Tmem94 (transmembrane protein 94) - Rat Genome Database

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Gene: Tmem94 (transmembrane protein 94) Rattus norvegicus
Analyze
Symbol: Tmem94
Name: transmembrane protein 94
RGD ID: 7685108
Description: Predicted to act upstream of or within embryonic brain development and embryonic heart tube development. Predicted to be located in membrane. Orthologous to human TMEM94 (transmembrane protein 94); INTERACTS WITH thioacetamide; (1->4)-beta-D-glucan (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: developmental pluripotency-associated protein 2-like; LOC102553252
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,490,496 - 101,525,983 (+)NCBIGRCr8
mRatBN7.210100,991,523 - 101,027,046 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,991,573 - 101,027,394 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.010104,313,691 - 104,320,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,320,743 - 104,343,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,970,622 - 103,972,363 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1099,571,676 - 99,579,063 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
Tmem94
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,490,496 - 101,525,983 (+)NCBIGRCr8
mRatBN7.210100,991,523 - 101,027,046 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,991,573 - 101,027,394 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.010104,313,691 - 104,320,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,320,743 - 104,343,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,970,622 - 103,972,363 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1099,571,676 - 99,579,063 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
TMEM94
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,456,635 - 75,500,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,441,159 - 75,500,452 (+)EnsemblGRCh38hg38GRCh38
GRCh371773,452,716 - 73,496,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,964,259 - 71,008,128 (+)NCBINCBI36Build 36hg18NCBI36
Celera1770,046,681 - 70,090,404 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,876,757 - 68,920,090 (+)NCBIHuRef
CHM1_11773,517,714 - 73,561,577 (+)NCBICHM1_1
T2T-CHM13v2.01776,350,056 - 76,393,782 (+)NCBIT2T-CHM13v2.0
Tmem94
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,656,245 - 115,689,859 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,656,259 - 115,690,192 (+)EnsemblGRCm39 Ensembl
GRCm3811115,765,419 - 115,799,033 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,765,433 - 115,799,366 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711115,626,747 - 115,660,347 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,581,608 - 115,615,123 (+)NCBIMGSCv36mm8
Celera11127,526,360 - 127,559,607 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.91NCBI
Tmem94
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555532,329,995 - 2,352,898 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555532,305,425 - 2,353,596 (+)NCBIChiLan1.0ChiLan1.0
TMEM94
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21991,499,570 - 91,542,950 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11796,322,719 - 96,365,298 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01769,407,161 - 69,449,735 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,957,741 - 75,000,604 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1774,972,761 - 75,000,598 (+)Ensemblpanpan1.1panPan2
TMEM94
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,031,459 - 5,067,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,945,418 - 5,055,648 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha95,710,790 - 5,746,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.095,701,574 - 5,737,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl95,617,104 - 5,737,347 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,740,676 - 5,776,491 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,850,826 - 5,886,641 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,911,936 - 5,947,750 (-)NCBIUU_Cfam_GSD_1.0
Tmem94
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,681,867 - 5,717,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594695,175 - 730,999 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936594695,180 - 729,723 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM94
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,870,096 - 5,905,345 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,870,092 - 5,905,789 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,963,992 - 5,965,413 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM94
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,178,237 - 46,223,931 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,177,181 - 46,202,463 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607716,944,169 - 17,031,905 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem94
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248015,282,318 - 5,305,525 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248015,262,610 - 5,306,230 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem94
96 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000005684   ⟹   ENSRNOP00000005684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10100,991,573 - 101,027,394 (+)Ensembl
Rnor_6.0 Ensembl10104,320,743 - 104,343,396 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103363   ⟹   ENSRNOP00000090458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,005,999 - 101,027,394 (+)Ensembl
RefSeq Acc Id: NM_001427145   ⟹   NP_001414074
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,490,496 - 101,525,983 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414074 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005684.5
  ENSRNOP00000090458.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000005684   ⟸   ENSRNOT00000005684
RefSeq Acc Id: ENSRNOP00000090458   ⟸   ENSRNOT00000103363
RefSeq Acc Id: NP_001414074   ⟸   NM_001427145
- UniProtKB: F1LUG5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LUG5-F1-model_v2 AlphaFold F1LUG5 1-1360 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7685108 AgrOrtholog
BioCyc Gene G2FUF-22653 BioCyc
Ensembl Genes ENSRNOG00000004032 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005684.8 UniProtKB/TrEMBL
  ENSRNOT00000103363.1 UniProtKB/TrEMBL
Gene3D-CATH Calcium-transporting ATPase, transmembrane domain UniProtKB/TrEMBL
InterPro ATPase_P-typ_TM_dom_sf UniProtKB/TrEMBL
  TMEM94 UniProtKB/TrEMBL
NCBI Gene LOC102553252 ENTREZGENE
PANTHER PTHR13219 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 94 UniProtKB/TrEMBL
PhenoGen Tmem94 PhenoGen
RatGTEx ENSRNOG00000004032 RatGTEx
Superfamily-SCOP SSF81665 UniProtKB/TrEMBL
UniProt A0A8I6AA40_RAT UniProtKB/TrEMBL
  F1LUG5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tmem94  transmembrane protein 94  LOC102553252  developmental pluripotency-associated protein 2-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102553252  developmental pluripotency-associated protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL