Glo1 (glyoxalase I) - Rat Genome Database

Name: Glo1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Glo1 (glyoxalase I) Chinchilla lanigera

Analyze

Symbol:

Glo1

Name:

glyoxalase I

RGD ID:

8759131

Description:

ENCODES a protein that exhibits lactoylglutathione lyase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN glutathione metabolic process (ortholog); methylglyoxal metabolic process (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN glyoxalase metabolic pathway; Leigh disease pathway; primary hyperoxaluria type 2 pathway; ASSOCIATED WITH anxiety disorder (ortholog); autistic disorder (ortholog); depressive disorder (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

lactoylglutathione lyase

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GLO1 (glyoxalase I)	NCBI	Ortholog
Mus musculus (house mouse):	Glo1 (glyoxalase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Glo1 (glyoxalase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GLO1 (glyoxalase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GLO1 (glyoxalase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Glo1 (glyoxalase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GLO1 (glyoxalase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GLO1 (glyoxalase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Glo1 (glyoxalase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	4,728,709 - 4,749,834 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	4,728,709 - 4,749,834 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anxiety disorder (ISO)

autistic disorder (ISO)

depressive disorder (ISO)

Diabetes Complications (ISO)

Diabetic Nephropathies (ISO)

diabetic retinopathy (ISO)

end stage renal disease (ISO)

esophagus squamous cell carcinoma (ISO)

genetic disease (ISO)

Kidney Reperfusion Injury (ISO)

melanoma (ISO)

type 2 diabetes mellitus (ISO)

vascular disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glutathione metabolic process (ISO)

methylglyoxal metabolic process (ISO)

negative regulation of apoptotic process (ISO)

osteoclast differentiation (ISO)

regulation of transcription by RNA polymerase II (ISO)

Cellular Component

cytosol (ISO)

nucleoplasm (ISO)

plasma membrane (ISO)

Molecular Function

lactoylglutathione lyase activity (ISO)

protein binding (ISO)

zinc ion binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glyoxalase metabolic pathway (ISO)

Leigh disease pathway (ISO)

primary hyperoxaluria type 2 pathway (ISO)

pyruvate decarboxylase deficiency pathway (ISO)

pyruvate dehydrogenase E1 deficiency pathway (ISO)

pyruvate kinase deficiency of red cells pathway (ISO)

pyruvate metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Glo1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	4,728,709 - 4,749,834 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	4,728,709 - 4,749,834 (+)	NCBI	ChiLan1.0	ChiLan1.0

GLO1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	38,675,925 - 38,703,145 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	38,675,925 - 38,703,145 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	38,643,701 - 38,670,921 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	38,751,679 - 38,778,930 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	38,751,697 - 38,778,895	NCBI
Celera	6	40,197,188 - 40,224,451 (-)	NCBI		Celera
Cytogenetic Map	6	p21.2	NCBI
HuRef	6	38,361,494 - 38,388,795 (-)	NCBI		HuRef
CHM1_1	6	38,645,758 - 38,673,043 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	38,500,476 - 38,527,717 (-)	NCBI		T2T-CHM13v2.0

Glo1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	30,811,835 - 30,831,633 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	30,803,910 - 30,845,845 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	30,592,861 - 30,612,659 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	30,584,936 - 30,626,871 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	30,729,806 - 30,749,604 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	29,807,695 - 29,826,707 (-)	NCBI		MGSCv36	mm8
MGSCv36	17	30,319,873 - 30,339,606 (-)	NCBI		MGSCv36	mm8
Celera	2	35,035,059 - 35,036,311 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	15.69	NCBI

Glo1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	8,665,061 - 8,683,095 (-)	NCBI		GRCr8
mRatBN7.2	20	8,663,617 - 8,681,661 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	8,662,801 - 8,681,649 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	9,355,240 - 9,374,295 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	8,716,413 - 8,735,468 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	9,192,465 - 9,211,480 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	9,273,589 - 9,291,608 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	9,273,594 - 9,291,610 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	11,461,655 - 11,479,690 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	8,900,984 - 8,919,001 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	8,901,210 - 8,919,228 (-)	NCBI
Celera	20	10,191,302 - 10,209,289 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

GLO1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	53,155,138 - 53,182,369 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	49,025,050 - 49,052,295 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	38,247,881 - 38,275,098 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	39,434,750 - 39,461,971 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	39,434,746 - 39,461,971 (-)	Ensembl	panpan1.1		panPan2

GLO1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	7,584,141 - 7,609,615 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	7,585,531 - 7,609,550 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	7,600,020 - 7,625,500 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	8,048,947 - 8,078,703 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	8,049,266 - 8,078,652 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	7,587,392 - 7,612,855 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	7,664,812 - 7,690,339 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	7,770,412 - 7,795,893 (-)	NCBI		UU_Cfam_GSD_1.0

Glo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	43,029,925 - 43,049,491 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	20,910,629 - 20,930,295 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	20,910,696 - 20,928,583 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GLO1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	34,157,535 - 34,183,528 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	34,156,194 - 34,183,560 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	39,244,145 - 39,271,510 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GLO1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	33,446,134 - 33,472,240 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	33,446,145 - 33,473,699 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	38,633,681 - 38,659,829 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Glo1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	19,533,719 - 19,551,794 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	19,533,730 - 19,549,483 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013517101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01034369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01034370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01047861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000018716 ⟹ ENSCLAP00000018534

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955437	4,728,709 - 4,749,834 (+)	Ensembl

RefSeq Acc Id:

XM_013517101 ⟹ XP_013372555

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955437	4,728,709 - 4,749,834 (+)	NCBI

Sequence:

show sequence

GCCCCGCGGCGCCATCGCGCTGTCTCTAGTGGAAGCGGCCCTGGGGAGTGTGCGGTTTGCCGGT
GCAGCTCAGTCCAGTCCCTGATACTTCGGTGTGGCCATGGCCGAACCTCAGCCCGCGAGCTGCG
GCCTTACTGACGAGGCCGCATTCAGTTGCTGCTCCGACGCAGACCCCAGCACCAAGGATTTTTT
GTTGCAGCAGACTATGCTACGAGTTAAGGATCCTAAGAAGTCTTTGGATTTTTATACTAGAGTT
CTTGGAATGACGCTACTCGAAAAATTCGATTTTCCTGCTATGAAATTTTCACTCTATTTCTTGG
CTTATGAAGATAAAAGTGATATCCCCAAAGACAAAAAAGAAAAAATAGCATGGGCCTTCTCCAG
GAAAGCTACGCTTGAGTTGACGCACAACTGGGGCACTGAAGATGATGACAGCCAGAATTACCAC
AATGGTAATTCAGACCCTCGGGGATTTGGTCACATTGGAATTGCTGTTCCTGATGTATATGGTG
CTTGTAAAAGATTTGAAGAACTGGGAGTCAAATTTGTGAAGAAACCTGATGATGGTAAAATGAA
AGGCCTGGCATTTATTCAAGATCCTGACGGCTACTGGATTGAAATTTTGAGTCCTAACAAAATG
AGTGAACTCTGCCTTTGAGATGTCAGTGAGGATGGAAATAAGCAGGAATGATGTGACTCAAGAT
GCTCAGAAAGCAGACACGGAGGACTGATGGATCTATGTTCCAACTCAAATCATTCTTAAGTCCT
TTTCCCTTCCTTTTCAGCTGTTCTGTTGTTTTGGTTTTTTGCCTCTTCTTTCATTCTGGTTTTA
AAGTAGTGCTTTATTTTATGACCTTGAGTACAGTTGTGTAACTTTACTTTTTAGGTGATAATTT
GAACAGTTCCCTTCAGAGGCTGCATTTGCTGCCTTTTAGTTCCTAAATAGCACCTCTCTTCAAG
TCTTCCTTTGAATCATCATTTCTTAAAAAAAAAAAAAATTAACATTTTTCCGGGAGCTATCTTC
TGGGGTTTCCGTTCCTCAGAAATAGCTTTTCAGGATGGAAGGTAAGGAATACCGAACAAACTTG
CAACTTCACATGTACTTCAAACGGTATGAAGTGTTCATTTTACAAAAGAGAAGGTACTCTTGAG
AACCGTTCAGAATCATGCTGTCAAGGACACTGACAGAAAACTAATTTTTTATTTATAAAATTCT
TTTAAAGTTCAAGGACTAATTTCATGTATTTGGGAATGAGGAAGAAGAGTGGTAGACTGTTTGC
TGGATACTCAAACAGCAGACAAGGCTGTAGCATACTATCTCTCATTTAATCCTCCAACTAGCCT
ATGAAAAAGAAAGCAGGTAGACATGTAAAATAACTTCAATGAATTGAAGGCAGT

hide sequence

Protein Sequences


Protein RefSeqs	XP_013372555	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000018534
	ENSCLAP00000018534.1

RefSeq Acc Id:	XP_013372555 ⟸ XM_013517101
- UniProtKB:	A0A8C2YRS2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEPQPASCGLTDEAAFSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLLEKFDFP AMKFSLYFLAYEDKSDIPKDKKEKIAWAFSRKATLELTHNWGTEDDDSQNYHNGNSDPRGFGHI GIAVPDVYGACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILSPNKMSELCL hide sequence

RefSeq Acc Id:

ENSCLAP00000018534 ⟸ ENSCLAT00000018716

Protein Domains

VOC

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000012717	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000018716	ENTREZGENE
	ENSCLAT00000018716.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.180.10	UniProtKB/TrEMBL
InterPro	Glyas_Bleomycin-R_OHBP_Dase	UniProtKB/TrEMBL
	Glyas_Fos-R_dOase_dom	UniProtKB/TrEMBL
	Glyoxalase_1	UniProtKB/TrEMBL
	Glyoxalase_1_CS	UniProtKB/TrEMBL
	VOC	UniProtKB/TrEMBL
NCBI Gene	Glo1	ENTREZGENE
PANTHER	LACTOYLGLUTATHIONE LYASE	UniProtKB/TrEMBL
	LACTOYLGLUTATHIONE LYASE GLYOXALASE I	UniProtKB/TrEMBL
Pfam	Glyoxalase	UniProtKB/TrEMBL
PROSITE	GLYOXALASE_I_1	UniProtKB/TrEMBL
	GLYOXALASE_I_2	UniProtKB/TrEMBL
	VOC	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54593	UniProtKB/TrEMBL
UniProt	A0A8C2YRS2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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