Lss (lanosterol synthase) - Rat Genome Database

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Gene: Lss (lanosterol synthase) Chinchilla lanigera
Analyze
Symbol: Lss
Name: lanosterol synthase
RGD ID: 8763230
Description: ENCODES a protein that exhibits lanosterol synthase activity (ortholog); INVOLVED IN cholesterol biosynthetic process (ortholog); regulation of protein stability (ortholog); steroid biosynthetic process (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH alopecia-mental retardation syndrome 4 (ortholog); autistic disorder (ortholog); Axenfeld-Rieger syndrome type 3 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); lipid droplet (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540742,633,658 - 42,653,399 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540742,633,658 - 42,653,399 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Lss
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540742,633,658 - 42,653,399 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540742,633,658 - 42,653,399 (-)NCBIChiLan1.0ChiLan1.0
LSS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382146,188,446 - 46,228,774 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2146,188,141 - 46,228,824 (-)EnsemblGRCh38hg38GRCh38
GRCh372147,608,360 - 47,648,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362146,432,788 - 46,473,119 (-)NCBINCBI36Build 36hg18NCBI36
Build 342146,433,466 - 46,473,119NCBI
Celera2132,720,748 - 32,761,140 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2132,990,213 - 33,031,026 (-)NCBIHuRef
CHM1_12147,167,889 - 47,208,226 (-)NCBICHM1_1
T2T-CHM13v2.02144,570,708 - 44,611,332 (-)NCBIT2T-CHM13v2.0
Lss
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391076,367,303 - 76,392,973 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1076,367,422 - 76,392,972 (+)EnsemblGRCm39 Ensembl
GRCm381076,531,565 - 76,557,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1076,531,588 - 76,557,138 (+)EnsemblGRCm38mm10GRCm38
MGSCv371075,994,372 - 76,016,679 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,975,343 - 75,997,650 (+)NCBIMGSCv36mm8
Celera1077,576,142 - 77,598,449 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.1NCBI
Lss
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,090,641 - 12,118,230 (-)NCBIGRCr8
mRatBN7.22012,091,138 - 12,118,858 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,092,774 - 12,118,762 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2012,789,080 - 12,815,472 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,150,002 - 12,176,395 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02012,621,780 - 12,648,174 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02012,844,522 - 12,870,474 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2012,842,884 - 12,870,497 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,337,114 - 15,338,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02015,000,298 - 15,027,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42012,507,575 - 12,534,612 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12012,507,801 - 12,534,839 (-)NCBI
Celera2013,590,952 - 13,616,816 (-)NCBICelera
Cytogenetic Map20p12NCBI
LSS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22242,290,120 - 42,328,031 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12137,162,576 - 37,201,020 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02132,535,564 - 32,571,379 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12145,787,252 - 45,822,181 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2145,787,252 - 45,822,181 (-)Ensemblpanpan1.1panPan2
LSS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13139,479,255 - 39,502,439 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3139,480,581 - 39,503,042 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3138,707,040 - 38,730,234 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03139,120,352 - 39,143,563 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3139,120,357 - 39,143,585 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13138,982,033 - 39,005,248 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03138,942,696 - 38,965,462 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03139,460,908 - 39,484,125 (-)NCBIUU_Cfam_GSD_1.0
Lss
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497138,779,602 - 38,807,151 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936778323,014 - 351,102 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936778323,120 - 351,100 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LSS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.213218,517,444 - 218,539,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LSS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,809,065 - 89,846,295 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl289,811,698 - 89,846,242 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605418,194,151 - 18,231,629 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lss
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474531,306,807 - 31,325,199 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474531,301,648 - 31,325,283 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017621   ⟹   ENSCLAP00000017451
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540742,633,658 - 42,653,399 (-)Ensembl
RefSeq Acc Id: XM_013505726   ⟹   XP_013361180
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540742,633,658 - 42,653,399 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013361180 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017451
  ENSCLAP00000017451.1
Reference Protein Sequences
RefSeq Acc Id: XP_013361180   ⟸   XM_013505726
- UniProtKB: A0A8C2VLI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000017451   ⟸   ENSCLAT00000017621
Protein Domains
Squalene cyclase C-terminal   Squalene cyclase N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011987 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017621 ENTREZGENE
  ENSCLAT00000017621.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/TrEMBL
InterPro SQ_cyclase_C UniProtKB/TrEMBL
  SQ_cyclase_N UniProtKB/TrEMBL
  Squalene_cyclase UniProtKB/TrEMBL
  Terpene_synthase_CS UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/TrEMBL
NCBI Gene Lss ENTREZGENE
PANTHER LANOSTEROL SYNTHASE UniProtKB/TrEMBL
  PTHR11764 UniProtKB/TrEMBL
Pfam SQHop_cyclase_C UniProtKB/TrEMBL
  SQHop_cyclase_N UniProtKB/TrEMBL
PROSITE TERPENE_SYNTHASES UniProtKB/TrEMBL
Superfamily-SCOP SSF48239 UniProtKB/TrEMBL
UniProt A0A8C2VLI9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-17 Lss  lanosterol synthase    lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)  Symbol and/or name change 5135510 APPROVED