IL15 (interleukin 15) - Rat Genome Database

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Keyword

Gene: IL15 (interleukin 15) Homo sapiens

Symbol:

IL15

Name:

interleukin 15

Description:

The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

IL-15; interleukin-15; MGC9721; OTTHUMP00000164616; OTTHUMP00000164617; OTTHUMP00000218093; OTTHUMP00000228804; OTTHUMP00000228805

Orthologs:

Mus musculus : Il15 (interleukin 15) MGI
Rattus norvegicus : Il15 (interleukin 15)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	4	142,342,674 - 142,440,065	+	NCBI
Human Genome Assembly HuRef	4	138,287,515 - 138,384,970	+	NCBI
Human Genome Assembly GRCh37	4	142,557,749 - 142,655,140	+	NCBI
Human Genome Assembly Build 36	4	142,777,204 - 142,874,062	+	NCBI
Human Cytogenetic Map	4	q31		NCBI
Human Genome Assembly	4	142,997,904 - 143,012,216		NCBI