Opn5 (opsin 5) - Rat Genome Database

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Gene: Opn5 (opsin 5) Mus musculus
Analyze
Symbol: Opn5
Name: opsin 5
RGD ID: 737574
MGI Page MGI
Description: Enables 11-cis retinal binding activity and G protein-coupled photoreceptor activity. Involved in entrainment of circadian clock by photoperiod; hyaloid vascular plexus regression; and phototransduction, UV. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human OPN5 (opsin 5).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-coupled receptor 136; G-protein coupled receptor 136; G-protein coupled receptor PGR12; Gpr1; Gpr136; Ne; Neuropsin; opsin-5; PGR; PGR12; TMEM13
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391742,867,670 - 42,922,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1742,867,674 - 42,922,286 (-)EnsemblGRCm39 Ensembl
GRCm381742,556,779 - 42,611,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1742,556,783 - 42,611,395 (-)EnsemblGRCm38mm10GRCm38
MGSCv371742,693,732 - 42,748,262 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361742,020,267 - 42,074,797 (-)NCBIMGSCv36mm8
Celera1745,969,490 - 46,026,568 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
membrane  (IEA)
plasma membrane  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12679517   PMID:14623098   PMID:14623103   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:21267068   PMID:21873635   PMID:22043319   PMID:22972991   PMID:24403072   PMID:24965600   PMID:26392540   PMID:27701413   PMID:28267150   PMID:30240620   PMID:30936473   PMID:31607531  
PMID:32414324   PMID:32543667   PMID:32879486   PMID:34031241   PMID:34743323   PMID:36064446   PMID:37857760   PMID:38206094  


Genomics

Comparative Map Data
Opn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391742,867,670 - 42,922,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1742,867,674 - 42,922,286 (-)EnsemblGRCm39 Ensembl
GRCm381742,556,779 - 42,611,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1742,556,783 - 42,611,395 (-)EnsemblGRCm38mm10GRCm38
MGSCv371742,693,732 - 42,748,262 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361742,020,267 - 42,074,797 (-)NCBIMGSCv36mm8
Celera1745,969,490 - 46,026,568 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.65NCBI
OPN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38647,782,032 - 47,826,381 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl647,781,982 - 47,832,780 (+)EnsemblGRCh38hg38GRCh38
GRCh37647,749,768 - 47,794,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36647,857,757 - 47,902,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 34647,857,756 - 47,900,394NCBI
Celera649,306,026 - 49,350,372 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef647,477,682 - 47,522,032 (+)NCBIHuRef
CHM1_1647,752,716 - 47,797,055 (+)NCBICHM1_1
T2T-CHM13v2.0647,623,816 - 47,668,165 (+)NCBIT2T-CHM13v2.0
Opn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,865,610 - 25,913,315 (+)NCBIGRCr8
mRatBN7.2918,368,393 - 18,416,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,368,416 - 18,415,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx926,956,058 - 27,004,844 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0932,030,602 - 32,079,396 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0930,316,445 - 30,365,243 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0921,045,457 - 21,092,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl921,045,457 - 21,093,172 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0919,906,290 - 19,953,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4914,124,601 - 14,171,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1914,121,922 - 14,169,169 (+)NCBI
Celera916,070,854 - 16,117,985 (+)NCBICelera
Cytogenetic Map9q13NCBI
Opn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543712,171,544 - 12,213,264 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543712,171,544 - 12,197,409 (+)NCBIChiLan1.0ChiLan1.0
OPN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2562,277,660 - 62,320,452 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1658,143,757 - 58,188,013 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0647,364,955 - 47,409,199 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1648,628,456 - 48,672,673 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl648,628,478 - 48,658,119 (+)Ensemblpanpan1.1panPan2
OPN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11215,831,311 - 15,858,121 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1215,831,311 - 15,877,721 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1215,797,418 - 15,824,184 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01216,333,888 - 16,360,664 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1216,333,888 - 16,380,319 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11215,843,016 - 15,869,767 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01215,935,312 - 15,964,118 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01216,083,053 - 16,111,818 (+)NCBIUU_Cfam_GSD_1.0
Opn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494651,193,882 - 51,223,130 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647612,722,563 - 12,766,512 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647612,740,038 - 12,766,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl742,476,125 - 42,527,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1742,476,125 - 42,507,181 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
OPN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11724,478,464 - 24,509,720 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1724,478,672 - 24,508,814 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604447,794,660 - 47,840,617 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Opn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475413,307,738 - 13,332,287 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475413,307,738 - 13,332,287 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Opn5
1907 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:243
Count of miRNA genes:180
Interacting mature miRNAs:211
Transcripts:ENSMUST00000068355
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3098790348039703Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173311897454107028Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
1301474Hcbip2_mhexachlorobenzene induced porphyria 2 (mouse)Not determined173779305545622654Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse

Markers in Region
BB453217  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381742,575,076 - 42,575,182UniSTSGRCm38
MGSCv371742,712,025 - 42,712,131UniSTSGRCm37
Celera1745,987,766 - 45,987,872UniSTS
Cytogenetic Map17B3UniSTS
Whitehead/MRC_RH17548.51UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000068355   ⟹   ENSMUSP00000063542
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1742,867,674 - 42,922,286 (-)Ensembl
GRCm38.p6 Ensembl1742,556,783 - 42,611,395 (-)Ensembl
RefSeq Acc Id: NM_181753   ⟹   NP_861418
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391742,867,674 - 42,922,204 (-)NCBI
GRCm381742,556,783 - 42,611,313 (-)NCBI
MGSCv371742,693,732 - 42,748,262 (-)RGD
Celera1745,969,490 - 46,026,568 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006524453   ⟹   XP_006524516
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391742,867,670 - 42,922,149 (-)NCBI
GRCm381742,556,779 - 42,611,258 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017317518   ⟹   XP_017173007
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391742,905,503 - 42,922,321 (-)NCBI
GRCm381742,594,612 - 42,611,430 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_861418   ⟸   NM_181753
- UniProtKB: Q80T51 (UniProtKB/Swiss-Prot),   Q7TQP1 (UniProtKB/Swiss-Prot),   Q059L5 (UniProtKB/Swiss-Prot),   Q8BYI2 (UniProtKB/Swiss-Prot),   Q6VZZ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006524516   ⟸   XM_006524453
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017173007   ⟸   XM_017317518
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000063542   ⟸   ENSMUST00000068355

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6VZZ7-F1-model_v2 AlphaFold Q6VZZ7 1-377 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2662912 AgrOrtholog
Ensembl Genes ENSMUSG00000043972 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000068355 ENTREZGENE
  ENSMUST00000068355.8 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Peropsin UniProtKB/Swiss-Prot
  Retinal_BS UniProtKB/Swiss-Prot
KEGG Report mmu:353344 UniProtKB/Swiss-Prot
MGD MGI:2662912 ENTREZGENE
NCBI Gene 353344 ENTREZGENE
PANTHER OPSIN UniProtKB/Swiss-Prot
  OPSIN-5 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Opn5 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  PEROPSIN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
  OPSIN UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt OPN5_MOUSE UniProtKB/Swiss-Prot
  Q059L5 ENTREZGENE
  Q6VZZ7 ENTREZGENE
  Q7TQP1 ENTREZGENE
  Q80T51 ENTREZGENE
  Q8BYI2 ENTREZGENE
UniProt Secondary Q059L5 UniProtKB/Swiss-Prot
  Q7TQP1 UniProtKB/Swiss-Prot
  Q80T51 UniProtKB/Swiss-Prot
  Q8BYI2 UniProtKB/Swiss-Prot