Gene: FGF18 (fibroblast growth factor 18)
Homo sapiens
Symbol:
FGF18
Name:
fibroblast growth factor 18
Description:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
FGF-18; fibroblast growth factor 18; OTTHUMP00000161023; ZFGF5
Orthologs:
Mus musculus : Fgf18
(fibroblast growth factor 18)
MGI
Fgf18
(fibroblast growth factor 18)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 171,074,286 - 171,112,114 + NCBI Human Genome Assembly HuRef 5 165,944,447 - 165,981,862 + NCBI Human Genome Assembly GRCh37 5 170,846,667 - 170,884,630 + NCBI Human Genome Assembly Build 36 5 170,779,272 - 170,816,781 + NCBI Human Cytogenetic Map 5 q34 NCBI Human Genome Assembly 5 170,779,271 - 170,816,781 NCBI
Model
Gene Ontology Annotations
Biological Process anatomical structure morphogenesis TAS 2290271 PMID:9742123 PINC PMID:9742123 angiogenesis IEA Ensembl:ENSMUSP00000020507 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cell-cell signaling TAS 2290271 PMID:9742123 PINC PMID:9742123 chondrocyte development IEA Ensembl:ENSMUSP00000020507 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 endochondral ossification IEA Ensembl:ENSMUSP00000020507 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 epidermal growth factor receptor signaling pathway TAS 2290271 Reactome:REACT_9417 Reactome Reactome:REACT_9417 fibroblast growth factor receptor signaling pathway TAS 2290271 Reactome:REACT_9390 Reactome Reactome:REACT_9390 fibroblast growth factor receptor signaling pathway TAS 2290271 Reactome:REACT_9510 Reactome Reactome:REACT_9510 fibroblast growth factor receptor signaling pathway TAS 2290271 Reactome:REACT_9508 Reactome Reactome:REACT_9508 fibroblast growth factor receptor signaling pathway TAS 2290271 Reactome:REACT_9470 Reactome Reactome:REACT_9470 fibroblast growth factor receptor signaling pathway TAS 2290271 Reactome:REACT_9452 Reactome Reactome:REACT_9452 fibroblast growth factor receptor signaling pathway TAS 2290271 Reactome:REACT_9439 Reactome Reactome:REACT_9439 fibroblast growth factor receptor signaling pathway TAS 2290271 Reactome:REACT_9413 Reactome Reactome:REACT_9413 fibroblast growth factor receptor signaling pathway TAS 2290271 Reactome:REACT_9396 Reactome Reactome:REACT_9396 innate immune response TAS 2290271 Reactome:REACT_6802 Reactome Reactome:REACT_6802 insulin receptor signaling pathway TAS 2290271 Reactome:REACT_498 Reactome Reactome:REACT_498 intramembranous ossification IEA Ensembl:ENSMUSP00000020507 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 lung development IEA Ensembl:ENSMUSP00000020507 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 nervous system development IEA Ensembl:ENSRNOP00000064983 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 neurotrophin TRK receptor signaling pathway TAS 2290271 Reactome:REACT_11061 Reactome Reactome:REACT_11061 phosphatidylinositol-mediated signaling TAS 2290271 Reactome:REACT_12464 Reactome Reactome:REACT_12464 positive regulation of cell proliferation IEA Ensembl:ENSMUSP00000020507 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of chondrocyte differentiation IEA Ensembl:ENSMUSP00000020507 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of ERK1 and ERK2 cascade IEA Ensembl:ENSMUSP00000020507 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA Ensembl:ENSMUSP00000020507 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 signal transduction TAS 2290271 PMID:9742123 PINC PMID:9742123
2293399 PRSTS257_H Prostate tumor susceptibility QTL 257 (human) Prostate tumor susceptibility 5 152069094 178069094 Human 2293403 PRSTS252_H Prostate tumor susceptibility QTL 252 (human) Prostate tumor susceptibility 5 152069094 178069094 Human 2293409 PRSTS254_H Prostate tumor susceptibility QTL 254 (human) Prostate tumor susceptibility 5 152069094 178069094 Human 2293419 PRSTS253_H Prostate tumor susceptibility QTL 253 (human) Prostate tumor susceptibility 5 152069094 178069094 Human 1581521 BP67_H Blood pressure QTL 67 (human) 2.7 .001 Blood pressure pulse pressure 5 153876555 179876555 Human 1559352 BW80_H Body weight QTL 80 (human) 2.48 .0006 Body weight body mass index 5 153876555 179876555 Human 1643555 GLUCO20_H Glucose level QTL 20 (human) .04 Glucose level non-insulin-dependent 5 153876555 179876555 Human 1643311 BW228_H Body weight QTL 228 (human) 1.17 Body weight body mass index 5 156032616 180901521 Human 1643361 BW307_H Body weight QTL 307 (human) 2.04 .0015 Body weight BMI 5 156032616 180901521 Human 2292866 PRSTS93_H Prostate tumor susceptibility QTL 93 (human) Prostate tumor susceptibility 5 156032616 180901521 Human 1559406 SCL115_H Serum cholesterol level QTL 115 (human) 1.97 Lipid level LDL cholesterol 5 160248435 180901521 Human 1643513 BW264_H Body Weight QTL 264 (human) 1.8 .00202 Body weight body mass index 5 160248435 180901521 Human 1643414 BW279_H Body Weight QTL 279 (human) 1.87 .002 Body weight 5 160248435 180901521 Human 2289550 SLEP21_H Serum leptin level QTL 21 (human) Hormone level leptin 5 160248435 180901521 Human 2289409 BW320_H Body weight QTL 320 (human) 3.5 .0002 Body weight lean mass 5 160351322 180901521 Human 2293381 PRSTS255_H Prostate tumor susceptibility QTL 255 (human) Prostate tumor susceptibility 5 164807428 180901521 Human 2293383 PRSTS256_H Prostate tumor susceptibility QTL 256 (human) Prostate tumor susceptibility 5 164807428 180901521 Human 2293408 PRSTS258_H Prostate tumor susceptibility QTL 258 (human) Prostate tumor susceptibility 6 164807428 180901521 Human 1357378 BW72_H Body weight QTL 72 (human) .0039 Body weight body mass index percentile 5 166988371 180901521 Human 2316063 GLUCO204_H Glucose level QTL 204 (human) .033 Glucose level 5 166988371 180901521 Human 2316676 GLUCO242_H Glucose level QTL 242 (human) 2.9 .000129 Glucose level 5 168999336 171340920 Human
Gene Ontology Annotations
