BDKRB2 (bradykinin receptor B2) - Rat Genome Database

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Gene: BDKRB2 (bradykinin receptor B2) Homo sapiens
Analyze
Symbol: BDKRB2
Name: bradykinin receptor B2
RGD ID: 737386
HGNC Page HGNC:1030
Description: Enables several functions, including bradykinin receptor activity; protein heterodimerization activity; and type 1 angiotensin receptor binding activity. Involved in arachidonic acid secretion and vasodilation. Located in Golgi apparatus; endosome; and plasma membrane. Implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Biomarker of asthma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: B2 bradykinin receptor; B2R; BK-2; BK-2 receptor; BK2; BKR2; BRB2; DKFZp686O088
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,204,839 - 96,244,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,204,679 - 96,244,166 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,671,176 - 96,710,501 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,740,950 - 95,780,542 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,740,949 - 95,780,536NCBI
Celera1476,726,862 - 76,766,386 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1476,856,277 - 76,895,774 (+)NCBIHuRef
CHM1_11496,610,085 - 96,649,595 (+)NCBICHM1_1
T2T-CHM13v2.01490,436,088 - 90,475,413 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-noradrenaline  (ISO)
1,2-dichloroethane  (ISO)
15-acetyldeoxynivalenol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3',5'-cyclic GMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxycyclophosphamide  (ISO)
5-fluorouracil  (EXP)
6-oxoprostaglandin F1alpha  (ISO)
8-Br-cAMP  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
allyl isothiocyanate  (EXP)
amlodipine  (ISO)
aristolochic acid A  (EXP)
atenolol  (EXP)
atropine  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (ISO)
capsaicin  (EXP,ISO)
captopril  (ISO)
carbon nanotube  (ISO)
ceruletide  (ISO)
CGP 52608  (EXP)
chondroitin sulfate  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (EXP)
cyclophosphamide  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
fenvalerate  (ISO)
fonofos  (EXP)
formaldehyde  (EXP)
genistein  (ISO)
gentamycin  (ISO)
Hexamethonium  (ISO)
icatibant  (EXP,ISO)
irbesartan  (EXP)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
methoxychlor  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-Nitrosopyrrolidine  (EXP)
nickel atom  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
O-methyleugenol  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (EXP)
PD123319  (ISO)
perfluorohexanesulfonic acid  (ISO)
perindopril  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
potassium dichromate  (ISO)
Pranoprofen  (ISO)
propranolol  (ISO)
ramiprilat  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
streptozocin  (ISO)
sulforaphane  (EXP)
terbufos  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (EXP)
valsartan  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors. Abdouh M, etal., Br J Pharmacol. 2008 May;154(1):136-43. Epub 2008 Mar 3.
2. Efficacy and tolerability of Icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma. Akbary AM, etal., Immunopharmacology. 1996 Jun;33(1-3):238-42.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. Bertram CM, etal., J Leukoc Biol. 2009 Mar;85(3):544-52. Epub 2008 Nov 26.
5. Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. Bujalska M and Makulska-Nowak H, Neuro Endocrinol Lett. 2009 Mar;30(1):144-52.
6. Autoradiographic distribution and alterations of kinin B(2) receptors in the brain and spinal cord of streptozotocin-diabetic rats. Campos MM, etal., Synapse. 2005 Dec 1;58(3):184-92.
7. Splanchnic hyposensitivity to glypressin in a hemorrhage-transfused common bile duct-ligated rat model of portal hypertension: role of nitric oxide and bradykinin. Chen CT, etal., Hepatogastroenterology. 2009 Sep-Oct;56(94-95):1261-7.
8. Pharmacologic and autoradiographic evidence for an up-regulation of kinin B(2) receptors in the spinal cord of spontaneously hypertensive rats. Cloutier F, etal., Br J Pharmacol. 2002 Apr;135(7):1641-54.
9. Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist -BK in a F98 glioma rat model: an MRI study. Cote J, etal., Neuropeptides. 2010 Apr;44(2):177-85. Epub 2010 Jan 18.
10. Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X. Dabek J, etal., Scand Cardiovasc J. 2007 Dec;41(6):391-6.
11. Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats. Ellis KM, etal., Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):166-78. Epub 2004 Jan 15.
12. Effects of the bradykinin B2 receptor antagonist S 16118 (p-guanidobenzoyl-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin) in different in vivo animal models of inflammation. Feletou M, etal., J Pharmacol Exp Ther. 1995 Jun;273(3):1078-84.
13. Cyclooxygenase inhibitors attenuate bradykinin-induced vasoconstriction in septic isolated rat lungs. Fischer LG, etal., Anesth Analg. 2000 Mar;90(3):625-31.
14. Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists. Gama Landgraf R, etal., Inflamm Res. 2004 Feb;53(2):78-83. Epub 2004 Jan 26.
15. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
16. Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough. Grilo A, etal., Pharmacogenet Genomics. 2011 Jan;21(1):10-7.
17. +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease. Hopkinson NS, etal., Am J Clin Nutr. 2006 Apr;83(4):912-7.
18. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Kakoki M, etal., Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.
19. Polymorphisms in the bradykinin B2 receptor gene and childhood asthma. Kusser B, etal., Biol Chem. 2001 May;382(5):885-9.
20. Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus. Lee YJ and Tsai JC, Metabolism. 2001 Nov;50(11):1346-50.
21. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Leeb-Lundberg LM, etal., Pharmacol Rev. 2005 Mar;57(1):27-77.
22. Effects of an orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisy. Majima M, etal., Br J Pharmacol. 1997 Jun;121(4):723-30.
23. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
24. Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough. Mukae S, etal., Hypertension. 2000 Jul;36(1):127-31.
25. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. Mukae S, etal., J Hum Hypertens. 2002 Dec;16(12):857-63.
26. Autoradiographic analysis of rat brain kinin B1 and B2 receptors: normal distribution and alterations induced by epilepsy. Ongali B, etal., J Comp Neurol 2003 Jul 7;461(4):506-19.
27. Role of kinin B1 and B2 receptors in a rat model of neuropathic pain. Petcu M, etal., Int Immunopharmacol. 2008 Feb;8(2):188-96. Epub 2007 Sep 29.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia. Poole S, etal., Br J Pharmacol. 1999 Feb;126(3):649-56.
30. Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats. Qadri F, etal., Can J Physiol Pharmacol 2002 Apr;80(4):258-63.
31. Comparative nasal effects of bradykinin, kallidin and [Des-Arg9]-bradykinin in atopic rhinitic and normal volunteers. Rajakulasingam K, etal., J Physiol. 1991 Jun;437:577-87.
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Bradykinin down-regulates LPS-induced eosinophil accumulation in the pleural cavity of mice through type 2-kinin receptor activation: a role for prostaglandins. Silva AR, etal., Br J Pharmacol. 1999 May;127(2):569-75.
35. Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy. Spillmann F, etal., Int Immunopharmacol 2002 Dec;2(13-14):1823-32.
36. Targeted deletion of B2-kinin receptors protects against the development of diabetic nephropathy. Tan Y, etal., Am J Physiol Renal Physiol. 2007 Oct;293(4):F1026-35. Epub 2007 Jun 27.
37. Treatment of severe pulmonary hypertension: a bradykinin receptor 2 agonist B9972 causes reduction of pulmonary artery pressure and right ventricular hypertrophy. Taraseviciene-Stewart L, etal., Peptides. 2005 Aug;26(8):1292-300.
38. Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen. Turner P, etal., J Allergy Clin Immunol. 2001 Jan;107(1):105-13.
39. Hypotension in transgenic mice overexpressing human bradykinin B2 receptor. Wang DZ, etal., Hypertension. 1997 Jan;29(1 Pt 2):488-93.
40. Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans. Woo SW, etal., J Clin Pharm Ther. 2009 Oct;34(5):561-7.
41. Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy. Yuhki K, etal., J Pharmacol Exp Ther. 2004 Dec;311(3):1218-24. Epub 2004 Aug 17.
Additional References at PubMed
PMID:1314587   PMID:1329734   PMID:2834384   PMID:4322742   PMID:6055465   PMID:7779089   PMID:7779090   PMID:7835885   PMID:7916737   PMID:8063797   PMID:8302267   PMID:8394991  
PMID:8652530   PMID:8777990   PMID:8900488   PMID:10085087   PMID:10188626   PMID:10469138   PMID:10510297   PMID:10653985   PMID:10681501   PMID:10748135   PMID:10993080   PMID:11324803  
PMID:11409654   PMID:11446495   PMID:11517230   PMID:11710536   PMID:11747451   PMID:11908480   PMID:11954665   PMID:12025967   PMID:12039525   PMID:12063092   PMID:12107246   PMID:12130679  
PMID:12177051   PMID:12450400   PMID:12477932   PMID:12481150   PMID:12489797   PMID:12640257   PMID:12705334   PMID:12851878   PMID:14499231   PMID:14607851   PMID:15033977   PMID:15112434  
PMID:15114524   PMID:15117835   PMID:15161928   PMID:15281091   PMID:15301669   PMID:15489334   PMID:15634338   PMID:15643125   PMID:15643126   PMID:15654972   PMID:15664511   PMID:15664665  
PMID:15771553   PMID:15805101   PMID:15894833   PMID:16144969   PMID:16263113   PMID:16294326   PMID:16344560   PMID:16461337   PMID:16489763   PMID:16740128   PMID:16754659   PMID:16950802  
PMID:17030791   PMID:17077303   PMID:17110500   PMID:17207964   PMID:17299793   PMID:17303584   PMID:17327486   PMID:17328065   PMID:17363739   PMID:17420253   PMID:17522594   PMID:17569300  
PMID:17593394   PMID:18039523   PMID:18096516   PMID:18180402   PMID:18187413   PMID:18240029   PMID:18258629   PMID:18430865   PMID:18467203   PMID:18577888   PMID:18672896   PMID:18810490  
PMID:18927465   PMID:18938142   PMID:19017652   PMID:19074839   PMID:19082699   PMID:19086053   PMID:19110485   PMID:19120546   PMID:19339996   PMID:19404481   PMID:19420105   PMID:19456859  
PMID:19565561   PMID:19578796   PMID:19580784   PMID:19628666   PMID:19716087   PMID:19725054   PMID:19854233   PMID:19885862   PMID:19913121   PMID:20036225   PMID:20044476   PMID:20045189  
PMID:20050188   PMID:20189583   PMID:20201926   PMID:20300066   PMID:20473401   PMID:20511677   PMID:20592051   PMID:20602751   PMID:20628086   PMID:20856803   PMID:20944660   PMID:20952631  
PMID:21108627   PMID:21145390   PMID:21210858   PMID:21451024   PMID:21586566   PMID:21600887   PMID:21602894   PMID:21626144   PMID:21719759   PMID:21871009   PMID:21873635   PMID:21986469  
PMID:22016392   PMID:22047990   PMID:22108573   PMID:22304584   PMID:22468762   PMID:22653778   PMID:22706224   PMID:22706620   PMID:22810586   PMID:22900090   PMID:22935637   PMID:23093849  
PMID:23127247   PMID:23132855   PMID:23176367   PMID:23224295   PMID:23243416   PMID:23275384   PMID:23351078   PMID:23362199   PMID:23428345   PMID:23454239   PMID:23588115   PMID:23597562  
PMID:23613132   PMID:23730990   PMID:23805043   PMID:23824909   PMID:23826374   PMID:24047499   PMID:24211782   PMID:24236827   PMID:24304135   PMID:24401952   PMID:24667918   PMID:25078958  
PMID:25109623   PMID:25289859   PMID:25529519   PMID:25641172   PMID:25713410   PMID:25842860   PMID:25970620   PMID:26235941   PMID:26360782   PMID:26362411   PMID:26588817   PMID:26764266  
PMID:26907838   PMID:26955769   PMID:26982743   PMID:27007662   PMID:27696692   PMID:28069442   PMID:28077802   PMID:28099911   PMID:28298427   PMID:28757212   PMID:29034546   PMID:29334504  
PMID:29894755   PMID:30206938   PMID:30236981   PMID:30478260   PMID:30817230   PMID:31059006   PMID:31360266   PMID:31552837   PMID:31586073   PMID:32114020   PMID:32361393   PMID:33412234  
PMID:33497625   PMID:33686021   PMID:33961781   PMID:34384552   PMID:35038454   PMID:35132089   PMID:36075965   PMID:36142237   PMID:37703419  


Genomics

Comparative Map Data
BDKRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,204,839 - 96,244,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,204,679 - 96,244,166 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,671,176 - 96,710,501 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,740,950 - 95,780,542 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,740,949 - 95,780,536NCBI
Celera1476,726,862 - 76,766,386 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1476,856,277 - 76,895,774 (+)NCBIHuRef
CHM1_11496,610,085 - 96,649,595 (+)NCBICHM1_1
T2T-CHM13v2.01490,436,088 - 90,475,413 (+)NCBIT2T-CHM13v2.0
Bdkrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,529,431 - 105,561,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,529,485 - 105,561,496 (+)EnsemblGRCm39 Ensembl
GRCm3812105,563,172 - 105,595,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,563,226 - 105,595,237 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,801,382 - 106,831,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612105,964,222 - 105,994,121 (+)NCBIMGSCv36mm8
Celera12106,797,782 - 106,827,683 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.76NCBI
Bdkrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,237,055 - 130,267,205 (+)NCBIGRCr8
mRatBN7.26124,472,317 - 124,502,497 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,472,566 - 124,502,497 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,593,665 - 124,623,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,888,932 - 124,918,906 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,250,138 - 124,280,235 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,399,468 - 129,429,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,399,468 - 129,429,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,615,812 - 138,622,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,744,781 - 129,748,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,748,527 - 129,752,598 (+)NCBI
Celera6122,039,524 - 122,069,422 (+)NCBICelera
RH 3.4 Map6815.41RGD
Cytogenetic Map6q32NCBI
Bdkrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543816,511,759 - 16,537,172 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543816,514,300 - 16,537,160 (-)NCBIChiLan1.0ChiLan1.0
BDKRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21597,363,214 - 97,404,173 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11496,579,702 - 96,620,931 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01476,832,833 - 76,873,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11496,157,122 - 96,196,253 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1496,156,494 - 96,196,253 (+)Ensemblpanpan1.1panPan2
BDKRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1864,974,588 - 65,005,682 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl864,974,997 - 65,003,407 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,490,876 - 64,519,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0865,246,390 - 65,277,067 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl865,246,390 - 65,274,792 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,919,488 - 64,947,871 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0864,980,727 - 65,009,155 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0865,304,383 - 65,332,835 (+)NCBIUU_Cfam_GSD_1.0
Bdkrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086409,528,206 - 9,533,778 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936604548,847 - 549,956 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936604548,844 - 551,031 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BDKRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7117,438,713 - 117,472,005 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17117,438,622 - 117,472,005 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BDKRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12474,084,907 - 74,125,604 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,118,210 - 74,122,909 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605361,236,289 - 61,276,664 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bdkrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247348,513,814 - 8,539,036 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247348,513,601 - 8,538,838 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BDKRB2
19 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2		 pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.2(chr14:95787358-96453757)x3 copy number gain See cases [RCV000052089] Chr14:95787358..96453757 [GRCh38]
Chr14:96253695..96920094 [GRCh37]
Chr14:95323448..95989847 [NCBI36]
Chr14:14q32.13-32.2		 uncertain significance
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:95524407-106879501)x1 copy number loss See cases [RCV000136032] Chr14:95524407..106879501 [GRCh38]
Chr14:95990744..107287708 [GRCh37]
Chr14:95060497..106358753 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
NC_000014.9:g.95696766_96390792dup duplication Acute myeloid leukemia [RCV000190405]|Primary myelofibrosis [RCV000190404]|Thrombocythemia 1 [RCV000190403]|Thrombocythemia 1 [RCV000190406] Chr14:95696766..96390792 [GRCh38]
Chr14:96163103..96857129 [GRCh37]
Chr14:14q32.13-32.2		 likely pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
NM_001379692.1(BDKRB2):c.621C>A (p.Asn207Lys) single nucleotide variant Inborn genetic diseases [RCV003247886] Chr14:96240949 [GRCh38]
Chr14:96707286 [GRCh37]
Chr14:14q32.2		 uncertain significance
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3 copy number gain See cases [RCV000512497] Chr14:73750741..107285437 [GRCh37]
Chr14:14q24.2-32.33		 pathogenic
GRCh37/hg19 14q32.2(chr14:96641506-97154180)x3 copy number gain not provided [RCV000683609] Chr14:96641506..97154180 [GRCh37]
Chr14:14q32.2		 uncertain significance
GRCh37/hg19 14q31.2-32.2(chr14:84783137-96908198)x1 copy number loss not provided [RCV000683625] Chr14:84783137..96908198 [GRCh37]
Chr14:14q31.2-32.2		 pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q32.2(chr14:96679050-96688669)x1 copy number loss not provided [RCV000751100] Chr14:96679050..96688669 [GRCh37]
Chr14:14q32.2		 benign
GRCh37/hg19 14q32.12-32.33(chr14:91969028-107285437)x3 copy number gain not provided [RCV000848687] Chr14:91969028..107285437 [GRCh37]
Chr14:14q32.12-32.33		 pathogenic
NM_001379692.1(BDKRB2):c.1062G>A (p.Gly354=) single nucleotide variant not provided [RCV000882344] Chr14:96241390 [GRCh38]
Chr14:96707727 [GRCh37]
Chr14:14q32.2		 likely benign
NM_001379692.1(BDKRB2):c.933T>C (p.Asp311=) single nucleotide variant not provided [RCV000906020] Chr14:96241261 [GRCh38]
Chr14:96707598 [GRCh37]
Chr14:14q32.2		 benign
NM_001379692.1(BDKRB2):c.1114A>G (p.Thr372Ala) single nucleotide variant Inborn genetic diseases [RCV003251274] Chr14:96241442 [GRCh38]
Chr14:96707779 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.599A>C (p.Glu200Ala) single nucleotide variant Inborn genetic diseases [RCV003275559] Chr14:96240927 [GRCh38]
Chr14:96707264 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.1061G>A (p.Gly354Glu) single nucleotide variant not provided [RCV000970276] Chr14:96241389 [GRCh38]
Chr14:96707726 [GRCh37]
Chr14:14q32.2		 benign
NM_001379692.1(BDKRB2):c.*21T>A single nucleotide variant Hereditary angioedema with normal C1Inh [RCV001027409] Chr14:96241525 [GRCh38]
Chr14:96707862 [GRCh37]
Chr14:14q32.2		 not provided
GRCh37/hg19 14q32.2(chr14:96509822-96832238)x3 copy number gain not provided [RCV001006653] Chr14:96509822..96832238 [GRCh37]
Chr14:14q32.2		 uncertain significance
GRCh37/hg19 14q31.2-32.2(chr14:84783523-96907490)x1 copy number loss Deletion syndrome [RCV001004048] Chr14:84783523..96907490 [GRCh37]
Chr14:14q31.2-32.2		 pathogenic
GRCh37/hg19 14q32.13-32.31(chr14:95871795-102457523)x1 copy number loss not provided [RCV001827727] Chr14:95871795..102457523 [GRCh37]
Chr14:14q32.13-32.31		 pathogenic
NC_000014.8:g.(?_90429459)_(97347545_?)dup duplication not provided [RCV003109490] Chr14:90429459..97347545 [GRCh37]
Chr14:14q32.11-32.2		 uncertain significance
NC_000014.8:g.(?_95080779)_(97347545_?)dup duplication not provided [RCV003113847] Chr14:95080779..97347545 [GRCh37]
Chr14:14q32.13-32.2		 uncertain significance
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33		 pathogenic
GRCh37/hg19 14q31.2-32.33(chr14:84537502-107285437)x3 copy number gain not provided [RCV002472581] Chr14:84537502..107285437 [GRCh37]
Chr14:14q31.2-32.33		 pathogenic
GRCh37/hg19 14q31.1-32.2(chr14:81593708-97059276)x3 copy number gain not provided [RCV002472541] Chr14:81593708..97059276 [GRCh37]
Chr14:14q31.1-32.2		 likely pathogenic
NM_001379692.1(BDKRB2):c.364G>A (p.Asp122Asn) single nucleotide variant Inborn genetic diseases [RCV002684987] Chr14:96240692 [GRCh38]
Chr14:96707029 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.466T>C (p.Tyr156His) single nucleotide variant Inborn genetic diseases [RCV002848543] Chr14:96240794 [GRCh38]
Chr14:96707131 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.934G>A (p.Val312Ile) single nucleotide variant Inborn genetic diseases [RCV002744959] Chr14:96241262 [GRCh38]
Chr14:96707599 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.301G>A (p.Ala101Thr) single nucleotide variant Inborn genetic diseases [RCV002640897] Chr14:96240629 [GRCh38]
Chr14:96706966 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.845G>T (p.Cys282Phe) single nucleotide variant Inborn genetic diseases [RCV002826544] Chr14:96241173 [GRCh38]
Chr14:96707510 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.919G>A (p.Glu307Lys) single nucleotide variant Inborn genetic diseases [RCV002641129] Chr14:96241247 [GRCh38]
Chr14:96707584 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.626C>A (p.Thr209Asn) single nucleotide variant Inborn genetic diseases [RCV002769329] Chr14:96240954 [GRCh38]
Chr14:96707291 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.511G>A (p.Val171Met) single nucleotide variant Inborn genetic diseases [RCV003196068] Chr14:96240839 [GRCh38]
Chr14:96707176 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.185C>A (p.Pro62His) single nucleotide variant Inborn genetic diseases [RCV003206584] Chr14:96240513 [GRCh38]
Chr14:96706850 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.862A>G (p.Ile288Val) single nucleotide variant Inborn genetic diseases [RCV003192625] Chr14:96241190 [GRCh38]
Chr14:96707527 [GRCh37]
Chr14:14q32.2		 likely benign
NM_001379692.1(BDKRB2):c.235C>G (p.Leu79Val) single nucleotide variant Inborn genetic diseases [RCV003204392] Chr14:96240563 [GRCh38]
Chr14:96706900 [GRCh37]
Chr14:14q32.2		 uncertain significance
NM_001379692.1(BDKRB2):c.41G>A (p.Arg14His) single nucleotide variant Inborn genetic diseases [RCV003355998] Chr14:96237148 [GRCh38]
Chr14:96703485 [GRCh37]
Chr14:14q32.2		 likely benign
GRCh37/hg19 14q31.3-32.33(chr14:88580184-107285437)x3 copy number gain not provided [RCV003485051] Chr14:88580184..107285437 [GRCh37]
Chr14:14q31.3-32.33		 pathogenic
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3 copy number gain not provided [RCV003485036] Chr14:58894502..107227240 [GRCh37]
Chr14:14q23.1-32.33		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3638
Count of miRNA genes:770
Interacting mature miRNAs:908
Transcripts:ENST00000306005, ENST00000539359, ENST00000542454, ENST00000554311
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
PMC150944P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371496,706,886 - 96,707,457UniSTSGRCh37
Build 361495,776,639 - 95,777,210RGDNCBI36
Celera1476,762,605 - 76,763,176RGD
HuRef1476,891,993 - 76,892,564UniSTS
RH70880  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371496,707,531 - 96,707,720UniSTSGRCh37
Build 361495,777,284 - 95,777,473RGDNCBI36
Celera1476,763,250 - 76,763,439RGD
Cytogenetic Map14q32.1-q32.2UniSTS
HuRef1476,892,638 - 76,892,827UniSTS
GeneMap99-GB4 RH Map14261.84UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 398 30 111 23 82 12 608 107 411 93 292 163 23 507 401
Low 2002 1439 1206 300 221 155 2907 1146 1424 284 761 1329 146 1 697 1696 3 2
Below cutoff 24 1313 390 287 978 283 799 927 1882 34 377 83 5 690 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_000623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001379692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF378542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI095360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY275465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA096163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC422332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M88714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S45489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S56772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U35875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000539359   ⟹   ENSP00000438376
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,204,839 - 96,241,607 (+)Ensembl
RefSeq Acc Id: ENST00000542454   ⟹   ENSP00000439459
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,204,679 - 96,244,166 (+)Ensembl
RefSeq Acc Id: ENST00000554311   ⟹   ENSP00000450482
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1496,204,839 - 96,244,164 (+)Ensembl
RefSeq Acc Id: NM_000623   ⟹   NP_000614
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,204,839 - 96,244,164 (+)NCBI
GRCh371496,671,016 - 96,710,666 (+)NCBI
Build 361495,740,950 - 95,780,542 (+)NCBI Archive
HuRef1476,856,277 - 76,895,774 (+)ENTREZGENE
CHM1_11496,610,085 - 96,649,595 (+)NCBI
T2T-CHM13v2.01490,436,088 - 90,475,413 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001379692   ⟹   NP_001366621
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,204,839 - 96,244,164 (+)NCBI
T2T-CHM13v2.01490,436,088 - 90,475,413 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_000614   ⟸   NM_000623
- UniProtKB: P30411 (UniProtKB/Swiss-Prot),   B4DRL4 (UniProtKB/TrEMBL),   Q68DM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001366621   ⟸   NM_001379692
- UniProtKB: P30411 (UniProtKB/Swiss-Prot),   B4DRL4 (UniProtKB/TrEMBL),   Q68DM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000439459   ⟸   ENST00000542454
RefSeq Acc Id: ENSP00000438376   ⟸   ENST00000539359
RefSeq Acc Id: ENSP00000450482   ⟸   ENST00000554311
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30411-F1-model_v2 AlphaFold P30411 1-391 view protein structure

Promoters
RGD ID:7228571
Promoter ID:EPDNEW_H20029
Type:multiple initiation site
Name:BDKRB2_2
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20030  EPDNEW_H20032  EPDNEW_H20034  EPDNEW_H20035  EPDNEW_H20033  EPDNEW_H20036  EPDNEW_H20037  EPDNEW_H20038  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,204,605 - 96,204,665EPDNEW
RGD ID:7228567
Promoter ID:EPDNEW_H20030
Type:initiation region
Name:BDKRB2_1
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20029  EPDNEW_H20032  EPDNEW_H20034  EPDNEW_H20035  EPDNEW_H20033  EPDNEW_H20036  EPDNEW_H20037  EPDNEW_H20038  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,204,839 - 96,204,899EPDNEW
RGD ID:7228573
Promoter ID:EPDNEW_H20032
Type:initiation region
Name:BDKRB2_6
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20030  EPDNEW_H20029  EPDNEW_H20034  EPDNEW_H20035  EPDNEW_H20033  EPDNEW_H20036  EPDNEW_H20037  EPDNEW_H20038  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,237,183 - 96,237,243EPDNEW
RGD ID:7228579
Promoter ID:EPDNEW_H20033
Type:single initiation site
Name:BDKRB2_8
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20030  EPDNEW_H20029  EPDNEW_H20032  EPDNEW_H20034  EPDNEW_H20035  EPDNEW_H20036  EPDNEW_H20037  EPDNEW_H20038  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,238,747 - 96,238,807EPDNEW
RGD ID:7228575
Promoter ID:EPDNEW_H20034
Type:single initiation site
Name:BDKRB2_3
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20030  EPDNEW_H20029  EPDNEW_H20032  EPDNEW_H20035  EPDNEW_H20033  EPDNEW_H20036  EPDNEW_H20037  EPDNEW_H20038  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,239,108 - 96,239,168EPDNEW
RGD ID:7228577
Promoter ID:EPDNEW_H20035
Type:initiation region
Name:BDKRB2_4
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20030  EPDNEW_H20029  EPDNEW_H20032  EPDNEW_H20034  EPDNEW_H20033  EPDNEW_H20036  EPDNEW_H20037  EPDNEW_H20038  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,241,391 - 96,241,451EPDNEW
RGD ID:7228581
Promoter ID:EPDNEW_H20036
Type:initiation region
Name:BDKRB2_9
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20030  EPDNEW_H20029  EPDNEW_H20032  EPDNEW_H20034  EPDNEW_H20035  EPDNEW_H20033  EPDNEW_H20037  EPDNEW_H20038  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,241,694 - 96,241,754EPDNEW
RGD ID:7228583
Promoter ID:EPDNEW_H20037
Type:initiation region
Name:BDKRB2_5
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20030  EPDNEW_H20029  EPDNEW_H20032  EPDNEW_H20034  EPDNEW_H20035  EPDNEW_H20033  EPDNEW_H20036  EPDNEW_H20038  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,243,064 - 96,243,124EPDNEW
RGD ID:7228585
Promoter ID:EPDNEW_H20038
Type:initiation region
Name:BDKRB2_7
Description:bradykinin receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20030  EPDNEW_H20029  EPDNEW_H20032  EPDNEW_H20034  EPDNEW_H20035  EPDNEW_H20033  EPDNEW_H20036  EPDNEW_H20037  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381496,243,501 - 96,243,561EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1030 AgrOrtholog
COSMIC BDKRB2 COSMIC
Ensembl Genes ENSG00000168398 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000539359.1 UniProtKB/Swiss-Prot
  ENST00000542454.2 UniProtKB/Swiss-Prot
  ENST00000554311 ENTREZGENE
  ENST00000554311.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000168398 GTEx
HGNC ID HGNC:1030 ENTREZGENE
Human Proteome Map BDKRB2 Human Proteome Map
InterPro Brdyknn_2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Brdyknn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:624 UniProtKB/Swiss-Prot
NCBI Gene 624 ENTREZGENE
OMIM 113503 OMIM
PANTHER B2 BRADYKININ RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB BDKRB2 RGD, PharmGKB
PRINTS BRADYKININR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRADYKINNB2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DRL4 ENTREZGENE, UniProtKB/TrEMBL
  BKRB2_HUMAN UniProtKB/Swiss-Prot
  L8EC45_HUMAN UniProtKB/TrEMBL
  P30411 ENTREZGENE
  Q68DM8 ENTREZGENE, UniProtKB/TrEMBL