MAT2A (methionine adenosyltransferase II, alpha)

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General
Array IDs

Gene: MAT2A (methionine adenosyltransferase II, alpha) Homo sapiens

Symbol:

MAT2A

Name:

methionine adenosyltransferase II, alpha

Description:

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

adoMet synthase 2; adoMet synthetase 2; MAT 2; MAT-II; MATA2; MATII; methionine adenosyltransferase 2; OTTHUMP00000160677; OTTHUMP00000204973; S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthetase isoform type-2; SAMS2

Orthologs:

Mus musculus : Mat2a (methionine adenosyltransferase II, alpha) MGI
Rattus norvegicus : Mat2a (methionine adenosyltransferase II, alpha)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	85,630,191 - 85,636,494	+	NCBI
Human Genome Assembly HuRef	2	85,662,610 - 85,669,745	+	NCBI
Human Genome Assembly GRCh37	2	85,766,101 - 85,772,403	+	NCBI
Human Genome Assembly Build 36	2	85,619,799 - 85,625,914	+	NCBI
Human Cytogenetic Map	2	p11.2		NCBI
Human Genome Assembly	2	85,677,945 - 85,684,059		NCBI

Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation (Toggle Detail/Summary View)

Gene-Chemical Interaction Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
(-)-epigallocatechin 3-gallate	multiple interactions	EXP		6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAT2A mRNA	CTD	PMID:22079256
1,2,4-trimethylbenzene	increases expression	ISO	RGD:619985	6480464	pseudocumene results in increased expression of MAT2A protein	CTD	PMID:17337753
17beta-estradiol	increases expression	EXP		6480464	Estradiol results in increased expression of MAT2A mRNA	CTD	PMID:19167446 PMID:23019147
17beta-estradiol	increases expression	EXP		6480464	Estradiol results in increased expression of MAT2A mRNA	CTD	PMID:23019147
2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:732781	6480464	Tetrachlorodibenzodioxin results in increased expression of MAT2A mRNA	CTD	PMID:19465110
2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:732781	6480464	Tetrachlorodibenzodioxin affects the expression of MAT2A mRNA	CTD	PMID:21570461
3H-1,2-dithiole-3-thione	decreases expression	ISO	RGD:619985	6480464	1,2-dithiol-3-thione results in decreased expression of MAT2A mRNA	CTD	PMID:19162173
4-phenylbutyric acid	decreases expression	EXP		6480464	4-phenylbutyric acid results in decreased expression of MAT2A mRNA	CTD	PMID:14583596
7,12-dimethyltetraphene	affects expression	ISO	RGD:732781	6480464	9,10-Dimethyl-1,2-benzanthracene affects the expression of MAT2A mRNA	CTD	PMID:21785161
acetaldehyde	decreases expression	EXP		6480464	Acetaldehyde results in decreased expression of MAT2A mRNA	CTD	PMID:23416264
all-trans-retinoic acid	decreases expression	EXP		6480464	Tretinoin results in decreased expression of MAT2A mRNA	CTD	PMID:15498508
arsenic atom	affects expression	EXP		6480464	Arsenic affects the expression of MAT2A mRNA	CTD	PMID:18487201
benzo[a]pyrene	increases expression	EXP		6480464	Benzo(a)pyrene results in increased expression of MAT2A mRNA	CTD	PMID:20106945
benzo[a]pyrene	affects expression	ISO	RGD:732781	6480464	Benzo(a)pyrene affects the expression of MAT2A mRNA	CTD	PMID:22342234
benzo[a]pyrene	increases expression	ISO	RGD:732781	6480464	Benzo(a)pyrene results in increased expression of MAT2A mRNA	CTD	PMID:21569818 PMID:22228805
benzo[a]pyrene	increases expression	ISO	RGD:732781	6480464	Benzo(a)pyrene results in increased expression of MAT2A mRNA	CTD	PMID:21569818
benzo[a]pyrene	decreases expression	ISO	RGD:732781	6480464	Benzo(a)pyrene results in decreased expression of MAT2A mRNA	CTD	PMID:19770486
benzo[a]pyrene	multiple interactions	ISO	RGD:732781	6480464	[Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of MAT2A mRNA	CTD	PMID:21715664
bis(2-ethylhexyl) phthalate	multiple interactions	ISO	RGD:619985	6480464	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAT2A promoter	CTD	PMID:23359474
bisphenol A	decreases expression	ISO	RGD:732781	6480464	bisphenol A results in decreased expression of MAT2A mRNA	CTD	PMID:21932408
bisphenol A	multiple interactions	ISO	RGD:619985	6480464	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAT2A promoter	CTD	PMID:23359474
cadmium sulfate	decreases expression	EXP		6480464	cadmium sulfate results in decreased expression of MAT2A mRNA	CTD	PMID:21783983
cadmium sulfate	decreases expression	EXP		6480464	cadmium sulfate results in decreased expression of MAT2A mRNA	CTD	PMID:12064557 PMID:21783983
cadmium sulfate	decreases expression	EXP		6480464	cadmium sulfate results in decreased expression of MAT2A mRNA	CTD	PMID:21783983 PMID:12064557
chloroprene	increases expression	ISO	RGD:619985	6480464	Chloroprene results in increased expression of MAT2A mRNA	CTD	PMID:23125180
chloroprene	increases expression	ISO	RGD:732781	6480464	Chloroprene results in increased expression of MAT2A mRNA	CTD	PMID:23125180
choline	multiple interactions	ISO	RGD:732781	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAT2A mRNA	CTD	PMID:20938992
clofibrate	decreases expression	ISO	RGD:732781	6480464	Clofibrate results in decreased expression of MAT2A mRNA	CTD	PMID:17585979
cobalt dichloride	decreases expression	EXP		6480464	cobaltous chloride results in decreased expression of MAT2A mRNA	CTD	PMID:19320972
cocaine	affects expression	ISO	RGD:619985	6480464	Cocaine affects the expression of MAT2A mRNA	CTD	PMID:20187946
copper atom	decreases expression	ISO	RGD:619985	6480464	Copper results in decreased expression of MAT2A mRNA	CTD	PMID:22465980
copper(0)	decreases expression	ISO	RGD:619985	6480464	Copper results in decreased expression of MAT2A mRNA	CTD	PMID:22465980
copper(2+) sulfate	increases expression	EXP		6480464	Copper Sulfate results in increased expression of MAT2A mRNA	CTD	PMID:19549813
Delta(9)-tetrahydrocannabinol	decreases expression	ISO	RGD:732781	6480464	Tetrahydrocannabinol results in decreased expression of MAT2A mRNA	CTD	PMID:12237329
dibutyl phthalate	multiple interactions	ISO	RGD:619985	6480464	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAT2A promoter	CTD	PMID:23359474
dimethyl sulfoxide	increases activity	ISO	RGD:732781	6480464	Dimethyl Sulfoxide results in increased activity of MAT2A protein	CTD	PMID:8373829
ethanol	decreases expression	EXP		6480464	Ethanol results in decreased expression of MAT2A mRNA	CTD	PMID:17869084
fenofibrate	decreases expression	EXP		6480464	Fenofibrate results in decreased expression of MAT2A mRNA	CTD	PMID:16569247
folic acid	multiple interactions	ISO	RGD:732781	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAT2A mRNA	CTD	PMID:20938992
formaldehyde	decreases expression	EXP		6480464	Formaldehyde results in decreased expression of MAT2A mRNA	CTD	PMID:20655997
hydrogen peroxide	affects expression	EXP		6480464	Hydrogen Peroxide affects the expression of MAT2A mRNA	CTD	PMID:20044591
L-methionine	multiple interactions	ISO	RGD:732781	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAT2A mRNA	CTD	PMID:20938992
lead diacetate	decreases expression	ISO	RGD:732781	6480464	lead acetate results in decreased expression of MAT2A mRNA	CTD	PMID:21829687
menadione	affects expression	EXP		6480464	Vitamin K 3 affects the expression of MAT2A mRNA	CTD	PMID:20044591
nickel dichloride	decreases expression	EXP		6480464	nickel chloride results in decreased expression of MAT2A mRNA	CTD	PMID:17312168
paracetamol	affects expression	ISO	RGD:732781	6480464	Acetaminophen affects the expression of MAT2A mRNA	CTD	PMID:17562736
paracetamol	increases expression	ISO	RGD:619985	6480464	Acetaminophen results in increased expression of MAT2A mRNA	CTD	PMID:19103213
perfluorooctanoic acid	increases expression	ISO	RGD:619985	6480464	perfluorooctanoic acid results in increased expression of MAT2A mRNA	CTD	PMID:19162173
phenobarbital	multiple interactions	ISO	RGD:732781	6480464	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MAT2A mRNA]	CTD	PMID:19482888
phenobarbital	increases expression	ISO	RGD:732781	6480464	Phenobarbital results in increased expression of MAT2A mRNA	CTD	PMID:19482888
pirinixic acid	multiple interactions	EXP		6480464	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAT2A mRNA	CTD	PMID:19710929
pirinixic acid	increases expression	ISO	RGD:732781	6480464	pirinixic acid results in increased expression of MAT2A mRNA	CTD	PMID:17950772 more ...
pirinixic acid	increases expression	ISO	RGD:732781	6480464	pirinixic acid results in increased expression of MAT2A mRNA	CTD	PMID:18301758 more ...
pirinixic acid	increases expression	ISO	RGD:732781	6480464	pirinixic acid results in increased expression of MAT2A mRNA	CTD	PMID:18445702 more ...
pirinixic acid	multiple interactions	ISO	RGD:732781	6480464	PPARA protein promotes the reaction [pirinixic acid results in increased expression of MAT2A mRNA]	CTD	PMID:17950772
pirinixic acid	increases expression	ISO	RGD:732781	6480464	pirinixic acid results in increased expression of MAT2A mRNA	CTD	PMID:17950772 more ...
progesterone	decreases expression	EXP		6480464	Progesterone results in decreased expression of MAT2A mRNA	CTD	PMID:18037150
resveratrol	increases expression	EXP		6480464	resveratrol results in increased expression of MAT2A mRNA	CTD	PMID:19167446
S-adenosyl-L-methionine	increases chemical synthesis	ISO	RGD:732781	6480464	MAT2A protein results in increased chemical synthesis of S-Adenosylmethionine	CTD	PMID:8373829
tamibarotene	decreases expression	EXP		6480464	Am 80 results in decreased expression of MAT2A mRNA; more ...	CTD	PMID:15498508
tetrachloromethane	increases expression	ISO	RGD:619985	6480464	Carbon Tetrachloride results in increased expression of MAT2A mRNA	CTD	PMID:17485851
thioacetamide	increases expression	ISO	RGD:619985	6480464	Thioacetamide results in increased expression of MAT2A mRNA; more ...	CTD	PMID:10216131
trans-resveratrol	increases expression	EXP		6480464	resveratrol results in increased expression of MAT2A mRNA	CTD	PMID:19167446
valproic acid	affects expression	ISO	RGD:732781	6480464	Valproic Acid affects the expression of MAT2A mRNA	CTD	PMID:17292431 PMID:17963808
valproic acid	decreases expression	ISO	RGD:732781	6480464	Valproic Acid results in decreased expression of MAT2A mRNA	CTD	PMID:20546886 PMID:21427059
valproic acid	decreases expression	ISO	RGD:732781	6480464	Valproic Acid results in decreased expression of MAT2A mRNA	CTD	PMID:21427059 PMID:20546886
valproic acid	affects expression	ISO	RGD:732781	6480464	Valproic Acid affects the expression of MAT2A mRNA	CTD	PMID:17963808 PMID:17292431
valproic acid	decreases expression	ISO	RGD:732781	6480464	Valproic Acid results in decreased expression of MAT2A mRNA	CTD	PMID:21427059
zinc atom	multiple interactions	EXP		6480464	[PCI 5002 co-treated with Zinc] results in increased expression of MAT2A mRNA	CTD	PMID:18593933
zinc(0)	multiple interactions	EXP		6480464	[PCI 5002 co-treated with Zinc] results in increased expression of MAT2A mRNA	CTD	PMID:18593933

Gene Ontology Annotations

Biological Process

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
cellular nitrogen compound metabolic process		TAS		2290271	Reactome:REACT_13	Reactome	Reactome:REACT_13
methylation		TAS		2290271	Reactome:REACT_6946	Reactome	Reactome:REACT_6946
one-carbon metabolic process		IEA	UniProtKB-KW:KW-0554	2290271	GO_REF:0000037	UniProtKB	GO_REF:0000037
one-carbon metabolic process		IEA	UniProtKB-KW:KW-0554	2290271	GO_REF:0000038	UniProtKB	GO_REF:0000038
S-adenosylmethionine biosynthetic process		IEA	UniPathway:UPA00315	2290271	GO_REF:0000041	UniPathway	GO_REF:0000041
small molecule metabolic process		TAS		2290271	Reactome:REACT_111217	Reactome	Reactome:REACT_111217
sulfur amino acid metabolic process		TAS		2290271	Reactome:REACT_115639	Reactome	Reactome:REACT_115639
xenobiotic metabolic process		TAS		2290271	Reactome:REACT_13433	Reactome	Reactome:REACT_13433
xenobiotic metabolic process		TAS		2290271	Reactome:REACT_6959	Reactome	Reactome:REACT_6959

Cellular Component

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
cytosol		TAS		2290271	Reactome:REACT_6819	Reactome	Reactome:REACT_6819

Molecular Function

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
ATP binding		IEA	UniProtKB-KW:KW-0067	2290271	GO_REF:0000037	UniProtKB	GO_REF:0000037
ATP binding		IEA	UniProtKB-KW:KW-0067	2290271	GO_REF:0000038	UniProtKB	GO_REF:0000038
metal ion binding		IEA	UniProtKB-KW:KW-0479	2290271	GO_REF:0000037	UniProtKB	GO_REF:0000037
metal ion binding		IEA	UniProtKB-KW:KW-0479	2290271	GO_REF:0000038	UniProtKB	GO_REF:0000038
methionine adenosyltransferase activity		IEA	EC:2.5.1.6	2290271	GO_REF:0000003	UniProtKB	GO_REF:0000003

Molecular Pathway Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
cysteine and methionine metabolic pathway		IEA	RGD:737506	6907045		KEGG	hsa:00270
methionine cycle/metabolic pathway		TAS		7242425		RGD
methionine cycle/metabolic pathway		ISS		1359040		RGD

External Database Links
KEGG Pathway	Cysteine and methionine metabolism
	Metabolic pathways
Pathway Interaction Database	C-MYB transcription factor network (PID:200153)

Gene-Chemical Interaction Annotations

	(-)-epigallocatechin 3-gallate (EXP)
	1,2,4-trimethylbenzene (ISO)
	17beta-estradiol (EXP)
	2,3,7,8-tetrachlorodibenzodioxine (ISO)
	3H-1,2-dithiole-3-thione (ISO)
	4-phenylbutyric acid (EXP)
	7,12-dimethyltetraphene (ISO)
	acetaldehyde (EXP)
	all-trans-retinoic acid (EXP)
	arsenic atom (EXP)
	benzo[a]pyrene (EXP,ISO)
	bis(2-ethylhexyl) phthalate (ISO)
	bisphenol A (ISO)
	cadmium sulfate (EXP)
	chloroprene (ISO)
	choline (ISO)
	clofibrate (ISO)

	cobalt dichloride (EXP)
	cocaine (ISO)
	copper atom (ISO)
	copper(0) (ISO)
	copper(2+) sulfate (EXP)
	Delta(9)-tetrahydrocannabinol (ISO)
	dibutyl phthalate (ISO)
	dimethyl sulfoxide (ISO)
	ethanol (EXP)
	fenofibrate (EXP)
	folic acid (ISO)
	formaldehyde (EXP)
	hydrogen peroxide (EXP)
	L-methionine (ISO)
	lead diacetate (ISO)
	menadione (EXP)
	nickel dichloride (EXP)

	paracetamol (ISO)
	perfluorooctanoic acid (ISO)
	phenobarbital (ISO)
	pirinixic acid (EXP,ISO)
	progesterone (EXP)
	resveratrol (EXP)
	S-adenosyl-L-methionine (ISO)
	tamibarotene (EXP)
	tetrachloromethane (ISO)
	thioacetamide (ISO)
	trans-resveratrol (EXP)
	valproic acid (ISO)
	zinc atom (EXP)
	zinc(0) (EXP)

Gene Ontology Annotations

Biological Process

	cellular nitrogen compound metabolic process (TAS)
	methylation (TAS)
	one-carbon metabolic process (IEA)
	S-adenosylmethionine biosynthetic process (IEA)

	small molecule metabolic process (TAS)
	sulfur amino acid metabolic process (TAS)
	xenobiotic metabolic process (TAS)

Cellular Component

cytosol (TAS)

Molecular Function

	ATP binding (IEA)
	metal ion binding (IEA)

methionine adenosyltransferase activity (IEA)

Molecular Pathway Annotations

	cysteine and methionine metabolic pathway (IEA)
	methionine cycle/metabolic pathway (ISS,TAS)

External Database Links
KEGG Pathway	Cysteine and methionine metabolism
	Metabolic pathways
Pathway Interaction Database	C-MYB transcription factor network (PID:200153)

References - curated

1.	Garcia-Trevijano ER, etal., FASEB J 2000 Dec;14(15):2511-8.
2.	GOA_HUMAN data from the GO Consortium
3.	KEGG
4.	Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
5.	Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology
6.	RGD automated import pipeline for gene-chemical interactions

References - uncurated

PubMed	12477932
	12660248
	12671891
	1426236
	14530285
	15489334
	15815621
	16413417
	17631143
	18041713
	18423013
	18781797
	19019082
	19048023
	19048631
	19161160
	19322201
	19683694
	19913121
	20615890
	20628086
	20634891
	21139048
	21145461
	21247894
	21362551
	21406062
	21460102
	21890473
	21906983
	21963094
	21987572
	22318685
	22505724
	22863883
	22879628
	22939629
	22952844
	23000965
	23184937
	23349634
	7213623
	7665609
	9703951

RGD Disease Portals

MAT2A has been annotated in the following RGD Disease Portals.

Neurological Pathways

Respiratory Pathways

Genomics

Comparative Map Data

MAT2A (Homo sapiens)

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	85,630,191 - 85,636,494	+	NCBI
Human Genome Assembly HuRef	2	85,662,610 - 85,669,745	+	NCBI
Human Genome Assembly GRCh37	2	85,766,101 - 85,772,403	+	NCBI
Human Genome Assembly Build 36	2	85,619,799 - 85,625,914	+	NCBI
Human Cytogenetic Map	2	p11.2		NCBI
Human Genome Assembly	2	85,677,945 - 85,684,059		NCBI

Mat2a (Mus musculus)

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	6	72,432,799 - 72,439,558	-	NCBI
Mouse cM Map	6		-	NCBI
Mouse Celera Assembly	6	74,527,849 - 74,534,608	-	NCBI
Mouse Genome Assembly Build 37	6	72,382,793 - 72,389,552	-	NCBI
Mouse Genome Assembly Build 36.1	6	72,382,793 - 72,389,552	-	NCBI
Mouse Cytogenetic Map	6	C1		NCBI

Mat2a (Rattus norvegicus)

Map	Chr	Position	Strand	Source
Rat Cytogenetic Map	4	q33		NCBI
RGSC Genome Assembly v5.0	4	165,067,990 - 165,073,559	-	NCBI
RGSC Genome Assembly v3.4	4	105,739,943 - 105,745,472	-	NCBI
Rat Celera Assembly	4	93,642,240 - 93,647,807	-	NCBI
Genome Assembly 3.1	4	105,984,423 - 105,989,953	-	NCBI

Position Markers

ECD05697

Map	Chr	Position	Source
Human Alternate Assembly CRA_TCAGchr7v2	7	89,850,543 - 89,851,272	UniSTS
Human Genome Assembly HuRef	7	85,128,155 - 85,128,884	UniSTS
Human Genome Assembly HuRef	2	85,663,155 - 85,663,883	UniSTS
Human Genome Assembly GRCh37	7	90,519,781 - 90,520,510	UniSTS
Human Celera Assembly	7	85,223,784 - 85,224,513	RGD
Human Genome Assembly Build 36	7	90,357,717 - 90,358,446	RGD
Human Cytogenetic Map	2	p11.2	UniSTS
Human Cytogenetic Map	7	q21-q22	UniSTS

REN109121

Map	Chr	Position	Source
Human Alternate Assembly CRA_TCAGchr7v2	7	89,850,854 - 89,851,102	UniSTS
Human Genome Assembly HuRef	7	85,128,466 - 85,128,714	UniSTS
Human Genome Assembly HuRef	2	85,663,465 - 85,663,713	UniSTS
Human Genome Assembly GRCh37	7	90,520,092 - 90,520,340	UniSTS
Human Celera Assembly	7	85,224,095 - 85,224,343	RGD
Human Genome Assembly Build 36	7	90,358,028 - 90,358,276	RGD

REN109122

Map	Chr	Position	Source
Human Alternate Assembly CRA_TCAGchr7v2	7	89,851,099 - 89,851,351	UniSTS
Human Genome Assembly HuRef	7	85,128,711 - 85,128,963	UniSTS
Human Genome Assembly HuRef	2	85,663,710 - 85,663,962	UniSTS
Human Genome Assembly GRCh37	7	90,520,337 - 90,520,589	UniSTS
Human Celera Assembly	7	85,224,340 - 85,224,592	RGD
Human Genome Assembly Build 36	7	90,358,273 - 90,358,525	RGD

D3S3930

Map	Chr	Position	Source
Human Whitehead-YAC Contig Map	3		UniSTS
Human Genome Assembly HuRef	3	109,797,509 - 109,797,611	UniSTS
Human Genome Assembly HuRef	2	85,669,428 - 85,669,530	UniSTS
Human Genome Assembly GRCh37	3	112,414,470 - 112,414,572	UniSTS
Human Genome Assembly GRCh37	2	85,772,086 - 85,772,188	UniSTS
Human Celera Assembly	2	85,600,274 - 85,600,376	RGD
Human Celera Assembly	3	110,823,119 - 110,823,221	UniSTS
Human Genome Assembly Build 36	2	85,625,597 - 85,625,699	RGD
Human Cytogenetic Map	2	p11.2	UniSTS
Human Cytogenetic Map	2	p12	UniSTS

QTLs in Region (Human Genome Assembly GRCh37)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558699	HRV2_H	Heart rate variability QTL 2 (human)	1.81		Heart rate variability	low-frequency power	2	59291776	208725006	Human
1578611	SCL132_H	Serum cholesterol level QTL 132 (human)	2		Lipid level	HDL cholesterol	2	60139274	86139274	Human
2289213	BW346_H	Body weight QTL 346 (human)		.003	Body fat amount	percent fat	2	60139274	86139274	Human
1643504	BW283_H	Body Weight QTL 283 (human)	1.71	.0025	Body weight		2	65520531	91520531	Human
2314585	INSUL9_H	Insulin level QTL 9 (human)	2.35	.057268	Insulin level	fasting	2	65520531	91520531	Human
1298483	BP10_H	Blood pressure QTL 10 (human)	3.92		Blood pressure	diastolic	2	72075436	98075436	Human
1576346	MYI10_H	Myocardial infarction susceptibility QTL 10 (human)	3.3		Myocardial infarction susceptibility	early-onset	2	72075436	98075436	Human
1576334	MYI2_H	Myocardial infarction susceptibility QTL 2 (human)	3.82		Myocardial infarction susceptibility	early-onset	2	72075436	98075436	Human
2314570	INSUL12_H	Insulin level QTL 12 (human)	2.62	.031075	Insulin level	insulin resistance	2	72075436	98075436	Human
2293377	PRSTS236_H	Prostate tumor susceptibility QTL 236 (human)	1.58		Prostate tumor susceptibility		2	72075436	98075436	Human
1300023	BP46_H	Blood pressure QTL 46 (human)	2.26	.00062	Blood pressure	systolic	2	75830381	218576756	Human
2289379	BW419_H	Body weight QTL 419 (human)	3.57	.00002	Body morphometry		2	79763534	102419860	Human
2289436	BW397_H	Body weight QTL 397 (human)	4.04		Body weight	BMI	2	85488426	156283230	Human

Sequence

Nucleotide Sequences

Nucleotide RefSeqs	NG_029183	(Get FASTA)	Search GEO for Microarray Profiles
	NM_005911	(Get FASTA)	Search GEO for Microarray Profiles
GenBank Nucleotide	ABBA01075756	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01075757	(Get FASTA)	Search GEO for Microarray Profiles
	AC016753	(Get FASTA)	Search GEO for Microarray Profiles
	AK291126	(Get FASTA)	Search GEO for Microarray Profiles
	AK293841	(Get FASTA)	Search GEO for Microarray Profiles
	AK297758	(Get FASTA)	Search GEO for Microarray Profiles
	AK297797	(Get FASTA)	Search GEO for Microarray Profiles
	AK303877	(Get FASTA)	Search GEO for Microarray Profiles
	AK308591	(Get FASTA)	Search GEO for Microarray Profiles
	AK308758	(Get FASTA)	Search GEO for Microarray Profiles
	AK309338	(Get FASTA)	Search GEO for Microarray Profiles
	AK316411	(Get FASTA)	Search GEO for Microarray Profiles
	AMYH01010496	(Get FASTA)	Search GEO for Microarray Profiles
	BC001686	(Get FASTA)	Search GEO for Microarray Profiles
	BC001854	(Get FASTA)	Search GEO for Microarray Profiles
	BI549760	(Get FASTA)	Search GEO for Microarray Profiles
	CH471053	(Get FASTA)	Search GEO for Microarray Profiles
	DC322518	(Get FASTA)	Search GEO for Microarray Profiles
	DQ083239	(Get FASTA)	Search GEO for Microarray Profiles
	X68836	(Get FASTA)	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_005911

RefSeq Status:

REVIEWED

Type:

CODING

Protein Acc Id:

NP_005902

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	85,630,191 - 85,636,494	+	NCBI
Human Genome Assembly HuRef	2	85,662,610 - 85,669,745	+	ENTREZGENE
Human Genome Assembly GRCh37	2	85,766,101 - 85,772,403	+	ENTREZGENE
Human Genome Assembly Build 36	2	85,619,799 - 85,625,914	+	NCBI Archive

Protein Sequences

Protein RefSeqs	NP_005902	(Get FASTA)
GenBank Protein	AAH01686	(Get FASTA)
	AAH01854	(Get FASTA)
	AAY24339	(Get FASTA)
	AAY85355	(Get FASTA)
	ADZ15336	(Get FASTA)
	BAF83815	(Get FASTA)
	BAG57239	(Get FASTA)
	BAG60107	(Get FASTA)
	BAG60136	(Get FASTA)
	BAG64814	(Get FASTA)
	BAH14782	(Get FASTA)
	CAA48726	(Get FASTA)
	EAW99511	(Get FASTA)
	EAW99512	(Get FASTA)
	EAW99513	(Get FASTA)
	EAW99514	(Get FASTA)
	P31153	(Get FASTA)

Promoters

RGD ID:

6797307

Promoter ID:

HG_KWN:33549

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

ENST00000409017, ENST00000410008, NM_005911, OTTHUMT00000329404, OTTHUMT00000329405, OTTHUMT00000329406, OTTHUMT00000329407, OTTHUMT00000329409, OTTHUMT00000329410, OTTHUMT00000329411, OTTHUMT00000329412, UC010FGK.1

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	2	85,619,346 - 85,620,467	+	MPROMDB

RGD ID:

6851364

Promoter ID:

EP73480

Type:

single initiation site

Name:

HS_MAT2A

Description:

Methionine adenosyltransferase II, alpha.

SO ACC ID:

SO:0000170

Source:

EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

NEDO full length human cDNA sequencing project.; Oligo-capping

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	2	85,619,802 - 85,619,862		EPD

RGD ID:

6797781

Promoter ID:

HG_KWN:33550

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell_12Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid

Transcripts:

OTTHUMT00000329413, UC010FGM.1

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	2	85,620,811 - 85,622,317	+	MPROMDB

RGD ID:

6856370

Promoter ID:

EPDNEW_H1350

Type:

initiation region

Name:

GSTM1_1

Description:

glutathione S-transferase mu 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	1	110,230,464 - 110,230,524		EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
COSMIC	MAT2A	COSMIC
Ensembl Genes	ENSG00000168906	ENTREZGENE
Ensembl Protein	ENSP00000303147	ENTREZGENE
Ensembl Transcript	ENST00000306434	ENTREZGENE
Entrez Gene	4144	ENTREZGENE
Germonline	ENSG00000168906
HGNC ID	6904	ENTREZGENE
HomoloGene Group ID	38112	ENTREZGENE
HPRD ID	03275	ENTREZGENE
InterPro	ADOMET_SYNTHASE_CS	UniProtKB/Swiss-Prot
	S-AdoMet_synt_C	UniProtKB/Swiss-Prot
	S-AdoMet_synt_central	UniProtKB/Swiss-Prot
	S-AdoMet_synt_N	UniProtKB/Swiss-Prot
	S-AdoMet_synthetase	UniProtKB/Swiss-Prot
	S-AdoMet_synthetase_sfam	UniProtKB/Swiss-Prot
IPI	IPI00010157	UniProtKB/Swiss-Prot
	IPI00916229	UniProtKB/TrEMBL
KEGG Report	hsa:4144	ENTREZGENE, UniProtKB/Swiss-Prot
OMIM	601468	OMIM
PANTHER	S-AdoMet_synt	UniProtKB/Swiss-Prot
Pfam	S-AdoMet_synt_C	UniProtKB/Swiss-Prot
	S-AdoMet_synt_M	UniProtKB/Swiss-Prot
	S-AdoMet_synt_N	UniProtKB/Swiss-Prot
PharmGKB	PA30647	PharmGKB
PIRSF	MAT	UniProtKB/Swiss-Prot
PROSITE	ADOMET_SYNTHASE_1	UniProtKB/Swiss-Prot
	ADOMET_SYNTHASE_2	UniProtKB/Swiss-Prot
Superfamily-SCOP	S-AdoMet_synt	UniProtKB/Swiss-Prot
TIGRFAMs	MetK	UniProtKB/Swiss-Prot
UniGene	Hs.516157	ENTREZGENE
UniProt	B4DN45_HUMAN	UniProtKB/TrEMBL
	METK2_HUMAN	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-17	MAT2A	methionine adenosyltransferase II, alpha	MAT2A	methionine adenosyltransferase II, alpha	Symbol and/or name change	39860	APPROVED
2011-07-27	MAT2A	methionine adenosyltransferase II, alpha	MAT2A	methionine adenosyltransferase II, alpha	Symbol and/or name change	39860	APPROVED

More on MAT2A

Entrez Gene

Ensembl Gene

Genome Browser:

(hg18) (hg19)

RGD Object Information
RGD ID:	737506
Created:	2004-02-06
Species:	Homo sapiens
Last Modified:	2013-04-30
Status:	ACTIVE