Zfp658 (zinc finger protein 658) - Rat Genome Database

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Gene: Zfp658 (zinc finger protein 658) Rattus norvegicus
Analyze
Symbol: Zfp658
Name: zinc finger protein 658
RGD ID: 7541917
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus; INTERACTS WITH 1,2-dimethylhydrazine (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog); arsane (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100362658; LOC102546648; uncharacterized LOC102546648; uncharacterized protein LOC102546648; zinc finger protein 175; zinc finger protein 175-like; zinc finger protein 658-like
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,129,001 - 103,143,510 (+)NCBIGRCr8
mRatBN7.2193,992,467 - 94,005,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,992,469 - 94,005,687 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0199,483,176 - 99,496,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,486,253 - 99,496,209 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,552,436 - 100,582,520 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4193,932,169 - 93,976,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera188,268,498 - 88,281,749 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Zfp658
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,129,001 - 103,143,510 (+)NCBIGRCr8
mRatBN7.2193,992,467 - 94,005,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,992,469 - 94,005,687 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0199,483,176 - 99,496,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,486,253 - 99,496,209 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,552,436 - 100,582,520 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4193,932,169 - 93,976,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera188,268,498 - 88,281,749 (+)NCBICelera
Cytogenetic Map1q22NCBI
ZNF782
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38996,816,164 - 96,933,806 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl996,816,269 - 96,875,623 (-)EnsemblGRCh38hg38GRCh38
GRCh37999,578,551 - 99,616,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36998,619,094 - 98,656,210 (-)NCBINCBI36Build 36hg18NCBI36
Celera970,020,598 - 70,057,714 (-)NCBICelera
Cytogenetic Map9q22.33NCBI
HuRef969,190,144 - 69,227,261 (-)NCBIHuRef
CHM1_1999,726,312 - 99,763,429 (-)NCBICHM1_1
T2T-CHM13v2.09108,957,160 - 109,105,571 (-)NCBIT2T-CHM13v2.0
Zfp175
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,211,794 - 43,225,566 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,211,680 - 43,224,885 (+)EnsemblGRCm39 Ensembl
GRCm38743,562,202 - 43,576,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,562,256 - 43,575,461 (+)EnsemblGRCm38mm10GRCm38
MGSCv37750,817,740 - 50,830,831 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,426,848 - 43,443,503 (+)NCBIMGSCv36mm8
Celera747,042,618 - 47,048,949 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.25NCBI
ZNF782
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21142,601,425 - 42,639,151 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1942,597,426 - 42,640,588 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0967,848,283 - 67,870,501 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1995,968,232 - 95,991,743 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl996,030,591 - 96,068,074 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl995,968,232 - 95,991,680 (-)Ensemblpanpan1.1panPan2
ZNF782
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1170,049,972 - 70,108,165 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl170,050,380 - 70,106,766 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha170,813,212 - 70,871,579 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0170,349,670 - 70,407,617 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl170,349,714 - 70,407,613 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1170,163,268 - 70,221,165 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0169,929,109 - 69,983,761 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0170,637,411 - 70,695,321 (+)NCBIUU_Cfam_GSD_1.0
Znf782
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049446,368,392 - 6,420,710 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936487612,112 - 636,221 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936487584,922 - 637,166 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF782
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1025,283,987 - 25,341,575 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11025,283,962 - 25,341,650 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21076,653,516 - 76,658,795 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF782
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112106,356,141 - 106,425,954 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603894,704,440 - 94,782,494 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zfp658
185 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:165
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000032403, ENSRNOT00000074820
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 51 18 20
Low 3 43 57 41 19 41 8 10 23 17 19 11 8
Below cutoff 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000074820   ⟹   ENSRNOP00000067320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl193,992,469 - 94,005,687 (+)Ensembl
Rnor_6.0 Ensembl199,486,253 - 99,496,209 (+)Ensembl
RefSeq Acc Id: NM_001420023   ⟹   NP_001406952
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,129,089 - 103,142,251 (+)NCBI
mRatBN7.2193,992,526 - 94,005,689 (+)NCBI
RefSeq Acc Id: XM_008759440   ⟹   XP_008757662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,129,001 - 103,143,510 (+)NCBI
mRatBN7.2193,992,467 - 94,005,689 (+)NCBI
Rnor_6.0199,483,176 - 99,496,427 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759441   ⟹   XP_008757663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,129,016 - 103,143,510 (+)NCBI
mRatBN7.2193,992,467 - 94,005,689 (+)NCBI
Rnor_6.0199,483,176 - 99,496,427 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001406952 (Get FASTA)   NCBI Sequence Viewer  
  XP_008757662 (Get FASTA)   NCBI Sequence Viewer  
  XP_008757663 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067320
  ENSRNOP00000067320.1
Reference Protein Sequences
RefSeq Acc Id: XP_008757662   ⟸   XM_008759440
- Peptide Label: isoform X1
- UniProtKB: M0RCK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757663   ⟸   XM_008759441
- Peptide Label: isoform X1
- UniProtKB: M0RCK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067320   ⟸   ENSRNOT00000074820
RefSeq Acc Id: NP_001406952   ⟸   NM_001420023
- UniProtKB: M0RCK0 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RCK0-F1-model_v2 AlphaFold M0RCK0 1-883 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7541917 AgrOrtholog
BioCyc Gene G2FUF-59840 BioCyc
Ensembl Genes ENSRNOG00000023233 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074820.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:102546648 UniProtKB/TrEMBL
NCBI Gene LOC102546648 ENTREZGENE
PANTHER ZINC FINGER PROTEIN ZIC 1 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN ZIC AND GLI UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp658 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023233 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt M0RCK0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-20 Zfp658  zinc finger protein 658  LOC102546648  uncharacterized LOC102546648  Name and Symbol changed 629549 APPROVED
2015-07-29 LOC102546648  uncharacterized LOC102546648  LOC100362658  zinc finger protein 658-like  Data merged from RGD:2324300 737654 PROVISIONAL
2013-12-17 LOC102546648  uncharacterized LOC102546648      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-06 LOC100362658  zinc finger protein 658-like      Symbol and Name status set to provisional 70820 PROVISIONAL