Hand1 (heart and neural crest derivatives expressed 1) - Rat Genome Database

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Gene: Hand1 (heart and neural crest derivatives expressed 1) Mus musculus
Analyze
Symbol: Hand1
Name: heart and neural crest derivatives expressed 1
RGD ID: 737011
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including circulatory system development; regulation of transcription by RNA polymerase II; and trophoblast giant cell differentiation. Located in nucleolus and nucleoplasm. Is expressed in several structures, including alimentary system; early conceptus; heart and pericardium; nervous system; and urinary system. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bHLHa; bHLHa27; eHA; Ehan; eHAND; Ehand1; extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; heart and neural crest derivatives expressed transcript 1; heart- and neural crest derivatives-expressed protein 1; helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast; Hxt; Th1; Thin; thing-1; Thing1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391157,719,539 - 57,722,973 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1157,719,531 - 57,723,644 (-)EnsemblGRCm39 Ensembl
GRCm381157,828,713 - 57,832,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1157,828,705 - 57,832,818 (-)EnsemblGRCm38mm10GRCm38
MGSCv371157,642,215 - 57,645,649 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361157,644,908 - 57,648,342 (-)NCBIMGSCv36mm8
Celera1162,581,753 - 62,585,188 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1135.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alisphenoid bone morphology  (IAGP)
abnormal amnion morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal chorioallantoic fusion  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo implantation  (IAGP)
abnormal embryo turning  (IAGP)
abnormal extraembryonic endoderm formation  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal heart apex morphology  (IAGP)
abnormal heart atrium morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart septum morphology  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal interventricular septum muscular part morphology  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal maxillary prominence morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal metencephalon morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nasal capsule morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal palate development  (IAGP)
abnormal parietal yolk sac morphology  (IAGP)
abnormal pharyngeal arch development  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal placenta development  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal Reichert's cartilage morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal somite development  (IAGP)
abnormal spongiotrophoblast cell morphology  (IAGP)
abnormal telencephalon development  (IAGP)
abnormal tongue position  (IAGP)
abnormal trophoblast giant cell morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
absent middle ear ossicles  (IAGP)
absent nasal bone  (IAGP)
absent nasal septum  (IAGP)
absent temporal bone squamous part  (IAGP)
absent vitelline blood vessels  (IAGP)
basisphenoid bone hypoplasia  (IAGP)
cardiac edema  (IAGP)
cardiac hypertrophy  (IAGP)
common ventricle  (IAGP)
cyanosis  (IAGP)
decreased body length  (IAGP)
decreased cell proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased heart left ventricle size  (IAGP)
decreased heart right ventricle size  (IAGP)
decreased maxillary shelf size  (IAGP)
decreased palatine bone horizontal plate size  (IAGP)
decreased spongiotrophoblast cell number  (IAGP)
decreased trophoblast giant cell number  (IAGP)
dilated heart  (IAGP)
double outlet right ventricle  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged allantois  (IAGP)
enlarged heart  (IAGP)
excessive folding of visceral yolk sac  (IAGP)
failure of heart looping  (IAGP)
frontal bone hypoplasia  (IAGP)
hemopericardium  (IAGP)
hemorrhage  (IAGP)
impaired placental function  (IAGP)
increased cell death  (IAGP)
interparietal bone hypoplasia  (IAGP)
lethality during fetal growth through weaning, incomplete penetrance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
mandible hypoplasia  (IAGP)
middle ear ossicle hypoplasia  (IAGP)
midline facial cleft  (IAGP)
nasal bone hypoplasia  (IAGP)
neonatal lethality  (IAGP)
no abnormal phenotype detected  (IAGP)
overriding aortic valve  (IAGP)
pale yolk sac  (IAGP)
pericardial effusion  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premaxilla hypoplasia  (IAGP)
pterygoid bone hypoplasia  (IAGP)
short Meckel's cartilage  (IAGP)
short premaxilla  (IAGP)
small ectoplacental cone  (IAGP)
small frontal bone  (IAGP)
small mandible  (IAGP)
small nasal bone  (IAGP)
temporal bone squamous part hypoplasia  (IAGP)
thin left ventricle myocardium compact layer  (IAGP)
thin myocardium  (IAGP)
thin ventricular wall  (IAGP)
trabecula carnea hypoplasia  (IAGP)
ventricular hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
zygomatic bone hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Lu MF, etal., Nature 1999 Sep 16;401(6750):276-8.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy. Thattaliyath BD, etal., Biochem Biophys Res Commun 2002 Oct 4;297(4):870-5.
9. Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Wang CC, etal., Dev Biol 2000 Aug 15;224(2):152-67.
10. Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Wei L, etal., Development 2002 Apr;129(7):1705-14.
Additional References at PubMed
PMID:7649392   PMID:7671815   PMID:7791788   PMID:7814632   PMID:8533092   PMID:8948587   PMID:9136933   PMID:9162005   PMID:9171826   PMID:9192865   PMID:9500550   PMID:9500551  
PMID:9576835   PMID:9671575   PMID:9799236   PMID:9811571   PMID:9876177   PMID:10021345   PMID:10189962   PMID:10192400   PMID:10349636   PMID:10393122   PMID:10477299   PMID:10499586  
PMID:10529425   PMID:10611232   PMID:10625532   PMID:10679931   PMID:10807864   PMID:10837126   PMID:10882515   PMID:10892744   PMID:10922068   PMID:10924525   PMID:10973481   PMID:11042159  
PMID:11073884   PMID:11076684   PMID:11076861   PMID:11217851   PMID:11238910   PMID:11297508   PMID:11572777   PMID:11784028   PMID:11854453   PMID:11923873   PMID:12015300   PMID:12070084  
PMID:12074552   PMID:12122109   PMID:12221099   PMID:12370779   PMID:12392994   PMID:12441287   PMID:12466851   PMID:12477932   PMID:12527753   PMID:12571099   PMID:12648486   PMID:12666206  
PMID:12761855   PMID:12858532   PMID:12909338   PMID:14516662   PMID:14573514   PMID:14636580   PMID:14659802   PMID:14667410   PMID:14681479   PMID:15070745   PMID:15073150   PMID:15073151  
PMID:15143159   PMID:15172687   PMID:15196947   PMID:15351717   PMID:15361625   PMID:15363409   PMID:15459098   PMID:15475956   PMID:15509787   PMID:15525990   PMID:15576406   PMID:15618518  
PMID:15680351   PMID:15735646   PMID:15767668   PMID:15788452   PMID:15843407   PMID:15843409   PMID:15843414   PMID:15901664   PMID:15902305   PMID:15936338   PMID:15964823   PMID:16043483  
PMID:16141072   PMID:16141073   PMID:16396910   PMID:16492970   PMID:16496285   PMID:16530167   PMID:16537572   PMID:16554359   PMID:16581799   PMID:16680724   PMID:16759287   PMID:16765933  
PMID:16801545   PMID:16870172   PMID:17050624   PMID:17259303   PMID:17289015   PMID:17397913   PMID:17507395   PMID:17531968   PMID:17573777   PMID:17576928   PMID:17601530   PMID:17609388  
PMID:17764670   PMID:17891141   PMID:17965409   PMID:18000065   PMID:18028541   PMID:18163532   PMID:18287559   PMID:18292603   PMID:18328475   PMID:18448564   PMID:18448675   PMID:18539270  
PMID:18557763   PMID:18583422   PMID:18667074   PMID:18697905   PMID:18724272   PMID:18794365   PMID:19004760   PMID:19060921   PMID:19090619   PMID:19144722   PMID:19185569   PMID:19211672  
PMID:19228596   PMID:19233126   PMID:19376125   PMID:19389368   PMID:19530136   PMID:19727199   PMID:19777594   PMID:19884348   PMID:20059953   PMID:20139090   PMID:20211142   PMID:20368287  
PMID:20412781   PMID:20417598   PMID:20501333   PMID:20506548   PMID:20573702   PMID:20651287   PMID:20652949   PMID:20737509   PMID:20824138   PMID:20837524   PMID:20876643   PMID:20882677  
PMID:20929948   PMID:20941780   PMID:20975697   PMID:21094155   PMID:21145505   PMID:21237142   PMID:21267068   PMID:21302256   PMID:21304516   PMID:21350214   PMID:21558373   PMID:21559426  
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PMID:23372768   PMID:23555309   PMID:23665443   PMID:23776237   PMID:23911935   PMID:24086110   PMID:24146773   PMID:24352558   PMID:24595170   PMID:24680892   PMID:24855001   PMID:24857828  
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PMID:37709743   PMID:38404688  


Genomics

Comparative Map Data
Hand1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391157,719,539 - 57,722,973 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1157,719,531 - 57,723,644 (-)EnsemblGRCm39 Ensembl
GRCm381157,828,713 - 57,832,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1157,828,705 - 57,832,818 (-)EnsemblGRCm38mm10GRCm38
MGSCv371157,642,215 - 57,645,649 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361157,644,908 - 57,648,342 (-)NCBIMGSCv36mm8
Celera1162,581,753 - 62,585,188 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1135.27NCBI
HAND1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385154,474,972 - 154,478,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5154,474,972 - 154,478,227 (-)EnsemblGRCh38hg38GRCh38
GRCh375153,854,532 - 153,857,787 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365153,834,725 - 153,838,017 (-)NCBINCBI36Build 36hg18NCBI36
Build 345153,834,725 - 153,838,017NCBI
Celera5149,930,197 - 149,933,489 (-)NCBICelera
Cytogenetic Map5q33.2NCBI
HuRef5148,995,253 - 148,998,545 (-)NCBIHuRef
CHM1_15153,286,949 - 153,290,241 (-)NCBICHM1_1
T2T-CHM13v2.05155,008,931 - 155,012,186 (-)NCBIT2T-CHM13v2.0
Hand1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81042,507,117 - 42,509,684 (-)NCBIGRCr8
mRatBN7.21042,006,646 - 42,009,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1042,006,651 - 42,009,213 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1046,669,274 - 46,671,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01046,159,536 - 46,162,103 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01041,663,162 - 41,665,729 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01043,250,729 - 43,253,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1043,250,745 - 43,253,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01043,050,068 - 43,052,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41043,423,366 - 43,425,933 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11043,436,993 - 43,439,556 (-)NCBI
Celera1041,298,555 - 41,301,122 (-)NCBICelera
Cytogenetic Map10q22NCBI
Hand1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554088,848,559 - 8,851,994 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554088,848,723 - 8,851,804 (-)NCBIChiLan1.0ChiLan1.0
HAND1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24149,682,104 - 149,685,485 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15147,821,649 - 147,825,030 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05149,876,970 - 149,880,269 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15155,875,100 - 155,878,374 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5155,875,935 - 155,878,166 (-)Ensemblpanpan1.1panPan2
HAND1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1455,231,061 - 55,234,640 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl455,231,481 - 55,234,265 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha455,122,337 - 55,125,872 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0455,665,601 - 55,669,141 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl455,665,977 - 55,668,761 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1455,496,014 - 55,499,549 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0455,594,450 - 55,597,985 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0456,097,022 - 56,100,557 (+)NCBIUU_Cfam_GSD_1.0
Hand1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213109,840,418 - 109,843,804 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365158,289,315 - 8,293,175 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365158,289,764 - 8,292,937 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAND1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1668,677,963 - 68,683,342 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11668,679,977 - 68,683,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21674,589,577 - 74,592,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HAND1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12356,928,164 - 56,935,675 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2356,928,676 - 56,931,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603420,731,670 - 20,734,953 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hand1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473334,731,671 - 34,733,759 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473334,731,671 - 34,733,759 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hand1
164 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1019
Count of miRNA genes:406
Interacting mature miRNAs:490
Transcripts:ENSMUST00000036917, ENSMUST00000108845, ENSMUST00000160392
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse

Markers in Region
Hand1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381157,829,410 - 57,829,669UniSTSGRCm38
MGSCv371157,642,912 - 57,643,171UniSTSGRCm37
Celera1162,582,451 - 62,582,710UniSTS
Cytogenetic Map11B1.3UniSTS
cM Map1132.0UniSTS
U21226  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381157,829,262 - 57,829,444UniSTSGRCm38
MGSCv371157,642,764 - 57,642,946UniSTSGRCm37
Celera1162,582,303 - 62,582,485UniSTS
Cytogenetic Map11B1.3UniSTS
Whitehead_YAC11 UniSTS
Hand1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
Hand1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381157,831,262 - 57,831,481UniSTSGRCm38
Celera1162,584,303 - 62,584,522UniSTS
Cytogenetic Map11B1.3UniSTS
Hand1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
Hand1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
Hand1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
Hand1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS
cM Map1132.0UniSTS
Hand1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000036917   ⟹   ENSMUSP00000046999
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1157,719,533 - 57,722,973 (-)Ensembl
GRCm38.p6 Ensembl1157,828,707 - 57,832,147 (-)Ensembl
RefSeq Acc Id: ENSMUST00000108845   ⟹   ENSMUSP00000104473
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1157,722,520 - 57,723,644 (-)Ensembl
GRCm38.p6 Ensembl1157,831,694 - 57,832,818 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160392   ⟹   ENSMUSP00000124951
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1157,719,531 - 57,723,644 (-)Ensembl
GRCm38.p6 Ensembl1157,828,705 - 57,832,818 (-)Ensembl
RefSeq Acc Id: NM_008213   ⟹   NP_032239
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391157,719,539 - 57,722,973 (-)NCBI
GRCm381157,828,713 - 57,832,147 (-)ENTREZGENE
MGSCv371157,642,215 - 57,645,649 (-)RGD
Celera1162,581,753 - 62,585,188 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032239   ⟸   NM_008213
- UniProtKB: Q61099 (UniProtKB/Swiss-Prot),   Q64279 (UniProtKB/Swiss-Prot),   Q5SQG1 (UniProtKB/TrEMBL),   Q80UL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000124951   ⟸   ENSMUST00000160392
RefSeq Acc Id: ENSMUSP00000046999   ⟸   ENSMUST00000036917
RefSeq Acc Id: ENSMUSP00000104473   ⟸   ENSMUST00000108845
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64279-F1-model_v2 AlphaFold Q64279 1-216 view protein structure

Promoters
RGD ID:8674732
Promoter ID:EPDNEW_M15397
Type:multiple initiation site
Name:Hand1_1
Description:Mus musculus heart and neural crest derivatives expressed 1 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381157,832,012 - 57,832,072EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103577 AgrOrtholog
Ensembl Genes ENSMUSG00000037335 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000036917 ENTREZGENE
  ENSMUST00000036917.3 UniProtKB/Swiss-Prot
  ENSMUST00000108845.3 UniProtKB/TrEMBL
  ENSMUST00000160392.9 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:103577 ENTREZGENE
NCBI Gene 15110 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hand1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HAND1_MOUSE UniProtKB/Swiss-Prot
  Q5SQG0_MOUSE UniProtKB/TrEMBL
  Q5SQG1 ENTREZGENE, UniProtKB/TrEMBL
  Q61099 ENTREZGENE
  Q64279 ENTREZGENE
  Q80UL7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q61099 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-08 Hand1  heart and neural crest derivatives expressed 1    heart and neural crest derivatives expressed transcript 1  Symbol and/or name change 5135510 APPROVED