Zfp748 (zinc finger protein 748) - Rat Genome Database

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Gene: Zfp748 (zinc finger protein 748) Rattus norvegicus
Analyze
Symbol: Zfp748 (Ensembl: LOC102549842)
Name: zinc finger protein 748 (Ensembl:zinc finger protein 91-like)
RGD ID: 7600894
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to several human genes including ZNF208 (zinc finger protein 208); ZNF729 (zinc finger protein 729); and ZNF91 (zinc finger protein 91); INTERACTS WITH acrylamide; bisphenol A; Monobutylphthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102549842; zinc finger protein 208; zinc finger protein 208-like; zinc finger protein 91-like
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,903,789 - 36,919,795 (-)NCBIGRCr8
mRatBN7.2135,075,408 - 35,091,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl135,074,172 - 35,091,389 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx134,936,692 - 34,952,699 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,927,542 - 40,943,549 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0135,102,292 - 35,118,295 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0137,947,138 - 37,966,046 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,896,780 - 37,957,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0139,328,320 - 39,347,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera133,641,613 - 33,660,547 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp748
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8136,903,789 - 36,919,795 (-)NCBIGRCr8
mRatBN7.2135,075,408 - 35,091,416 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl135,074,172 - 35,091,389 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx134,936,692 - 34,952,699 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0140,927,542 - 40,943,549 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0135,102,292 - 35,118,295 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0137,947,138 - 37,966,046 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl137,896,780 - 37,957,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0139,328,320 - 39,347,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera133,641,613 - 33,660,547 (-)NCBICelera
Cytogenetic Map1p11NCBI
Zfp748
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391367,686,758 - 67,701,257 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1367,686,760 - 67,701,949 (-)EnsemblGRCm39 Ensembl
GRCm381367,538,641 - 67,553,152 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1367,538,641 - 67,553,830 (-)EnsemblGRCm38mm10GRCm38
MGSCv371367,639,590 - 67,654,088 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361368,037,756 - 68,052,254 (-)NCBIMGSCv36mm8
Celera1369,752,879 - 69,767,385 (+)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1334.54NCBI

Variants

.
Variants in Zfp748
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:612
Count of miRNA genes:272
Interacting mature miRNAs:336
Transcripts:ENSRNOT00000071889
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 17 2 17 2 49 24 33 8
Low 3 42 40 39 2 39 8 10 25 11 8 3 8
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071889   ⟹   ENSRNOP00000067564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl135,074,172 - 35,091,389 (-)Ensembl
Rnor_6.0 Ensembl137,951,840 - 37,957,412 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079626   ⟹   ENSRNOP00000074910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl137,896,780 - 37,957,412 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085560   ⟹   ENSRNOP00000074124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl137,918,572 - 37,957,400 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112714   ⟹   ENSRNOP00000082151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl135,074,172 - 35,089,104 (-)Ensembl
RefSeq Acc Id: NM_001401867   ⟹   NP_001388796
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,903,792 - 36,919,795 (-)NCBI
mRatBN7.2135,075,413 - 35,091,416 (-)NCBI
RefSeq Acc Id: XM_008758701   ⟹   XP_008756923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8136,903,789 - 36,918,571 (-)NCBI
mRatBN7.2135,075,408 - 35,090,195 (-)NCBI
Rnor_6.0137,947,138 - 37,964,418 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001388796 (Get FASTA)   NCBI Sequence Viewer  
  XP_008756923 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067564
  ENSRNOP00000067564.3
  ENSRNOP00000082151
  ENSRNOP00000082151.1
Reference Protein Sequences
RefSeq Acc Id: XP_008756923   ⟸   XM_008758701
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000074910   ⟸   ENSRNOT00000079626
RefSeq Acc Id: ENSRNOP00000074124   ⟸   ENSRNOT00000085560
RefSeq Acc Id: ENSRNOP00000067564   ⟸   ENSRNOT00000071889
RefSeq Acc Id: ENSRNOP00000082151   ⟸   ENSRNOT00000112714
RefSeq Acc Id: NP_001388796   ⟸   NM_001401867
- UniProtKB: M0RD67 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RD67-F1-model_v2 AlphaFold M0RD67 1-889 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7600894 AgrOrtholog
BioCyc Gene G2FUF-61838 BioCyc
Ensembl Genes ENSRNOG00000049259 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071889 ENTREZGENE
  ENSRNOT00000071889.3 UniProtKB/TrEMBL
  ENSRNOT00000112714.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:102549842 UniProtKB/TrEMBL
NCBI Gene LOC102549842 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 485 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp748 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049259 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZUL1_RAT UniProtKB/TrEMBL
  M0RD67 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-14 Zfp748  zinc finger protein 748  LOC102549842  zinc finger protein 91-like  Name and Symbol changed 629549 APPROVED
2013-12-18 LOC102549842  zinc finger protein 91-like      Symbol and Name status set to provisional 70820 PROVISIONAL