Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)

Gene: Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1) Chinchilla lanigera

Analyze

Symbol:

Atp1a1

Name:

ATPase Na+/K+ transporting subunit alpha 1

RGD ID:

8750112

Description:

ENCODES a protein that exhibits ADP binding (ortholog); ankyrin binding (ortholog); ATP binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); cellular response to steroid hormone stimulus (ortholog); heart contraction (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); catecholaminergic polymorphic ventricular tachycardia 1 (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); caveola (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ATPase, Na+/K+ transporting, alpha 1 polypeptide; sodium/potassium-transporting ATPase subunit alpha-1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	19,536,634 - 19,564,580 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955435	19,537,224 - 19,563,631 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoma (ISO)

adrenal cortical adenoma (ISO)

catecholaminergic polymorphic ventricular tachycardia 1 (ISO)

Charcot-Marie-Tooth Disease Type 2A2 (ISO)

Charcot-Marie-Tooth disease type 2DD (ISO)

genetic disease (ISO)

hyperhomocysteinemia (ISO)

hypertension (ISO)

HYPOMAGNESEMIA, SEIZURES, AND INTELLECTUAL DISABILITY 2 (ISO)

intellectual disability (ISO)

Marfanoid Mental Retardation Syndrome, Autosomal (ISO)

myocardial infarction (ISO)

Myocardial Ischemia (ISO)

Myocardial Reperfusion Injury (ISO)

primary hyperaldosteronism (ISO)

prostate cancer (ISO)

sensorineural hearing loss (ISO)

Transmissible Gastroenteritis, of Swine (ISO)

vestibular disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to mechanical stimulus (ISO)

cellular response to steroid hormone stimulus (ISO)

heart contraction (ISO)

intracellular potassium ion homeostasis (ISO)

intracellular sodium ion homeostasis (ISO)

membrane hyperpolarization (ISO)

membrane repolarization (ISO)

negative regulation of glucocorticoid biosynthetic process (ISO)

negative regulation of heart contraction (ISO)

osmosensory signaling pathway (ISO)

positive regulation of heart contraction (ISO)

positive regulation of striated muscle contraction (ISO)

potassium ion import across plasma membrane (ISO)

potassium ion transport (ISO)

regulation of blood pressure (ISO)

regulation of cardiac muscle cell contraction (ISO)

regulation of sodium ion transport (ISO)

regulation of the force of heart contraction (ISO)

response to glycoside (ISO)

response to xenobiotic stimulus (ISO)

sodium ion export across plasma membrane (ISO)

sodium ion homeostasis (ISO)

sodium ion transport (ISO)

transmembrane transport (ISO)

Cellular Component

apical plasma membrane (ISO)

basolateral plasma membrane (ISO)

caveola (ISO)

endoplasmic reticulum (ISO)

endosome (ISO)

Golgi apparatus (ISO)

intercalated disc (ISO)

lateral plasma membrane (ISO)

membrane (ISO)

organelle membrane (ISO)

plasma membrane (ISO)

postsynaptic density (ISO)

protein-containing complex (ISO)

sarcolemma (ISO)

sodium:potassium-exchanging ATPase complex (ISO)

sperm flagellum (ISO)

T-tubule (ISO)

Molecular Function

ADP binding (ISO)

ankyrin binding (ISO)

ATP binding (ISO)

ATPase binding (ISO)

P-type potassium transmembrane transporter activity (ISO)

P-type sodium:potassium-exchanging transporter activity (ISO)

phosphatase activity (ISO)

phosphatidylinositol 3-kinase binding (ISO)

potassium ion binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

protein heterodimerization activity (ISO)

protein kinase binding (ISO)

protein-folding chaperone binding (ISO)

sodium ion binding (ISO)

steroid hormone binding (ISO)

transmembrane transporter binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acebutolol pharmacodynamics pathway (ISO)

adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway (ISO)

alfentanil pharmacodynamics pathway (ISO)

amiloride pharmacodynamics pathway (ISO)

amiodarone pharmacodynamics pathway (ISO)

amlodipine pharmacodynamics pathway (ISO)

atenolol pharmacodynamics pathway (ISO)

bendroflumethiazide pharmacodynamics pathway (ISO)

betaxolol pharmacodynamics pathway (ISO)

bisoprolol pharmacodynamics pathway (ISO)

bumetanide pharmacodynamics pathway (ISO)

bupivacaine pharmacodynamics pathway (ISO)

bupranolol drug pathway (ISO)

bupranolol pharmacodynamics pathway (ISO)

buprenorphine pharmacodynamics pathway (ISO)

carvedilol pharmacodynamics pathway (ISO)

chloroprocaine pharmacodynamics pathway (ISO)

chlorothiazide pharmacodynamics pathway (ISO)

chlorthalidone pharmacodynamics pathway (ISO)

citalopram pharmacodynamics pathway (ISO)

cocaine pharmacodynamics pathway (ISO)

codeine and morphine pharmacodynamics pathway (ISO)

cystinuria pathway (ISO)

desipramine pharmacodynamics pathway (ISO)

diltiazem pharmacodynamics pathway (ISO)

diphenoxylate pharmacodynamics pathway (ISO)

disopyramide pharmacodynamics pathway (ISO)

dobutamine pharmacodynamics pathway (ISO)

eplerenone pharmacodynamics pathway (ISO)

escitalopram pharmacodynamics pathway (ISO)

esmolol pharmacodynamics pathway (ISO)

etacrynic acid pharmacodynamics pathway (ISO)

ethylmorphine pharmacodynamics pathway (ISO)

fentanyl pharmacodynamics pathway (ISO)

flecainde pharmacodynamics pathway (ISO)

fluoxetine pharmacodynamics pathway (ISO)

fosphenytoin pharmacodynamics pathway (ISO)

furosemide pharmacodynamics pathway (ISO)

Hartnup disease pathway (ISO)

heroin pharmacodynamics pathway (ISO)

hydrochlorothiazide pharmacodynamics pathway (ISO)

hydrocodone pharmacodynamics pathway (ISO)

hydroflumethiazide pharmacodynamics pathway (ISO)

hydromorphone pharmacodynamics pathway (ISO)

ibutilide pharmacodynamics pathway (ISO)

iminoglycinuria pathway (ISO)

imipramine pharmacodynamics pathway (ISO)

isoprenaline pharmacodynamics pathway (ISO)

isradipine pharmacodynamics pathway (ISO)

lactose degradation pathway (ISO)

levacetylmethadol pharmacodynamics pathway (ISO)

levobunolol pharmacodynamics pathway (ISO)

levobupivacaine phgarmacodynamics pathway (ISO)

levorphanol pharmacodynamics pathway (ISO)

lidocaine pharmacodynamics pathway (ISO)

lysinuric protein intolerance pathway (ISO)

mepivacaine pharmacodynamics pathway (ISO)

methadone pharmacodynamics pathway (ISO)

metolazone pharmacodynamics pathway (ISO)

metoprolol pharmacodynamics pathway (ISO)

mexiletine pharmacodynamics pathway (ISO)

nadolol pharmacodynamics pathway (ISO)

nalbuphine pharmacodynamics pathway (ISO)

naloxone pharmacodynamics pathway (ISO)

naltrexone pharmacodynamics pathway (ISO)

nebivolol pharmacodynamics pathway (ISO)

nicotine pharmacodynamics pathway (ISO)

nifedipine pharmacodynamics pathway (ISO)

nimodipine pharmacodynamics pathway (ISO)

nisoldipine pharmacodynamics pathway (ISO)

nitrendipine pharmacodynamics pathway (ISO)

oxybuprocaine pharmacodynamics pathway (ISO)

oxycodone pharmacodynamics pathway (ISO)

oxymorphone pharmacodynamics pathway (ISO)

penbutolol pharmacodynamics pathway (ISO)

pentazocine pharmacodynamics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

pindolol pharmacodynamics pathway (ISO)

prilocaine pharmacodynamics pathway (ISO)

procainamide pharmacodynamics pathway (ISO)

procaine pharmacodynamics pathway (ISO)

propranolol pharmacodynamics pathway (ISO)

quinidine pharmacodynamics pathway (ISO)

remifentanil pharmacodynamics pathway (ISO)

ropivacaine pharmacodynamics pathway (ISO)

sotalol pharmacodynamics pathway (ISO)

spironolactone pharmacodynamics pathway (ISO)

timolol pharmacodynamics pathway (ISO)

torasemide pharmacodynamics pathway (ISO)

tramadol pharmacodynamics pathway (ISO)

trehalose degradation pathway (ISO)

triamterene pharmacodynamics pathway (ISO)

trichlormethiazide pharmacodynamics pathway (ISO)

verapamil pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Atp1a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	19,536,634 - 19,564,580 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955435	19,537,224 - 19,563,631 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATP1A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	116,373,244 - 116,404,774 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	116,372,668 - 116,410,261 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	116,915,866 - 116,947,396 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	116,717,359 - 116,748,919 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	116,627,877 - 116,659,436	NCBI
Celera	1	115,144,421 - 115,176,022 (+)	NCBI		Celera
Cytogenetic Map	1	p13.1	NCBI
HuRef	1	114,773,961 - 114,805,562 (+)	NCBI		HuRef
CHM1_1	1	117,030,620 - 117,062,221 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	116,381,314 - 116,412,844 (+)	NCBI		T2T-CHM13v2.0

Atp1a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	101,483,535 - 101,512,023 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	101,483,535 - 101,512,000 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	101,576,219 - 101,604,707 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	101,576,219 - 101,604,684 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	101,380,146 - 101,408,580 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	101,705,284 - 101,733,721 (-)	NCBI		MGSCv36	mm8
Celera	3	103,788,093 - 103,816,528 (-)	NCBI		Celera
Cytogenetic Map	3	F2.2	NCBI
cM Map	3	44.3	NCBI

Atp1a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	191,709,311 - 191,737,414 (-)	NCBI		GRCr8
mRatBN7.2	2	189,020,722 - 189,048,826 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	189,020,722 - 189,048,837 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	196,653,579 - 196,681,622 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	194,505,708 - 194,533,839 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	189,331,424 - 189,359,536 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	204,003,742 - 204,032,023 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	204,003,742 - 204,032,023 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	223,440,514 - 223,469,880 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	196,657,749 - 196,687,242 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	196,620,502 - 196,649,996 (-)	NCBI
Celera	2	181,455,492 - 181,483,650 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

ATP1A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	109,022,509 - 109,054,043 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	108,622,152 - 108,653,661 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	86,162,401 - 86,193,883 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	121,212,161 - 121,232,876 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	121,212,488 - 121,243,099 (-)	Ensembl	panpan1.1		panPan2

ATP1A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	53,828,482 - 53,847,043 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	53,813,976 - 53,847,167 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	53,476,043 - 53,494,904 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	54,699,283 - 54,728,846 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	54,699,543 - 54,728,855 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	53,747,272 - 53,766,129 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	53,783,159 - 53,802,012 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	54,356,732 - 54,375,594 (+)	NCBI		UU_Cfam_GSD_1.0

Atp1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	12,904,636 - 12,933,790 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936627	1,554,873 - 1,584,638 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936627	1,555,151 - 1,584,370 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP1A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	104,353,508 - 104,384,547 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	104,353,506 - 104,384,321 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	114,431,993 - 114,451,892 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	4	q1.6-q2.3	NCBI

ATP1A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	17,319,440 - 17,351,054 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	17,315,117 - 17,351,054 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	20,010,534 - 20,042,335 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp1a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	12,099,435 - 12,127,737 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	12,099,523 - 12,127,437 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005389040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01033432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01033433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01021062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000008305 ⟹ ENSCLAP00000008179

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955435	19,536,634 - 19,564,580 (+)	Ensembl

RefSeq Acc Id:

XM_005389040 ⟹ XP_005389097

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955435	19,537,224 - 19,563,631 (+)	NCBI

Sequence:

show sequence

TTAGGAAGTGAGGAGGAGGCGCAGGCTCGAGCTGCGGCGGGGTCTGGGGCGCAGAGCGGCGCCG
GGAGGAGGCGGACACGTGGCAGAAGAAGCGGCAGCGGCCCCGGCGGCGGCGGCGGCAGCAGCCT
GGGCGGCGGCATCGGCCCTCCCGCTCCGCGGCAGCCCTAGCTCCCTCCCCTCGGCTCCCCCGGC
CCCGCTCGCCCGGCCGGGAGCTGCTCTCTGCTCTCCCTGCTCTCCAGCAACAGGACCGCGCGCC
GCGCGCCGAGCACCGCCACCATGGGGAAGGGGGTTGGACGTGATAAATATGAACCCGCAGCCGT
TTCAGAACAAGGCGACAAAAAGAGCAGAAAGGCCAAGAAAGAGAGGGATATGGATGAACTGAAG
AAAGAAGTTTCTATGGATGACCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAG
ACTTGAGCCGCGGCTTAACCGCTGCTCGGGCTGCTGAGATCCTGGCCCGAGATGGTCCTAATTC
CCTCACACCCCCTCCCACTACACCTGAATGGGTCAAATTCTGCCGGCAGCTGTTTGGAGGGTTC
TCGATGTTACTGTGGATTGGAGCAATACTTTGCTTCTTGGCCTATGGCATTGAAAGTTTAAGCA
TGGAAGAGGGACCTTCAAACGATAATCTGTATCTTGGTGTGGTGCTGTCTGCTGTCGTCATCAT
AACTGGCTGTTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATTATGGATTCCTTCAAAAAC
ATGGTCCCTCAGCAAGCTCTAGTGATTCGAAATGGTGAGAAAATGAGCATCAATGCAGAAGATG
TTGTAGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACAGAATCCCTGCTGATCTCCGAATCAT
ATCTGCAAATGGCTGCAAGGTGGATAACTCCTCCCTCACTGGTGAATCAGAACCCCAGACTAGG
TCTCCGGATTTCACAAATGAAAATCCCTTGGAGACCAGGAATATTGCCTTTTTTTCAACCAACT
GTGTCGAAGGCACTGCTCGTGGCATTGTTGTGTACACTGGGGACCGCACTGTGATGGGAAGGAT
TGCTACCCTGGCTTCTGGGCTAGAAGGAGGCCAGACACCCATTGCTGCAGAAATTGAACATTTC
ATCCACATCATCACGGGTGTGGCTGTGTTCCTGGGAGTGTCTTTCTTCATCCTTTCTCTAATCC
TCGAGTACACCTGGCTTGAGGCTGTCATCTTCCTCATTGGCATTATCGTAGCCAATGTGCCAGA
AGGATTGCTGGCCACTGTCACGGTGTGTCTGACGCTTACTGCCAAACGCATGGCGCGGAAGAAC
TGCTTGGTGAAGAACTTAGAAGCTGTGGAAACGTTGGGATCCACATCTACCATCTGCTCAGATA
AAACTGGAACTCTGACTCAAAACCGAATGACAGTGGCCCACATGTGGTTTGACAATCAAATCCA
TGAAGCTGATACAACAGAGAATCAGAGCGGTGTCTCATTCGACAAGACCTCAGCCACCTGGCTT
GCTCTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACATAC
CTATTCTTAAGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTGTTAAAATGCATTGAGCT
GTGCTGTGGATCTGTGAAGGATATGAGAGACAGATATGCCAAGATCGTGGAGATACCGTTCAAC
TCCACCAACAAGTACCAGTTATCCATTCATAAGAACCCCAACACAAACGAGCCACGACACCTGT
TGGTGATGAAGGGCGCTCCGGAGAGGATCCTGGACCGGTGCAACTCTATCCTCCTCCATGGCAA
GGAACAGCCCCTGGACGAGGAGCTGAAGGATGCTTTTCAGAACGCCTACCTGGAGCTGGGTGGC
CTTGGAGAGCGAGTGCTGGGTTTCTGCCACCTTCATCTACCAGATGAACAGTTTCCAGAAGGGT
TCCAGTTTGACACTGATGAAGTGAATTTCCCCCTGGATAATCTCTGCTTTGTTGGGCTCATCTC
CATGATCGACCCCCCTCGGGCTGCTGTTCCTGATGCCGTGGGCAAATGTCGAAGCGCGGGAATT
AAGGTCATCATGGTCACGGGAGACCATCCAATCACAGCGAAAGCCATTGCCAAAGGCGTGGGCA
TCATCTCAGAGGGCAACGAGACTGTGGAAGACATCGCTGCCCGCCTCAACATCCCAGTGAGCCA
GGTGAACCCCAGAGATGCCAAGGCCTGTGTCCTACATGGCAGTGACCTGAAGGACATGAGCCCA
GAGCAGCTGGATGACATTTTGAAGCACCACACTGAGATTGTGTTTGCCAGGACATCCCCTCAAC
AGAAGCTTATCATTGTGGAAGGCTGCCAGAGACAGGGTGCTATTGTGGCCGTCACTGGTGATGG
TGTCAATGACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCAGGCTCC
GACGTGTCTAAACAAGCTGCTGACATGATTCTTTTGGATGACAACTTTGCCTCAATTGTGACTG
GAGTAGAAGAAGGTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTACACCCTAACCAG
TAACATTCCAGAGATCACCCCCTTCCTGATATTTATTATTGCAAACATTCCACTACCACTGGGG
ACTGTCACCATCCTCTGCATTGACTTAGGCACTGACATGGTCCCTGCCATCTCACTGGCGTATG
AGCAAGCTGAGAGTGACATCATGAAAAGACAGCCCAGAAACCCCAAAACTGACAAGCTCGTGAA
CGAGCGGCTGATCAGCATGGCCTATGGACAGATCGGTATGATCCAGGCCCTCGGGGGCTTCTTC
ACTTACTTTGTGATTCTGGCTGAGAATGGCTTCCTTCCAATTCACTTGTTGGGCCTCCGTGTGG
ACTGGGATGACCGCTGGATCAATGACATGGAAGACAGCTATGGGCAGCAGTGGACCTACGAGCA
GAGGAAAATCGTGGAGTTCACTTGCCACACAGCCTTCTTCGTCAGTATTGTGGTGGTGCAGTGG
GCCGACTTGATCATCTGCAAGACCCGGAGGAATTCCGTTTTCCAGCAGGGGATGAAGAACAAGA
TCTTAATATTTGGCCTCTTTGAAGAGACAGCCCTTGCTGCTTTCCTTTCCTACTGCCCTGGAAT
GGGTGTTGCCCTTAGGATGTATCCCCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCC
CTGCTCATCTTCGTGTACGACGAAGTCAGGAAGCTCATCATCAGGCGGCGCCCTGGCGGCTGGG
TGGAGAAGGAAACCTACTACTAGTCCCCATCCTGCACGCCACCGAGCATCATGCCACACACTCT
GCATCCACCCCCATCCCCCTTTGTGTACTTCAGTCTCGGAGTTCAGAACTCTACCCTGGTAGGA
AAGCGCCGGAGCATGTGGGGGAAGCCAGATGTCCTGGAATGAAGCATGTAGCTATAACGGGGGG
TGGGGGGGGGCTGCCTGAAAACATCCATCTACGGGAATGACAGCAGGGGAAGGTTTTTATGTGC
CTTTTTGTTTTTGTAAAAAAGGAAAATCTGGAAAGACTGAAAGAATACATTTTATATCTGGATT
TTTACAAATAAAGATGGCTATTATAATGGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005389097	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000008179
	ENSCLAP00000008179.1

RefSeq Acc Id:

XP_005389097 ⟸ XM_005389040

- UniProtKB:

A0A8C2V201 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGKGVGRDKYEPAAVSEQGDKKSRKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLT
AARAAEILARDGPNSLTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIESLSMEEGPSN
DNLYLGVVLSAVVIITGCFSYYQEAKSSKIMDSFKNMVPQQALVIRNGEKMSINAEDVVVGDLV
EVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR
GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLE
AVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQ
NRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENIPILKRAV
AGDASESALLKCIELCCGSVKDMRDRYAKIVEIPFNSTNKYQLSIHKNPNTNEPRHLLVMKGAP
ERILDRCNSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLHLPDEQFPEGFQFDTDE
VNFPLDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNE
TVEDIAARLNIPVSQVNPRDAKACVLHGSDLKDMSPEQLDDILKHHTEIVFARTSPQQKLIIVE
GCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRL
IFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDI
MKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWI
NDMEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLF
EETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY

hide sequence

RefSeq Acc Id:

ENSCLAP00000008179 ⟸ ENSCLAT00000008305

Protein Domains

Cation-transporting P-type ATPase N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000005733	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000008305	ENTREZGENE
	ENSCLAT00000008305.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1110.10	UniProtKB/TrEMBL
	3.40.50.1000	UniProtKB/TrEMBL
	Calcium-transporting ATPase, cytoplasmic transduction domain A	UniProtKB/TrEMBL
	Calcium-transporting ATPase, transmembrane domain	UniProtKB/TrEMBL
InterPro	ATPase_P-typ_cation-transptr_C	UniProtKB/TrEMBL
	ATPase_P-typ_cation-transptr_N	UniProtKB/TrEMBL
	ATPase_P-typ_cyto_dom_N	UniProtKB/TrEMBL
	ATPase_P-typ_P_site	UniProtKB/TrEMBL
	ATPase_P-typ_TM_dom_sf	UniProtKB/TrEMBL
	ATPase_P-typ_transduc_dom_A_sf	UniProtKB/TrEMBL
	HAD-like_sf	UniProtKB/TrEMBL
	HAD_sf	UniProtKB/TrEMBL
	P-type_ATPase_IIC	UniProtKB/TrEMBL
	P_typ_ATPase	UniProtKB/TrEMBL
	P_typ_ATPase_HD_dom	UniProtKB/TrEMBL
NCBI Gene	Atp1a1	ENTREZGENE
PANTHER	SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA	UniProtKB/TrEMBL
	SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1	UniProtKB/TrEMBL
Pfam	Cation_ATPase	UniProtKB/TrEMBL
	Cation_ATPase_C	UniProtKB/TrEMBL
	Cation_ATPase_N	UniProtKB/TrEMBL
	E1-E2_ATPase	UniProtKB/TrEMBL
PRINTS	CATATPASE	UniProtKB/TrEMBL
	NAKATPASE	UniProtKB/TrEMBL
PROSITE	ATPASE_E1_E2	UniProtKB/TrEMBL
SMART	Cation_ATPase_N	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56784	UniProtKB/TrEMBL
	SSF81653	UniProtKB/TrEMBL
	SSF81660	UniProtKB/TrEMBL
	SSF81665	UniProtKB/TrEMBL
UniProt	A0A8C2V201	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Atp1a1	ATPase Na+/K+ transporting subunit alpha 1		ATPase, Na+/K+ transporting, alpha 1 polypeptide	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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Imported Annotations - SMPDB