Gene: Casq2 (calsequestrin 2)
Mus musculus
Symbol:
Casq2
Name:
calsequestrin 2
Description:
ENCODES a protein that exhibits calcium ion binding (ortholog); protein homodimerization activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN negative regulation of potassium ion transmembrane transporter activity; negative regulation of potassium ion transport; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH abnormal heartbeat; abnormal myocardial fiber morphology; abnormal myocardial fiber physiology; ASSOCIATED WITH Aortic Stenosis, Supravalvular (ortholog); Diabetic Cardiomyopathies (ortholog); Heart Failure (ortholog); FOUND IN Z disc; cytoplasm (ortholog); intracellular (ortholog); INTERACTS WITH 4,4'-diaminodiphenylmethane; benzo[a]pyrene; bisphenol A
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AA033488; AW146219; calsequestrin, cardiac muscle isoform; calsequestrin-2; cardiac calsequestrin; cCSQ; ESTM52; MGC115896; OTTMUSP00000040615; OTTMUSP00000050846; OTTMUSP00000050847
Orthologs:
Homo sapiens : CASQ2
(calsequestrin 2 (cardiac muscle))
HGNC
Rattus norvegicus : Casq2
(calsequestrin 2 (cardiac muscle))
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 102,086,510 - 102,146,514 + NCBI Mouse cM Map 3 + NCBI Mouse Celera Assembly 3 104,291,185 - 104,350,741 + NCBI Mouse Genome Assembly Build 37 3 101,890,433 - 101,950,437 + NCBI Mouse Genome Assembly Build 36.1 3 101,879,888 - 101,950,172 + NCBI Mouse Cytogenetic Map 3 F3 NCBI
Model
Gene-Chemical Interaction Annotations
17beta-estradiol multiple interactions ISO RGD:737298 6480464 [Estradiol binds to ESR2 protein] which results in increased expression of CASQ2 mRNA CTD PMID:20404318 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737298 6480464 Tetrachlorodibenzodioxin results in increased expression of CASQ2 mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737298 6480464 Tetrachlorodibenzodioxin results in increased expression of CASQ2 mRNA CTD PMID:20106945 PMID:21632981 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4,4'-diaminodiphenylmethane results in decreased expression of CASQ2 mRNA CTD PMID:18648102 ammonium chloride affects expression ISO RGD:2276 6480464 Ammonium Chloride affects the expression of CASQ2 mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CASQ2 mRNA CTD PMID:22228805 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:2276 6480464 Diethylhexyl Phthalate results in decreased expression of CASQ2 mRNA CTD PMID:20920545 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CASQ2 protein CTD PMID:23418087 bisphenol A affects methylation EXP 6480464 bisphenol A affects the methylation of CASQ2 promoter CTD PMID:23418087 chlorpyrifos increases expression ISO RGD:2276 6480464 Chlorpyrifos results in increased expression of CASQ2 mRNA CTD PMID:18668222 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of CASQ2 mRNA CTD PMID:21266533 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of CASQ2 mRNA CTD PMID:17361019 PMID:21266533
Biological Process
cellular response to caffeine ISO UniProtKB:O14958 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of potassium ion transmembrane transporter activity IDA 2290270 MGI:MGI:5430859|PMID:21063088 BHF-UCL MGI:MGI:5430859 PMID:21063088 negative regulation of potassium ion transport IDA 2290270 MGI:MGI:5430859|PMID:21063088 BHF-UCL MGI:MGI:5430859 PMID:21063088 negative regulation of ryanodine-sensitive calcium-release channel activity ISO UniProtKB:O14958 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of ryanodine-sensitive calcium-release channel activity ISO UniProtKB:P51868 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein polymerization ISO UniProtKB:O14958 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of cardiac muscle cell contraction ISO UniProtKB:P51868 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IDA 2290270 MGI:MGI:1202079|PMID:9525981 MGI MGI:MGI:1202079 PMID:9525981 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO UniProtKB:P51868 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO UniProtKB:O14958 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of cell communication by electrical coupling ISO UniProtKB:O14958 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of heart rate ISO UniProtKB:O14958 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of membrane repolarization IDA 2290270 MGI:MGI:5430859|PMID:21063088 BHF-UCL MGI:MGI:5430859 PMID:21063088 regulation of muscle contraction TAS 2290270 MGI:MGI:2153332|PMID:11784029 MGI MGI:MGI:2153332 PMID:11784029 sequestering of calcium ion ISO UniProtKB:O14958 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177
Cellular Component
cytoplasm ISO UniProtKB:O14958 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 intracellular ISO UniProtKB:O14958 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 sarcoplasmic reticulum TAS 2290270 MGI:MGI:2153332|PMID:11784029 MGI MGI:MGI:2153332 PMID:11784029 sarcoplasmic reticulum ISO UniProtKB:P51868 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 Z disc IDA 2290270 MGI:MGI:3849347|PMID:19383796 MGI MGI:MGI:3849347 PMID:19383796 Z disc ISO UniProtKB:P51868 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868
Molecular Function
calcium ion binding ISO UniProtKB:O14958 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein homodimerization activity ISO UniProtKB:P51868 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein kinase C binding ISO UniProtKB:P51868 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868
4141669 Vmmt18_m vertebral morphology and mechanical traits 18 (mouse) Not determined 3 68203118 102203263 Mouse 4142498 Hctq1_m hematocrit QTL 1 (mouse) Not determined 3 68985423 102985534 Mouse 1357796 Trmq5_m T cell ratio modifier QTL 5 (mouse) Not determined 3 70067069 104067190 Mouse 1301422 Sle11_m systematic lupus erythematosus susceptibility 11 (mouse) Not determined 3 70105519 104105657 Mouse 1300595 Tmevd2_m Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse) Not determined 3 75359917 109360164 Mouse 1301392 Eae3_m susceptibility to experimental allergic encephalomyelitis 3 (mouse) Not determined 3 79445337 113445444 Mouse 4142423 Prtia1_m pristane induced arthritis 1 (mouse) Not determined 3 79885628 113885768 Mouse 1357629 Ssta5_m susceptibility to Salmonella typhimurium antigens 5 (mouse) Not determined 3 79885628 113885768 Mouse 1301277 nctm1_m Nakano cataract modifier 1 (mouse) Not determined 3 80083059 114083208 Mouse 1301947 Pcfm3_m periosteal circumference and femur length 3 (mouse) Not determined 3 80981259 114981404 Mouse 1301904 Iba2_m induction of brown adipocytes 2 (mouse) Not determined 3 82043650 116043791 Mouse 1301862 Tchol1_m total cholesterol level 1 (mouse) Not determined 3 83269519 117269667 Mouse 1302181 Lvic2_m liver iron content 2 (mouse) Not determined 3 83269519 117269667 Mouse 1300752 Ap6q_m alcohol preference 6 QTL (mouse) Not determined 3 83360598 117360744 Mouse 1301388 Hdlq21_m HDL QTL 21 (mouse) Not determined 3 83360598 117360744 Mouse 1301272 Cfsw1_m cystic fibrosis survival to weaning 1 (mouse) Not determined 3 83779519 117779651 Mouse 4142099 Cq3_m cholesterol QTL 3 (mouse) Not determined 3 84785525 118785674 Mouse 4141455 Bwq8_m body weight QTL 8 (mouse) Not determined 3 84785525 118785674 Mouse 4141747 Tbqt4_m tibia bone quality traits 4 (mouse) Not determined 3 84827765 118827914 Mouse 4142178 Ctrq2_m C. trachomatis resistance QTL 2 (mouse) Not determined 3 89036582 137410211 Mouse 1357489 Trmq6_m T cell ratio modifier QTL 6 (mouse) Not determined 3 90272538 124272674 Mouse 1301349 Pgia26_m proteoglycan induced arthritis 26 (mouse) Not determined 3 92147135 126147252 Mouse 4141299 Ascla4_m atherosclerotic lesion area 4 (mouse) Not determined 3 98533310 132533466 Mouse 1302114 Tbs1_m tuberculosis severity 1 (mouse) Not determined 3 98833374 132833519 Mouse 4141312 Cia21_m collagen induced arthritis 21 (mouse) Not determined 3 100551791 103641386 Mouse 4142363 Wbcq2_m white blood cell quantitative locus 2 (mouse) Not determined 3 101145575 135145718 Mouse