410 (-)	NCBI		Celera
Cytogenetic Map	6	A1	NCBI
cM Map	6	1.99	NCBI

Pon3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	34,323,546 - 34,350,244 (-)	NCBI		GRCr8
mRatBN7.2	4	33,356,983 - 33,383,681 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	33,349,168 - 33,383,855 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	38,316,014 - 38,342,716 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	34,242,154 - 34,268,854 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	32,651,934 - 32,678,640 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	30,311,981 - 30,338,679 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	30,311,982 - 30,338,679 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	30,218,888 - 30,245,586 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	30,000,505 - 30,027,203 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	30,039,834 - 30,066,533 (-)	NCBI
Celera	4	28,883,809 - 28,910,507 (-)	NCBI		Celera
Cytogenetic Map	4	q21	NCBI

PON3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	113,197,534 - 113,238,696 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	161,462,173 - 161,503,379 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	87,314,788 - 87,354,020 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	100,902,432 - 100,941,611 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	100,902,432 - 100,941,611 (-)	Ensembl	panpan1.1		panPan2

PON3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	20,615,180 - 20,642,807 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	20,565,641 - 20,642,985 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	20,174,181 - 20,202,180 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	20,437,560 - 20,465,291 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	20,437,057 - 20,465,276 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	20,582,215 - 20,609,982 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	20,317,344 - 20,345,279 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	20,574,717 - 20,602,546 (-)	NCBI		UU_Cfam_GSD_1.0

Pon3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	33,933,867 - 33,961,080 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936585	4,902,289 - 4,929,556 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936585	4,902,430 - 4,928,377 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PON3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	74,991,277 - 75,017,942 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	74,983,040 - 75,017,947 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	82,185,788 - 82,193,864 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PON3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	53,645,406 - 53,675,066 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	53,645,384 - 53,674,812 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	50,670,307 - 50,702,561 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pon3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624813	2,022,482 - 2,051,330 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624813	2,023,025 - 2,051,319 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005388063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01030957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01030958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01087076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000014044 ⟹ ENSCLAP00000013888

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955432	11,942,922 - 11,983,504 (-)	Ensembl

RefSeq Acc Id:

XM_005388063 ⟹ XP_005388120

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955432	11,945,383 - 11,983,417 (-)	NCBI

Sequence:

show sequence

GGGGAGAAGGGAGCAGAGGACAGGTCCCGCGCGGAAACGTGGCCTTAGAAGCCGCGCGTGGAAG
TTTCAGGGGGCGGCTCCCCGGGAACCAGCCCCGTGACCTTGCCCGTGACCTTGCCCGTGACCTT
GCCCGCGCCCGGCGCAGTGCACGCGGGCAGCGCCCTGCCCGCCCCCCTTGAGGCCGGGCCGGGC
CGGGCTGGGGCGGTGCGAGCCCGGAGCAGCGAGTGCGAGGCGCTGCTGGGCCCCGTGCGCACAG
AGACAATGGGGAAGCTGGCGACGCTGACCCTGCTGGGGGCCAGCCTGGCCTTCCTGGGGCAGAG
GTTTTCGGCGTTTAGAGAAAGAATGAACGCATCTCGCGAAGTGGAGCCGGTAGAACTCCAGCAC
TGCCACCTGATTGAGAAACTCGAAAATGGCTCTGAAGATATCGATATTCTCCCTACGGGGCTGG
CTTTTATCTCTACTGGATTAAAATATCCAGGCATGCCAGACTTTGCACCAGATGAGCCAGGAAG
AATCTTCTTGATGGATCTGAATGAGCCAGCCCCCAAGGCACAAGCACTAAAGATCAGTGATGGA
TTTGACACAGAGCTGTTTAACCCACATGGCATCAGTACTTTCATCAACAAAGAAGGCACTGTGT
ACCTTTATGTGGTGAATCACCCTCACATGGAGTCCACCGTGGAGATATTTAAATTTGAAGAACA
GCAACGATCTCTTGTACACCTGAAAACTATAAAACATGAACTTCTCAAAAGTTTGAATGACATT
GTGGTGGTTGGACCTGAACAATTTTATGCCACCAGAGACCACTATTTTACCAACTTCTTTTTGG
CACTTCTTGAGATGTTCTTAGATCCTCACTGGACTTACGTCGTGTTCTACAGCCCAAGCGAGGT
CAAAGTGGTAGCCAAAGGGTTTGGTTCTGCCAATGGAATAACAGTCTCACGGGACCAGAAGTAT
ATCTATGTAGCTGATGTAACAGATAAGAACATTCATGTAATGGAAAAACAAGAAAACTGGGATT
TAACTCAACTGAAGGTAATACAATTGGAAACCTTAGTGGATAACCTGACTGTTGATCCTGCCAC
GGGAGATATTTTAGCAGGATGCCATCCTAATGTTCTGAAGCTGCTGAACTATGACCCTAAGGAT
CCTCCAGGGTCAGAGGTACTACGCATCCAGAATGTTTTATCGGACAAGCCGACGGTGAGCACTG
TCTACGCCAATAATGGTTCTGTGCTTCAGGGCAGCTCGGTGGCTTCGACGTACCATGGGAAAAT
TCTCATAGGCACTGTGTTTCACAAAGCTCTTTACTGTGTGCTCTAGACTTCAGATGTCCCAAAA
TCTCTATATGATTTGTCATGTTATGATAAGTTTAAAAGGAGTGCAGAGAAATTACATAATAGTC
ACCAAATGACAAGTTAGGTGAGCGACAGTCCACCAAGAAACCAGAGTGCACCTCGCTGTCAAAT
ATCTCCAGTATTCTTCTACAATAAGAACTGTGGGCTGTGGCCATGGAAGTTGCTGCCTCACTAA
GAGCCTTTGATAATTGTGGCACAATTGCCTTCAACAACTGTGATACTGAGTCTCCAGCACTCCA
GTCCAGAAGAAAAGTCATGCTCAAGAAGCTACGATTTCTCTCCTCTCAGTTTTGGTGGAGACCA
ACTGCTAATCGAGTGCCCCTGCGTTCAGCTAAAAGCAGGAATTAGTATGAGACTGTCCAAAGCC
ATGCATTCTTAGGGCTGGGAATGTAGCTCAGCAGCATAAGCGCCTGCCTGGCAAGAGCAAGGTC
CTGGGTTCGATTCCCGGTACCAAAAAATAAAAGCAAAAAAGCCCAAAGCCATACATTCTCCCCA
AGCGCAGGGGCATCCCAATCAGAGAAATTTGCCAGATACATAGGGCTGATGGGGTCATTTGTAG
TAGATCTTTCTTTGTATTGATACTTGTGCATCAAGTACTGCTAATCCTGCTCTGCTCTGAATCG
TGAAATGCAGCCTTAGGGCAGTTATCTTGCACCGCTTTCAGCTTGCTCTGCTGCTCATTTCAAT
AAGCATTTACTAAGCAACCTCCTGTATACTTGGCACTAATAAACCTGAAATGAATAAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005388120	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000013888
	ENSCLAP00000013888.1

RefSeq Acc Id:

XP_005388120 ⟸ XM_005388063

- UniProtKB:

A0A8C2VKA1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGKLATLTLLGASLAFLGQRFSAFRERMNASREVEPVELQHCHLIEKLENGSEDIDILPTGLAF
ISTGLKYPGMPDFAPDEPGRIFLMDLNEPAPKAQALKISDGFDTELFNPHGISTFINKEGTVYL
YVVNHPHMESTVEIFKFEEQQRSLVHLKTIKHELLKSLNDIVVVGPEQFYATRDHYFTNFFLAL
LEMFLDPHWTYVVFYSPSEVKVVAKGFGSANGITVSRDQKYIYVADVTDKNIHVMEKQENWDLT
QLKVIQLETLVDNLTVDPATGDILAGCHPNVLKLLNYDPKDPPGSEVLRIQNVLSDKPTVSTVY
ANNGSVLQGSSVASTYHGKILIGTVFHKALYCVL

hide sequence

RefSeq Acc Id:

ENSCLAP00000013888 ⟸ ENSCLAT00000014044

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000009609	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000014044	ENTREZGENE
	ENSCLAT00000014044.1	UniProtKB/TrEMBL
Gene3D-CATH	2.120.10.30	UniProtKB/TrEMBL
InterPro	6-blade_b-propeller_TolB-like	UniProtKB/TrEMBL
	Arylesterase	UniProtKB/TrEMBL
	Paraoxonase2	UniProtKB/TrEMBL
NCBI Gene	Pon3	ENTREZGENE
PANTHER	PARAOXONASE	UniProtKB/TrEMBL
	SERUM PARAOXONASE/LACTONASE 3	UniProtKB/TrEMBL
Pfam	Arylesterase	UniProtKB/TrEMBL
PRINTS	PARAOXONASE	UniProtKB/TrEMBL
	PARAOXONASE2	UniProtKB/TrEMBL
Superfamily-SCOP	Calcium-dependent phosphotriesterase	UniProtKB/TrEMBL
UniProt	A0A8C2VKA1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD