Chrm3 (cholinergic receptor, muscarinic 3, cardiac) - Rat Genome Database

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Gene: Chrm3 (cholinergic receptor, muscarinic 3, cardiac) Mus musculus
Analyze
Symbol: Chrm3
Name: cholinergic receptor, muscarinic 3, cardiac
RGD ID: 737208
MGI Page MGI
Description: Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within cholinergic synaptic transmission; positive regulation of smooth muscle contraction; and saliva secretion. Is active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AChR M3; Chrm-; Chrm-3; M3; M3R; mm3 mAChR; muscarinic acetylcholine receptor 3; muscarinic acetylcholine receptor M3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39139,925,522 - 10,411,131 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl139,925,522 - 10,410,883 (-)EnsemblGRCm39 Ensembl
GRCm38139,875,486 - 10,361,062 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl139,875,486 - 10,360,847 (-)EnsemblGRCm38mm10GRCm38
MGSCv37139,875,859 - 10,360,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36139,875,859 - 10,360,049 (-)NCBIMGSCv36mm8
Celera139,820,205 - 10,316,018 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map133.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2-deoxy-D-glucose  (EXP)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
4-DAMP methiodide  (ISO)
4-DAMP(1+)  (ISO)
6-propyl-2-thiouracil  (ISO)
acetylcholine  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
atropine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bethanechol  (ISO)
bisphenol A  (ISO)
brucine  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
caracurine VII  (ISO)
carbachol  (EXP,ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
darifenacin  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichlorvos  (ISO)
diethylstilbestrol  (ISO)
dimethoate  (ISO)
disulfoton  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fipronil  (ISO)
fructose  (ISO)
furan  (ISO)
furtrethonium  (ISO)
genistein  (EXP,ISO)
glycidol  (ISO)
guanosine 5'-[beta,gamma-imido]triphosphate  (ISO)
hexacosan-1-ol  (ISO)
histamine  (EXP)
hydrogen chloride  (ISO)
inulin  (EXP)
ketamine  (ISO)
KT 5720  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (ISO)
methscopolamine  (ISO)
methylmercury chloride  (ISO)
metoclopramide  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (EXP)
nafenopin  (ISO)
nickel atom  (ISO)
oxotremorine M  (ISO)
oxybutynin  (ISO)
pancuronium  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
parathion-methyl  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
picrotoxin  (ISO)
Pipecuronium  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rocuronium  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
Solifenacin succinate  (EXP)
staurosporine  (ISO)
streptozocin  (ISO)
strychnine  (ISO)
sunitinib  (ISO)
taurodeoxycholic acid  (EXP)
taurolithocholic acid  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thiopental  (ISO)
tiotropium bromide  (ISO)
tolterodine tartrate  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tropicamide  (ISO)
valproic acid  (EXP,ISO)
vecuronium bromide  (ISO)
vorinostat  (ISO)
zinc oxide  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal brain wave pattern  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal frequency of paradoxical sleep  (IAGP)
abnormal gallbladder physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal histamine physiology  (IAGP)
abnormal inhibitory postsynaptic currents  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal submandibular gland physiology  (IAGP)
abnormal urinary bladder morphology  (IAGP)
abnormal urinary bladder physiology  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased bronchoconstrictive response  (IAGP)
decreased circulating glucagon level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased digestive secretion  (IAGP)
decreased food intake  (IAGP)
decreased glucagon secretion  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased insulin secretion  (IAGP)
decreased salivation  (IAGP)
decreased vasodilation  (IAGP)
distended urinary bladder  (IAGP)
hydronephrosis  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired contractility of ileal smooth muscle  (IAGP)
impaired contractility of urinary bladder detrusor smooth muscle  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired glucose tolerance  (IAGP)
impaired pupillary reflex  (IAGP)
impaired smooth muscle contractility  (IAGP)
improved glucose tolerance  (IAGP)
increased fluid intake  (IAGP)
increased insulin sensitivity  (IAGP)
mydriasis  (IAGP)
postnatal growth retardation  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Muscarinic receptor antagonists for overactive bladder. Abrams P and Andersson KE, BJU Int. 2007 Nov;100(5):987-1006.
2. Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro. Asano K, etal., Int J Chron Obstruct Pulmon Dis. 2008;3(4):781-9.
3. Mediation by M3-muscarinic receptors of both endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat. Boulanger CM, etal., Br J Pharmacol. 1994 Jun;112(2):519-24.
4. Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts. Haag S, etal., Eur Respir J. 2008 Sep;32(3):555-62. Epub 2008 May 14.
5. Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness. Lin LH, etal., Eur J Pharmacol. 2008 Apr 28;584(2-3):398-404. Epub 2008 Feb 19.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Morphological and molecular characteristics of "difficult" asthma. Selivanova PA, etal., J Asthma. 2010 Apr;47(3):269-75.
16. Muscarinic signaling in the brain. Thiele A Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.
17. Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Yamada M, etal., Nature 2001 Mar 8;410(6825):207-12.
18. Distinct roles of cholinergic receptors in small cell lung cancer cells. Zhang S, etal., Anticancer Res. 2010 Jan;30(1):97-106.
Additional References at PubMed
PMID:2848036   PMID:7648406   PMID:7874308   PMID:8889548   PMID:10349636   PMID:10549128   PMID:10944224   PMID:11042159   PMID:11076861   PMID:11130978   PMID:11217851   PMID:11472062  
PMID:11959688   PMID:11961069   PMID:12106668   PMID:12151512   PMID:12477932   PMID:12486155   PMID:12538821   PMID:12675128   PMID:12713643   PMID:12859343   PMID:12925702   PMID:14610273  
PMID:14645675   PMID:14681479   PMID:14724830   PMID:14977875   PMID:14985093   PMID:15122990   PMID:15130910   PMID:15146045   PMID:15147302   PMID:15220195   PMID:15263021   PMID:15266016  
PMID:15574798   PMID:15661360   PMID:15691866   PMID:15913791   PMID:15919709   PMID:15933222   PMID:15965495   PMID:15965496   PMID:16110248   PMID:16141072   PMID:16141073   PMID:16243899  
PMID:16319319   PMID:16322052   PMID:16405887   PMID:16602821   PMID:16753580   PMID:16919269   PMID:16956767   PMID:17008557   PMID:17084710   PMID:17099717   PMID:17242410   PMID:17463038  
PMID:17872906   PMID:17878406   PMID:17919190   PMID:18078830   PMID:18206430   PMID:18287559   PMID:18344611   PMID:18437633   PMID:18483237   PMID:18524769   PMID:18559515   PMID:18755247  
PMID:19213795   PMID:19332541   PMID:19332789   PMID:19407017   PMID:19494266   PMID:19549818   PMID:19575010   PMID:19657040   PMID:19752163   PMID:19855129   PMID:19858481   PMID:19940190  
PMID:19966055   PMID:20023174   PMID:20197056   PMID:20197374   PMID:20427660   PMID:20439723   PMID:20440069   PMID:20463237   PMID:20541544   PMID:20595784   PMID:20665816   PMID:20707271  
PMID:20940295   PMID:21078968   PMID:21115639   PMID:21335473   PMID:21676931   PMID:21677750   PMID:21705482   PMID:21785809   PMID:21873635   PMID:21873683   PMID:22077972   PMID:22302687  
PMID:22525375   PMID:22726658   PMID:22730439   PMID:22871384   PMID:22910223   PMID:23232510   PMID:23242454   PMID:23312282   PMID:23397297   PMID:23407022   PMID:23742744   PMID:23747049  
PMID:23776234   PMID:23889852   PMID:24028210   PMID:24114586   PMID:24156289   PMID:24408978   PMID:24565843   PMID:24694019   PMID:24695728   PMID:24695732   PMID:24952961   PMID:25143365  
PMID:25381025   PMID:25629518   PMID:25800153   PMID:26002583   PMID:26084221   PMID:26169369   PMID:26516777   PMID:26527617   PMID:26785775   PMID:26901532   PMID:27167157   PMID:27173511  
PMID:27534441   PMID:27733612   PMID:27978539   PMID:27989802   PMID:28254942   PMID:28578927   PMID:28619712   PMID:28687610   PMID:29401598   PMID:29959237   PMID:30001145   PMID:30157420  
PMID:30196290   PMID:30914695   PMID:30955929   PMID:31451647   PMID:31875697   PMID:31875848   PMID:31913277   PMID:31914675   PMID:32325033   PMID:32708537   PMID:32927021   PMID:32955432  
PMID:33122522   PMID:33477687   PMID:34200187   PMID:34244422   PMID:34314386   PMID:34321999   PMID:35427599   PMID:35870560   PMID:37508553  


Genomics

Comparative Map Data
Chrm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39139,925,522 - 10,411,131 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl139,925,522 - 10,410,883 (-)EnsemblGRCm39 Ensembl
GRCm38139,875,486 - 10,361,062 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl139,875,486 - 10,360,847 (-)EnsemblGRCm38mm10GRCm38
MGSCv37139,875,859 - 10,360,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36139,875,859 - 10,360,049 (-)NCBIMGSCv36mm8
Celera139,820,205 - 10,316,018 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map133.72NCBI
CHRM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381239,386,568 - 239,915,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1239,386,565 - 239,915,452 (+)EnsemblGRCh38hg38GRCh38
GRCh371239,549,868 - 240,078,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361237,858,996 - 238,139,343 (+)NCBINCBI36Build 36hg18NCBI36
Build 341236,118,413 - 236,398,756NCBI
Celera1213,047,986 - 213,328,202 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1210,250,783 - 210,531,551 (+)NCBIHuRef
CHM1_11241,065,995 - 241,346,299 (+)NCBICHM1_1
T2T-CHM13v2.01238,798,998 - 239,328,607 (+)NCBIT2T-CHM13v2.0
Chrm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81764,696,549 - 65,158,622 (+)NCBIGRCr8
mRatBN7.21760,005,137 - 60,467,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1760,005,202 - 60,467,278 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1763,209,233 - 63,671,688 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01767,212,340 - 67,674,776 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01761,366,663 - 61,834,600 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01763,990,599 - 64,463,222 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1763,990,599 - 63,994,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01765,753,665 - 66,217,211 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41771,214,906 - 71,218,463 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11771,081,449 - 71,229,296 (+)NCBI
Celera1760,109,356 - 60,562,246 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Chrm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955492958,949 - 960,721 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955492958,347 - 1,429,832 (-)NCBIChiLan1.0ChiLan1.0
CHRM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v219,253,466 - 9,776,967 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan119,478,692 - 10,000,031 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01214,931,514 - 215,452,739 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11219,927,079 - 220,446,830 (+)NCBIpanpan1.1PanPan1.1panPan2
CHRM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.14504,663 - 999,550 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl4506,990 - 520,613 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha4547,625 - 1,042,706 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.04528,395 - 1,026,611 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.14522,413 - 1,023,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.04628,064 - 1,134,213 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.04882,752 - 1,377,924 (-)NCBIUU_Cfam_GSD_1.0
Chrm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934437,787,915 - 38,208,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648413,954,887 - 13,956,659 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648413,953,141 - 14,373,174 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,828,231 - 51,830,003 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,818,625 - 52,363,662 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,361,402 - 55,363,168 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHRM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12576,772,212 - 77,009,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2577,001,477 - 77,003,249 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605578,598,053 - 79,113,674 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477510,949,983 - 10,951,755 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477510,948,075 - 11,427,898 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrm3
16566 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:133
Interacting mature miRNAs:135
Transcripts:ENSMUST00000063093
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301890Adip7_madiposity 7 (mouse)Not determined13123454672Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123454672Mouse
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123454672Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse

Markers in Region
44.MMHAP91FLG5.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381310,310,986 - 10,311,144UniSTSGRCm38
MGSCv371310,310,232 - 10,310,390UniSTSGRCm37
Celera1310,266,216 - 10,266,374UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Whitehead_YAC13 UniSTS
MHAa7c12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381310,317,557 - 10,317,707UniSTSGRCm38
MGSCv371310,316,803 - 10,316,953UniSTSGRCm37
Celera1310,272,786 - 10,272,936UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Whitehead_YAC13 UniSTS
D13Mit172  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381310,081,042 - 10,081,188UniSTSGRCm38
MGSCv371310,080,288 - 10,080,434UniSTSGRCm37
Celera1310,024,473 - 10,024,619UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Whitehead Genetic132.2UniSTS
Whitehead_YAC13 UniSTS
D13Mit215  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381310,046,277 - 10,046,502UniSTSGRCm38
MGSCv371310,045,523 - 10,045,748UniSTSGRCm37
Celera139,989,500 - 9,989,725UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Whitehead Genetic132.2UniSTS
Whitehead/MRC_RH13162.45UniSTS
03.MMHAP32FLA3.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38139,931,241 - 9,931,397UniSTSGRCm38
MGSCv37139,930,487 - 9,930,643UniSTSGRCm37
Celera139,874,477 - 9,874,633UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Whitehead/MRC_RH13150.69UniSTS
Chrm3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38139,877,083 - 9,878,140UniSTSGRCm38
MGSCv37139,876,329 - 9,877,386UniSTSGRCm37
Celera139,820,675 - 9,821,732UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
cM Map137.0UniSTS
D7S2508  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381310,052,185 - 10,052,934UniSTSGRCm38
MGSCv371310,051,431 - 10,052,180UniSTSGRCm37
Celera139,995,410 - 9,996,159UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
fb54b04.x1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381310,359,112 - 10,360,435UniSTSGRCm38
MGSCv371310,358,358 - 10,359,681UniSTSGRCm37
Celera1310,314,327 - 10,315,650UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Chrm3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38139,877,742 - 9,877,929UniSTSGRCm38
MGSCv37139,876,988 - 9,877,175UniSTSGRCm37
Celera139,821,334 - 9,821,521UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001428369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC126043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC146596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC153132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF264050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000063093   ⟹   ENSMUSP00000055579
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl139,927,265 - 9,929,034 (-)Ensembl
GRCm38.p6 Ensembl139,877,229 - 9,878,998 (-)Ensembl
RefSeq Acc Id: ENSMUST00000187510   ⟹   ENSMUSP00000140131
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl139,925,522 - 10,410,880 (-)Ensembl
GRCm38.p6 Ensembl139,875,486 - 10,360,844 (-)Ensembl
RefSeq Acc Id: ENSMUST00000190395
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1310,265,730 - 10,410,599 (-)Ensembl
GRCm38.p6 Ensembl1310,215,694 - 10,360,563 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223242
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1310,170,520 - 10,410,883 (-)Ensembl
GRCm38.p6 Ensembl1310,120,484 - 10,360,847 (-)Ensembl
RefSeq Acc Id: NM_033269   ⟹   NP_150372
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39139,926,649 - 10,410,839 (-)NCBI
GRCm38139,876,613 - 10,360,803 (-)NCBI
MGSCv37139,875,859 - 10,360,049 (-)RGD
Celera139,820,205 - 10,316,018 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516468   ⟹   XP_006516531
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39139,925,522 - 10,411,131 (-)NCBI
GRCm38139,875,486 - 10,361,062 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_150372   ⟸   NM_033269
- UniProtKB: Q64055 (UniProtKB/Swiss-Prot),   Q9ERZ3 (UniProtKB/Swiss-Prot),   Q542R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006516531   ⟸   XM_006516468
- Peptide Label: isoform X1
- UniProtKB: Q64055 (UniProtKB/Swiss-Prot),   Q9ERZ3 (UniProtKB/Swiss-Prot),   Q542R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000140131   ⟸   ENSMUST00000187510
RefSeq Acc Id: ENSMUSP00000055579   ⟸   ENSMUST00000063093
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ERZ3-F1-model_v2 AlphaFold Q9ERZ3 1-589 view protein structure

Promoters
RGD ID:8679568
Promoter ID:EPDNEW_M17815
Type:single initiation site
Name:Chrm3_2
Description:Mus musculus cholinergic receptor, muscarinic 3, cardiac , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17816  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381310,236,536 - 10,236,596EPDNEW
RGD ID:6823779
Promoter ID:MM_KWN:13215
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Spleen
Transcripts:ENSMUST00000063093,   NM_033269
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361310,359,714 - 10,360,214 (-)MPROMDB
RGD ID:8679570
Promoter ID:EPDNEW_M17816
Type:initiation region
Name:Chrm3_1
Description:Mus musculus cholinergic receptor, muscarinic 3, cardiac , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17815  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381310,360,840 - 10,360,900EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88398 AgrOrtholog
Ensembl Genes ENSMUSG00000046159 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000063093.10 UniProtKB/Swiss-Prot
  ENSMUST00000187510 ENTREZGENE
  ENSMUST00000187510.7 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Musac_Ach_M3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Musac_Ach_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12671 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88398 ENTREZGENE
NCBI Gene 12671 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MUSCARINIC ACETYLCHOLINE RECEPTOR M3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CHRM3 RGD
PhenoGen Chrm3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MUSCARINICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MUSCRINICM3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ACM3_MOUSE UniProtKB/Swiss-Prot
  Q542R4 ENTREZGENE, UniProtKB/TrEMBL
  Q64055 ENTREZGENE
  Q9ERZ3 ENTREZGENE
UniProt Secondary Q64055 UniProtKB/Swiss-Prot